The Bmx tyrosine kinase induces activation of the stat signaling pathway, which is specifically inhibited by protein kinase Cδ

Blood

Volumn 90, Issue 11, 1997, Pages 4341-4353

  Saharinen, Pipsa ^b   Ekman, Niklas ^b   Sarvas, Krista ^b   Parker, Peter ^b   Alitalo, Kari ^b   Silvennoinen, Olli ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; PROTEIN TYROSINE KINASE;

ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HEMATOPOIESIS; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL; RECEPTOR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0030697510     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.11.4341     Document Type: Article

References (70)

1. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O: Signalling through the hematopoietic cytokine receptors. Annu Rev Immunol 13:369, 1995
2. Rawlings DJ, Witte ON: The Btk subfamily of cytoplasmic tyrosine kinases: Structure, regulation and function. Semin Immunol 7:237, 1995
3. Kaukonen J, Lahtinen I, Laine S, Alitalo K, Palotie A: Bmx tyrosine kinase is expressed in granulocytes and myeloid leukaemias. Br J Haematol 94:455, 1996
4. Tamagnone L, Lahtinen I, Mustonen T, Virtaneva K, Francis F, Muscatelli F, Alitalo R, Smith CIE, Larsson C, Alitalo K: Bmx, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene 9:3683, 1994
5. Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON: Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72:279, 1993
6. Vihinen M, Cooper MD, de Saint Basile G, Fischer A, Good RA, Hendriks RW, Kinnon C, Kwan SP, Litman GW, Notarangelo LD, Ochs HD, Rosen FS, Vetrie D, Webster ADB, Zegers BJM, Smith CIE: International study group: BTKbase: A database of XLA-causing mutations. Immunol Today 16:460, 1995
7. Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM: Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3:301, 1995
8. Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Muller S, Kantor AB, Herzenberg LA, Rosen FS, Sideras P: Defective B cell development and function in Btk deficient mice. Immunity 3:283, 1995
9. Liao XC, Littman DR: Altered T cell receptor signalling and disrupted T cell development in mice lacking ltk. Immunity 3:757, 1995
10. Kawakami Y, Yao L, Miura T, Tsukada S, Witte ON, Kawakami T: Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon FcεRI crosslinking. Mol Cell Biol 14:5108, 1994
11. Aoki Y, Isselbacher KJ, Pillai S: Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells. Proc Natl Acad Sci USA 91:10606, 1994
12. De Weers M, Brouns GS, Hinshelwood S, Kinnon C, Scuurman RKB, Hendriks RW, Borst J: B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia. Proc Natl Acad Sci USA 269:23857, 1994
13. Sato S, Katagiri T, Takaki S, Kikuchi Y, Hitoshi Y, Yonehara S, Tsukada S, Kitamura D, Watanabe T, Witte O: IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. J Exp Med 180:101, 1994
14. Matsuda T, Takahashi-Tezuka M, Fukada T, Okuyama Y, Fujitani Y, Tsukada S, Mano H, Hirai H, Witte ON, Hirano T: Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines. Blood 85:627, 1995
15. Tang B, Mano H, Yi T, Ihle JN: Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. Mol Cell Biol 14:8432, 1994
16. Mano H, Yamashita Y, Sato K, Yazaki Y, Hirai H: Tec protein-tyrosine kinase is involved in interleukin-3 signalling pathway. Blood 85:343, 1995
17. August A, Gibson S, Kawakami Y, Kawakami T, Mills GB, Dupont B: CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/ EMT in the human Jurkat leukemic T-cell line. Proc Natl Acad Sci USA 91:9347, 1994
18. Kawakami Y, Yao L, Tashiro M, Gibson S, Mills BG, Kawakami T: Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on FcεRI cross-linking on mast cells. J Immunol 155:3556, 1996
19. Takata M, Kurosaki T: A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2. J Exp Med 184:31, 1996
20. Cheng G, Ye ZS, Baltimore D: Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. Proc Natl Acad Sci USA 91:8152, 1994
21. Mahajan S, Fargnoli J, Burkhardt AL, Kut SA, Saouaf SJ, Bolen JB: Src family protein tyrosine kinase induce autoactivation of Bruton's tyrosine kinase. Mol Cell Biol 15:5304, 1995
22. Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP: Activation of Btk by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822, 1996
23. Park H, Wahl MI, Afar DEH, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON: Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4:515, 1996
24. Tsukada S, Rawlings DJ, Witte ON: Role of Bruton's tyrosine kinase in immunodeficiency. Curr Opin Immunol 6:623, 1994
25. Yao L, Kawakami Y, Kawakami T: The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc Natl Acad Sci USA 91:9175, 1994
26. Schindler C, Darnell JE Jr: Transcriptional responses to polypeptide ligands: The Jak/Stat pathway. Annu Rev Biochem 64:621, 1995
27. Wen Z, Zhong Z, Darnell JE Jr: Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phophorylation. Cell 82:241, 1995
28. Kaplan MH, Sun YL, Hoey T, Grusby MJ: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174, 1996
29. Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DAA, Doherty PC, Grosweld GC, Ihle JN: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171, 1996
30. Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DAA, Doherty PC, Grosweld G, Paul WE, Ihle JN: Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630, 1996
31. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S: Essential role of Stat6 in IL-4 signalling. Nature 380:627, 1996
32. Silvennoinen O, Ihle JN, Schlessinger J, Levy DE: Interferon-induced nuclear signalling by Jak protein tyrosine kinases. Nature 366:583, 1993
33. Silvennoinen O, Witthuhn BA, Quelle FW, Cleveland JL, Yi T, Ihle JN: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci USA 90:8429, 1993
34. Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A: Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signalling pathways. Science 233:859, 1986
35. Olivier AR, Parker PJ: Expression and characterisation of PKC-δ. Eur J Biochem 200:805, 1991
36. Schaap D, Parker PJ: Expression, purification and characterization of protein kinase C-ε. J Biol Chem 265:7301, 1990
37. Ways DK, Posekany K, deVente J, Gams T, Chen J, Hooker J, Qin W, Cook P, Fletcher D, Parker P: Overexpression of protein kinase C-zeta stimulates leukemic cell differentiation. Cell Growth Differ 5:1195, 1994
38. Pine R, Canova A, Schindler C: Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFNα and IFNγ, and is likely to autoregulate the p91 gene. EMBO J 13:158, 1994
39. Sliva D, Wood TJ, Schindler C, Lobie PE, Norstedt G: Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA element. J Biol Chem 269:26208, 1994
40. Couture C, Baier G, Oetken C, Williams S, Telford D, Marie-Cardine A, Baier-Bitterlich G, Fischer S, Burn P, Altman A: Activation of p561ck by p72syk through physical association and N-terminal tyrosine phosphorylation. Mol Cell Biol 14:5249, 1994
41. Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE Jr: Proteins of transcription factor ISGF-3: One gene encodes the 91- and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci USA 89:7836, 1992
42. Zhong Z, Wen Z, Darnell JE Jr: Stat3 and Stat4: Members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 91:4806, 1994
43. Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 13:2182, 1994
44. Mui ALF, Wakao H, O'Farrel AM, Harada N, Miyajima A: Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two Stat5 homologs. EMBO J 14:1166, 1995
45. Chaikin E, Ziltener HJ, Razin E: Protein kinase C plays an inhibitory role in interleukin 3- and interleukin 4-mediated mast cell proliferation. J Biol Chem 265:22109, 1990
46. Petricoin E III, David M, Igarashi K, Benjamin C, Ling L, Goelz S, Finbloom DS, Larner AC: Inhibition of alpha interferon but not gamma interferon signal transduction by phorbol esters is mediated by a tyrosine phosphatase. Mol Cell Biol 16:1419, 1996
47. Kanda K, Decker T, Aman P, Wahlstrom M, von Gabain A, Kallin B: The EBNA2-related resistance towards alpha interferon (IFN-alpha) in Burkitt's lymphoma cells affects induction of IFN-induced genes but not the activation of transcription factor ISGF-3. Mol Cell Biol 12:4930, 1992
