Suppression of primary t-cell responses and induction of alloantigen-specific hyporesponsiveness in vitro by the Janus kinase inhibitor tyrphostin AG490

Transplantation

Volumn 70, Issue 8, 2000, Pages 1215-1225

  Säemann, Marcus D ^a   Böhmig, Georg A ^a   Österreicher, Christoph H ^a   Staffler, Günther ^a   Diakos, Christos ^a   Krieger, Peter Michael ^a   Hörl, Walter H ^a   Stockinger, Hannes ^a   Zlabinger, Gerhard J ^a,b  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD69 ANTIGEN; CELL SURFACE MARKER; CYTOKINE RECEPTOR; ENZYME INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; JANUS KINASE; LYMPHOCYTE ANTIGEN; MONOCLONAL ANTIBODY CD3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; TYRPHOSTIN;

APOPTOSIS; ARTICLE; CALCIUM MOBILIZATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DNA SYNTHESIS; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; MIXED LYMPHOCYTE CULTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0034721912     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200010270-00016     Document Type: Article

References (40)

1. Biology of the interleukin-2-receptor
2. The role of Jak3 in lymphoid development, activation, and signaling
3. JAK/STAT signaling by cytokine receptors
4. Developmental defects of lymphoid cells in JAK3 kinase-deficient mice
5. Defective lymphoid development in mice lacking JAK3
6. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking JAK3
7. Randomized trial of basiliximab versus placebo for control of cellular rejection in renal allograft recipients: CHIB 201 International Study Group
8. Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation
9. Intragraft IL-15 transcripts are increased in human allograft rejection
10. Immunopharmacology of rapamycin
11. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors
12. Tyrphostins. 2. Hetorocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases
13. Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor
14. Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis
15. Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis
16. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response
17. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
18. 2+) mobilization after stimulation with mitogens or anti-CD3 antibodies
19. A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
20. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
21. Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells
22. Mutations of JAK3 gene in patients with autosomal severe combined immune deficiency (SCID)
23. Mutation of JAK3 in a patient with SCID: Essential role of JAK3 in lymphoid development
24. Interleukin-2 regulates its own receptors
25. Involvement of p21ras activation in T cell CD69 expression
26. A cell culture model for T lymphocyte clonal anergy
27. Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor
28. Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T-cell receptor signaling
29. The jak family tyrosine kinase jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells
30. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain
31. Interleukin-2: Inception, impact, and implications
32. Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen
33. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
34. Development of autologous, oligoclonal, poorly functioning T lymphocytes in a patient with autosomal recessive severe combined immunodeficiency caused by defects of the Jak3 tyrosine kinase
35. T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis
36. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
37. Reversal of in vitro T cell anergy by IL-2 stimulation
38. Models for T cell anergy: Is there a common molecular mechanism?
39. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
40. Prevention oft cell anergy by signaling through the γc chain of the IL-2 receptor