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Volumn 10, Issue 15, 2004, Pages 1767-1784

Therapeutic potential of Janus kinase 3 (JAK3) inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 BROMO 4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (3' BROMO 4' HYDROXYPHENYL)AMINO 6,7 DIMETHOXYQUINAZOLINE; 4 (3',5' DIBROMO 4' HYDROXYPHENYL)AMINO 6,7 DIMETHOXYQUINAZOLINE; 4 (3,5 DIBROMO 4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4' HYDROXYPHENYL)AMINO 6,7 DIMETHOXYQUINAZOLINE; AZATHIOPRINE; CT 2576; CYCLOSPORIN A; ENZYME INHIBITOR; FUSIDATE SODIUM; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; JANUS KINASE; JANUS KINASE 3 INHIBITOR; LEFLUNOMIDE; METHOTREXATE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PNU 156804; PREDNISOLONE; PROTEIN TYROSINE KINASE INHIBITOR; RAPAMYCIN; ROQUINIMEX; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; STAT6 PROTEIN; TACROLIMUS; TYRPHOSTIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 2442464602     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612043384529     Document Type: Review
Times cited : (26)

References (234)
  • 1
    • 0026081302 scopus 로고
    • Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase
    • Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol 1991; 11: 2057-2065.
    • (1991) Mol. Cell Biol. , vol.11 , pp. 2057-2065
    • Wilks, A.F.1    Harpur, A.G.2    Kurban, R.R.3    Ralph, S.J.4    Zurcher, G.5    Ziemiecki, A.6
  • 3
    • 0028268381 scopus 로고
    • Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases
    • Takahashi T, Shirasawa T. Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases. FEBS Lett 1994; 342: 124-128.
    • (1994) FEBS Lett. , vol.342 , pp. 124-128
    • Takahashi, T.1    Shirasawa, T.2
  • 4
    • 0025278593 scopus 로고
    • Identification and chromosomal mapping of new human tyrosine kinase genes
    • Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R. Identification and chromosomal mapping of new human tyrosine kinase genes. Oncogene 1990; 5: 277-282.
    • (1990) Oncogene , vol.5 , pp. 277-282
    • Krolewski, J.J.1    Lee, R.2    Eddy, R.3    Shows, T.B.4    Dalla-Favera, R.5
  • 5
    • 0026632288 scopus 로고
    • A protin tyrosine kinase in the interferon alpha/beta signaling pathway
    • Velazquez L, Fellous M, Stark GR, Pellegrini S. A protin tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 1992; 70: 313-322.
    • (1992) Cell , vol.70 , pp. 313-322
    • Velazquez, L.1    Fellous, M.2    Stark, G.R.3    Pellegrini, S.4
  • 6
    • 0027914830 scopus 로고
    • The protein tyrosine kinase JAK1 complements defects in intrferon-alpha/beta and-gamma signal transduction
    • Muller M, Briscoe J, Laxton C, Guschin D, Ziemicki A, Silvennoinen O, et al. The protein tyrosine kinase JAK1 complements defects in intrferon-alpha/beta and-gamma signal transduction. Nature 1993; 366: 114-116.
    • (1993) Nature , vol.366 , pp. 114-116
    • Muller, M.1    Briscoe, J.2    Laxton, C.3    Guschin, D.4    Ziemicki, A.5    Silvennoinen, O.6
  • 7
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and Stats: Biological implications
    • Leonard WJ, O'Shea JJ. Jaks and Stats: Biological implications. Annu Rev Immunol 1998; 16: 293-322.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 8
    • 0036256836 scopus 로고    scopus 로고
    • Series introduction. JAK-STAT signaling in human disease
    • Schindler CW. Series introduction. JAK-STAT signaling in human disease. J Clin Invest 2002; 109(9): 1133-7.
    • (2002) J. Clin. Invest. , vol.109 , Issue.9 , pp. 1133-1137
    • Schindler, C.W.1
  • 10
    • 0027327484 scopus 로고
    • JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    • Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, et al. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 1993; 74: 227-36.
    • (1993) Cell , vol.74 , pp. 227-236
    • Witthuhn, B.A.1    Quelle, F.W.2    Silvennoinen, O.3    Yi, T.4    Tang, B.5    Miura, O.6
  • 11
    • 0037138370 scopus 로고    scopus 로고
    • Signaling through the JAK/STAT pathway, recent advances and future challenges
    • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002; 285(1-2): 1-24.
    • (2002) Gene , vol.285 , Issue.1-2 , pp. 1-24
    • Kisseleva, T.1    Bhattacharya, S.2    Braunstein, J.3    Schindler, C.W.4
  • 12
    • 0029855513 scopus 로고    scopus 로고
    • Coupling of the IL2 receptor complex with non-receptor protien tyrosine kinases
    • Miyazaki T, Taniguchi T. Coupling of the IL2 receptor complex with non-receptor protien tyrosine kinases. Cancer Surveys 1996; 27: 25-39.
    • (1996) Cancer Surveys , vol.27 , pp. 25-39
    • Miyazaki, T.1    Taniguchi, T.2
  • 13
  • 14
    • 0028921573 scopus 로고
    • Jaks and Stats in signaling by the cytokine receptor superfamily
    • Ihle JN, Kerr IR. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 1995; 11: 69-74.
    • (1995) Trends Genet. , vol.11 , pp. 69-74
    • Ihle, J.N.1    Kerr, I.R.2
  • 15
    • 0036304625 scopus 로고    scopus 로고
    • Role of the leukemia-associated transcription factor STAT3 in platelet physiology
    • Vassilev AO, Lorenz DR, Tibbles HE, Uckun FM. Role of the leukemia-associated transcription factor STAT3 in platelet physiology. Leuk Lymphoma 2002; 43(7): 1461-7.
    • (2002) Leuk. Lymphoma , vol.43 , Issue.7 , pp. 1461-1467
    • Vassilev, A.O.1    Lorenz, D.R.2    Tibbles, H.E.3    Uckun, F.M.4
  • 16
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JEJ, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264: 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.J.1    Kerr, I.M.2    Stark, G.R.3
  • 17
    • 0028301958 scopus 로고
    • Molecular cloning of L-JAK, a Janus family protein kinase expressed i natural killer cels and activated leukocytes
    • Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, et al. Molecular cloning of L-JAK, a Janus family protein kinase expressed i natural killer cels and activated leukocytes. Proc Natl Acad Sci USA 1994; 91: 6374-6378.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6374-6378
    • Kawamura, M.1    McVicar, D.W.2    Johnston, J.A.3    Blake, T.B.4    Chen, Y.Q.5    Lal, B.K.6
  • 18
    • 0029865748 scopus 로고    scopus 로고
    • Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells
    • Gurniak CB, Berg LJ. Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood 1996; 87(8): 3151-3160.
    • (1996) Blood , vol.87 , Issue.8 , pp. 3151-3160
    • Gurniak, C.B.1    Berg, L.J.2
  • 20
    • 0028786653 scopus 로고
    • Regulation of JAK3 expression and activation in human B cells and B cell malignancies
    • Tortolani PJ, Lal BK, Riva A, Johnston JA, Chen YQ, Reaman GH, et al. Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J Immunol 1995; 155: 5220-5226.
    • (1995) J. Immunol. , vol.155 , pp. 5220-5226
    • Tortolani, P.J.1    Lal, B.K.2    Riva, A.3    Johnston, J.A.4    Chen, Y.Q.5    Reaman, G.H.6
  • 21
  • 22
    • 0028171065 scopus 로고
    • Interaction of IL-2R beta and gama c chains with Jak1 an Jak3: Implications for XSCID and XCID
    • Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, et al. Interaction of IL-2R beta and gama c chains with Jak1 an Jak3: implications for XSCID and XCID. Science 1994; 266: 1042-1045.
    • (1994) Science , vol.266 , pp. 1042-1045
    • Russell, S.M.1    Johnston, J.A.2    Noguchi, M.3    Kawamura, M.4    Bacon, C.M.5    Friedmann, M.6
  • 23
    • 0027403374 scopus 로고
    • Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
    • Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, et al. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993; 73: 147-157.
    • (1993) Cell , vol.73 , pp. 147-157
    • Noguchi, M.1    Yi, H.2    Rosenblatt, H.M.3    Filipovich, A.H.4    Adelstein, S.5    Modi, W.S.6
  • 24
    • 0029924265 scopus 로고    scopus 로고
    • The molecular basis of X-linked severe combined immunodeficiency: Defective cytokine receptor signaling
    • Leonard WJ. The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu Rev Med 1996; 47: 229-239.
    • (1996) Annu. Rev. Med. , vol.47 , pp. 229-239
    • Leonard, W.J.1
  • 25
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995; 377: 65-68.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1    Villa, A.2    Giliani, S.3    Sacco, M.G.4    Frattini, A.5    Porta, F.6
  • 26
    • 0028857954 scopus 로고
    • Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
    • Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 1995; 270: 797-800.
    • (1995) Science , vol.270 , pp. 797-800
    • Russell, S.M.1    Tayebi, N.2    Nakajima, H.3    Riedy, M.C.4    Roberts, J.L.5    Aman, M.J.6
  • 27
    • 0030862399 scopus 로고    scopus 로고
    • Human severe combined immunodeficiency: Genetic phenotypic and functional diversity in one hundred eight infants
    • Buckley RH, Schiff RI, Schiff SE, Markert ML, Williams LW, Harville TO, et al. Human severe combined immunodeficiency: genetic phenotypic and functional diversity in one hundred eight infants. J Pediatr 1997; 130: 378-387.
    • (1997) J. Pediatr. , vol.130 , pp. 378-387
    • Buckley, R.H.1    Schiff, R.I.2    Schiff, S.E.3    Markert, M.L.4    Williams, L.W.5    Harville, T.O.6
  • 29
    • 0029550822 scopus 로고
    • Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
    • Park SY, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, et al. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 1995; 3: 771-782.
    • (1995) Immunity , vol.3 , pp. 771-782
    • Park, S.Y.1    Saijo, K.2    Takahashi, T.3    Osawa, M.4    Arase, H.5    Hirayama, N.6
  • 30
    • 0028799457 scopus 로고
    • Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
    • Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 1995; 270: 794-797.
    • (1995) Science , vol.270 , pp. 794-797
    • Thomis, D.C.1    Gurniak, C.B.2    Tivol, E.3    Sharpe, A.H.4    Berg, L.J.5
  • 31
    • 0028925778 scopus 로고
    • Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
    • Cao X, Shores EW, Hu LI J, Anver MR, Kelsall BL, Rusell SM, et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995; 2: 223-238.
    • (1995) Immunity , vol.2 , pp. 223-238
    • Cao, X.1    Shores, E.W.2    Hu, L.I.J.3    Anver, M.R.4    Kelsall, B.L.5    Rusell, S.M.6
  • 33
    • 0037047025 scopus 로고    scopus 로고
    • The common gamma chain (gamma c) is required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3
    • Habib T, Senadheera S, Weinberg K, Kaushansky K. The common gamma chain (gamma c) is required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 2002; 41: 8725-8731.
