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Volumn 179, Issue 1, 2005, Pages 30-53

N-Methyl-d-aspartate receptors as a target for improved antipsychotic agents: Novel insights and clinical perspectives

Author keywords

Antipsychotic; D Cycloserine; D Serine; GlycineB; Kynurenate; NMDA; Schizophrenia

Indexed keywords

7 CHLORO 4 HYDROXY 3 (3 PHENOXYPHENYL) 2 QUINOLONE; CYCLOSERINE; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NEUROLEPTIC AGENT; OLANZAPINE; ORG 24598; RISPERIDONE; S 18841; SARCOSINE; SSR 504734; UNCLASSIFIED DRUG;

EID: 17744399498     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-2199-1     Document Type: Review
Times cited : (218)

References (327)
  • 2
    • 4043141566 scopus 로고    scopus 로고
    • The somatodentritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems
    • Adell A, Artigas F (2004) The somatodentritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems. Neurosci Biobehav Res 28:415-431
    • (2004) Neurosci Biobehav Res , vol.28 , pp. 415-431
    • Adell, A.1    Artigas, F.2
  • 3
    • 0032859516 scopus 로고    scopus 로고
    • Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia
    • Adler CM, Malhotra AK, Elman I, Goldberg T, Egan M, Pickar D, Breier A (1999) Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia. Am J Psychiatry 156:1646-1649
    • (1999) Am J Psychiatry , vol.156 , pp. 1646-1649
    • Adler, C.M.1    Malhotra, A.K.2    Elman, I.3    Goldberg, T.4    Egan, M.5    Pickar, D.6    Breier, A.7
  • 4
    • 0034055690 scopus 로고    scopus 로고
    • Serotonin model of schizophrenia: Emerging role of glutamate mechanisms
    • Aghajanian GK, Marek GJ (2000) Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain Res Interactive 31:302-312
    • (2000) Brain Res Interactive , vol.31 , pp. 302-312
    • Aghajanian, G.K.1    Marek, G.J.2
  • 9
    • 2442695094 scopus 로고    scopus 로고
    • Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serine
    • Andersen JD, Pouzet B (2004) Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serine. Neuropsychopharmacology 29:1080-1090
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1080-1090
    • Andersen, J.D.1    Pouzet, B.2
  • 10
    • 0036467265 scopus 로고    scopus 로고
    • Effects of scopolamine and D-cycloserine on non-spatial reference memory in rats
    • Andersen JM, Lindberg V, Myhrer T (2002) Effects of scopolamine and D-cycloserine on non-spatial reference memory in rats. Behav Brain Res 129:211-216
    • (2002) Behav Brain Res , vol.129 , pp. 211-216
    • Andersen, J.M.1    Lindberg, V.2    Myhrer, T.3
  • 11
    • 0344430059 scopus 로고    scopus 로고
    • Memantine attenuates the increase in striatal preproenkephalin mRNA expression and development of haloperidol induced persistent oral dyskinesias in rats
    • Andreassen OA, Waage J, Finsen B, Jorgensen HA (2003) Memantine attenuates the increase in striatal preproenkephalin mRNA expression and development of haloperidol induced persistent oral dyskinesias in rats. Brain Res 994:188-192
    • (2003) Brain Res , vol.994 , pp. 188-192
    • Andreassen, O.A.1    Waage, J.2    Finsen, B.3    Jorgensen, H.A.4
  • 12
    • 0030881619 scopus 로고    scopus 로고
    • Clozapine and haloperidol modulate NMDA- And non-NMDA receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro
    • Arvanov VL, Liang X, Schwartz J, Grossman S, Wang RY (1997) Clozapine and haloperidol modulate NMDA- and non-NMDA receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro. J Pharmacol Exp Ther 283:226-234
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 226-234
    • Arvanov, V.L.1    Liang, X.2    Schwartz, J.3    Grossman, S.4    Wang, R.Y.5
  • 14
    • 0033026480 scopus 로고    scopus 로고
    • Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-aspartate receptor antagonists in rats
    • Bakshi VP, Tricklebank M, Neijt HC, Lehmann-Masten V, Geyer MA (1999) Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-aspartate receptor antagonists in rats. J Pharmacol Exp Ther 288:643-652
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 643-652
    • Bakshi, V.P.1    Tricklebank, M.2    Neijt, H.C.3    Lehmann-Masten, V.4    Geyer, M.A.5
  • 15
    • 0034760532 scopus 로고    scopus 로고
    • Phencyclidine-induced dysregulation of dopamine response to amphetamine in prefrontal cortex and striatum
    • Balla A, Hashim A, Burch S, Javitt DC, Lajtha A, Sershen H (2001a) Phencyclidine-induced dysregulation of dopamine response to amphetamine in prefrontal cortex and striatum. Neurochem Res 26:1001-1006
    • (2001) Neurochem Res , vol.26 , pp. 1001-1006
    • Balla, A.1    Hashim, A.2    Burch, S.3    Javitt, D.C.4    Lajtha, A.5    Sershen, H.6
  • 16
    • 0034988360 scopus 로고    scopus 로고
    • Continuous phencyclidine treatment induces schizophrenia-like hyperreactivity of striatal dopamine release
    • Balla A, Koneru R, Smiley J, Sershen H, Javitt DC (2001b) Continuous phencyclidine treatment induces schizophrenia-like hyperreactivity of striatal dopamine release. Neuropsychopharmacology 25:157-164
    • (2001) Neuropsychopharmacology , vol.25 , pp. 157-164
    • Balla, A.1    Koneru, R.2    Smiley, J.3    Sershen, H.4    Javitt, D.C.5
  • 17
    • 0037209259 scopus 로고    scopus 로고
    • Subchronic continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release
    • Balla A, Sershen H, Serra M, Koneru R, Javitt DC (2003) Subchronic continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release. Neuropsychopharmacology 28:34-44
    • (2003) Neuropsychopharmacology , vol.28 , pp. 34-44
    • Balla, A.1    Sershen, H.2    Serra, M.3    Koneru, R.4    Javitt, D.C.5
  • 18
