Activation of the Jak3 pathway and myeloid differentiation

Leukemia and Lymphoma

Volumn 46, Issue 1, 2005, Pages 21-27

  Mangan, James K ^a   Reddy, E Premkumar ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Jak3; Myelpoiesis; Tyrosine kinases

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; GRANULOCYTE COLONY STIMULATING FACTOR; JANUS KINASE 3; MESSENGER RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR SP1;

BONE MARROW CELL; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; DOWN REGULATION; ENZYME ACTIVATION; GRANULOCYTE; HUMAN; MONOCYTE; MYELOPOIESIS; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SPLENOMEGALY; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; ENZYME ACTIVATION; HUMANS; JANUS KINASE 3; MYELOID CELLS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 12744255281     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190400005320     Document Type: Review

References (67)

1. Lotem, J. and Sachs, L. (2002) "Cytokine control of developmental programs in normal hematopoiesis and leukemia", Oncogene, 21, 3284-3294.
2. Rane, S.G. and Reddy, E.P. (2002) "JAKs, STATs, and Src kinases in hematopoiesis", Oncogene, 21, 3334-3358.
3. Ihle, J.N., Witthuhn, B.A., Quelle, F.W., Yamamoto, K. and Silvennoinen, O. (1995) "Signaling through the hematopoietic cytokine receptors", Annual Review of Immunology, 13, 369-398.
4. Darnell, J.E. Jr., Kerr, I.M. and Stark, G.R. (1994) "JAK-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins", Science, 264, 1415-1421
5. Leonard, W.J. (1996) "STATs and cytokine specificity". Nature Medicine, 2, 968-969.
6. Horvath, C.M. and Darnell, J.E. (1997) "The state of the STATs: recent developments in the study of signal transduction to the nucleus", Current Opinion in Cell Biology, 9, 233-239.
7. O'Shea, J.J. (1997) "Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet?" Immunity, 7 1-11.
8. Chaturvedi, P., Reddy, M.V. and Reddy, E.P. (1998) "Src kinases and not JAKs activate STATs during IL-3-induced myeloid cell proliferation", Oncogene, 16, 1749-1758.
9. Rane, S.G. and Reddy, E.P. (1994) "JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells", Oncogene, 9, 2415-2423.
10. Kawamura, M., McVicar, D.W., Johnston, J.A., Blake, T.B., Chen, Y.Q., Lal, B.K., et al. (1994) "Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes", Proceedings of the National Academy of Sciences, 91, 6374-6378.
11. Witthuhn, B.A., Silvennoinen, O., Miura, O., Lai, K.S., Cwik, C., Liu, E.T, et al. (1994) "Involvement of the Jak-3 Janus kinase in signaling by interleukins 2 and 4 in lymphoid and myeloid cells", Nature, 370, 153-157.
12. Johnston, J.A., Kawamura, M., Kirken, R.A., Chen, Y.Q., Blake, T.B., Shibuya, K., et al. (1994) "Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2", Nature, 370, 151-153.
13. Thomis, D.C., Gurniak, C.B., Tivol, E., Sharpe, A.H. and Berg, L.J. (1995) "Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking JAK3", Science, 270, 794-797.
14. Park, S.Y., Saijo, K., Takahashi, T., Osawa, M., Arase, H., Hirayama, N., et al. (1995) "Developmental defects of lymphoid cells in JAK3 kinase-deficient mice", Immunity, 3, 771-782.
15. Nosaka, T., van Deursen, J.M., Tripp, R.A., Thierfelder, W.E., Witthuhn, B.A., McMickle, A.P., et al. (1995) " Defective lymphoid development in mice lacking Jak3", Science, 270, 800-802.
16. Saijo, K., Park, S.Y., Ishida, Y., Arase, H. and Saito, T. (1997) "Crucial role of Jak3 in negative selection of self-reactive T cells", Journal of Experimental Medicine, 185, 351-356.
17. Cao, X., Shores, E.W., Hu-Li, J., Anver, M.R., Kelsall, B.L., Russell, S.M., et al. (1995) "Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain", Immunity, 2, 223-238.
18. DiSanto, J.P., Muller, W., Guy-Grand, D., Fischer, A. and Rajewsky, K. (1995) "Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain", Proceedings of the National Academy of Science, 92, 377-381.
19. c chains with Jak1 and Jak3: implications for XSCID and XCID", Science, 266, 1042-1045.
20. Miyazaki, T., Kawahara, A., Fujii, H., Nakagawa, Y., Minami, Y., Liu, Z.-J., et al. (1994) "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits", Science, 266, 1045-1047.
21. Boussiotis, V.A., Barber, D.L., Nakarai, T., Freeman, G.J., Gribben, J.G., Bernstein, G.M., et al. (1994) "Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor", Science, 266, 1039-1042.