    • (2002) Biochemistry , vol.41 , pp. 8725-8731
    • Habib, T.1    Senadheera, S.2    Weinberg, K.3    Kaushansky, K.4
  • 34
    • 0033571460 scopus 로고    scopus 로고
    • The JAK family tyrosine kinase JAK3 is required for IL-2 synthesis by naive/resting CD4+ T-cells
    • Thomis DC, Aramburu J, Berg LJ. The JAK family tyrosine kinase JAK3 is required for IL-2 synthesis by naive/resting CD4+ T-cells. J Immunol 1999; 163: 5411-5417.
    • (1999) J. Immunol. , vol.163 , pp. 5411-5417
    • Thomis, D.C.1    Aramburu, J.2    Berg, L.J.3
  • 35
    • 0035816692 scopus 로고    scopus 로고
    • Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex
    • Tomita K, Saijo K, Yamasaki S, Lida T, Nakatsu F, Arase H, et al. Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex. J Biol Chem 2001; 276: 25378-25385.
    • (2001) J. Biol. Chem. , vol.276 , pp. 25378-25385
    • Tomita, K.1    Saijo, K.2    Yamasaki, S.3    Lida, T.4    Nakatsu, F.5    Arase, H.6
  • 36
    • 0141426807 scopus 로고    scopus 로고
    • Prevention of islet allograft rejection in diabetic mice by targeting Janus kinase 3 with [4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline] (JANEX-1)
    • Cetkovic-Cvrlje M, Dragt AL, Uckun FM. Prevention of islet allograft rejection in diabetic mice by targeting Janus kinase 3 with [4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline] (JANEX-1). Drug Research 2003; 53: 648-654.
    • (2003) Drug Research , vol.53 , pp. 648-654
    • Cetkovic-Cvrlje, M.1    Dragt, A.L.2    Uckun, F.M.3
  • 37
    • 0036306320 scopus 로고    scopus 로고
    • Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor
    • Cetkovic-Cvrlje M, Roers BA, Schonhoff D, Waurzyniak B, Liu XP, Uckun FM. Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor. Leukemia and lymphoma 2002; 43: 1447-1553.
    • (2002) Leukemia and Lymphoma , vol.43 , pp. 1447-1553
    • Cetkovic-Cvrlje, M.1    Roers, B.A.2    Schonhoff, D.3    Waurzyniak, B.4    Liu, X.P.5    Uckun, F.M.6
  • 38
    • 2442528905 scopus 로고    scopus 로고
    • Targeting Janus kinase 3 (JAK3) in the treatment of leukemia and inflammatory diseases
    • in press
    • Cetkovic-Cvrlje M, Uckun FM. Targeting Janus kinase 3 (JAK3) in the treatment of leukemia and inflammatory diseases. AITE 2003; in press.
    • (2003) AITE
    • Cetkovic-Cvrlje, M.1    Uckun, F.M.2
  • 39
    • 0033053383 scopus 로고    scopus 로고
    • Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing anti-leukemic agents
    • Sudbeck EA, Liu X-P, Narla RK, Mahajan S, Ghosh S, Mao C, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing anti-leukemic agents. Clin Cancer Res 1999; 5: 1569-1582.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1569-1582
    • Sudbeck, E.A.1    Liu, X.-P.2    Narla, R.K.3    Mahajan, S.4    Ghosh, S.5    Mao, C.6
  • 40
    • 0030994917 scopus 로고    scopus 로고
    • Cyovaricin B, a new inhibitor of JAK-STAT signal transduction produced by stroptomyces torulosus
    • Yamashita N, Kazuo S, Kitamura M, Wakao H, Furihata K, Furihata K, et al. Cyovaricin B, a new inhibitor of JAK-STAT signal transduction produced by stroptomyces torulosus. J Antibiot 1997; 50: 440-442.
    • (1997) J. Antibiot. , vol.50 , pp. 440-442
    • Yamashita, N.1    Kazuo, S.2    Kitamura, M.3    Wakao, H.4    Furihata, K.5    Furihata, K.6
  • 41
    • 0031898875 scopus 로고    scopus 로고
    • Suppresion of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine
    • Wasik M, Nowak I, Zhang Q, Shaw L. Suppresion of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine. Leuk Lymphoma 1998; 28: 551-560.
    • (1998) Leuk. Lymphoma , vol.28 , pp. 551-560
    • Wasik, M.1    Nowak, I.2    Zhang, Q.3    Shaw, L.4
  • 42
    • 0033557695 scopus 로고    scopus 로고
    • Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression
    • Manna S, Aggarwal B. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. J Immunol 1999; 162: 2095-2102.
    • (1999) J. Immunol. , vol.162 , pp. 2095-2102
    • Manna, S.1    Aggarwal, B.2
  • 43
    • 0027501428 scopus 로고
    • Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide
    • Mattar T, Kochhar K, Bartlett R, Bremer E, Finnegan A. Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. FEBS Lett 1993; 334: 161-164.
    • (1993) FEBS Lett. , vol.334 , pp. 161-164
    • Mattar, T.1    Kochhar, K.2    Bartlett, R.3    Bremer, E.4    Finnegan, A.5
  • 44
    • 0031785254 scopus 로고    scopus 로고
    • α-Cyano-β-hydroxy-β-methyl-N-[4-(trifluoromethoxy phenyl]propenamide: An inhibitor of the EGF receptor tryosine kinase with potent cytotoxic activity against breast cancer cells
    • Ghosh S, Zheng Y, Jun X, Narla R, Mahajan S, Navara C, et al. α-Cyano-β-hydroxy-β-methyl-N-[4-(trifluoromethoxy phenyl]propenamide: an inhibitor of the EGF receptor tryosine kinase with potent cytotoxic activity against breast cancer cells. Clin Can Res 1998; 4: 2657-2668.
    • (1998) Clin. Can. Res. , vol.4 , pp. 2657-2668
    • Ghosh, S.1    Zheng, Y.2    Jun, X.3    Narla, R.4    Mahajan, S.5    Navara, C.6
  • 45
    • 0032519992 scopus 로고    scopus 로고
    • Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production
    • Siemasko K, Chong A, Jack H, Gong H, Williams J, Finnegan A. Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. J Immunol 1998, 160: 1581-1588.
    • (1998) J. Immunol. , vol.160 , pp. 1581-1588
    • Siemasko, K.1    Chong, A.2    Jack, H.3    Gong, H.4    Williams, J.5    Finnegan, A.6
  • 46
    • 0029083427 scopus 로고
    • Inhibition of protein phosphorylation modulates expression of the Jak family protein tyrosine kinases
    • Fiorucci G, Percario Z, Marcolin C, Coccia E, Affabris E, Romeo G. Inhibition of protein phosphorylation modulates expression of the Jak family protein tyrosine kinases. J Virol 1995; 69: 5833-5837.
    • (1995) J. Virol. , vol.69 , pp. 5833-5837
    • Fiorucci, G.1    Percario, Z.2    Marcolin, C.3    Coccia, E.4    Affabris, E.5    Romeo, G.6
  • 47
    • 0023258497 scopus 로고
    • Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60
    • Nakano H, Kobayashi E, Takahashi I, Tamaoki T, Kuzuu Y, Iba H. Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60. J Antibiot 1987; 40: 706-708.
    • (1987) J. Antibiot. , vol.40 , pp. 706-708
    • Nakano, H.1    Kobayashi, E.2    Takahashi, I.3    Tamaoki, T.4    Kuzuu, Y.5    Iba, H.6
  • 48
    • 0028866845 scopus 로고
    • Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2
    • Meggio F, Donella D, Ruzzene M, Brunati A, Cesaro L, Guerra B, et al. Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem 1995; 234: 317-322.
    • (1995) Eur. J. Biochem. , vol.234 , pp. 317-322
    • Meggio, F.1    Donella, D.2    Ruzzene, M.3    Brunati, A.4    Cesaro, L.5    Guerra, B.6
  • 49
    • 0033555270 scopus 로고    scopus 로고
    • Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine
    • Lamers M, Antson A, Hubbard R, Scott R, Williams D. Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine. J Mol Biol 1999; 285: 713-725.
    • (1999) J. Mol. Biol. , vol.285 , pp. 713-725
    • Lamers, M.1    Antson, A.2    Hubbard, R.3    Scott, R.4    Williams, D.5
  • 52
    • 0001123864 scopus 로고    scopus 로고
    • JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tryphostin AG-490 regulation of IL-2-mediated T cell response
    • Wang L, Kirken R, Erwin R, Yu C, Farrar W. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tryphostin AG-490 regulation of IL-2-mediated T cell response. J Immunol 1999; 162(7): 3897-3904.
    • (1999) J. Immunol. , vol.162 , Issue.7 , pp. 3897-3904
    • Wang, L.1    Kirken, R.2    Erwin, R.3    Yu, C.4    Farrar, W.5
  • 53
    • 2042503119 scopus 로고    scopus 로고
    • Tyrphostin AG-490 inhibits cytokine-mediatd JAK3/STAT5a/b signal transduction and cellula proliferation of antigen-activated human T-cells
    • Kirken RA, Erwin RA, Taub D, Murphy WJ, Behbod F, Wang L, et al. Tyrphostin AG-490 inhibits cytokine-mediatd JAK3/STAT5a/b signal transduction and cellula proliferation of antigen-activated human T-cells. J Leukoc Biol 1999; 65: 891-899.
    • (1999) J. Leukoc. Biol. , vol.65 , pp. 891-899
    • Kirken, R.A.1    Erwin, R.A.2    Taub, D.3    Murphy, W.J.4    Behbod, F.5    Wang, L.6
  • 54
    • 0035080519 scopus 로고    scopus 로고
    • Tyrphostin AG-490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts
    • Kirken RA, Erwin-Cohen R, Behbod F, Wang M, Stepkowski SM, Kahan BD. Tyrphostin AG-490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts. Transplant Proc 2001; 33:95.
    • (2001) Transplant. Proc. , vol.33 , pp. 95
    • Kirken, R.A.1    Erwin-Cohen, R.2    Behbod, F.3    Wang, M.4    Stepkowski, S.M.5    Kahan, B.D.6
  • 55
    • 0344466789 scopus 로고    scopus 로고
    • In vivo toxicity and pharmacokinetic features of the Janus kinase 3 inhibitor WHI-P131 [4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline]
    • Uckun FM, Ek O, Liu X-P, Chen C-L. In vivo toxicity and pharmacokinetic features of the Janus kinase 3 inhibitor WHI-P131 [4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline]. Clin. Cancer. Res. 1999; 5: 2954-2962.
    • (1999) Clin. Cancer. Res. , vol.5 , pp. 2954-2962
    • Uckun, F.M.1    Ek, O.2    Liu, X.-P.3    Chen, C.-L.4
  • 56
    • 0037079735 scopus 로고    scopus 로고
    • Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin
    • Stepkowski SM, Erwin-Cohen RA, Behbod F, Wang ME, Qu X, Tejpal N, et al. Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood 2002; 15: 680-9.