    • 0036703884 scopus 로고    scopus 로고
    • Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity
    • Ballard TM, Pauly-Evers M, Higgins GA, Ouagazzal AM, Mutel V, Borroni E, Kemp JA, Bluethmann H, Kew JNC (2002) Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity. J Neurosci 22:6713-6723
    • (2002) J Neurosci , vol.22 , pp. 6713-6723
    • Ballard, T.M.1    Pauly-Evers, M.2    Higgins, G.A.3    Ouagazzal, A.M.4    Mutel, V.5    Borroni, E.6    Kemp, J.A.7    Bluethmann, H.8    Kew, J.N.C.9
  • 19
    • 0027459199 scopus 로고
    • Subcortical excitatory amino acid levels after acute and subchronic administration of typical and atypical neuroleptics
    • Bardgett ME, Wrona CT, Newcomer JW, Csernansky JG (1993) Subcortical excitatory amino acid levels after acute and subchronic administration of typical and atypical neuroleptics. Eur J Pharmacol 230:245-250
    • (1993) Eur J Pharmacol , vol.230 , pp. 245-250
    • Bardgett, M.E.1    Wrona, C.T.2    Newcomer, J.W.3    Csernansky, J.G.4
  • 20
    • 2442663919 scopus 로고    scopus 로고
    • Identification of N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity
    • Barinka C, Sacha P, Sklenar J, Man P, Bezouska K, Slusher BS, Konvalinka J (2004) Identification of N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity. Protein Sci 13:1627-1635
    • (2004) Protein Sci , vol.13 , pp. 1627-1635
    • Barinka, C.1    Sacha, P.2    Sklenar, J.3    Man, P.4    Bezouska, K.5    Slusher, B.S.6    Konvalinka, J.7
  • 21
    • 0036854917 scopus 로고    scopus 로고
    • The selective glycine antagonist gavestinel lacks phencyclidine-like behavioural effects
    • Beardsley PM, Ratti E, Balster RL, Willetts J, Trist D (2002) The selective glycine antagonist gavestinel lacks phencyclidine-like behavioural effects. Behav Pharmacol 13:583-592
    • (2002) Behav Pharmacol , vol.13 , pp. 583-592
    • Beardsley, P.M.1    Ratti, E.2    Balster, R.L.3    Willetts, J.4    Trist, D.5
  • 24
    • 11144285440 scopus 로고    scopus 로고
    • NAAG reduces NMDA receptor current in CAI hippocampal pyramidal neurons of acute slices and dissociated neurons
    • Bergeron R, Coyle JT, Tsai G, Greene RW (2005) NAAG reduces NMDA receptor current in CAI hippocampal pyramidal neurons of acute slices and dissociated neurons. Neuropsychopharmacology 30:7-16
    • (2005) Neuropsychopharmacology , vol.30 , pp. 7-16
    • Bergeron, R.1    Coyle, J.T.2    Tsai, G.3    Greene, R.W.4
  • 25
    • 0035369037 scopus 로고    scopus 로고
    • A neuron-glia signalling network in the active brain
    • Bezzi P, Volterra A (2001) A neuron-glia signalling network in the active brain. Curr Opin Neurobiol 11:387-394
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 387-394
    • Bezzi, P.1    Volterra, A.2
  • 27
    • 0032797570 scopus 로고    scopus 로고
    • Differing effects of NMDA receptor subtype selective antagonists on dyskinesia in levodopa treated 1-methyl-4-phenyl-tetrahydropyridine monkeys
    • Blanchet PJ, Konitsiotis S, Whittemore ER, Zhou ZL, Woodward RM, Chase TN (1999) Differing effects of NMDA receptor subtype selective antagonists on dyskinesia in levodopa treated 1-methyl-4-phenyl-tetrahydropyridine monkeys. J Pharmacol Exp Ther 290:1034-1040
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 1034-1040
    • Blanchet, P.J.1    Konitsiotis, S.2    Whittemore, E.R.3    Zhou, Z.L.4    Woodward, R.M.5    Chase, T.N.6
  • 29
    • 0036627616 scopus 로고    scopus 로고
    • Integrative role for serotonergic and glutamatergic mechanisms in actions of NMDA antagonists: Relationships to antipsychotic drug actions on NMDA antagonist responsiveness
    • Breese GR, Knapp DJ, Moy SS (2002) Integrative role for serotonergic and glutamatergic mechanisms in actions of NMDA antagonists: relationships to antipsychotic drug actions on NMDA antagonist responsiveness. Neurosci Biobehav Rev 26:441-455
    • (2002) Neurosci Biobehav Rev , vol.26 , pp. 441-455
    • Breese, G.R.1    Knapp, D.J.2    Moy, S.S.3
  • 30
    • 12644293806 scopus 로고    scopus 로고
    • Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel position emission tomography method
    • Breier A, Su TP, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A (1997) Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel position emission tomography method. Proc Natl Acad Sci U S A 94:2569-2574
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2569-2574
    • Breier, A.1    Su, T.P.2    Saunders, R.3    Carson, R.E.4    Kolachana, B.S.5    De Bartolomeis, A.6
  • 32
    • 0032428348 scopus 로고    scopus 로고
    • An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant NMDA receptors
    • Brimecombe JC, Gallagher MJ, Lynch DR, Aizenman E (1998) An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant NMDA receptors. J Pharmacol Exp Ther 286:627-634
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 627-634
    • Brimecombe, J.C.1    Gallagher, M.J.2    Lynch, D.R.3    Aizenman, E.4
  • 34
    • 0035368610 scopus 로고    scopus 로고
    • Neuregulin and ErbB receptor signalling pathways in the nervous system
    • Buonanno A, Fischbach GD (2001) Neuregulin and ErbB receptor signalling pathways in the nervous system. Curr Opin Neurobiol 11:287-296
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 287-296
    • Buonanno, A.1    Fischbach, G.D.2
  • 36
    • 0032951092 scopus 로고    scopus 로고
    • Effects of (+)-HA-966, CGS-19755, phencyclidine, and dizocilpine on repeated acquisition of response chains in pigeons: Systemic manipulation of central glycine sites