22. Russell, S.M., Tayebi, N., Nakajima, H., Riedy, M.C., Roberts, J.L., Aman, M.J., et al. (1995) "Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development", Science, 270, 797-800.
23. Macchi, P., Villa, A., Giliani, S., Sacco, M.G., Frattini, A., Porta, F., et al. (1995) "Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)", Nature, 377 65-68.
24. Candotti, F., Oakes, S.A., Johnston, J.A., Giliani, S., Schumacher, R.F., Mella, P., et al. (1997) "Structural and functional basis for JAK3-deficient severe combined immunodeficiency", Blood, 90, 3996-4003.
25. Leonard, W.J. and O'Shea, J.J. (1998) "JAKS AND STATS: Biological implications", Annual Review of Immunology, 16, 293-322.
26. Kisseleva, T., Bhattacharya, S., Braunstein, J. and Schindler, C.W. (2002) "Signaling through the JAK/STAT pathway, recent advances and future challenges", Gene, 285, 1-24.
27. Grossman, W.J., Verbsky, J.W., Yang, L., Berg, L.J., Fields, L.E., Chaplin, D.D., et al. (1999) "Dysregulated myelopoiesis in mice lacking JAK3", Blood, 94, 932-939.
28. Suzuki, H., Kundig, T.M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., et al. (1995) "Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta", Science, 268, 1472-1476.
29. Rane, S.G., Mangan, J.K., Amanullah, A., Wong, B.C., Vora, R.K., Liebermann, D.A., et al. (2002) "Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells", Blood, 100, 2753-2762.
30. Mangan, J.K., Rane, S.G., Kang, A.D., Amanullah, A., Wong, B.C., and Reddy, E.P. (2004) "Mechanisms associated with IL-6-induced upregulation of Jak3 and its role in monocytic differentiation", Blood, 103, 4093-4101.
31. Reddy, E.P., Korapati, A., Chaturvedi, P. and Rane, S. (2000) "IL-3 signaling and the role of Src kinases, JAKs, and STATs: a covert liason unveiled", Oncogene, 19, 2532-2547.
32. Sudbeck, E.A., Liu, X.P., Narla, R.K., Mahajan, S., Ghosh, S., Mao, C., et al. (1999) "Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents", Clin. Cancer Res., 5, 1569-1582.
33. Saemann, M.D., Zeyda, M., Diakos, C., Szekeres, A., Bohmig, G.A., Kelemen, P., et al. (2003) "Suppression of early T-cell-receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154", Transplantation, 75, 1864-1872.
34. Amin, H.M., Medeiros, L.J., Ma, Y., Feretzaki, M., Das, P., Leventaki, V., et al. (2003) "Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma", Oncogene, 22, 5399-5407.
35. Saemann, M.D., Diakos, C., Kelemen, P., Kriehuber, E., Zeyda, M., Bohmig, G.A., et al. (2003) "Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3", Am. J. Transplant., 3, 1341-1349.
36. Revy, P., Hivroz, C., Andreu, G., Graber, P., Martinache, C., Fischer, A., and Durandy, A. (1999) "Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells". J. Immunol., 163, 787-793.
37. Mangan, J.K., and Reddy, E.P. (2004) Unpublished observations.
38. Bromberg, J.F., Wrzeszczynska, M.H., Devgan, G., Zhao, Y., Pestell, R.G., Albanese, C., et al. (1999) "Stat3 as an oncogene". Cell, 98, 295-303.
39. Aringer, M., Hofmann, S.R., Frucht, D.M., Chen, M., Centola, M., Morinobu, A., et al. (2003) "Characterization and analysis of the proximal Janus Kinase 3 promoter", Journal of Immunology, 170, 6057-6064.
40. Muthusamy, N., Barton, K. and Leiden, J.M. (1995) "Defective activation and survival of T cells lacking the Ets-1 transcription factor", Nature, 377, 639-642.
41. Nelson, B.H. and Willerford, D.M. (1998) "Biology of the interleukin-2 receptor", Advances in Immunology, 70, 1-81.
42. Tomita, K., Saijo, K., Yamasaki, S., Iida, T., Nakatsu, F., Arase, H., et al. (2001) "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex", Journal of Biological Chemistry, 276, 25378-25385.
43. Saffer, J.D., Jackson, S.P. and Annarella, M.B. (1991) "Developmental expression of Sp1 in the mouse", Molecular and Cellular Biology, 11, 2189-2199.
44. Nuchprayoon, I., Shang, J., Simkevich, C.P., Luo, M., Rosmarin, A.G. and Friedman, A.D. (1999) "An enhancer located between the neutrophil elastase and proteinase 3 promoters is activated by Sp1 and an Ets factor", Journal of Biological Chemistry, 274, 1085-1091.
45. Chen, H.M., Pahl, H.L., Scheibe, R.J., Zhang, D.-E. and Tenen, D.G. (1993) "The Sp1 transcription factor binds to the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity", Journal of Biological Chemistry, 268, 8230-8239.
