-
1
-
-
0033604579
-
Cytokines and JAK-STAT signaling
-
C. Schindler Cytokines and JAK-STAT signaling Exp. Cell Res. 253 1999 7 14
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 7-14
-
-
Schindler, C.1
-
2
-
-
0036233585
-
Cytokine signaling in 2002: New surprises in the JAK/STAT pathway
-
J.J. O'Shea Cytokine signaling in 2002: new surprises in the JAK/STAT pathway Cell 109 2002 S121 S131
-
(2002)
Cell
, vol.109
-
-
O'Shea, J.J.1
-
3
-
-
0036256836
-
JAK-STAT signaling in human disease
-
C. Schindler JAK-STAT signaling in human disease J. Clin. Invest. 109 2002 1133 1137
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1133-1137
-
-
Schindler, C.1
-
4
-
-
0032032328
-
Biochemical approaches to discovering modulators of the JAK-STAT pathway
-
P. Lamb Biochemical approaches to discovering modulators of the JAK-STAT pathway Drug Discov. Today 3 1998 122 130
-
(1998)
Drug Discov. Today
, vol.3
, pp. 122-130
-
-
Lamb, P.1
-
5
-
-
0034722896
-
STAT proteins: Novel molecular targets for cancer drug discovery
-
J. Turkson, and R. Jove STAT proteins: novel molecular targets for cancer drug discovery Oncogene 19 2000 6613 6626
-
(2000)
Oncogene
, vol.19
, pp. 6613-6626
-
-
Turkson, J.1
Jove, R.2
-
6
-
-
0041302153
-
Negative regulation of cytokine signaling and inflammatory diseases
-
K. Inagaki-Ohara Negative regulation of cytokine signaling and inflammatory diseases Curr. Opin. Pharmacol. 3 2003 435 442
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 435-442
-
-
Inagaki-Ohara, K.1
-
7
-
-
2442464602
-
Therapeutical potential of Janus kinase 3 (JAK3) inhibitors
-
M. Cetkovic-Cvrlje, and H.E. Tibbles Therapeutical potential of Janus kinase 3 (JAK3) inhibitors Curr. Pharm. Des. 10 2004 1767 1784
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1767-1784
-
-
Cetkovic-Cvrlje, M.1
Tibbles, H.E.2
-
9
-
-
0028857954
-
Mutation of JAK3 in a patient with SCID: Essential role of JAK3 in lymphoid development
-
S.M. Russell Mutation of JAK3 in a patient with SCID: essential role of JAK3 in lymphoid development Science 270 1995 797 800
-
(1995)
Science
, vol.270
, pp. 797-800
-
-
Russell, S.M.1
-
10
-
-
3042563551
-
JAK3 and the pathogenesis of severe combined immunodeficiency
-
J.J. O'Shea JAK3 and the pathogenesis of severe combined immunodeficiency Mol. Immunol. 41 2004 727 737
-
(2004)
Mol. Immunol.
, vol.41
, pp. 727-737
-
-
O'Shea, J.J.1
-
11
-
-
0027403374
-
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
-
M. Noguchi Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans Cell 73 1993 147 157
-
(1993)
Cell
, vol.73
, pp. 147-157
-
-
Noguchi, M.1
-
12
-
-
0035816692
-
Cytokine-independent JAK3 activation upon T cell receptor (TCR) stimulation through direct association of JAK3 and the TCR complex
-
K. Tomita Cytokine-independent JAK3 activation upon T cell receptor (TCR) stimulation through direct association of JAK3 and the TCR complex J. Biol. Chem. 276 2001 25378 25385
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25378-25385
-
-
Tomita, K.1
-
13
-
-
1342324584
-
CD40 on adult human airway epithelial cells: Expression and proinflammatory effects
-
F. Cagnoni CD40 on adult human airway epithelial cells: expression and proinflammatory effects J. Immunol. 172 2004 3205 3214
-
(2004)
J. Immunol.
, vol.172
, pp. 3205-3214
-
-
Cagnoni, F.1
-
14
-
-
0032863261
-
The Janus kinase family of protein tyrosine kinases and their role in signaling
-
T.C. Yeh, and S. Pellegrini The Janus kinase family of protein tyrosine kinases and their role in signaling Cell. Mol. Life Sci. 55 1999 1523 1534
-
(1999)
Cell. Mol. Life Sci.