    • Campbell CM, Butelman ER, Woods JH (1999) Effects of (+)-HA-966, CGS-19755, phencyclidine, and dizocilpine on repeated acquisition of response chains in pigeons: systemic manipulation of central glycine sites. J Pharmacol Exp Ther 289:521-527
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 521-527
    • Campbell, C.M.1    Butelman, E.R.2    Woods, J.H.3
  • 38
    • 0031971454 scopus 로고    scopus 로고
    • Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1-17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus
    • Caudle RM, Dubner R (1998) Ifenprodil blocks the excitatory effects of the opioid peptide dynorphin 1-17 on NMDA receptor-mediated currents in the CA3 region of the guinea pig hippocampus. Neuropeptides 32:87-95
    • (1998) Neuropeptides , vol.32 , pp. 87-95
    • Caudle, R.M.1    Dubner, R.2
  • 42
    • 0036082508 scopus 로고    scopus 로고
    • 1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex
    • 1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex. J Neurophysiol 87:2324-2336
    • (2002) J Neurophysiol , vol.87 , pp. 2324-2336
    • Chen, L.1    Yang, C.R.2
  • 43
    • 0035801580 scopus 로고    scopus 로고
    • Differential expression of AMPA receptor subunits in dopamine neurons of the rat brain: A double immunocytochemical study
    • Chen LW, Wei LC, Lang B, Ju G, Chan YS (2001) Differential expression of AMPA receptor subunits in dopamine neurons of the rat brain: a double immunocytochemical study. Neuroscience 106:149-160
    • (2001) Neuroscience , vol.106 , pp. 149-160
    • Chen, L.W.1    Wei, L.C.2    Lang, B.3    Ju, G.4    Chan, Y.S.5
  • 44
    • 0037320805 scopus 로고    scopus 로고
    • Glycine transporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo
    • Chen L, Muhlhauser M, Yang CR (2003) Glycine transporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo. J Neurophysiol 89:691-703
    • (2003) J Neurophysiol , vol.89 , pp. 691-703
    • Chen, L.1    Muhlhauser, M.2    Yang, C.R.3
  • 45
    • 0037108758 scopus 로고    scopus 로고
    • Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia
    • Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Cohen D (2002) Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A 99:13675-13680
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13675-13680
    • Chumakov, I.1    Blumenfeld, M.2    Guerassimenko, O.3    Cavarec, L.4    Palicio, M.5    Cohen, D.6
  • 46
    • 2942666210 scopus 로고    scopus 로고
    • Abnormalities of the NMDA receptor and associated intracellular molecules in the thalamus in schizophrenia and bipolar disorder
    • Clinton SM, Meador-Woodruff JH (2004a) Abnormalities of the NMDA receptor and associated intracellular molecules in the thalamus in schizophrenia and bipolar disorder. Neuropsychopharmacology 29:1353-1362
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1353-1362
    • Clinton, S.M.1    Meador-Woodruff, J.H.2
  • 47
    • 2642514620 scopus 로고    scopus 로고
    • Thalamic dysfunction in schizophrenia: Neurochemical, neuropathological, and in vivo imaging abnormalities
    • Clinton SM, Meador-Woodruff JH (2004b) Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities. Schizophr Res 69:237-253
    • (2004) Schizophr Res , vol.69 , pp. 237-253
    • Clinton, S.M.1    Meador-Woodruff, J.H.2
  • 48
    • 0038488293 scopus 로고    scopus 로고
    • Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia
    • Clinton SM, Haroutunian V, Davis KL, Meador-Woodruff JH (2003) Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia. Am J Psychiatry 160:1100-1109
    • (2003) Am J Psychiatry , vol.160 , pp. 1100-1109
    • Clinton, S.M.1    Haroutunian, V.2    Davis, K.L.3    Meador-Woodruff, J.H.4
  • 49
    • 0242499301 scopus 로고    scopus 로고
    • The genetics of schizophrenia: Glutamate not dopamine?
    • Collier DA (2003) The genetics of schizophrenia: glutamate not dopamine? Eur J Pharmacol 480:177-184
    • (2003) Eur J Pharmacol , vol.480 , pp. 177-184
    • Collier, D.A.1
  • 51
    • 0033577770 scopus 로고    scopus 로고
    • Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands
    • Cordi A, Lacoste JM, Audinot V, Millan MJ (1999) Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Bioorg Med Chem Lett 9:1409-1414
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 1409-1414
    • Cordi, A.1    Lacoste, J.M.2    Audinot, V.3    Millan, M.J.4
  • 52
    • 0030690403 scopus 로고    scopus 로고
    • The nagging question of the function of N-acetylaspartylglutamate
    • Coyle JT (1997) The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis 4:231-238
    • (1997) Neurobiol Dis , vol.4 , pp. 231-238
    • Coyle, J.T.1
  • 53
    • 2342582130 scopus 로고    scopus 로고
    • NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia
    • Coyle JT, Tsai G (2004) NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia. Int Rev Neurobiol 59:491-515
    • (2004) Int Rev Neurobiol , vol.59 , pp. 491-515
    • Coyle, J.T.1    Tsai, G.2
  • 54
    • 1542269069 scopus 로고    scopus 로고
    • Cerebral asymmetry and the lateralization of language: Core deficits in schizophrenia as pointers to the gene
    • Crow TJ (2004) Cerebral asymmetry and the lateralization of language: core deficits in schizophrenia as pointers to the gene. Curr Opin Psychiatry 17:97-106
    • (2004) Curr Opin Psychiatry , vol.17 , pp. 97-106
    • Crow, T.J.1
  • 55
    • 13244283050 scopus 로고    scopus 로고
    • Amino acid transporter SNATs localizes to glial cells in the rat brain
    • Cubelos B, Gonzalez-Gonzalez IM, Gimenez C, Zafra F (2005) Amino acid transporter SNATs localizes to glial cells in the rat brain. Glia 49:230-244
    • (2005) Glia , vol.49 , pp. 230-244
    • Cubelos, B.1    Gonzalez-Gonzalez, I.M.2    Gimenez, C.3    Zafra, F.4
