JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 3897-3904

  Wang, Li Hua ^a   Kirken, Robert A ^c,d   Erwin, Rebecca A ^c   Yu, Cheng Rong ^b   Farrar, William L ^a,b  

^a Lab of Molecular Immunoregulation   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN TYROSINE KINASE INHIBITOR; STAT3 PROTEIN; STAT5 PROTEIN; STAT5B PROTEIN; TYRPHOSTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; DNA BINDING; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; ELECTROPHORETIC MOBILITY; ENZYME ACTIVATION; ENZYME INHIBITION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; DNA; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INHIBITORS; INTERLEUKIN-2; JANUS KINASE 3; LYMPHOCYTE ACTIVATION; MILK PROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTORS, INTERLEUKIN-2; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATORS; TYRPHOSTINS;

EID: 0001123864     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Smith, K. A. 1992. Interleukin-2. Curr. Opin. Immunol. 4:271.
2. Horak, I., J. Lohler, A. Ma, and K. A. Smith. 1995. Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance. Immunol. Rev. 148:35.
3. Nebl, G., S. C. Meuer, and Y. Samstag. 1998. Cyclosporin A-resistant transactivation of the IL-2 promoter requires activity of okadaic acid-sensitive serine/ threonine phosphatases. J. Immunol. 161:1803.
4. Bemer, V., and P. Truffa-Bachi. 1996. T cell activation by concanavalin A in the presence of cyclosporin A: immunosuppressor withdrawal induces NFATp translocation and interleukin-2 gene transcription. Eur. J. Immunol. 26:1481.
5. Helmberg, A., N. Auphan, C. Caelles, and M. Karin. 1995. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14:452.
6. Paliogianni, F., A. Raptis, S. S. Ahuja, S. M. Najjar, and D. T. Boumpas. 1993. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT. J. Clin. Invest. 91:1481.
7. Kondo, M., T. Takeshita, N. Ishii, M. Nakamura, S. Watanabe, K. Arai, and K. Sugamura. 1993. Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262:1874.
8. Russell, S. M., A. D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M. C. Friedmann, A. Miyajima, R. K. Puri, W. E. Paul, and W. L. Leonard. 1993. Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 262:1880.
9. Smith, M. R., R. J. Duhe, and W. L. Farrar. 1997. Microinjected cDNA encoding JAK2 protein-tyrosine kinase induces DNA synthesis in NIH 3T3 cells. FEBS Lett. 408:327.
10. Kirken, R. A., H. Rui, M. G. Malabarba, O. M. Z. Howard, M. Kawamura, J. J. O'Shea, and W. L. Farrar. 1995. Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and Stat5 recruitment by a COOH-terminal region of the IL-2 receptor β-chain. Cytokine 7:689.
11. Russell, S. M., J. A. Johnston, M. Noguchi, M. Kawamura, C. M. Bacon, M. Friedman, M. Berg, B. A. Witthuhn, A. S. Goldman, F. C. Schmalstieg, et al. 1994. Interaction of IL-2R β and γ c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042.
12. Darnell, J. E. 1997. Stats and gene regulation. Science 277:1630.
13. Evans, G. A., M. A. Goldsmith, J. A. Johnston, W. D. Xu, S. R. Weiler, R. Erwin, O. M. Z. Howard, R. T. Abraham, J. J. Oshea, W. C. Green, and W. L. Farrar. 1995. Analysis of interleukin 2 dependent signal transduction through the SHC/ GRB2 adapter pathway-interleukin-2-dependent mitogenesis does not require SHC phosphorylation or receptor association. J. Biol. Chem. 270:28858.
14. O'Shea, J. J. 1997. Jaks, Stats, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7:1.
15. Winstrom, L. A., and T. C. Hunter. 1996. Intracellular signaling: putting JAKs on the kinase MAP. Curr. Biol. 6:668.
16. Thomis, T. C., and L. J. Berg. 1997. The role of Jak3 in lymphoid development, activation, and signaling. Curr. Opin. Immunol. 9:541.
17. Gazit, A., P. Yaish, C. Gilon, and A. Levitzki. 1989. Synthesis and biological activity of protein tyrosine kinase inhibitors. J. Med. Chem. 32:2344.
18. Levitzki, A., and A. Gazit. 1995. Tyrosine kinase inhibition: an approach to drug development. Science 267:1782.
19. Meydan, N., T. Grunberger, H. Dadi, M. Shahar, E. Arpaia, Z. Lapidot, J. S. Leeder, M. Freedman, A. Cohen, A. Gazit, A. Levitzki, and C. M. Roifman. 1996. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379:645.
20. Simon, H. U., S. Youseti, B. Dibbert, F. Levischaffer, and K. Blaser. 1997. Anti-apoptitic signals of granulocyte-macrophage colony stimulating factors are transduced via JAK2 tyrosine kinase in eosinophils. Eur. J. Immunol. 27:3536.
21. Marrero, M. B., B. Schieffer, B. Li, J. M. Sun, J. B. Harp, and B. N. Ling. 1997. Role of Janus kinase signal transducer and activator of transcription and mitogen-activated protein kinases cascades in angiotensin II-and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J. Biol. Chem. 272: 24684.