    • (2002) Blood , vol.15 , pp. 680-689
    • Stepkowski, S.M.1    Erwin-Cohen, R.A.2    Behbod, F.3    Wang, M.E.4    Qu, X.5    Tejpal, N.6
  • 57
    • 0031755916 scopus 로고    scopus 로고
    • Inhibition of human glioblastoma cell adhesion and invasion by 4-(4′-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3′-bromo-4′-hydroxylphenyl -amino-6,7-dimethoxyquinazoline (WHI-P154)
    • Narla RK, Liu XP, Klis D, Uckun FM. Inhibition of human glioblastoma cell adhesion and invasion by 4-(4′-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3′-bromo-4′-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154). Clin Cancer Res 1998; 4(10): 2463-71.
    • (1998) Clin. Cancer Res. , vol.4 , Issue.10 , pp. 2463-2471
    • Narla, R.K.1    Liu, X.P.2    Klis, D.3    Uckun, F.M.4
  • 58
    • 0033053383 scopus 로고    scopus 로고
    • Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
    • Sudbeck EA, Liu XP, Narla RK, Mahajan S, Ghosh S, Mao C, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res 1999; 5(6): 1569-82.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.6 , pp. 1569-1582
    • Sudbeck, E.A.1    Liu, X.P.2    Narla, R.K.3    Mahajan, S.4    Ghosh, S.5    Mao, C.6
  • 59
    • 0035469862 scopus 로고    scopus 로고
    • Targeting Janus Kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice
    • Cetkovic-Cvrlje M, Roers BA, Waurzyniak B, Liu XP, Uckun FM. Targeting Janus Kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice. Blood 2001; 98: 1607-13.
    • (2001) Blood , vol.98 , pp. 1607-1613
    • Cetkovic-Cvrlje, M.1    Roers, B.A.2    Waurzyniak, B.3    Liu, X.P.4    Uckun, F.M.5
  • 61
    • 0033180185 scopus 로고    scopus 로고
    • Stat5 activation is uniquely associated with cytokine signaling inperipheral T-cells
    • Moriggl R, Sexl V, Piekorz R, Topham D, Ihle JN. Stat5 activation is uniquely associated with cytokine signaling inperipheral T-cells. Immunity 1999; 11: 225-30.
    • (1999) Immunity , vol.11 , pp. 225-230
    • Moriggl, R.1    Sexl, V.2    Piekorz, R.3    Topham, D.4    Ihle, J.N.5
  • 62
    • 0033082138 scopus 로고    scopus 로고
    • Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
    • Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 1999; 10: 249-259.
    • (1999) Immunity , vol.10 , pp. 249-259
    • Moriggl, R.1    Topham, D.J.2    Teglund, S.3    Sexl, V.4    McKay, C.5    Wang, D.6
  • 63
    • 0037360589 scopus 로고    scopus 로고
    • Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabtes in NOD mice
    • Cetkovic-Cvrlje M, Dragt AL, Vassilev A, Liu XP, Uckun FM. Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabtes in NOD mice. Clin Immunol 2003; 106: 213-25.
    • (2003) Clin. Immunol. , vol.106 , pp. 213-225
    • Cetkovic-Cvrlje, M.1    Dragt, A.L.2    Vassilev, A.3    Liu, X.P.4    Uckun, F.M.5
  • 64
    • 0035869505 scopus 로고    scopus 로고
    • Concomitant inhibition of Janus Kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat allografts
    • Behbod F, Erwin-Cohen RA, Wang ME, Trawick BW, Qu X, Verani R, et al. Concomitant inhibition of Janus Kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat allografts. J Immunol 2001; 166: 3724-3732.
    • (2001) J. Immunol. , vol.166 , pp. 3724-3732
    • Behbod, F.1    Erwin-Cohen, R.A.2    Wang, M.E.3    Trawick, B.W.4    Qu, X.5    Verani, R.6
  • 65
    • 0034721912 scopus 로고    scopus 로고
    • Suppression of primary T-cell responses and induction nf alloantiogen-specific hyporesponsiveness in vitro by the Janus kinase inhibitor tyrphostin AG490
    • Saemann MD, Bohmig GA, Osterreicher CH, Staffler G, Diakos C, Krieger PM, et al. Suppression of primary T-cell responses and induction nf alloantiogen-specific hyporesponsiveness in vitro by the Janus kinase inhibitor tyrphostin AG490. Transplantation 2000; 70(8): 1215-25.
    • (2000) Transplantation , vol.70 , Issue.8 , pp. 1215-1225
    • Saemann, M.D.1    Bohmig, G.A.2    Osterreicher, C.H.3    Staffler, G.4    Diakos, C.5    Krieger, P.M.6
  • 66
    • 0033564946 scopus 로고    scopus 로고
    • New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kB and AP-1 activation
    • Mortellaro A, Songia S, Gnochi P, Ferrari M, Fornasiero C, D'Alessio R, et al. New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kB and AP-1 activation. J Immunol 1999; 162: 7102-09.
    • (1999) J. Immunol. , vol.162 , pp. 7102-7109
    • Mortellaro, A.1    Songia, S.2    Gnochi, P.3    Ferrari, M.4    Fornasiero, C.5    D'Alessio, R.6
  • 68
    • 0037708570 scopus 로고    scopus 로고
    • Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154
    • Saemann MD, Zeyda M, Diakos C, Szekeres A, Bohmig GA, Kelemen P, et al. Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154. Transplantation 2003; 75: 1864-1872.
    • (2003) Transplantation , vol.75 , pp. 1864-1872
    • Saemann, M.D.1    Zeyda, M.2    Diakos, C.3    Szekeres, A.4    Bohmig, G.A.5    Kelemen, P.6
  • 70
    • 0028964106 scopus 로고
    • Mismatched bone marrow transplantation
    • Henslee-Downey PJ. Mismatched bone marrow transplantation. Curr Opin Oncol 1995; 7(2): 115-121.
    • (1995) Curr. Opin. Oncol. , vol.7 , Issue.2 , pp. 115-121
    • Henslee-Downey, P.J.1
  • 71
    • 0028960807 scopus 로고
    • Graft-versus-host disease prophylaxis for matched unrelated donor bone marrow transplantation: Comparison between cyclosporine-methotrexate and cyclosporine-methotrexate-methylprednisolone
    • Leelasiri A, Greer JP, Stein RS, Goodman S, Brandt SA, Edwards JR, et al. Graft-versus-host disease prophylaxis for matched unrelated donor bone marrow transplantation: comparison between cyclosporine-methotrexate and cyclosporine-methotrexate-methylprednisolone. Bone Marrow Transplant 1995; 15: 401-405.
    • (1995) Bone Marrow Transplant. , vol.15 , pp. 401-405
    • Leelasiri, A.1    Greer, J.P.2    Stein, R.S.3    Goodman, S.4    Brandt, S.A.5    Edwards, J.R.6
  • 72
    • 0020975357 scopus 로고
    • Allogeneic bone marrow transplantation: Current status and future directions
    • O'Reilly RJ. Allogeneic bone marrow transplantation: current status and future directions. Blood 1983; 62: 941-964.
    • (1983) Blood , vol.62 , pp. 941-964
    • O'Reilly, R.J.1
  • 73
    • 0028535680 scopus 로고
    • Allogeneic bone marrow transplantation for leukemia
    • Butturini A, Gale RP. Allogeneic bone marrow transplantation for leukemia. Cur Opin Hematol 1994; 1: 402-405.
    • (1994) Cur. Opin. Hematol. , vol.1 , pp. 402-405
    • Butturini, A.1    Gale, R.P.2
  • 74
    • 0025008618 scopus 로고
    • Indications for marrow transplantation in acute lymphoblastic leukemia
    • Ramsay NK, Kersey JH. Indications for marrow transplantation in acute lymphoblastic leukemia. Blood 1990; 75: 815-818.
    • (1990) Blood , vol.75 , pp. 815-818
    • Ramsay, N.K.1    Kersey, J.H.2
  • 75
    • 0026658802 scopus 로고
    • In vitro separation of host specific graft-versus-host and graft-versus-leukemia cytotoxic T cell activities
    • Van Lochem E, De Gast B, Goulmy E. In vitro separation of host specific graft-versus-host and graft-versus-leukemia cytotoxic T cell activities. Bone Marrow Transplant 1992; 10: 181-183.
    • (1992) Bone Marrow Transplant. , vol.10 , pp. 181-183
    • Van Lochem, E.1    De Gast, B.2    Goulmy, E.3
  • 76
    • 0029127205 scopus 로고
    • Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation: Implications for graft-versus-leukemia reactivity
    • Faber LM, Van Luxemburg-Heijs SA, Veenhof WF, Willemze R, Falkenburg JH. Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation: implications for graft-versus-leukemia reactivity. Blood 1995: 2821-2828.
    • (1995) Blood , pp. 2821-2828
    • Faber, L.M.1    Van Luxemburg-Heijs, S.A.2    Veenhof, W.F.3    Willemze, R.4    Falkenburg, J.H.5
  • 77
    • 0027945477 scopus 로고
    • Distinct T-cell populations distinguish chronic myeloid leukaemia cells from lymphocytes in the same individual: A model for separating GVHD from GVL reactions
    • Datta AR, Barrett AJ, Jiang JZ, Guimaraes A, Mavroudis DA, van Rhee F, et al. Distinct T-cell populations distinguish chronic myeloid leukaemia cells from lymphocytes in the same individual: a model for separating GVHD from GVL reactions. Bone Marrow Transplant 1994; 14: 517-524.
    • (1994) Bone Marrow Transplant. , vol.14 , pp. 517-524
    • Datta, A.R.1    Barrett, A.J.2    Jiang, J.Z.3    Guimaraes, A.4    Mavroudis, D.A.5    van Rhee, F.6
  • 78
    • 0028817958 scopus 로고
    • An MHC-compatible allogeneic bone marrow donor with a distinct role of T-cell subsets in graft-versus-leukemia effect and lethal graft-versus-host disease
    • Aizawa S, Kamisaku H, Sado T. An MHC-compatible allogeneic bone marrow donor with a distinct role of T-cell subsets in graft-versus-leukemia effect and lethal graft-versus-host disease. Bone Marrow Transplant 1995; 16: 603-609.
    • (1995) Bone Marrow Transplant. , vol.16 , pp. 603-609
    • Aizawa, S.1    Kamisaku, H.2    Sado, T.3
  • 79
    • 0025784907 scopus 로고
    • Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow
    • Truitt RL, Atasoylu AA. Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow. Bone Marrow Transplant 1991; 8: 51-58.
    • (1991) Bone Marrow Transplant. , vol.8 , pp. 51-58
    • Truitt, R.L.1    Atasoylu, A.A.2
  • 80
    • 0027964454 scopus 로고
    • Graft-versus-myeloid leukemia responses following syngeneic and allogeneic bone marrow transplantation
    • Korngold R, Leighton C, Manser T. Graft-versus-myeloid leukemia responses following syngeneic and allogeneic bone marrow transplantation. Transplantation 1994; 56: 278-287.
    • (1994) Transplantation , vol.56 , pp. 278-287
    • Korngold, R.1    Leighton, C.2    Manser, T.3
  • 81
    • 0026763856 scopus 로고
    • A decrease in graft-versus-host disease without loss of graft-versus-leukemia reactivity after MHC-matched bone marrow transplantation by selective depletion of donor NK cells in vivo
    • Johnson BD, Truitt RL. A decrease in graft-versus-host disease without loss of graft-versus-leukemia reactivity after MHC-matched bone marrow transplantation by selective depletion of donor NK cells in vivo. Transplantation 1992; 54: 104-112.