  • 56
    • 0035369112 scopus 로고    scopus 로고
    • NMDA receptor subunits: Diversity, development and disease
    • Cull-Candy S, Brickley S, Farrant M (2001) NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11:327-335
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 327-335
    • Cull-Candy, S.1    Brickley, S.2    Farrant, M.3
  • 57
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1-105
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 58
    • 0032429754 scopus 로고    scopus 로고
    • Glycine and NMDA receptors: Physiological significance and possible therapeutic applications
    • Danysz W, Parsons CG (1998) Glycine and NMDA receptors: physiological significance and possible therapeutic applications. Pharmacol Rev 50:597-664
    • (1998) Pharmacol Rev , vol.50 , pp. 597-664
    • Danysz, W.1    Parsons, C.G.2
  • 59
    • 0141865766 scopus 로고    scopus 로고
    • Glutamine efflux from astrocytes is mediated by multiple pathways
    • Deitmer JW, Broer A, Broer S (2003) Glutamine efflux from astrocytes is mediated by multiple pathways. J Neurochem 87:127-135
    • (2003) J Neurochem , vol.87 , pp. 127-135
    • Deitmer, J.W.1    Broer, A.2    Broer, S.3
  • 60
    • 3042613492 scopus 로고    scopus 로고
    • Irreversible loss of subpopulation of cortical interneurons in the absence of a glutamatergic network
    • De Lima AD, Opitz T, Voigt T (2004) Irreversible loss of subpopulation of cortical interneurons in the absence of a glutamatergic network. Eur J Neurosci 19:2931-2943
    • (2004) Eur J Neurosci , vol.19 , pp. 2931-2943
    • De Lima, A.D.1    Opitz, T.2    Voigt, T.3
  • 61
    • 0034601688 scopus 로고    scopus 로고
    • Human serine racemase: Molecular cloning, genomic organization and functional analysis
    • De Miranda J, Santoro A, Engelender S, Wolosker H (2000) Human serine racemase: molecular cloning, genomic organization and functional analysis. Gene 256:183-188
    • (2000) Gene , vol.256 , pp. 183-188
    • De Miranda, J.1    Santoro, A.2    Engelender, S.3    Wolosker, H.4
  • 63
    • 0032831787 scopus 로고    scopus 로고
    • Chronic haloperidol treatment impairs glutamate transport in the rat striatum
    • De Souza IEJ, McBean GJ, Meredith GE (1999) Chronic haloperidol treatment impairs glutamate transport in the rat striatum. Eur J Pharmacol 382:139-142
    • (1999) Eur J Pharmacol , vol.382 , pp. 139-142
    • De Souza, I.E.J.1    McBean, G.J.2    Meredith, G.E.3
  • 68
    • 0042827492 scopus 로고    scopus 로고
    • Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons
    • Dolinska M, Zablocka B, Sonnewald U, Albrecht J (2004) Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons. Neurochem Int 44:75-89
    • (2004) Neurochem Int , vol.44 , pp. 75-89
    • Dolinska, M.1    Zablocka, B.2    Sonnewald, U.3    Albrecht, J.4
  • 69
    • 0034843740 scopus 로고    scopus 로고
    • N-Methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia
    • Dracheva S, Marras SA, Elhaken SL, Kramer FR, Davis KL, Haroutunian V (2001) N-Methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am J Psychiatry 158:1400-1410
    • (2001) Am J Psychiatry , vol.158 , pp. 1400-1410
    • Dracheva, S.1    Marras, S.A.2    Elhaken, S.L.3    Kramer, F.R.4    Davis, K.L.5    Haroutunian, V.6
  • 73
    • 0032824132 scopus 로고    scopus 로고
    • Safety and tolerability of aptiganel hydrochloride in patients with acute ischemic stroke
    • Dyker AG, Edwards KR, Fayad PB, Hormes JT, Lees KR (1999) Safety and tolerability of aptiganel hydrochloride in patients with acute ischemic stroke. Stroke 30:2038-2042
    • (1999) Stroke , vol.30 , pp. 2038-2042
    • Dyker, A.G.1    Edwards, K.R.2    Fayad, P.B.3    Hormes, J.T.4    Lees, K.R.5
  • 75
    • 0036096937 scopus 로고    scopus 로고
    • Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid
    • Erhardt S, Engberg G (2002) Increased phasic activity of dopaminergic neurones in the rat ventral tegmental area following pharmacologically elevated levels of endogenous kynurenic acid. Acta Physiol Scand 175:45-53
    • (2002) Acta Physiol Scand , vol.175 , pp. 45-53
    • Erhardt, S.1    Engberg, G.2
  • 76
  • 79
    • 0030665569 scopus 로고    scopus 로고
    • Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics
    • Evins AE, Amico E, Shih V, Goff DC (1997) Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics. J Neural Transm 104:761-766
    • (1997) J Neural Transm , vol.104 , pp. 761-766
    • Evins, A.E.1    Amico, E.2    Shih, V.3    Goff, D.C.4
  • 81
    • 0036641749 scopus 로고    scopus 로고
    • D-Cyclo-serine added to risperidone in primary negative symptoms of schizophrenia
    • Evins AE, Amico E, Posever TA, Toker R, Goff DC (2002) D-Cyclo-serine added to risperidone in primary negative symptoms of schizophrenia. Schizophr Res 56:19-23
    • (2002) Schizophr Res , vol.56 , pp. 19-23
    • Evins, A.E.1    Amico, E.2    Posever, T.A.3    Toker, R.4    Goff, D.C.5
  • 82
    • 0345830623 scopus 로고    scopus 로고
    • The NMDA receptor hypofunction model of psychosis
    • Farber NB (2003) The NMDA receptor hypofunction model of psychosis. Ann NY Acad Sci 1003:119-130
    • (2003) Ann NY Acad Sci , vol.1003 , pp. 119-130
    • Farber, N.B.1
  • 83
    • 0033045317 scopus 로고    scopus 로고
    • Cerebrospinal fluid glutamate inversely correlates with positive symptom severity in unmedicated male schizophrenic/schizoaffective patients
    • Faustman WO, Bardgett M, Faull KF, Pfefferbaum A, Csernansky JG (1999) Cerebrospinal fluid glutamate inversely correlates with positive symptom severity in unmedicated male schizophrenic/schizoaffective patients. Biol Psychiatry 45:68-75