, vol.55
, pp. 1523-1534
-
-
Yeh, T.C.1
Pellegrini, S.2
-
15
-
-
13344295097
-
Inhibition of acute lymphoblastic leukaemia by Jak-2 inhibitor
-
N. Meydan Inhibition of acute lymphoblastic leukaemia by Jak-2 inhibitor Nature 379 1996 645 648
-
(1996)
Nature
, vol.379
, pp. 645-648
-
-
Meydan, N.1
-
16
-
-
0034595097
-
Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways
-
K. Kumano Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways Biochem. Biophys. Res. Commun. 270 2000 209 214
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.270
, pp. 209-214
-
-
Kumano, K.1
-
17
-
-
0001123864
-
JAK3, STAT and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2 mediated T cell response
-
L. Wang JAK3, STAT and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2 mediated T cell response J. Immunol. 162 1999 3897 3904
-
(1999)
J. Immunol.
, vol.162
, pp. 3897-3904
-
-
Wang, L.1
-
18
-
-
0034689408
-
Napthyl ketones: A new class of Janus kinase 3 inhibitors
-
G.R. Brown Napthyl ketones: a new class of Janus kinase 3 inhibitors Bioorg. Med. Chem. Lett. 10 2000 575 579
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 575-579
-
-
Brown, G.R.1
-
19
-
-
0033053383
-
Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents
-
E.A. Sudbeck Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents Clin. Cancer Res. 5 1999 1569 1582
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1569-1582
-
-
Sudbeck, E.A.1
-
20
-
-
0033712415
-
Treatment of allergic asthma by targeting Janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′,5′-dibromo-4′- hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)
-
R. Malaviya Treatment of allergic asthma by targeting Janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′,5′- dibromo-4′-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97) J. Pharmacol. Exp. Ther. 295 2000 912 926
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 912-926
-
-
Malaviya, R.1
-
21
-
-
0037360589
-
Targeting JAK3 with JANEX-1 for prevention of autoimmune type I diabetes in NOD mice
-
M. Cetkovic-Cvrlje Targeting JAK3 with JANEX-1 for prevention of autoimmune type I diabetes in NOD mice Clin. Immunol. 106 2003 213 225
-
(2003)
Clin. Immunol.
, vol.106
, pp. 213-225
-
-
Cetkovic-Cvrlje, M.1
-
22
-
-
0033564946
-
New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-κB and AP-1 activation
-
A. Mortellaro New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-κB and AP-1 activation J. Immunol. 162 1999 7102 7109
-
(1999)
J. Immunol.
, vol.162
, pp. 7102-7109
-
-
Mortellaro, A.1
-
23
-
-
0037079735
-
Selective inhibitor of Janus kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin
-
S.M. Stepowski Selective inhibitor of Janus kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin Blood 99 2002 680 689
-
(2002)
Blood
, vol.99
, pp. 680-689
-
-
Stepowski, S.M.1
-
24
-
-
0343962142
-
The role of IL-2 in allograft rejection-A lesson learned from experimental work
-
S. Yun The role of IL-2 in allograft rejection-A lesson learned from experimental work Transplantation 69 2000 2480 2483
-
(2000)
Transplantation
, vol.69
, pp. 2480-2483
-
-
Yun, S.1
-
25
-
-
1842430919
-
Anti-cytokine therapy for the treatment of graft-versus-host disease
-
D.A. Jacobsohn, and G.B. Vogelsang Anti-cytokine therapy for the treatment of graft-versus-host disease Curr. Pharm. Des. 10 2004 1195 1205
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1195-1205
-
-
Jacobsohn, D.A.1
Vogelsang, G.B.2
-
26
-
-
0242332186
-
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
-
P.S. Changelian Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor Science 302 2003 875 878
-
(2003)
Science
, vol.302
, pp. 875-878
-
-
Changelian, P.S.1
-
27
-
-
0347478057
-
JAKing up immunosuppression
-
M. Sykes JAKing up immunosuppression Nat. Med. 9 2003 1458 1459
-
(2003)
Nat. Med.
, vol.9
, pp. 1458-1459
-
-
Sykes, M.1
-
28
-
-
0032872565
-
The role of cytokines, CTLA-4 and costimulation in transplant tolerance and rejection
-
Z. Dai, and F.G. Lakkis The role of cytokines, CTLA-4 and costimulation in transplant tolerance and rejection Curr. Opin. Immunol. 11 1999 504 508
-
(1999)
Curr. Opin. Immunol.
, vol.11
, pp. 504-508
-
-
Dai, Z.1
Lakkis, F.G.2
-
29
-
-
0036527429
-
Protein kinases - The major drug targets of the twenty-first century?
-
P. Cohen Protein kinases - the major drug targets of the twenty-first century? Nat. Rev. Drug Discov. 1 2002 309 315
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 309-315
-
-
Cohen, P.1
-
30
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
M.E.M. Noble Protein kinase inhibitors: insights into drug design from structure Science 303 2004 1800 1805
-
(2004)
Science
, vol.303
, pp. 1800-1805
-
-
Noble, M.E.M.1
-
31
-
-
0842346438
-
Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems
-
T. Pawson Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems Cell 116 2004 191 203
-
(2004)
Cell
, vol.116
, pp. 191-203
-
-
Pawson, T.1
-
32
-
-
0042592995
-
Non-phosphopeptide inhibitor for Lck SH2 domain: Solid-phase synthesis and structure activity relationship of rosmarinic acid analogs
-
S.H. Kang Non-phosphopeptide inhibitor for Lck SH2 domain: solid-phase synthesis and structure activity relationship of rosmarinic acid analogs Bull. Korean Chem. Soc. 24 2003 664 666
-
(2003)
Bull. Korean Chem. Soc.
