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Volumn 5, Issue 10, 1999, Pages 2954-2962

In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 [4-(4'Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline]

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4' HYDROXYPHENYL)AMINO 6,7 DIMETHOXYQUINAZOLINE; ANTINEOPLASTIC AGENT; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

EID: 0344466789     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (51)

References (20)
  • 1
    • 0029785080 scopus 로고    scopus 로고
    • A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9
    • Demoulin, J. B., Uyttenhove, C., Van Roost, E., DeLestre, B., Donckers, D., Van Snick, J., and Renauld, J. C. A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol. Cell. Biol., 16: 4710-4716, 1996.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4710-4716
    • Demoulin, J.B.1    Uyttenhove, C.2    Van Roost, E.3    DeLestre, B.4    Donckers, D.5    Van Snick, J.6    Renauld, J.C.7
  • 3
    • 0030738380 scopus 로고    scopus 로고
    • Rescue by cytokines of apoptotic cell death induced by IL-2 deprivation of human antigen-specific T cell clones
    • Kaneko, S., Suzuki, N., Koizumi, H. S., Yamamoto, S., and Sakane, T. Rescue by cytokines of apoptotic cell death induced by IL-2 deprivation of human antigen-specific T cell clones. Clin. Exp. Immunol., 109: 185-193, 1997.
    • (1997) Clin. Exp. Immunol. , vol.109 , pp. 185-193
    • Kaneko, S.1    Suzuki, N.2    Koizumi, H.S.3    Yamamoto, S.4    Sakane, T.5
  • 4
    • 0029782738 scopus 로고    scopus 로고
    • An epidermal growth factor receptor/JAK2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells
    • Nakamura, N., Chin, H., Miyasaka, N., and Miura, O. An epidermal growth factor receptor/JAK2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells. J. Biol. Chem., 277: 19483-19488, 1996.
    • (1996) J. Biol. Chem. , vol.277 , pp. 19483-19488
    • Nakamura, N.1    Chin, H.2    Miyasaka, N.3    Miura, O.4
  • 5
    • 0028786276 scopus 로고
    • The Janus protein tyrosine kinase family and its role in cytokine signaling
    • Ihle, J. N. The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv. Immunol., 60: 1-35, 1995.
    • (1995) Adv. Immunol. , vol.60 , pp. 1-35
    • Ihle, J.N.1
  • 6
    • 0032981804 scopus 로고    scopus 로고
    • Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery
    • Witthuhn, B. A., Williams, M. D., Kerawalla, H., and Uckun, F. M. Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery. Leuk. Lymphoma, 32: 289-297, 1999.
    • (1999) Leuk. Lymphoma , vol.32 , pp. 289-297
    • Witthuhn, B.A.1    Williams, M.D.2    Kerawalla, H.3    Uckun, F.M.4
  • 8
    • 0029784886 scopus 로고    scopus 로고
    • Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
    • Weber-Nordt, R. M., Egen, C., Wehinger, J., Ludwig, W., Gouilleux-Gruart, V., Mertelsmann, R., and Finke, J. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood, 88: 809-816, 1996.
    • (1996) Blood , vol.88 , pp. 809-816
    • Weber-Nordt, R.M.1    Egen, C.2    Wehinger, J.3    Ludwig, W.4    Gouilleux-Gruart, V.5    Mertelsmann, R.6    Finke, J.7
  • 9
    • 0033053383 scopus 로고    scopus 로고
    • Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
    • Sudbeck, E. A., Liu, X. P., Narla, R. K., Mahajan, S., Ghosh, S., Mao, C., and Uckun, F. M. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin. Cancer Res., 5: 1569-1582, 1999.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1569-1582
    • Sudbeck, E.A.1    Liu, X.P.2    Narla, R.K.3    Mahajan, S.4    Ghosh, S.5    Mao, C.6    Uckun, F.M.7
  • 10
    • 0032921686 scopus 로고    scopus 로고
    • A quantitative HPLC detection method for pharmacokinetic studies of the potent mast cell inhibitor 4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131)
    • Chen, C. L., Malaviya, R., Chen, H., Liu, X-P., and Uckun, F. M. A quantitative HPLC detection method for pharmacokinetic studies of the potent mast cell inhibitor 4-(4′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131). J. Chromatogr. B (Biomed. Sci.), 727: 205-212, 1999.
    • (1999) J. Chromatogr. B (Biomed. Sci.) , vol.727 , pp. 205-212
    • Chen, C.L.1    Malaviya, R.2    Chen, H.3    Liu, X.-P.4    Uckun, F.M.5
  • 11
    • 0032908020 scopus 로고    scopus 로고
    • Pharmacoikinetics and biologic activity of the novel mast cell inhibitor, 4-(3′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice
    • Chen, C. L., Malaviya, R., Navara, C., Chen, H., Bechard, B., Mitchltree, G., Eiu, X. P., and Uckun, F. M. Pharmacoikinetics and biologic activity of the novel mast cell inhibitor, 4-(3′-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice. Pharm. Res., 16: 117-122, 1999.
    • (1999) Pharm. Res. , vol.16 , pp. 117-122
    • Chen, C.L.1    Malaviya, R.2    Navara, C.3    Chen, H.4    Bechard, B.5    Mitchltree, G.6    Eiu, X.P.7    Uckun, F.M.8
  • 12
    • 0032802212 scopus 로고    scopus 로고
    • Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with potent antileukemic activity
    • Chen, C. L., Tai, H. L., Zhu, D. M., and Uckun, F. M. Pharmacokinetic features and metabolism of calphostin C, a naturally occurring perylenequinone with potent antileukemic activity. Pharm. Res., 16: 1003-1009, 1999.
    • (1999) Pharm. Res. , vol.16 , pp. 1003-1009
    • Chen, C.L.1    Tai, H.L.2    Zhu, D.M.3    Uckun, F.M.4
  • 16
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies, B., and Morris, T. Physiological parameters in laboratory animals and humans. Pharm. Res., 10: 1093-1095, 1993.
    • (1993) Pharm. Res. , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 18
    • 0021703938 scopus 로고
    • Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm
    • Boxenbaum, H. Interspecies pharmacokinetic scaling and the evolutionary-comparative paradigm. Drug Metab. Rev., 15: 1071-1121, 1984.
    • (1984) Drug Metab. Rev. , vol.15 , pp. 1071-1121
    • Boxenbaum, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.