    • (1999) Biol Psychiatry , vol.45 , pp. 68-75
    • Faustman, W.O.1    Bardgett, M.2    Faull, K.F.3    Pfefferbaum, A.4    Csernansky, J.G.5
  • 84
    • 1542269774 scopus 로고    scopus 로고
    • Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid
    • Feng B, Tse HW, Skifter DA, Morley R, Jane DE, Monaghan DT (2004) Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br J Pharmacol 141: 508-516
    • (2004) Br J Pharmacol , vol.141 , pp. 508-516
    • Feng, B.1    Tse, H.W.2    Skifter, D.A.3    Morley, R.4    Jane, D.E.5    Monaghan, D.T.6
  • 85
    • 0028947052 scopus 로고
    • Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic
    • Fitzgerald LW, Deutsch AY, Gassic G, Heinemann SE, Nestler EJ (1995) Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic. Drugs J Neurosci 95:2453-2461
    • (1995) Drugs J Neurosci , vol.95 , pp. 2453-2461
    • Fitzgerald, L.W.1    Deutsch, A.Y.2    Gassic, G.3    Heinemann, S.E.4    Nestler, E.J.5
  • 86
    • 0042924149 scopus 로고    scopus 로고
    • Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine
    • Flores C, Coyle JT (2003) Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine. Neuropsychopharmacology 28:1227-1234
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1227-1234
    • Flores, C.1    Coyle, J.T.2
  • 87
    • 0347985817 scopus 로고    scopus 로고
    • Functional characterization of brain peptide transporter in rat cortex: Identification of high-affinity type H+/peptide transporter PEPT2
    • Fujita T, Kishida T, Wada M, Okada N, Yamamoto A, Leibach FH, Ganapathy V (2004) Functional characterization of brain peptide transporter in rat cortex: identification of high-affinity type H+/peptide transporter PEPT2. Brain Res 997:52-61
    • (2004) Brain Res , vol.997 , pp. 52-61
    • Fujita, T.1    Kishida, T.2    Wada, M.3    Okada, N.4    Yamamoto, A.5    Leibach, F.H.6    Ganapathy, V.7
  • 88
    • 0141997717 scopus 로고    scopus 로고
    • Glutamate receptor genes as candidates for schizophrenia susceptibility
    • Fukumaki Y, Shibata H (2003) Glutamate receptor genes as candidates for schizophrenia susceptibility. Drug Dev Res 60:137-151
    • (2003) Drug Dev Res , vol.60 , pp. 137-151
    • Fukumaki, Y.1    Shibata, H.2
  • 89
    • 0035340978 scopus 로고    scopus 로고
    • Glial transporters for glutamate, glycine, and GABA III. Glycine transporters
    • Gadea A, Lopez-Colomé AM (2001) Glial transporters for glutamate, glycine, and GABA III. Glycine transporters. J Neurosci Res 64:218-222
    • (2001) J Neurosci Res , vol.64 , pp. 218-222
    • Gadea, A.1    Lopez-Colomé, A.M.2
  • 91
    • 0033914752 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors and expression of NMDA receptor subunits in subregions of human hippocampus: Effects of schizophrenia
    • Gao XM, Sakai K, Roberts RC, Conley RR, Dean B, Tamminga CA (2000) Ionotropic glutamate receptors and expression of NMDA receptor subunits in subregions of human hippocampus: effects of schizophrenia. Am J Psychiatry 157:1141-1149
    • (2000) Am J Psychiatry , vol.157 , pp. 1141-1149
    • Gao, X.M.1    Sakai, K.2    Roberts, R.C.3    Conley, R.R.4    Dean, B.5    Tamminga, C.A.6
  • 92
    • 0034724391 scopus 로고    scopus 로고
    • The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
    • Garcia RA, Vasudevan K, Buonanno A (2000) The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A 97:3596-3601
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 3596-3601
    • Garcia, R.A.1    Vasudevan, K.2    Buonanno, A.3
  • 93
    • 0345827429 scopus 로고    scopus 로고
    • GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism
    • Garrido Sanabria ER, Wozniak KM, Slusher BS, Keller A (2004) GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism. J Neurophysiol 91:182-193
    • (2004) J Neurophysiol , vol.91 , pp. 182-193
    • Garrido Sanabria, E.R.1    Wozniak, K.M.2    Slusher, B.S.3    Keller, A.4
  • 94
    • 0037475154 scopus 로고    scopus 로고
    • Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: An in vitro study
    • Gemperle AY, Enz A, Pozza MF, Lüthi A, Olpe HR (2003) Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study. Neuroscience 117:681-695
    • (2003) Neuroscience , vol.117 , pp. 681-695
    • Gemperle, A.Y.1    Enz, A.2    Pozza, M.F.3    Lüthi, A.4    Olpe, H.R.5
  • 95
    • 0037096325 scopus 로고    scopus 로고
    • Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: A novel excitatory amino acid input to midbrain dopamine neurons
    • Georges F, Aston-Jones G (2002) Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neurons. J Neurosci 22:5173-5187
    • (2002) J Neurosci , vol.22 , pp. 5173-5187
    • Georges, F.1    Aston-Jones, G.2
  • 97
    • 0034112445 scopus 로고    scopus 로고
    • Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioural tasks
    • Gerlai R, Pisacane P, Erickson S (2000) Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioural tasks. Behav Brain Res 109:219-227
    • (2000) Behav Brain Res , vol.109 , pp. 219-227
    • Gerlai, R.1    Pisacane, P.2    Erickson, S.3
  • 98
    • 0034917841 scopus 로고    scopus 로고
    • Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: A decade in review
    • Geyer MA, Kreba-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology 156:117-154
    • (2001) Psychopharmacology , vol.156 , pp. 117-154
    • Geyer, M.A.1    Kreba-Thomson, K.2    Braff, D.L.3    Swerdlow, N.R.4
  • 100
    • 0036307527 scopus 로고    scopus 로고
    • Implications of altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients
    • Gluck MR, Thomas RG, Haroutunian V (2002) Implications of altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients. Am J Psychiatry 159:1165-1173