    • (1992) Transplantation , vol.54 , pp. 104-112
    • Johnson, B.D.1    Truitt, R.L.2
  • 82
    • 0030004988 scopus 로고    scopus 로고
    • Graft-versus-host reactivity and graft-versus-leukemia effect in murine allogeneic bone marrow chimeras conditioned with total body irradiation or total lymphoid irradiation
    • Salam A, Waer M. Graft-versus-host reactivity and graft-versus-leukemia effect in murine allogeneic bone marrow chimeras conditioned with total body irradiation or total lymphoid irradiation. Transplantation 1996; 61: 826-830.
    • (1996) Transplantation , vol.61 , pp. 826-830
    • Salam, A.1    Waer, M.2
  • 83
    • 0028901018 scopus 로고
    • Enhancement of GVL effect with rhIL-2 following BMT in a murine model for acute myeloid leukemia in SJL/mice
    • Vourka-Karussis U, Karrusis D, Ackerstein A, Slavin S. Enhancement of GVL effect with rhIL-2 following BMT in a murine model for acute myeloid leukemia in SJL/mice. Exp Hematol 1995; 23: 196-201.
    • (1995) Exp. Hematol. , vol.23 , pp. 196-201
    • Vourka-Karussis, U.1    Karrusis, D.2    Ackerstein, A.3    Slavin, S.4
  • 84
    • 0028215558 scopus 로고
    • Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects
    • Sykes M, Harty MW, Szot GL, Pearson DA. Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects. Blood 1994; 83: 2560-2569.
    • (1994) Blood , vol.83 , pp. 2560-2569
    • Sykes, M.1    Harty, M.W.2    Szot, G.L.3    Pearson, D.A.4
  • 85
    • 0033561434 scopus 로고    scopus 로고
    • Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation
    • Tsukada N, Kobata T, Aizawa Y, Yagita H, Okumura K. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood 1999; 93: 2738-2747.
    • (1999) Blood , vol.93 , pp. 2738-2747
    • Tsukada, N.1    Kobata, T.2    Aizawa, Y.3    Yagita, H.4    Okumura, K.5
  • 86
    • 0028989604 scopus 로고
    • 2 fragments in vivo to modulate graft-versus-host disease without loss of graft-versus-leukemia reactivity after MHC-matched bone marrow transplantation
    • 2 fragments in vivo to modulate graft-versus-host disease without loss of graft-versus-leukemia reactivity after MHC-matched bone marrow transplantation. J Immunol 1995; 154: 5542-5554.
    • (1995) J. Immunol. , vol.154 , pp. 5542-5554
    • Johnson, B.D.1    McCabe, C.2    Hanke, C.A.3    Truitt, R.L.4
  • 89
    • 0023713979 scopus 로고
    • T cell depletion in bone marrow transplantation
    • Poynton C. T cell depletion in bone marrow transplantation. Bone Marrow Transplant 1988; 3: 265-279.
    • (1988) Bone Marrow Transplant. , vol.3 , pp. 265-279
    • Poynton, C.1
  • 91
    • 0022965430 scopus 로고
    • Bone marrow transplantation for patients with chronic myeloid leukemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukemic relapse
    • Apperly JF, Jones L, Hale G, Waldmann H, Hows J, Rombos Y, et al. Bone marrow transplantation for patients with chronic myeloid leukemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukemic relapse. Bone Marrow Transplant 1986; 1: 53-60.
    • (1986) Bone Marrow Transplant. , vol.1 , pp. 53-60
    • Apperly, J.F.1    Jones, L.2    Hale, G.3    Waldmann, H.4    Hows, J.5    Rombos, Y.6
  • 92
    • 0034307364 scopus 로고    scopus 로고
    • Cyclosporine, methotrexate, and methylprednisolone compared with cyclosporine and methotrexate for the prevention of graft-versus-host disease in bone marrow transplantation from HLA-identical sibling donor: A prospective randomized study
    • Ruutu T, Volin L, Parkkali T, Juvonen E, Elonen E. Cyclosporine, methotrexate, and methylprednisolone compared with cyclosporine and methotrexate for the prevention of graft-versus-host disease in bone marrow transplantation from HLA-identical sibling donor: a prospective randomized study. Blood 2000; 96: 2391-2398.
    • (2000) Blood , vol.96 , pp. 2391-2398
    • Ruutu, T.1    Volin, L.2    Parkkali, T.3    Juvonen, E.4    Elonen, E.5
  • 93
    • 0025087833 scopus 로고
    • What role for prednisone in prevention of graft-versus-host disease in patients undergoing marrow transplants
    • Storb R, Pepe M, Anasetti C. What role for prednisone in prevention of graft-versus-host disease in patients undergoing marrow transplants. Blood 1990; 76: 1037-1045.
    • (1990) Blood , vol.76 , pp. 1037-1045
    • Storb, R.1    Pepe, M.2    Anasetti, C.3
  • 94
    • 0026271647 scopus 로고
    • A prospective randomized trial of cyclosporine and methotrexate versus cyclosporine, methotrexate and prednisolone for prevention of graft-versus-host disease after HLA-identical sibling marrow transplantation for hematological malignancy
    • Atkinson K, Biggs J, Concannon A, Dodds A, Young S, Wilson F, et al. A prospective randomized trial of cyclosporine and methotrexate versus cyclosporine, methotrexate and prednisolone for prevention of graft-versus-host disease after HLA-identical sibling marrow transplantation for hematological malignancy. Aust NAJ Med 1991; 21: 850-856.
    • (1991) Aust. NAJ Med. , vol.21 , pp. 850-856
    • Atkinson, K.1    Biggs, J.2    Concannon, A.3    Dodds, A.4    Young, S.5    Wilson, F.6
  • 95
    • 0030914537 scopus 로고    scopus 로고
    • Cyclosporine and cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease: A prospective randomized trials
    • Deeg HJ, Lin D, Leisenring W, Boeckh M, Anasetti C, Appelbaum FR, et al. Cyclosporine and cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease: a prospective randomized trials. Blood 1997; 89: 3880-3887.
    • (1997) Blood , vol.89 , pp. 3880-3887
    • Deeg, H.J.1    Lin, D.2    Leisenring, W.3    Boeckh, M.4    Anasetti, C.5    Appelbaum, F.R.6
  • 96
    • 0029962417 scopus 로고    scopus 로고
    • Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia
    • Matherly LH, Taub JW. Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia. Leuk Lymphoma 1996; 21: 359-368.
    • (1996) Leuk. Lymphoma , vol.21 , pp. 359-368
    • Matherly, L.H.1    Taub, J.W.2
  • 97
    • 0036624846 scopus 로고    scopus 로고
    • Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model
    • Uckun FM, Roers BA, Waurzyniak B, Cetkovic-Cvrlje M. Janus kinase 3 inhibitor WHI-P131/JANEX-1 prevents graft-versus-host disease but spares the graft-versus-leukemia function of the bone marrow allografts in a murine bone marrow transplantation model. Blood 2002; 99: 4192-99.
    • (2002) Blood , vol.99 , pp. 4192-4199
    • Uckun, F.M.1    Roers, B.A.2    Waurzyniak, B.3    Cetkovic-Cvrlje, M.4
  • 98
    • 0026646694 scopus 로고
    • The murine autoimmune diabetes model: NOD and related strains
    • Dixon FJ, editor. Academic Press
    • Kikutani H, Makino S. The murine autoimmune diabetes model: NOD and related strains. In: Dixon FJ, editor. Adv. Immunol. N.Y.: Academic Press; 1992; p. 285-322.
    • (1992) Adv. Immunol. N.Y. , pp. 285-322
    • Kikutani, H.1    Makino, S.2
  • 99
    • 43949152435 scopus 로고
    • Prevention of diabetes in the NOD mouse: Implications for therapeutic intervention in human disease
    • Bowman MA, Leiter EH, Atkinson MA. Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today 1994; 15: 115-120.
    • (1994) Immunol. Today , vol.15 , pp. 115-120
    • Bowman, M.A.1    Leiter, E.H.2    Atkinson, M.A.3
  • 100
    • 0033858841 scopus 로고    scopus 로고
    • Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse
    • Thomas HE, Kay TWH. Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse. Diabetes Metabolism Res Rev 2000.
    • (2000) Diabetes Metabolism Res. Rev.
    • Thomas, H.E.1    Kay, T.W.H.2
  • 101
    • 0032701409 scopus 로고    scopus 로고
    • The role of CD4 vs. CD8 T cells in IDDM
    • Wong SF, Janeway CA. The role of CD4 vs. CD8 T cells in IDDM. J Autoiimunity 1999; 13: 290-295.
    • (1999) J. Autoiimunity , vol.13 , pp. 290-295
    • Wong, S.F.1    Janeway, C.A.2
  • 102
    • 0034010247 scopus 로고    scopus 로고
    • Genetic and immunological basis of autoimmune diabetes in the NOD mouse
    • Yoshida K, Kikutani H. Genetic and immunological basis of autoimmune diabetes in the NOD mouse. Rev Immunogenet 2000; 2: 140-146.
    • (2000) Rev. Immunogenet. , vol.2 , pp. 140-146
    • Yoshida, K.1    Kikutani, H.2
  • 103
    • 0003900737 scopus 로고    scopus 로고
    • NOD mice an related strains: Research applications in diabetes, AIDS, cancer and other diseases
    • Austin, Texas, USA: R.G. Landes Company
    • Leiter EH, Atkinson M. NOD mice an related strains: Research applications in diabetes, AIDS, cancer and other diseases. Austin, Texas, USA: R.G. Landes Company; 1997.
    • (1997)
    • Leiter, E.H.1    Atkinson, M.2
  • 105
    • 0025087648 scopus 로고
    • Preventive effect of a new immunosuppressant FK-506 on insulitis and diabetes in non-obese diabetic mice
    • Miyagawa J, Yamamoto K, Hanatusa T, et al. Preventive effect of a new immunosuppressant FK-506 on insulitis and diabetes in non-obese diabetic mice. Diabetologia 1990; 33: 503-505.
    • (1990) Diabetologia , vol.33 , pp. 503-505
    • Miyagawa, J.1    Yamamoto, K.2    Hanatusa, T.3
  • 106
    • 0029128811 scopus 로고
    • Effects of sodium fusidate in animal models of insulin-dependent diabetes mellitus and septic shock
    • Nicoletti F, Zaccone P, Dimarco R, Magro G, Grasso S, Morrone S, et al. Effects of sodium fusidate in animal models of insulin-dependent diabetes mellitus and septic shock. Immunology 1995; 85(4): 645-650.
