Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production

Journal of Immunology

Volumn 160, Issue 4, 1998, Pages 1581-1588

  Siemasko, Karyn ^a   Chong, Anita S F ^a   Jäck, Hans Martin ^b   Gong, Haihua ^a   Williams, James W ^a   Finnegan, Alison ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 4; LEFLUNOMIDE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; URIDINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; BINDING, COMPETITIVE; DNA-BINDING PROTEINS; GROWTH INHIBITORS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-4; ISOXAZOLES; JANUS KINASE 3; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYROSINE; URIDINE;

EID: 0032519992     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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