    • (2002) Am J Psychiatry , vol.159 , pp. 1165-1173
    • Gluck, M.R.1    Thomas, R.G.2    Haroutunian, V.3
  • 101
    • 0033013541 scopus 로고    scopus 로고
    • NMDA receptor subunit gene expression in the rat brain: A quantitative analysis of endogenous mRNA levels of NR1, NR2A, NR2B, NR2C, NR2D and NR3A
    • Goebel DJ, Poosch MS (1999) NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1, NR2A, NR2B, NR2C, NR2D and NR3A. Brain Res Mol Brain Res 69:164-170
    • (1999) Brain Res Mol Brain Res , vol.69 , pp. 164-170
    • Goebel, D.J.1    Poosch, M.S.2
  • 106
    • 3042640878 scopus 로고    scopus 로고
    • Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse
    • Golub MS, Germann SL, Lloyd KC (2004) Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res 153:159-170
    • (2004) Behav Brain Res , vol.153 , pp. 159-170
    • Golub, M.S.1    Germann, S.L.2    Lloyd, K.C.3
  • 107
    • 2542625175 scopus 로고    scopus 로고
    • Protein kinase C-dependent remodelling of glutamate transporter function
    • Gonzalez MI, Robinson MB (2004) Protein kinase C-dependent remodelling of glutamate transporter function. Mol Interv 4:48-58
    • (2004) Mol Interv , vol.4 , pp. 48-58
    • Gonzalez, M.I.1    Robinson, M.B.2
  • 108
    • 0033601963 scopus 로고    scopus 로고
    • NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia
    • Grimwood S, Slater P, Deakin JFW (1999) NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia. NeuroReport 10:461-465
    • (1999) NeuroReport , vol.10 , pp. 461-465
    • Grimwood, S.1    Slater, P.2    Deakin, J.F.W.3
  • 110
    • 2342451337 scopus 로고    scopus 로고
    • GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: Quantitative immunogold evidence for co-transmission
    • Gundersen V, Talgoy Holten A, Strom-Mathisen J (2004) GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission. Mol Cell Neurosci 26:156-165
    • (2004) Mol Cell Neurosci , vol.26 , pp. 156-165
    • Gundersen, V.1    Talgoy Holten, A.2    Strom-Mathisen, J.3
  • 113
    • 0037308528 scopus 로고    scopus 로고
    • Genes for schizophrenia? Recent findings and their pathophysiological implications
    • Harrison PJ, Owen MJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361:417-419
    • (2003) Lancet , vol.361 , pp. 417-419
    • Harrison, P.J.1    Owen, M.J.2
  • 114
    • 0141532459 scopus 로고    scopus 로고
    • Glutamate receptors and transporters in the hippocampus in schizophrenia
    • Harrison PJ, Law AJ, Eastwood SL (2003) Glutamate receptors and transporters in the hippocampus in schizophrenia. Ann NY Acad Sci 1003:94-101
    • (2003) Ann NY Acad Sci , vol.1003 , pp. 94-101
    • Harrison, P.J.1    Law, A.J.2    Eastwood, S.L.3
  • 116
    • 3042757433 scopus 로고    scopus 로고
    • Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat
    • Hashimoto A, Chiba Y (2004) Effect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat. Eur J Pharmacol 495:153-158
    • (2004) Eur J Pharmacol , vol.495 , pp. 153-158
    • Hashimoto, A.1    Chiba, Y.2
  • 119
    • 0032907911 scopus 로고    scopus 로고
    • 2 receptors and sigma receptors affect differently the NMDA-induced increase in intracellular calcium concentration: Involvement of protein kinase
    • 2 receptors and sigma receptors affect differently the NMDA-induced increase in intracellular calcium concentration: involvement of protein kinase. Synapse 31:20-28
    • (1999) Synapse , vol.31 , pp. 20-28
    • Hayashi, T.1    Su, T.P.2    Kagaya, A.3    Nishida, A.4    Shimizu, M.5    Yamawaki, S.6
  • 120
    • 0037547165 scopus 로고    scopus 로고
    • Inducible molecular switches for the study of long-term potentiation
    • Hedou G, Mansuy IM (2003) Inducible molecular switches for the study of long-term potentiation. Philos Trans R Soc Lond B Biol Sci 358:797-804
    • (2003) Philos Trans R Soc Lond B Biol Sci , vol.358 , pp. 797-804
    • Hedou, G.1    Mansuy, I.M.2
  • 121
    • 0025681473 scopus 로고
    • Dynorphin a and substance P in the cerebrospinal fluid of schizophrenic patients
    • Heikkilä L, Rimon R, Terenius L (1990) Dynorphin A and substance P in the cerebrospinal fluid of schizophrenic patients. Psychiatry Res 34:229-236
    • (1990) Psychiatry Res , vol.34 , pp. 229-236
    • Heikkilä, L.1    Rimon, R.2    Terenius, L.3
  • 122
    • 1542640509 scopus 로고    scopus 로고
    • Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain
    • Helboe L, Egebjerg J, Moller M, Thomsen C (2003) Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain. Eur J Neurosci 18:2227-2238
    • (2003) Eur J Neurosci , vol.18 , pp. 2227-2238
    • Helboe, L.1    Egebjerg, J.2    Moller, M.3    Thomsen, C.4
  • 123
    • 0033808423 scopus 로고    scopus 로고
    • NMDA receptor-based treatment approaches in schizophrenia: The first decade
    • Heresco-Levy U (2000) NMDA receptor-based treatment approaches in schizophrenia: the first decade. Int J Neuropsychopharmacol 3:243-258
    • (2000) Int J Neuropsychopharmacol , vol.3 , pp. 243-258
    • Heresco-Levy, U.1
  • 124
    • 0344827184 scopus 로고    scopus 로고
    • Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality
    • Heresco-Levy U (2003) Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry 27:1113-1123
    • (2003) Prog Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 1113-1123
    • Heresco-Levy, U.1
  • 125
    • 0348047434 scopus 로고    scopus 로고
    • Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: A retrospective analysis
    • Heresco-Levy U, Javitt DC (2004) Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis. Schizophr Res 66:89-96
