The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing

Journal of Leukocyte Biology

Volumn 76, Issue 6, 2004, Pages 1248-1255

  Conklyn, Maryrose ^a   Andresen, Catharine ^a   Changelian, Paul ^a   Kudlacz, Elizabeth ^a  

^a PFIZER INC   (United States)

Author keywords

CD69; IL 15; Memory T cells; Transplantation

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CYTOKINE RECEPTOR; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 9; JANUS KINASE; JANUS KINASE 3; JANUS KINASE 3 INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELL COUNT; CELL SURVIVAL; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CYNOMOLGUS MONKEY; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; HOMEOSTASIS; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; MONKEY; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REBOUND; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSPLANTATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; INTERLEUKIN-15; JANUS KINASE 3; KILLER CELLS, NATURAL; MACACA FASCICULARIS; MALE; PROTEIN-TYROSINE KINASES; PYRIMIDINES; PYRROLES;

ANIMALIA; JANUS; MACACA FASCICULARIS;

EID: 10044296324     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0504282     Document Type: Article

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