    • (1995) Immunology , vol.85 , Issue.4 , pp. 645-650
    • Nicoletti, F.1    Zaccone, P.2    Dimarco, R.3    Magro, G.4    Grasso, S.5    Morrone, S.6
  • 107
    • 0028046103 scopus 로고
    • Prevention of diabetes mellitus in non-obese diabetic mice by linomide, a novel immunomodulating drug
    • Gross DJ, Sidi H, Weiss L, Kalland T, Rosenmann E, Slavin S. Prevention of diabetes mellitus in non-obese diabetic mice by linomide, a novel immunomodulating drug. Diabetologia 1994; 37(12): 1195-1201.
    • (1994) Diabetologia , vol.37 , Issue.12 , pp. 1195-1201
    • Gross, D.J.1    Sidi, H.2    Weiss, L.3    Kalland, T.4    Rosenmann, E.5    Slavin, S.6
  • 108
    • 0025685639 scopus 로고
    • An immunomodulating protein Ling Zhi-8 (LZ-8) prevents insulitiis in non-obese diabetic mice
    • Kino K, Misumoto K, Sone T, et al. An immunomodulating protein Ling Zhi-8 (LZ-8) prevents insulitiis in non-obese diabetic mice. Diabetologia 1990; 33: 713-718.
    • (1990) Diabetologia , vol.33 , pp. 713-718
    • Kino, K.1    Misumoto, K.2    Sone, T.3
  • 110
    • 0026636411 scopus 로고
    • Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice
    • Baeder WL, Sredy J, Sehgal SN, Chang JY, Adams LM. Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice. Clin Exp Immunol 1992; 89: 174-178.
    • (1992) Clin. Exp. Immunol. , vol.89 , pp. 174-178
    • Baeder, W.L.1    Sredy, J.2    Sehgal, S.N.3    Chang, J.Y.4    Adams, L.M.5
  • 111
    • 0025165344 scopus 로고
    • The immunosuppressant FK-506 prevents progression of diabetes in nonobese diabetic mice
    • Kurasawa K, Koike T, Matsumura R, et al. The immunosuppressant FK-506 prevents progression of diabetes in nonobese diabetic mice. Clin Immunol Immunopathol 1990; 57: 274-279.
    • (1990) Clin. Immunol. Immunopathol. , vol.57 , pp. 274-279
    • Kurasawa, K.1    Koike, T.2    Matsumura, R.3
  • 112
    • 0027471528 scopus 로고
    • Protection against hyperglycemia in female nonobese diabetic mice treated with 15-deoxyspergualin
    • Strandell E, Sandler S. Protection against hyperglycemia in female nonobese diabetic mice treated with 15-deoxyspergualin. Autoimmunity 1992; 14: 159-165.
    • (1992) Autoimmunity , vol.14 , pp. 159-165
    • Strandell, E.1    Sandler, S.2
  • 113
    • 0027466555 scopus 로고
    • Prevention of insulitis and diabetes in in NOD mice by administration of FK506
    • Kai N, Motojima K, Tsunoda T, Kanematsu T. Prevention of insulitis and diabetes in in NOD mice by administration of FK506. Transplantation 1993; 55: 936-940.
    • (1993) Transplantation , vol.55 , pp. 936-940
    • Kai, N.1    Motojima, K.2    Tsunoda, T.3    Kanematsu, T.4
  • 114
    • 0027730267 scopus 로고
    • Lessons learned from the use of cyclosporine for insulin-dependent diabetes mellitus
    • Mahon JL, Dupre J, Stiller CR. Lessons learned from the use of cyclosporine for insulin-dependent diabetes mellitus. Annals NY Acad Sci 1993; 696: 351-363.
    • (1993) Annals NY Acad. Sci. , vol.696 , pp. 351-363
    • Mahon, J.L.1    Dupre, J.2    Stiller, C.R.3
  • 115
    • 0026070231 scopus 로고
    • Complications associated with immunosuppressive therapy and their management
    • Min DI, Monaco AP. Complications associated with immunosuppressive therapy and their management. Pharmacotherapy 1991; 11: 119S-125S.
    • (1991) Pharmacotherapy , vol.11
    • Min, D.I.1    Monaco, A.P.2
  • 116
    • 0031871335 scopus 로고    scopus 로고
    • An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
    • Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab Rev 1998; 14: 129-151.
    • (1998) Diabetes Metab. Rev. , vol.14 , pp. 129-151
    • Rabinovitch, A.1
  • 118
    • 0028890866 scopus 로고
    • Th1 and Th2 CD4(+) T cells in the pathogenesis of organ-specific autoimmune diseases
    • Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4(+) T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 1995; 16(1): 34-38.
    • (1995) Immunol. Today , vol.16 , Issue.1 , pp. 34-38
    • Liblau, R.S.1    Singer, S.M.2    McDevitt, H.O.3
  • 119
    • 0035061536 scopus 로고    scopus 로고
    • Tolerance to islet autoantigens in type 1 diabetes
    • Bach JF, Chatenoud L. Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol 2001; 19: 131-161.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 131-161
    • Bach, J.F.1    Chatenoud, L.2
  • 121
    • 0035575760 scopus 로고    scopus 로고
    • Cutting edge: Interactions through the IL-10 receptor regulate autoimmune diabetes
    • Philips JM, Parish NM, Drage M, Cooke A. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes. J Immunol 2001; 167: 6087-91.
    • (2001) J. Immunol. , vol.167 , pp. 6087-6091
    • Philips, J.M.1    Parish, N.M.2    Drage, M.3    Cooke, A.4
  • 123
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T-cells
    • Groux H, Bigler M, de Vries JE, Roncarolo MG. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T-cells. J Exp Med 1996; 184: 1-8.
    • (1996) J. Exp. Med. , vol.184 , pp. 1-8
    • Groux, H.1    Bigler, M.2    de Vries, J.E.3    Roncarolo, M.G.4
  • 124
    • 0028222756 scopus 로고
    • Recombinant human IL-1O prevents the onset of diabetes in the nonobese diabetic mouse
    • Pennline KJ, Roquegaffney E, Monahan M. Recombinant human IL-1O prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 1994; 71(2): 169-175.
    • (1994) Clin. Immunol. Immunopathol. , vol.71 , Issue.2 , pp. 169-175
    • Pennline, K.J.1    Roquegaffney, E.2    Monahan, M.3
  • 125
    • 0031131886 scopus 로고    scopus 로고
    • A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice
    • Zheng XX, Steele AW, Hancock WW, Steven AC, Nickerson PW, Roy-Chaudhury P, et al. A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. J Immunol 1997; 158: 4507-13.
    • (1997) J. Immunol. , vol.158 , pp. 4507-4513
    • Zheng, X.X.1    Steele, A.W.2    Hancock, W.W.3    Steven, A.C.4    Nickerson, P.W.5    Roy-Chaudhury, P.6
  • 126
    • 0017179001 scopus 로고
    • Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
    • Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 1976; 193: 415-417.
    • (1976) Science , vol.193 , pp. 415-417
    • Like, A.A.1    Rossini, A.A.2
  • 128
    • 73649197648 scopus 로고
    • Studies on the diabetogenic action of streptozotocin
    • Rakieten N. Studies on the diabetogenic action of streptozotocin. Canc Chemother Rep 1963; 29: 91-98.
    • (1963) Canc. Chemother. Rep. , vol.29 , pp. 91-98
    • Rakieten, N.1
  • 129
    • 0017691490 scopus 로고
    • Genetic influence of the streptozotocin-induced insulitis and hyperglycemia
    • Rossini AA, Appel MC, Williams RM, Like AA. Genetic influence of the streptozotocin-induced insulitis and hyperglycemia. Diabetes 1977; 29: 916-920.
    • (1977) Diabetes , vol.29 , pp. 916-920
    • Rossini, A.A.1    Appel, M.C.2    Williams, R.M.3    Like, A.A.4
  • 130
    • 8544252407 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes in mice lacking αβ T cells
    • Elliott JI, Dewchand H, Altmann DM. Streptozotocin-induced diabetes in mice lacking αβ T cells. Clin Exp Immunol 1997; 109: 116-120.
    • (1997) Clin. Exp. Immunol. , vol.109 , pp. 116-120
    • Elliott, J.I.1    Dewchand, H.2    Altmann, D.M.3
  • 131
    • 0000244371 scopus 로고
    • IDDM. Lessons from the low-dose streptozotocin model in mice
    • Kolb H, Kroncke K-D. IDDM. Lessons from the low-dose streptozotocin model in mice. Diabetes Review 1993; 1: 116-126.
    • (1993) Diabetes Review , vol.1 , pp. 116-126
    • Kolb, H.1    Kroncke, K.-D.2
  • 133
    • 0023205953 scopus 로고
    • Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozotocin
    • Herold KC, Montag AG, Fitch FW. Treatment with anti-T-lymphocyte antibodies prevents induction of insulitis in mice given multiple doses of streptozotocin. Diabetes 1987; 36: 796-801.
    • (1987) Diabetes , vol.36 , pp. 796-801
    • Herold, K.C.1    Montag, A.G.2    Fitch, F.W.3
  • 134
    • 0022548796 scopus 로고
    • An H-2 allo-antiserum preserves beta-cell function in mice made diabetic by low-dose streptozotocin
    • Bonnevie-Nielsen V, Lernmark A. An H-2 allo-antiserum preserves beta-cell function in mice made diabetic by low-dose streptozotocin. Diabetes 1986; 35: 570-3.
    • (1986) Diabetes , vol.35 , pp. 570-573
    • Bonnevie-Nielsen, V.1    Lernmark, A.2
  • 135
    • 0025881584 scopus 로고
    • Cells mediating allograft rejection
    • Hall BM. Cells mediating allograft rejection. Transplantation 1991; 51: 1141-51.
    • (1991) Transplantation , vol.51 , pp. 1141-1151
    • Hall, B.M.1
  • 136
    • 0028014460 scopus 로고
    • Signal transduction by lymphocyte antigen receptors
    • Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell 1994; 76: 263-274.
    • (1994) Cell , vol.76 , pp. 263-274
    • Weiss, A.1    Littman, D.R.2
  • 137
    • 0034093737 scopus 로고    scopus 로고
    • Signal transduction by the TCR for antigen
    • Kane LP, Lin J, Weiss A. Signal transduction by the TCR for antigen. Curr Opin Immunol 2000; 12: 242-249.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 242-249
    • Kane, L.P.1    Lin, J.2    Weiss, A.3
  • 138
    • 0343962142 scopus 로고    scopus 로고
    • The role of IL-2 in allograft rejection - A lesson learned from experimental work
    • Yun S, Sawyer GJ, Zhang X, Gustafsson K, Fabre JW. The role of IL-2 in allograft rejection - A lesson learned from experimental work. Transplantation 2000; 69: 2480-2483.
    • (2000) Transplantation , vol.69 , pp. 2480-2483
    • Yun, S.1    Sawyer, G.J.2    Zhang, X.3    Gustafsson, K.4    Fabre, J.W.5
  • 139
    • 0031571310 scopus 로고    scopus 로고
    • IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection
    • Mueller R, Davis JD, Krahl T, Sarvetnick N. IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection. J Immunol 1997; 159: 1599-603.
