Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N- (2,5-dibromophenyl)propenamide

Journal of Biological Chemistry

Volumn 274, Issue 14, 1999, Pages 9587-9599

  Mahajan, Sandeep ^a,b   Ghosh, Sutapa ^b   Sudbeck, Elise A ^b   Zheng, Yaguo ^b   Downs, Suzanne ^a,b   Hupke, Michael ^a,b   Uckun, Fatih M ^a,b  

^a Parker Hughes Cancer Center   (United States)

^b PARKER HUGHES INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CYANO BETA HYDROXY BETA METHYL N (2,5 DIBROMOPHENYL)PROPENAMIDE; ANTILEUKEMIC AGENT; ARGININE; ASPARTIC ACID; CERAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; INSULIN RECEPTOR KINASE; LEUCINE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TYROSINE; UNCLASSIFIED DRUG; VINCRISTINE;

AMINO ACID COMPOSITION; ANIMAL CELL; APOPTOSIS; ARTICLE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; LEUKEMIA; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTINEOPLASTIC AGENTS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; JANUS KINASE 1; JANUS KINASE 2; MODELS, MOLECULAR; NITRILES; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, INSULIN; SPHINGOSINE; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VINCRISTINE;

ANIMALIA; UNIDENTIFIED BACULOVIRUS;

EID: 0033515450     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.14.9587     Document Type: Article

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