, vol.24
, pp. 664-666
-
-
Kang, S.H.1
-
33
-
-
0034687218
-
Structure-based design of novel bicyclic nonpeptide inhibitors for the src SH2 domain
-
W.C. Shakespeare Structure-based design of novel bicyclic nonpeptide inhibitors for the src SH2 domain J. Med. Chem. 43 2000 3815 3819
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3815-3819
-
-
Shakespeare, W.C.1
-
34
-
-
0031018904
-
Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking
-
S. Giorgetti-Peraldi Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking Mol. Cell. Biol. 17 1997 1180 1188
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1180-1188
-
-
Giorgetti-Peraldi, S.1
-
35
-
-
0035910063
-
Combining multiple structure and sequence alignments to improve sequence detection and alignment: Application to the SH2 domains of Janus kinases
-
B. Al-Lazikani Combining multiple structure and sequence alignments to improve sequence detection and alignment: application to the SH2 domains of Janus kinases Proc. Natl. Acad. Sci. U. S. A. 98 2001 14796 14801
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 14796-14801
-
-
Al-Lazikani, B.1
-
36
-
-
0031009816
-
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals
-
M. Chen The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals Proc. Natl. Acad. Sci. U. S. A. 94 1997 6910 6915
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 6910-6915
-
-
Chen, M.1
-
37
-
-
0033071270
-
The N-termini of FAK and JAKs contain divergent band 4.1 domains
-
J. Girault The N-termini of FAK and JAKs contain divergent band 4.1 domains Trends Biochem. Sci. 24 1999 54 57
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 54-57
-
-
Girault, J.1
-
38
-
-
0034283003
-
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
-
K. Hamada Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain EMBO J. 19 2000 4449 4462
-
(2000)
EMBO J.
, vol.19
, pp. 4449-4462
-
-
Hamada, K.1
-
39
-
-
0034724536
-
Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
-
M. Pearson Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain Cell 101 2000 259 270
-
(2000)
Cell
, vol.101
, pp. 259-270
-
-
Pearson, M.1
-
40
-
-
18244393495
-
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases
-
Y-J. Zhou Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases Mol. Cell 8 2001 959 969
-
(2001)
Mol. Cell
, vol.8
, pp. 959-969
-
-
Zhou, Y.-J.1
-
41
-
-
0034012330
-
Regulation of the JAK2 tyrosine kinase domain by its pseudokinase domain
-
P. Saharinen Regulation of the JAK2 tyrosine kinase domain by its pseudokinase domain Mol. Cell. Biol. 20 2000 3387 3395
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3387-3395
-
-
Saharinen, P.1
-
42
-
-
0033578618
-
Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis
-
R. Malaviya, and F.M. Uckun Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis J. Biol. Chem. 274 1999 27028 27038
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27028-27038
-
-
Malaviya, R.1
Uckun, F.M.2
-
43
-
-
0031785620
-
Infectious Th1 and Th2 autoimmunity in diabetes-prone mice
-
J. Tian Infectious Th1 and Th2 autoimmunity in diabetes-prone mice Immunol. Rev. 164 1998 119 127
-
(1998)
Immunol. Rev.
, vol.164
, pp. 119-127
-
-
Tian, J.1
-
44
-
-
0029164841
-
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
-
P. Macchi Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID) Nature 377 1995 65 68
-
(1995)
Nature
, vol.377
, pp. 65-68
-
-
MacChi, P.1
-
45
-
-
0028786653
-
Regulation of JAK3 expression and activation in human B cells and B cells malignancies
-
P.J. Tortolani Regulation of JAK3 expression and activation in human B cells and B cells malignancies J. Immunol. 155 1995 5220 5226
-
(1995)
J. Immunol.
, vol.155
, pp. 5220-5226
-
-
Tortolani, P.J.1
-
46
-
-
0033976059
-
The Jak-Stat pathway in normal and perturbed hematopoiesis
-
A.C. Ward The Jak-Stat pathway in normal and perturbed hematopoiesis Blood 95 2000 19 29
-
(2000)
Blood
, vol.95
, pp. 19-29
-
-
Ward, A.C.1
-
47
-
-
0025881584
-
Cells mediating allograft rejection
-
B.M. Hall Cells mediating allograft rejection Transplantation 51 1991 1141 1151
-
(1991)
Transplantation
, vol.51
, pp. 1141-1151
-
-
Hall, B.M.1
-
48
-
-
0142027137
-
Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3
-
M.D. Saemann Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3 Am. J. Transplant. 3 2003 1341 1349
-
(2003)
Am. J. Transplant.
, vol.3
, pp. 1341-1349
-
-
Saemann, M.D.1
|