46. Noti, J.D., Reinemann, B.C. and Petrus, M.N. (1996) "Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription", Molecular and Cellular Biology, 16, 2940-2950.
47. Noti, J.D., Johnson, A.K. and Dillon, J.D. (2000) "Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3", Journal of Biological Chemistry, 275, 8959-8969.
48. Zhang, D.-E., Hetherington, C.J., Tan, S., Dziennis, S.E., Gonzalez, D.A., Chen, H.M., et al. (1994) "Sp1 is a critical factor for the monocytic expression of human CD14", Journal of Biological Chemistry, 269, 11425-11434.
49. Rosmarin, A.G., Luo, M., Caprio, D.G., Shang, J. and Simkevich, C.P. (1998) "Sp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (β2 leukocyte integrin) promoter", Journal of Biological Chemistry, 273, 13097-13103.
50. Heydemann, A., Juang, G., Hennessy, K., Parmacek, M.S. and Simon, M.C. (1996) "The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor", Molecular and Cellular Biology, 16, 1676-1686.
51. Piedrafita, F.J., Molander, R.B., Vansant, G., Orlova, E.A., Pfahl, M. and Reynolds, W.F. (1996) "An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element", Journal of Biological Chemistry, 271, 14412-14420.
52. Khanna-Gupta, A., Zibello, T., Simkevich, C., Rosmarin, A.G. and Berliner, N. (2000) "Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation", Blood, 95 3734-3741.
53. Hauses, M., Tönjes, R.R. and Grez, M. (1998) "The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic cell kinase (HCK) gene through the binding of two adjacent GC boxes within the HCK-promoter-proximal region", Journal of Biological Chemistry, 273, 31844-31852.
54. Emili, A., Greenblatt, J. and Ingles, C.J. (1994) "Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein", Molecular and Cellular Biology, 14, 1582-1593.
55. Tenen, D.G., Hromas, R., Licht, J.D. and Zhang, D.-E. (1997) "Transcription factors, normal myeloid development, and leukemia", Blood, 90, 489-519.
56. Look, D.C., Pelletier, M.R., Tidwell, R.M., Roswit, W.T. and Holtzman, M.J. (1995) "Stat1 depends on transcriptional synergy with Sp1", Journal of Biological Chemistry, 270, 30264-30267.
57. Martino, A., Holmes, J.H. 4th, Lord, J.D., Moon, J.J. and Nelson, B.H. (2001) "Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2", Journal of Immunology, 166, 1723-1729.
58. Cantwell, C.A., Sterneck, E. and Johnson, P.F. (1998) "Interleukin-6-specific activation of the C/EBPδ gene in hepatocytes is mediated by Stat3 and Sp1", Molecular and Cellular Biology, 18, 2108-2117.
59. de Koning, J.P., Soede-Bobok, A.A., Ward, A.C., Schelen, A.M., Antonissen, C., van Leeuwen, D., et al. (2000) "STAT3-mediated differentiation and survival of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27 (Kip1)", Oncogene, 19, 3290-3298.
60. McLemore, M.L., Grewal, S., Liu, F., Archambault, A., Poursine-Laurent, J., Haug, J., et al. (2001) " STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation", Immunity, 14, 193-204.
61. Minami, M., Inoue, M., Wei, S., Takeda, K., Matsumoto, M., Kishimoto, T., et al. (1996) "STAT3 activation is a critical step in the gp130-mediated terminal differentiation and growth arrest of a myeloid cell line", Proceedings of the National Academy of Science 93 3963-3966.
62. Nakajima, K., Yamanaka, Y., Nakae, K., Kojima, H., Ichiba, M., Kiuchi, N., et al. (1996) "A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells", European Molecular Biology Organization Journal, 15, 3651-3658.
63. Nicholson, S.E., Oates, A.C., Harpur, A.G., Ziemiecki, A., Wilks, A.F. and Layton, J.E. (1994) "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation", Proceedings of the National Academy of Science, 91, 2985-2988.
64. Tian, S.S., Lamb, P., Seidel, H.M., Stein, R.B. and Rosen, J. (1994) "Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor", Blood, 84, 1760-1764.
65. Lütticken, C., Wegenka, U.M., Yuan, J., Buschmann, J., Schindler, C., Ziemieki, A., et al. (1994) "Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130", Science, 263, 89-92.
66. Matsuda, T., Yamanaka, Y. and Hirano, T. (1994) "Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells", Biochemical and Biophysical Research Communications, 200, 821-828.
67. Stahl, N., Boulton, T.G., Farruggella, T., Ip, N.Y., Davis, S., Witthuhn, B.A., et al. (1994) "Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components", Science, 263, 92-95.