    • (2004) Schizophr Res , vol.66 , pp. 89-96
    • Heresco-Levy, U.1    Javitt, D.C.2
  • 126
    • 0001182422 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia
    • Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Shimoni J (1998) Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia. Int J Neuropsychopharmacol 1:131-136
    • (1998) Int J Neuropsychopharmacol , vol.1 , pp. 131-136
    • Heresco-Levy, U.1    Javitt, D.C.2    Ermilov, M.3    Mordel, C.4    Silipo, G.5    Shimoni, J.6
  • 128
    • 0036184549 scopus 로고    scopus 로고
    • Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia
    • Heresco-Levy U, Ermilov M, Shimoni J, Shapira B, Silipo G, Javitt DC (2002) Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia. Am J Psychiatry 159:480-482
    • (2002) Am J Psychiatry , vol.159 , pp. 480-482
    • Heresco-Levy, U.1    Ermilov, M.2    Shimoni, J.3    Shapira, B.4    Silipo, G.5    Javitt, D.C.6
  • 129
    • 1442333154 scopus 로고    scopus 로고
    • High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia
    • Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC (2004) High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry 55:165-171
    • (2004) Biol Psychiatry , vol.55 , pp. 165-171
    • Heresco-Levy, U.1    Ermilov, M.2    Lichtenberg, P.3    Bar, G.4    Javitt, D.C.5
  • 130
    • 0037370176 scopus 로고    scopus 로고
    • Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: Evidence for an involvement of NR2B NMDA receptors in response inhibition
    • Higgins GA, Ballard TM, Huwyler J, Kemp JA, Gill R (2003) Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology 44:324-341
    • (2003) Neuropharmacology , vol.44 , pp. 324-341
    • Higgins, G.A.1    Ballard, T.M.2    Huwyler, J.3    Kemp, J.A.4    Gill, R.5
  • 131
    • 0036859330 scopus 로고    scopus 로고
    • Antiepileptic drugs in schizophrenia: A review
    • Hosak L, Libiger J (2002) Antiepileptic drugs in schizophrenia: a review. Eur Psychiatry 17:371-378
    • (2002) Eur Psychiatry , vol.17 , pp. 371-378
    • Hosak, L.1    Libiger, J.2
  • 132
    • 0029910263 scopus 로고    scopus 로고
    • NMDA receptor RNA correlation with antemortem cognitive impairment in schizophrenia
    • Humphries CR, Mortimer A, Hirsch SR (1996) NMDA receptor RNA correlation with antemortem cognitive impairment in schizophrenia. NeuroReport 7:2051-2055
    • (1996) NeuroReport , vol.7 , pp. 2051-2055
    • Humphries, C.R.1    Mortimer, A.2    Hirsch, S.R.3
  • 138
    • 0028258111 scopus 로고
    • Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis
    • Ishimaru M, Kurumaji A, Toru M (1994) Increases in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: evidence for glutamate hypothesis. Biol Psychiatry 35:84-95
    • (1994) Biol Psychiatry , vol.35 , pp. 84-95
    • Ishimaru, M.1    Kurumaji, A.2    Toru, M.3
  • 139
    • 12444281048 scopus 로고    scopus 로고
    • A microsatellite repeat in the promoter of the NMDA receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia
    • Itokawa MK, Yamada K, Yoshitsugu K (2003) A microsatellite repeat in the promoter of the NMDA receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia. Pharmacogenetics 13:271-278
    • (2003) Pharmacogenetics , vol.13 , pp. 271-278
    • Itokawa, M.K.1    Yamada, K.2    Yoshitsugu, K.3
  • 140
    • 1842510043 scopus 로고    scopus 로고
    • Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins
    • Iwamoto T, Yamada Y, Hori K, Watanabe Y, Sobue K, Inui M (2004) Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins. J Neurochem 89:100-108
    • (2004) J Neurochem , vol.89 , pp. 100-108
    • Iwamoto, T.1    Yamada, Y.2    Hori, K.3    Watanabe, Y.4    Sobue, K.5    Inui, M.6
  • 141
    • 2942537881 scopus 로고    scopus 로고
    • NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
    • Jackson ME, Homayoun H, Moghaddam B (2004) NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex. Proc Natl Acad Sci U S A 101:8467-8472
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8467-8472
    • Jackson, M.E.1    Homayoun, H.2    Moghaddam, B.3
  • 142
    • 2542551968 scopus 로고    scopus 로고
    • A steroid modulatory domain on NR2B controls NMDA receptor proton sensitivity
    • Jang MK, Mierke DF, Russek SJ, Farb DH (2004) A steroid modulatory domain on NR2B controls NMDA receptor proton sensitivity. Proc Natl Acad Sci U S A 101:8198-8203
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8198-8203
    • Jang, M.K.1    Mierke, D.F.2    Russek, S.J.3    Farb, D.H.4
  • 143
    • 0037426583 scopus 로고    scopus 로고
    • Protein kinase C is involved in clozapine's facilitation of NMDA- And electrically evoked responses in pyramidal cells of the medial prefrontal cortex
    • Jardemark KE, Ninan I, Liang X, Wang RY (2003) Protein kinase C is involved in clozapine's facilitation of NMDA- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex. Neuroscience 118:501-512
    • (2003) Neuroscience , vol.118 , pp. 501-512
    • Jardemark, K.E.1    Ninan, I.2    Liang, X.3    Wang, R.Y.4
  • 144
    • 0036667177 scopus 로고    scopus 로고
    • Glycine modulators in schizophrenia
    • Javitt DC (2002) Glycine modulators in schizophrenia. Curr Opin Investig Drugs 3:1067-1072
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 1067-1072
    • Javitt, D.C.1
  • 145
    • 0031024622 scopus 로고    scopus 로고
    • Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: Implications for schizophrenia and substance abuse
    • Javitt DC, Frusciante M (1997) Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse. Psychopharmacology 129:96-98
    • (1997) Psychopharmacology , vol.129 , pp. 96-98
    • Javitt, D.C.1    Frusciante, M.2