    • (1997) J. Immunol. , vol.159 , pp. 1599-1603
    • Mueller, R.1    Davis, J.D.2    Krahl, T.3    Sarvetnick, N.4
  • 140
    • 0013195631 scopus 로고    scopus 로고
    • IL-2 and IL-4 double knockout mice reject islet allografts: A role for novel T cell growth factors in allograft rejection
    • Li XC, Roy-Chaudhury P, Hancock WW, Manfro R, Zand MS, Li Y, et al. IL-2 and IL-4 double knockout mice reject islet allografts: A role for novel T cell growth factors in allograft rejection. J Immunol 1998; 161: 890-896.
    • (1998) J. Immunol. , vol.161 , pp. 890-896
    • Li, X.C.1    Roy-Chaudhury, P.2    Hancock, W.W.3    Manfro, R.4    Zand, M.S.5    Li, Y.6
  • 141
    • 0029962080 scopus 로고    scopus 로고
    • The interleukin-2 receptor gamma-chain: Its role in multiple cytokine receptor complexes and T cell development in XSCID
    • Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, Ohbo K, et al. The interleukin-2 receptor gamma-chain: its role in multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol 1996; 14: 179-205.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 179-205
    • Sugamura, K.1    Asao, H.2    Kondo, M.3    Tanaka, N.4    Ishii, N.5    Ohbo, K.6
  • 143
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targting
    • Schorlc HT, Holyschke T, Hunig T, Schimpl A, Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targting. Nature 1991; 252: 621-624.
    • (1991) Nature , vol.252 , pp. 621-624
    • Schorlc, H.T.1    Holyschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 144
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521-530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 145
    • 0029028363 scopus 로고
    • Deregulated T cell activation an autoimmunity in mice lacking interleukin-2 receptor β
    • Suzuki HT, Kundig M, Furlonger C, Wakeham A, Timms E, Matsuyama T, et al. Deregulated T cell activation an autoimmunity in mice lacking interleukin-2 receptor β. Science 1995; 268: 1472-1476.
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.T.1    Kundig, M.2    Furlonger, C.3    Wakeham, A.4    Timms, E.5    Matsuyama, T.6
  • 146
    • 0030272248 scopus 로고    scopus 로고
    • Interleukin-2 and its receptors: Recent advances and new immunological functions
    • Theze J, Alzari PM, Bertoglio J. Interleukin-2 and its receptors: recent advances and new immunological functions. Immunol Today 1996; 17: 481-486.
    • (1996) Immunol. Today , vol.17 , pp. 481-486
    • Theze, J.1    Alzari, P.M.2    Bertoglio, J.3
  • 147
    • 0005618532 scopus 로고    scopus 로고
    • Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival
    • Li XC, Ima A, Li Y, Zheng XX, Malek TR, Strom TB. Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival. J Immunol 2000; 164: 1193-1199.
    • (2000) J. Immunol. , vol.164 , pp. 1193-1199
    • Li, X.C.1    Ima, A.2    Li, Y.3    Zheng, X.X.4    Malek, T.R.5    Strom, T.B.6
  • 148
    • 0029806297 scopus 로고    scopus 로고
    • Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy
    • Bennett WM, DeMattos A, Meyer MM, Andoh T, Barry JM. Chronic cyclosporine nephropathy: the Achilles' heel of immunosuppressive therapy. Kidney Int 1996; 50: 1089-1100.
    • (1996) Kidney Int. , vol.50 , pp. 1089-1100
    • Bennett, W.M.1    DeMattos, A.2    Meyer, M.M.3    Andoh, T.4    Barry, J.M.5
  • 149
    • 0035191706 scopus 로고    scopus 로고
    • Neurotoxicity of immunosuppressive drugs
    • Wijdicks EF. Neurotoxicity of immunosuppressive drugs. Liver Transpl 2001; 7: 937-42.
    • (2001) Liver Transpl. , vol.7 , pp. 937-942
    • Wijdicks, E.F.1
  • 154
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with Type I deabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM, Lakey JRT, Ryan EA, Korbutt GS, Toth E, Warnock GL, et al. Islet transplantation in seven patients with Type I deabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.T.2    Ryan, E.A.3    Korbutt, G.S.4    Toth, E.5    Warnock, G.L.6
  • 155
    • 0028607044 scopus 로고
    • Posttransplant diabetes mellitus - A review
    • Jindal RM. Posttransplant diabetes mellitus - a review. Transplantation 1994, 58: 1289-.
    • (1994) Transplantation , vol.58 , pp. 1289
    • Jindal, R.M.1
  • 156
    • 0034106815 scopus 로고    scopus 로고
    • Towards a specific immunosuppression for pancreas and islet grafts
    • Jindal RM, Dubernard J-M. Towards a specific immunosuppression for pancreas and islet grafts. Clin Transplant 2000; 14: 242-245.
    • (2000) Clin. Transplant. , vol.14 , pp. 242-245
    • Jindal, R.M.1    Dubernard, J.-M.2
  • 158
    • 0033567135 scopus 로고    scopus 로고
    • Islet cell damage associated with tacrolimus and cyclosporine: Morphological features in pancreas allograft biopsies and clinical correlation
    • Drachenberg CB, Klassen DK, Weir MR, Wiland A, Fink JC, Bartlett ST, et al. Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation. Transplantation 1999; 68: 396-402.
    • (1999) Transplantation , vol.68 , pp. 396-402
    • Drachenberg, C.B.1    Klassen, D.K.2    Weir, M.R.3    Wiland, A.4    Fink, J.C.5    Bartlett, S.T.6
  • 159
    • 0027390728 scopus 로고
    • Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506
    • Herold KC, Nagamatsu S, Buse JB, Kulsakdinun P, Steiner DE. Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506. Transplantation 1993; 55: 186-192.
    • (1993) Transplantation , vol.55 , pp. 186-192
    • Herold, K.C.1    Nagamatsu, S.2    Buse, J.B.3    Kulsakdinun, P.4    Steiner, D.E.5
  • 160
    • 0027925168 scopus 로고
    • New concepts about the mast cell
    • Galli SJ. New concepts about the mast cell. N Engl J Med 1993; 328(4): 257-65.
    • (1993) N. Engl. J. Med. , vol.328 , Issue.4 , pp. 257-265
    • Galli, S.J.1
  • 161
    • 0028581989 scopus 로고
    • Atopic allergy and other hypersensitivities
    • de Vries JE. Atopic allergy and other hypersensitivities. Curr Opin Immunol 1994; 6(6): 835-7.
    • (1994) Curr. Opin. Immunol. , vol.6 , Issue.6 , pp. 835-837
    • de Vries, J.E.1
  • 163
    • 0027925168 scopus 로고
    • New concepts about the mast cell
    • Galli SJ. New concepts about the mast cell. N Engl J Med 1993; 328(4): 257-65.
    • (1993) N. Engl. J. Med. , vol.328 , Issue.4 , pp. 257-265
    • Galli, S.J.1
  • 165
    • 0027419575 scopus 로고
    • Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation
    • Malaviya R, Jakschik BA. Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J Biol Chem 1993; 268(7): 4939-44.
    • (1993) J. Biol. Chem. , vol.268 , Issue.7 , pp. 4939-4944
    • Malaviya, R.1    Jakschik, B.A.2
  • 169
    • 0028167526 scopus 로고
    • Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro
    • Spada CS, Nieves AL, Krauss AH, Woodward DF. Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro. J Leukoc Biol 1994; 55(2): 183-91.
    • (1994) J. Leukoc. Biol. , vol.55 , Issue.2 , pp. 183-191
    • Spada, C.S.1    Nieves, A.L.2    Krauss, A.H.3    Woodward, D.F.4
  • 170
    • 0027080131 scopus 로고
    • Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis
    • Zhang Y, Ramos BF, Jakschik BA. Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis. Science 1992; 258(5090): 1957-9.
    • (1992) Science , vol.258 , Issue.5090 , pp. 1957-1959
    • Zhang, Y.1    Ramos, B.F.2    Jakschik, B.A.3
  • 172
    • 0031283045 scopus 로고    scopus 로고
    • Effects of leukotrienes B4 (LTB4) and D4 (LTD4) on motility of isolated normodense human eosinophils and neutrophils
    • Spada CS, Krauss AH, Nieves AL, Woodward DF. Effects of leukotrienes B4 (LTB4) and D4 (LTD4) on motility of isolated normodense human eosinophils and neutrophils. Adv Exp Med Biol 1997: 699-706.
    • (1997) Adv. Exp. Med. Biol. , pp. 699-706
    • Spada, C.S.1    Krauss, A.H.2    Nieves, A.L.3    Woodward, D.F.4
  • 173
    • 0030810734 scopus 로고    scopus 로고
    • Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice
    • Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, et al. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med 1997; 186(3): 449-54.
    • (1997) J. Exp. Med. , vol.186 , Issue.3 , pp. 449-454
    • Takeda, K.1    Hamelmann, E.2    Joetham, A.3    Shultz, L.D.4    Larsen, G.L.5    Irvin, C.G.6
  • 174
    • 0026687304 scopus 로고
    • The pathobiology of bronchial asthma
    • Arm JP, Lee TH. The pathobiology of bronchial asthma. Adv Immunol 1992; 51: 323-82.
    • (1992) Adv. Immunol. , vol.51 , pp. 323-382
    • Arm, J.P.1    Lee, T.H.2
  • 175
    • 0000966697 scopus 로고
    • Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4
    • Dahlen SE, Hansson G, Hedqvist P, Bjorck T, Granstrom E, Dahlen B. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proc Natl Acad Sci USA 1983; 80(6): 1712-6.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , Issue.6 , pp. 1712-1716
    • Dahlen, S.E.1    Hansson, G.2    Hedqvist, P.3    Bjorck, T.4    Granstrom, E.5    Dahlen, B.6
  • 177
    • 0033590513 scopus 로고    scopus 로고
    • Treatment of asthma with drugs modifying the leukotriene pathway
    • Drazen JM, Israel E, O'Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 1999; 340(3): 197-206.
    • (1999) N. Engl. J. Med. , vol.340 , Issue.3 , pp. 197-206
    • Drazen, J.M.1    Israel, E.2    O'Byrne, P.M.3
  • 178
    • 0031025167 scopus 로고    scopus 로고
    • The use of 5-lipoxygenase inhibitors and leukotriene receptor antagonists in the treatment of chronic asthma
    • Sorkness CA. The use of 5-lipoxygenase inhibitors and leukotriene receptor antagonists in the treatment of chronic asthma. Pharmacotherapy 1997; 17(1 Pt 2): 50S-54S.
    • (1997) Pharmacotherapy , vol.17 , Issue.1 PART 2
    • Sorkness, C.A.1
  • 179
    • 0026722686 scopus 로고
    • Mast cell mediators regulate vascular permeability changes in Arthus reaction
    • Ramos BF, Zhang Y, Angkachatchai V, Jakschik BA. Mast cell mediators regulate vascular permeability changes in Arthus reaction. J Pharmacol Exp Ther 1992; 262(2): 559-65.