48. Petricoin E III, David M, Fang H, Grimley P, Larner AC, Vande Pol S: Human cancer cell lines express a negative transcriptional regulator of the interferon regulatory factor family of DNA binding proteins. Mol Cell Biol 14:1477, 1994
49. Quelle FW, Thierfelder W, Witthuhn BA, Tang B, Cohen S, Ihle JN: Phosphorylation and activation of the DNA binding activity of purified Stall by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J Biol Chem 270:20775, 1995
50. David M, Wong L, Flavell R, Thompson SA, Wells A, Larner AC, Johnson GR: STAT activation by epidermal growth factor (EGF) and amphiregulin. J Biol Chem 271:9185, 1996
51. Leaman DW, Pisharody S, Flickinger TW, Commane MA, Schlessinger J, Kerr IM, Levy DE, Stark GR: Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol Cell Biol 16:369, 1996
52. Vignais ML, Sadowski HB, Watling D, Rogers NC, Gilman M: Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol Cell Biol 16:1759, 1996
53. Henttinen T, Levy DE, Silvennoinen O, Hurme M: Activation of the signal transducer and transcription (STAT) signalling pathway in a primary T cell response. J Immunol 155:4582, 1995
54. Karras JG, Wang Z, Coniglio SJ, Frank DA, Rothstein TL: Antigen-receptor engagement in B cells induces nuclear expression of Stat5 and Stat6 proteins that bind and transactivate an IFN-γ activation site. J Immunol 157:39, 1996
55. Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, Jove R: Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269:81, 1995
56. Cao X, Tay A, Guy GR, Tan YH: Activation and association of Stat3 with Src in v-Src transformed cell lines. Mol Cell Biol 16:1595, 1996
57. Chaturvedi P, Sharma S, Reddy EP: Abrogation of interleukin-3 dependence of myeloid cells by the v-Src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol Cell Biol 17:3295, 1997
58. Cambell GS, Yu C-L, Jove R, Carter-Su C: Constitutive activation of Jak1 in Src-transformed cells. J Biol Chem 272:2591, 1997
59. Goulleux-Gruart V, Goilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, Weber-Nordt R, Dusanter-Fourt I, Dreyfus F, Groner B, Prin L: STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87:1692, 1996
60. Weber-Nordt RM, Egen C, Wehinger J, Ludwig W, Goilleux-Gruart V, Mertelsman R, Finke J: Constituve activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood 88:809, 1996
61. Carlesso N, Frank DA, Griffin JD: Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med 183:811, 1996
62. BCR/ABL induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 271:31704, 1996
63. Soltoff SP, Toker A: Carbacol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase Cδ in salivary gland epithelial cells. J Biol Chem 270:13490, 1995
64. Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, Yuspa SH: Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase Cδ. J Biol Chem 271:5325, 1996
65. Haleem-Smith H, Chang EY, Szallasi Z, Blmberg PM, Rivera J: Tyrosine phosphorylation of protein kinase C-δ in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition. Proc Natl Acad Sci USA 92:9112, 1995
66. Rivard N, McKenzie FR, Brondello JM, Pouyssegur J: The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G-protein-coupled receptors. J Biol Chem 270:11017, 1995
67. Uchida T, Matozaki T, Matsuda K, Suzuki T, Matozaki S, Nakano O, Wada K, Konda Y, Sakamoto C, Kasuga M: Phorbol ester stimulates the activity of a protein tyrosine phosphatase containing SH2 domains (PTP1C) in HL-60 leukemia cells by increasing gene expression. J Biol Chem 268:11845, 1993
68. Yi T, Mui ALF, Krystal G, Ihle JN: Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis. Mol Cell Biol 13:7577, 1993
69. Yi T, Zhang J, Miura O, Ihle JN: Hematopoietic cell phosphatase associates with erythropoietin (EPO) receptor after EPO-induced receptor tyrosine phosphorylation: Identification of potential binding sites. Blood 85:87, 1995
70. Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80:729, 1995