22. McWhinney, C. D., R. A. Hunt, K. M. Conrad, D. K. Dostal, and K. M. Baker. 1997. The type I angiotensin II receptor couples to Stat1 and Stat3 activation through JAK2 kinase in neonatal rat cardiac myocytes. J. Mol. Cell. Cardiol. 29:2513.
23. Nielsen, M., K. Kaltoft, M. Nordahl, C. Ropke, C. Geisler, T. Mustelin, P. Dobson, A. Svejgaard, and N. Odum. 1997. Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG-490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc. Natl. Acad. Sci. USA 94:6764.
24. Malabarba, M. G., H. Rui, H. H. Deutsch, J. Chung, F. S. Kalthoff, W. L. Farrar, and R. A. Kirken. 1996. Interleukin-13 is a potent activator of JAK3 and Stat6 in cells expressing interleukin-2 receptor-γ and interleukin-4 receptor-α. Biochem. J. 319:865.
25. Malabarba, M. G., R. A. Kirken, H. Rui, K. Koettnitz, M. Kawamura, J. J. O'Shea, F. S. Kalthoff, and W. L. Farrar. 1995. Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor α. J. Biol. Chem. 270:9630.
26. Higuchi, M., H. Asao, N. Tanaka, K. Oda, T. Takeshita, M. Nakamura, J. Van-Snick, and K. Sugamura. 1996. Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line. Eur. J. Immunol. 6:1322.
27. Liu, K. D., S. L. Gaffen, M. A. Goldsmith, and W. C. Green. 1997. Janus kinases in interleukin-2-mediated signaling-JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation. Curr. Biol. 7:817.
28. Noguchi, M., Y. Nakamura, S. M. Russell, S. F. Ziegler, M. Tsang, X. Cao, and W. Leonard. 1993. Interleukin-2 receptor γ chain: a functional component of the interleukin-7 receptor. Science 262:1877.
29. Oakes, S. A., F. Candotti, J. A. Johnston, Y. Q. Chen, J. J. Ryan, N. Taylor, X. Liu, L. Hennighausen, L. D. Notarangelo, W. E. Paul, R. M. Blaese, and J. J. O'Shea. 1996. Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways. Immunity 5:605.
30. Liu, X., G. W. Robinson, F. Gouilleux, B. Groner, and L. Hennighausen. 1995. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. Proc. Natl. Acad. Sci. USA 92:8831.
31. Wakao, H., F. Gouilleux, and B. Groner. 1994. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J. 13: 2182.
32. Kirken, R. A., M. G. Malabarba, J. Xu, L. DaSilva, R. A. Erwin, X. Liu, L. Hennighausen, H. Rui, and W. L. Farrar. 1997. Two discrete regions of interleukin-2 (IL-2) receptor-β independently mediate IL-2 activation of a PD98059/rapamycin/wortmannin insensitive Stat5a/b serine kinase. J. Biol. Chem. 272:5459.
33. Fu, X. Y. 1992. A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s). Cell 70:323.
34. Howard, O. M. Z., R. A. Kirken, G. G. Garcia, R. H. Hackett, and W. L. Farrar. 1995. Structural domains of IL-2 receptor β critical for signal transduction: kinase association and nuclear complex formation. Biochem. J. 306:217.
35. Evans, G. A., G. G. Garcia, R. Erwin, O. M. Howard, W. L. Farrar. 1994. Pervanadate simulates the effects of interleukin-2 (IL-2) in human T cells and provides evidence for the activation of two distinct tyrosine kinase pathways by IL-2. J. Biol. Chem. 269:23407.
36. Huang, C., W. Y. Ma, M. R. Young, N. Colburn, Z. Dong. 1998. Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells. Proc. Natl. Acad. Sci. USA 95:156.
37. Frost, J. A., T. D. Geppert, M. H. Cobb, J. R. Feramisco. 1994. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proc. Natl. Acad. Sci. USA 91:3844.
38. Russell, S. M., N. Tayebi, H. Nakajima, M. C. Riedy, J. L. Roberts, M. J. Aman, T. S. Migone, M. Noguchi, M. L. Markert, and R. H. Buckley. 1995. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270:797.
39. Macchi, P., A. Villa, S. Gillani, M. G. Sacco, A. Frattini, F. Porta, A. G. Ugazio, J. A. Johnston, F. Candotti, and J. J. O'Shea. 1995. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID), Nature 377:65.
40. O'Shea, J. J., L. D. Notarangelo, J. A. Johnston, and F. Candotti. 1997. Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency. J. Clin. Immunol. 17:431.
41. Leaman, D. W., S. Leung, X. Li, and G. R. Stark, 1996. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J. 10:1578.
42. Wen, Z., Z. Zhong, J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241.
43. Zhang, X., J. Blenis, H. C. Li, C. Schindler, and S. Chen-Kiang. 1995. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267:1990.
44. David, M., E. Petricoin III, C. Benjamin, R. Pine, M. J. Weber, and A. C. Larner. 1995. Requirement for MAP kinase (ERK2) activity in interferon α-and interferon β-stimulated gene expression through STAT proteins. Science 269:1721.
45. Migone, T. S., J. X. Lin, A. Cereseto, J. C. Mulloy, J. J. O'Shea, G. Franchini, and W. J. Leonard. 1995. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269:79.
46. Dutton, R. W. 1996 The regulation of the development of CD8 effector T cells. J. Immunol. 157:4287.