    • (1992) J. Pharmacol. Exp. Ther. , vol.262 , Issue.2 , pp. 559-565
    • Ramos, B.F.1    Zhang, Y.2    Angkachatchai, V.3    Jakschik, B.A.4
  • 180
    • 0027340363 scopus 로고
    • Leukotriene E4 and granulocytic infiltration into asthmatic airways
    • Laitinen LA, Laitinen A, Haahtela T, Vilkka V, Spur BW, Lee TH. Leukotriene E4 and granulocytic infiltration into asthmatic airways. Lancet 1993; 341(8851): 989-90.
    • (1993) Lancet , vol.341 , Issue.8851 , pp. 989-990
    • Laitinen, L.A.1    Laitinen, A.2    Haahtela, T.3    Vilkka, V.4    Spur, B.W.5    Lee, T.H.6
  • 181
    • 0032007844 scopus 로고    scopus 로고
    • Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages
    • Brock TG, McNish RW, Peters-Golden M. Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. Biochem J 1998; 329(Pt 3): 519-25.
    • (1998) Biochem. J. , vol.329 , Issue.PART 3 , pp. 519-525
    • Brock, T.G.1    McNish, R.W.2    Peters-Golden, M.3
  • 182
    • 0026647917 scopus 로고
    • Stimulation of leukotriene production and membrane translocation of 5- lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells
    • Wong A, Cook MN, Hwang SM, Sarau HM, Foley JJ, Crooke ST. Stimulation of leukotriene production and membrane translocation of 5- lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells. Biochemistry 1992; 31(16): 4046-53.
    • (1992) Biochemistry , vol.31 , Issue.16 , pp. 4046-4053
    • Wong, A.1    Cook, M.N.2    Hwang, S.M.3    Sarau, H.M.4    Foley, J.J.5    Crooke, S.T.6
  • 183
    • 0027323992 scopus 로고
    • 5-lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase
    • Abramovitz M, Wong E, Cox ME, Richardson CD, Li C, Vickers PJ. 5-lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. Eur J Biochem 1993; 215(1): 105-11.
    • (1993) Eur. J. Biochem. , vol.215 , Issue.1 , pp. 105-111
    • Abramovitz, M.1    Wong, E.2    Cox, M.E.3    Richardson, C.D.4    Li, C.5    Vickers, P.J.6
  • 184
    • 0028280329 scopus 로고
    • (R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: Effects on anti-IgE challenge in human airways
    • Gorenne I, Labat C, Gascard JP, Norel X, Muller-Peddinghaus R, Mohrs KH, et al. (R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways. J Pharmacol Exp Ther 1994; 268(2): 868-72.
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , Issue.2 , pp. 868-872
    • Gorenne, I.1    Labat, C.2    Gascard, J.P.3    Norel, X.4    Muller-Peddinghaus, R.5    Mohrs, K.H.6
  • 185
    • 0029809520 scopus 로고    scopus 로고
    • Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents
    • Smith LJ. Leukotrienes in asthma. The potential therapeutic role of antileukotriene agents. Arch Intern Med 1996; 156(19): 2181-9.
    • (1996) Arch. Intern. Med. , vol.156 , Issue.19 , pp. 2181-2189
    • Smith, L.J.1
  • 186
    • 0030840649 scopus 로고    scopus 로고
    • Inhibition of interleukin-5 with a monoclonal antibody attenuates allergic inflammation
    • Danzig M, Cuss F. Inhibition of interleukin-5 with a monoclonal antibody attenuates allergic inflammation. Allergy 1997; 52: 787-794.
    • (1997) Allergy , vol.52 , pp. 787-794
    • Danzig, M.1    Cuss, F.2
  • 187
    • 0033578618 scopus 로고    scopus 로고
    • Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis
    • Malaviya R, Uckun FM. Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis. J Biol Chem 1999; 274: 27028-38.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27028-27038
    • Malaviya, R.1    Uckun, F.M.2
  • 188
    • 0033590987 scopus 로고    scopus 로고
    • Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated Type 1 hypersensitivity reactions
    • Malaviya R, Uckun F. Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated Type 1 hypersensitivity reactions. Biochem Biophys Res Commun 1999; 257: 807-813.
    • (1999) Biochem. Biophys. Res. Commun. , vol.257 , pp. 807-813
    • Malaviya, R.1    Uckun, F.2
  • 189
    • 0033712415 scopus 로고    scopus 로고
    • Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)
    • Malaviya R, Chen CL, Navara C, Liu XP, Keenan M, Waurzyniak B, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). The Journal of Pharmacology and Experimental Therapeutics 2000; 295(3): 912-26.
    • (2000) The Journal of Pharmacology and Experimental Therapeutics , vol.295 , Issue.3 , pp. 912-926
    • Malaviya, R.1    Chen, C.L.2    Navara, C.3    Liu, X.P.4    Keenan, M.5    Waurzyniak, B.6
  • 190
    • 0033712415 scopus 로고    scopus 로고
    • Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)
    • Malaviya R, Chen CL, Navara C, Liu XP, Keenan M, Waurzyniak B, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′, 5′-dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). J Pharmacol Exp Ther 2000; 295(3): 912-26.
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , Issue.3 , pp. 912-926
    • Malaviya, R.1    Chen, C.L.2    Navara, C.3    Liu, X.P.4    Keenan, M.5    Waurzyniak, B.6
  • 191
    • 0033712415 scopus 로고    scopus 로고
    • Treatment of allergic asthma by targeting Janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3″,5″-dibromo-4″-hydroxyphenyl) amino-6,7-dimethoxyquinazoline (WHI-P97)
    • Malaviya R, Chen CL, Navara C, Malaviya R, Liu XP, Keenan M, et al. Treatment of allergic asthma by targeting Janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3″,5″-dibromo-4″-hydroxyphenyl) amino-6,7-dimethoxyquinazoline (WHI-P97). J Pharmacol Exp Ther 2000; 295: 912-26.
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 912-926
    • Malaviya, R.1    Chen, C.L.2    Navara, C.3    Malaviya, R.4    Liu, X.P.5    Keenan, M.6
  • 192
    • 0033578618 scopus 로고    scopus 로고
    • Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis
    • Malaviya R, Zhu D, Dibirdik I, Uckun FM. Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis. J Biol Chem 1999; 274(38): 27028-38.
    • (1999) J. Biol. Chem. , vol.274 , Issue.38 , pp. 27028-27038
    • Malaviya, R.1    Zhu, D.2    Dibirdik, I.3    Uckun, F.M.4
  • 193
    • 0033529313 scopus 로고    scopus 로고
    • The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphos-phatidylinositol- anchored molecule CD48
    • Malaviya R, Gao Z, Thankavel K, van der Merwe PA, Abraham SN. The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphos-phatidylinositol- anchored molecule CD48. Proc Natl Acad Sci USA 1999; 96(14): 8110-5.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , Issue.14 , pp. 8110-8115
    • Malaviya, R.1    Gao, Z.2    Thankavel, K.3    van der Merwe, P.A.4    Abraham, S.N.5
  • 195
    • 0036098398 scopus 로고    scopus 로고
    • In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase
    • Uckun FM, Zheng Y, Cetkovic-Cvrlje M, Vassilev A, Lisowski E, Waurzyniak B, et al. In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase. Clin Cancer Res 2002; 8(5): 1224-33.
    • (2002) Clin. Cancer Res. , vol.8 , Issue.5 , pp. 1224-1233
    • Uckun, F.M.1    Zheng, Y.2    Cetkovic-Cvrlje, M.3    Vassilev, A.4    Lisowski, E.5    Waurzyniak, B.6
  • 197
    • 0037439493 scopus 로고    scopus 로고
    • A prospective cohort study determining the prevalence of thrombotic events in children with acute lymphoblastic leukemia and a central venous line who are treated with L-asparaginase
    • Mitchell LG. A prospective cohort study determining the prevalence of thrombotic events in children with acute lymphoblastic leukemia and a central venous line who are treated with L-asparaginase. Cancer 2003; 97(2): 508-16.
    • (2003) Cancer , vol.97 , Issue.2 , pp. 508-516
    • Mitchell, L.G.1
  • 199
    • 0037335940 scopus 로고    scopus 로고
    • Thromboembolic disease involving the superior vena cava and brachiocephalic veins
    • Otten TR, Stein PD, Patel KC, Mustafa S, Silbergleit A. Thromboembolic disease involving the superior vena cava and brachiocephalic veins. Chest 2003; 123(3): 809-12.
    • (2003) Chest , vol.123 , Issue.3 , pp. 809-812
    • Otten, T.R.1    Stein, P.D.2    Patel, K.C.3    Mustafa, S.4    Silbergleit, A.5
  • 200
    • 0037262675 scopus 로고    scopus 로고
    • Diagnosis of venous thromboembolic disease in cancer patients
    • 139; discussion 139-44
    • Gomes MP, Deitcher SR. Diagnosis of venous thromboembolic disease in cancer patients. Oncology (Huntingt) 2003; 17(1): 126-35, 139; discussion 139-44.
    • (2003) Oncology (Huntingt) , vol.17 , Issue.1 , pp. 126-135
    • Gomes, M.P.1    Deitcher, S.R.2
  • 202
    • 0035947684 scopus 로고    scopus 로고
    • Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation
    • Tibbles HE, Vassilev A, Wendorf H, Schonhoff D, Zhu D, Lorenz D, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem 2001; 276(21): 17815-22.
    • (2001) J. Biol. Chem. , vol.276 , Issue.21 , pp. 17815-17822
    • Tibbles, H.E.1    Vassilev, A.2    Wendorf, H.3    Schonhoff, D.4    Zhu, D.5    Lorenz, D.6
  • 203
    • 0029052479 scopus 로고
    • Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Kato T, Miyazaki H, Handa M, et al. Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets. Blood 1995; 86(1): 23-7.
    • (1995) Blood , vol.86 , Issue.1 , pp. 23-27
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Kato, T.4    Miyazaki, H.5    Handa, M.6
  • 204
    • 0036295597 scopus 로고    scopus 로고
    • Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions
    • Tibbles HE, Navara CS, Hupke MA, Vassilev AO, Uckun FM. Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions. Biochem Biophys Res Commun 2002; 292(4): 987-91.
    • (2002) Biochem. Biophys. Res. Commun. , vol.292 , Issue.4 , pp. 987-991
    • Tibbles, H.E.1    Navara, C.S.2    Hupke, M.A.3    Vassilev, A.O.4    Uckun, F.M.5
  • 205
    • 0033120870 scopus 로고    scopus 로고
    • Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines
    • Liu RY, Fan C, Garcia R, Jove R, Zuckerman KS. Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines. Blood 1999; 93(7): 2369-79.
    • (1999) Blood , vol.93 , Issue.7 , pp. 2369-2379
    • Liu, R.Y.1    Fan, C.2    Garcia, R.3    Jove, R.4    Zuckerman, K.S.5
  • 207
    • 0030945262 scopus 로고    scopus 로고
    • Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets
    • Miyakawa Y, Oda A, Druker BJ, Ozaki K, Handa M, Ohashi H, et al. Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Blood 1997; 89(8): 2789-98.
