Photochemical preparation of a pyridone containing tetracycle: A Jak protein kinase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 8, 2002, Pages 1219-1223

  Thompson, James E ^a   Cubbon, Rose M ^a   Cummings, Richard T ^a   Wicker, Linda S ^a   Frankshun, Robert ^a   Cunningham, Barry R ^a   Cameron, Patricia M ^a   Meinke, Peter T ^a   Liverton, Nigel ^a   Weng, Youmin ^a   DeMartino, Julie A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1,1 DIMETHYLETHYL) 9 FLUORO 1H BENZ[H]ISOQUINOLIN 3 ONE[5,6 D]IMIDAZOLE; 2 (1,1 DIMETHYLETHYL) 9 FLUORO 3,6 DIHYDRO 7H BENZ[H]IMIDAZ[4,5 F]ISOQUINOLIN 7 ONE; IMIDAZOLE DERIVATIVE; INTERLEUKIN 2; INTERLEUKIN 4; ISOPROTEIN; JANUS KINASE; PROTEIN KINASE INHIBITOR; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; IC 50; IRRADIATION; NONHUMAN; PHOTOCHEMISTRY; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SPECTRAL SENSITIVITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL DIVISION; DNA-BINDING PROTEINS; ENZYME INHIBITORS; INTERLEUKIN-2; INTERLEUKIN-4; JANUS KINASE 3; MICE; MILK PROTEINS; PHOSPHORYLATION; PHOTOCHEMISTRY; PROTEIN-TYROSINE KINASES; PYRIDONES; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

MURINAE;

EID: 0037156334     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00106-3     Document Type: Article

References (31)