    • (1997) Blood , vol.89 , Issue.8 , pp. 2789-2798
    • Miyakawa, Y.1    Oda, A.2    Druker, B.J.3    Ozaki, K.4    Handa, M.5    Ohashi, H.6
  • 208
    • 0034099094 scopus 로고    scopus 로고
    • Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets
    • Schulze H, Ballmaier M, Welte K, Germeshausen M. Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets. Exp Hematol 2000; 28(3): 294-304.
    • (2000) Exp. Hematol. , vol.28 , Issue.3 , pp. 294-304
    • Schulze, H.1    Ballmaier, M.2    Welte, K.3    Germeshausen, M.4
  • 209
    • 0032981804 scopus 로고    scopus 로고
    • Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery
    • Witthuhn BA, Williams MD, Kerawalla H, Uckun FM. Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery. Leuk. Lymphoma 1999; 32: 289-297.
    • (1999) Leuk. Lymphoma , vol.32 , pp. 289-297
    • Witthuhn, B.A.1    Williams, M.D.2    Kerawalla, H.3    Uckun, F.M.4
  • 210
    • 0042165931 scopus 로고    scopus 로고
    • Neurodegeneration in amyotrophic lateral sclerosis: The role of oxidative stress and altered homeostasis of metals
    • Carri, Mt, Ferri A, Cozzolino M, Calabrese L, Rotilio G. Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals. Brain Res Bull 2003; 61(4): 365-374.
    • (2003) Brain Res. Bull. , vol.61 , Issue.4 , pp. 365-374
    • Carri, Mt.1    Ferri, A.2    Cozzolino, M.3    Calabrese, L.4    Rotilio, G.5
  • 211
    • 0034614353 scopus 로고    scopus 로고
    • A specific inhibitor of Janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis
    • Trieu VN, Liu R, Liu XP, Uckun FM. A specific inhibitor of Janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2000; 267(1): 22-5.
    • (2000) Biochem. Biophys. Res. Commun. , vol.267 , Issue.1 , pp. 22-25
    • Trieu, V.N.1    Liu, R.2    Liu, X.P.3    Uckun, F.M.4
  • 212
    • 0035122351 scopus 로고    scopus 로고
    • Stimulation of Bruton's tyrosine kinase (BTK) and mositol 1,4,5-trisphosphate production in leukemia and lymphoma cells exposed to low energy electromagnetic fields
    • Dibirdik I, Bofenkamp M, Skeben P, Uckun F. Stimulation of Bruton's tyrosine kinase (BTK) and mositol 1,4,5-trisphosphate production in leukemia and lymphoma cells exposed to low energy electromagnetic fields. Leuk Lymphoma 2000; 40(1-2): 149-56.
    • (2000) Leuk. Lymphoma , vol.40 , Issue.1-2 , pp. 149-156
    • Dibirdik, I.1    Bofenkamp, M.2    Skeben, P.3    Uckun, F.4
  • 213
    • 0000561483 scopus 로고    scopus 로고
    • Alpha-cyano-N-(2,5-dibromophenyl)-beta-hydroxybut-2-enamide
    • Ghosh S, Uckun FM. Alpha-cyano-N-(2,5-dibromophenyl)-beta-hydroxybut-2-enamide. Acta Crystallogr C 1999; 55 (Pt 8): 1364-5.
    • (1999) Acta. Crystallogr. C. , vol.55 , Issue.PART 8 , pp. 1364-1365
    • Ghosh, S.1    Uckun, F.M.2
  • 215
    • 0032504249 scopus 로고    scopus 로고
    • Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells
    • Goodman PA, Niehoff LB, Uckun FM. Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells. J Biol Chem 1998; 273(28): 17742-8.
    • (1998) J. Biol. Chem. , vol.273 , Issue.28 , pp. 17742-17748
    • Goodman, P.A.1    Niehoff, L.B.2    Uckun, F.M.3
  • 216
    • 0037063364 scopus 로고    scopus 로고
    • Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA)
    • Heinonen JE, Smith CI, Nore BF. Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA). FEBS Lett 2002; 527(1-3): 274-8.
    • (2002) FEBS Lett. , vol.527 , Issue.1-3 , pp. 274-278
    • Heinonen, J.E.1    Smith, C.I.2    Nore, B.F.3
  • 218
    • 0033515450 scopus 로고    scopus 로고
    • Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamidel
    • Mahajan S, Ghosh S, Sudbeck EA, Zheng Y, Downs S, Hupke M, et al. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2, 5-dibromophenyl)propenamidel. J Biol Chem 1999; 274(14): 9587-99.
    • (1999) J. Biol. Chem. , vol.274 , Issue.14 , pp. 9587-9599
    • Mahajan, S.1    Ghosh, S.2    Sudbeck, E.A.3    Zheng, Y.4    Downs, S.5    Hupke, M.6
  • 219
    • 0035903207 scopus 로고    scopus 로고
    • Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells
    • Mahajan S, Vassilev A, Sun N, Ozer Z, Mao C, Uckun FM. Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells. J Biol Chem 2001; 276(33): 31216-28.
    • (2001) J. Biol. Chem. , vol.276 , Issue.33 , pp. 31216-31228
    • Mahajan, S.1    Vassilev, A.2    Sun, N.3    Ozer, Z.4    Mao, C.5    Uckun, F.M.6
  • 220
    • 0035511832 scopus 로고    scopus 로고
    • 2,4,6-Trihydroxy-alpha-p-methoxyphenylacetophenone (Compound D-58) is a potent inhibitor of allergic reactions
    • Malaviya R, Vassilev A, Uckun FM. 2,4,6-Trihydroxy-alpha-p-methoxyphenylacetophenone (Compound D-58) is a potent inhibitor of allergic reactions. Am J Ther 2001; 8(6): 417-24.
    • (2001) Am. J. Ther. , vol.8 , Issue.6 , pp. 417-424
    • Malaviya, R.1    Vassilev, A.2    Uckun, F.M.3
  • 221
    • 0035798646 scopus 로고    scopus 로고
    • Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia
    • Mao C, Zhou M, Uckun FM. Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia. J Biol Chem 2001; 276(44): 41435-43.
    • (2001) J. Biol. Chem. , vol.276 , Issue.44 , pp. 41435-41443
    • Mao, C.1    Zhou, M.2    Uckun, F.M.3
  • 222
    • 0033053383 scopus 로고    scopus 로고
    • Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
    • Sudbeck EA, Liu XP, Narla RK, Mahajan S, Ghosh S, Mao C, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res 1999; 5(6): 1569-82.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.6 , pp. 1569-1582
    • Sudbeck, E.A.1    Liu, X.P.2    Narla, R.K.3    Mahajan, S.4    Ghosh, S.5    Mao, C.6
  • 223
    • 0036247866 scopus 로고    scopus 로고
    • A dual function anti-leukemic agent with anti-thrombotic activity
    • Tibbles H, Vassilev A, Uckun FM. A dual function anti-leukemic agent with anti-thrombotic activity. Leuk Lymphoma 2002; 43(5): 1121-7.
    • (2002) Leuk. Lymphoma , vol.43 , Issue.5 , pp. 1121-1127
    • Tibbles, H.1    Vassilev, A.2    Uckun, F.M.3
  • 224
    • 0029838226 scopus 로고    scopus 로고
    • BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells
    • Uckun FM, Waddick KG, Mahajan S, Jun X, Takata M, Bolen J, et al. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science 1996; 273(5278): 1096-100.
    • (1996) Science , vol.273 , Issue.5278 , pp. 1096-1100
    • Uckun, F.M.1    Waddick, K.G.2    Mahajan, S.3    Jun, X.4    Takata, M.5    Bolen, J.6
  • 225
    • 0031708849 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis
    • Uckun FM. Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis. Biochem Pharmacol 1998; 56(6): 683-91.
    • (1998) Biochem. Pharmacol. , vol.56 , Issue.6 , pp. 683-691
    • Uckun, F.M.1
  • 227
    • 0034778207 scopus 로고    scopus 로고
    • Rationally designed anti-mitotic agents with proapoptotic activity
    • Uckun FM. Rationally designed anti-mitotic agents with proapoptotic activity. Curr Pharm Des 2001; 7(16): 1627-39.
    • (2001) Curr. Pharm. Des. , vol.7 , Issue.16 , pp. 1627-1639
    • Uckun, F.M.1
  • 228
    • 0033555546 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex
    • Vassilev A, Ozer Z, Navara C, Mahajan S, Uckun FM. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. J Biol Chem 1999; 274(3): 1646-56.
    • (1999) J. Biol. Chem. , vol.274 , Issue.3 , pp. 1646-1656
    • Vassilev, A.1    Ozer, Z.2    Navara, C.3    Mahajan, S.4    Uckun, F.M.5
  • 229
    • 0032435749 scopus 로고    scopus 로고
    • Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells
    • Zhu DM, Narla RK, Fang WH, Chia NC, Uckun FM. Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells. Clin Cancer Res 1998; 4(12): 2967-76.
    • (1998) Clin. Cancer Res. , vol.4 , Issue.12 , pp. 2967-2976
    • Zhu, D.M.1    Narla, R.K.2    Fang, W.H.3    Chia, N.C.4    Uckun, F.M.5
  • 230
    • 0034130450 scopus 로고    scopus 로고
    • Calpain inhibitor II induces caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells as well as some solid tumor cells
    • Zhu DM, Uckun FM. Calpain inhibitor II induces caspase-dependent apoptosis in human acute lymphoblastic leukemia and non-Hodgkin's lymphoma cells as well as some solid tumor cells. Clin Cancer Res 2000; 6(6): 2456-63.
    • (2000) Clin. Cancer Res. , vol.6 , Issue.6 , pp. 2456-2463
    • Zhu, D.M.1    Uckun, F.M.2
  • 231
    • 0036839007 scopus 로고    scopus 로고
    • SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells
    • Zhu DM, Tibbles HE, Vassilev AO, Uckun FM. SYK and LYN mediate B-cell receptor-independent calcium-induced apoptosis in DT-40 lymphoma B-cells. Leuk Lymphoma 2002; 43(11): 2165-70.
    • (2002) Leuk. Lymphoma , vol.43 , Issue.11 , pp. 2165-2170
    • Zhu, D.M.1    Tibbles, H.E.2    Vassilev, A.O.3    Uckun, F.M.4
  • 232
    • 0037265517 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor as the expecting sword for the treatment of severe sepsis
    • Murata A. Granulocyte colony-stimulating factor as the expecting sword for the treatment of severe sepsis. Curr Pharm Design 2003; 9(14): 1115-20.
    • (2003) Curr. Pharm. Design , vol.9 , Issue.14 , pp. 1115-1120
    • Murata, A.1
  • 233
    • 0035993373 scopus 로고    scopus 로고
    • Cytokine modulation for anti-allergic treatment
    • Pullerits T. Cytokine modulation for anti-allergic treatment. Curr Pharm Design 2002; 8(20): 1845-53.
    • (2002) Curr. Pharm. Design , vol.8 , Issue.20 , pp. 1845-1853
    • Pullerits, T.1
  • 234
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • Wilhelm S, Chien DS. BAY 43-9006: preclinical data. Curr Pharm Design 2002; 8(25): 2255-7.
    • (2002) Curr. Pharm. Design , vol.8 , Issue.25 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.S.2


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