  • 146
    • 0030811293 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide
    • Javitt DC, Sershen H, Hashim A, Lajtha A (1997) Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide. Neuropsychopharmacology 17:202-204
    • (1997) Neuropsychopharmacology , vol.17 , pp. 202-204
    • Javitt, D.C.1    Sershen, H.2    Hashim, A.3    Lajtha, A.4
  • 147
    • 0033558578 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors
    • Javitt DC, Balla A, Sershen H, Lajtha A (1999) Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors. Biol Psychiatry 45:668-679
    • (1999) Biol Psychiatry , vol.45 , pp. 668-679
    • Javitt, D.C.1    Balla, A.2    Sershen, H.3    Lajtha, A.4
  • 148
    • 0034015991 scopus 로고    scopus 로고
    • Inhibition of striatal dopamine release by glycine and glycyldodecylamide
    • Javitt DC, Sershen H, Hashim A, Lajtha A (2000) Inhibition of striatal dopamine release by glycine and glycyldodecylamide. Brain Res Bull 52:213-216
    • (2000) Brain Res Bull , vol.52 , pp. 213-216
    • Javitt, D.C.1    Sershen, H.2    Hashim, A.3    Lajtha, A.4
  • 150
    • 0037150760 scopus 로고    scopus 로고
    • A novel alanine-insensitive D-serine transporter in rat brain synaptosomal membranes
    • Javitt DC, Balla A, Sershen H (2002) A novel alanine-insensitive D-serine transporter in rat brain synaptosomal membranes. Brain Res 941:146-149
    • (2002) Brain Res , vol.941 , pp. 146-149
    • Javitt, D.C.1    Balla, A.2    Sershen, H.3
  • 151
    • 0842286593 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced dopaminergic dysregulation by NMDA receptor/glycine-site agonists
    • Javitt DC, Balla A, Burch S, Suckow R, Xie S, Sershen H (2004a) Reversal of phencyclidine-induced dopaminergic dysregulation by NMDA receptor/glycine- site agonists. Neuropsychopharmacology 29:300-307
    • (2004) Neuropsychopharmacology , vol.29 , pp. 300-307
    • Javitt, D.C.1    Balla, A.2    Burch, S.3    Suckow, R.4    Xie, S.5    Sershen, H.6
  • 152
    • 13844262108 scopus 로고    scopus 로고
    • Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: Implications for mechanisms of action
    • in press
    • Javitt DC, Duncan L, Balla A, Sershen H (2004b) Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action. Mol Psychiatry, in press
    • (2004) Mol Psychiatry
    • Javitt, D.C.1    Duncan, L.2    Balla, A.3    Sershen, H.4
  • 153
    • 0037083818 scopus 로고    scopus 로고
    • Impaired visual memory in rats reared in isolation is reversed by D-cycloserine in the adult rat
    • Johannesen TS, Myhrer T (2002) Impaired visual memory in rats reared in isolation is reversed by D-cycloserine in the adult rat. Eur J Pharmacol 437:73-77
    • (2002) Eur J Pharmacol , vol.437 , pp. 73-77
    • Johannesen, T.S.1    Myhrer, T.2
  • 154
    • 0036046749 scopus 로고    scopus 로고
    • D-Cycloserine for Alzheimer's disease
    • Cochrane review. Wiley, Chichester, UK
    • Jones R, Laake K, Oeksengaard AR (2004) D-Cycloserine for Alzheimer's disease (Cochrane review). In: The Cochrane Library, Issue 2. Wiley, Chichester, UK
    • (2004) The Cochrane Library , Issue.2
    • Jones, R.1    Laake, K.2    Oeksengaard, A.R.3
  • 156
    • 0029812141 scopus 로고    scopus 로고
    • Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit
    • Kadotani H, Hirano T, Masugi M, Nakamura K, Nakao K, Katsuki M, Nakanishi S (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci 16:7859-7867
    • (1996) J Neurosci , vol.16 , pp. 7859-7867
    • Kadotani, H.1    Hirano, T.2    Masugi, M.3    Nakamura, K.4    Nakao, K.5    Katsuki, M.6    Nakanishi, S.7
  • 157
    • 3042817423 scopus 로고    scopus 로고
    • Quantitative demonstration of extracellular glutamine concentrations in rat brain, and its elevation in vivo by system a transporter inhibitor, alpha-(methylamino) isobutyrate
    • Kanamori K, Ross BD (2004) Quantitative demonstration of extracellular glutamine concentrations in rat brain, and its elevation in vivo by system A transporter inhibitor, alpha-(methylamino) isobutyrate. J Neurochem 90:203-210
    • (2004) J Neurochem , vol.90 , pp. 203-210
    • Kanamori, K.1    Ross, B.D.2
  • 158
    • 0442295161 scopus 로고    scopus 로고
    • Treatment models and designs for intervention research during the psychotic prodrome
    • Kane JM, Krystal J, Correll CU (2003) Treatment models and designs for intervention research during the psychotic prodrome. Schizophr Bull 29:747-756
    • (2003) Schizophr Bull , vol.29 , pp. 747-756
    • Kane, J.M.1    Krystal, J.2    Correll, C.U.3
  • 159
    • 0036384325 scopus 로고    scopus 로고
    • 2 receptors - Implications for models of schizophrenia
    • 2 receptors - implications for models of schizophrenia. Mol Psychiatry 7:837-844
    • (2002) Mol Psychiatry , vol.7 , pp. 837-844
    • Kapur, S.1    Seeman, P.2
  • 160
    • 0035133115 scopus 로고    scopus 로고
    • Glycine reduces novelty- And methamphetamine-induced locomotor activity in neonatal ventral hippocampal damaged rats
    • Kato K, Shishido T, Ono M, Shishido K, Kobayashi M, Niwa S (2001) Glycine reduces novelty- and methamphetamine-induced locomotor activity in neonatal ventral hippocampal damaged rats. Neuropsychopharmacolgy 24:330-332
    • (2001) Neuropsychopharmacolgy , vol.24 , pp. 330-332
    • Kato, K.1    Shishido, T.2    Ono, M.3    Shishido, K.4    Kobayashi, M.5    Niwa, S.6
  • 163
    • 0041920952 scopus 로고    scopus 로고
    • The glycine transporter type 1 inhibitor N-[3-(4′-fluorophenyl)-3- (4″-phenyl-phnoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior
    • Kinney GG, Sur C, Burno M, Mallorga PJ, Williams JB, Figueros DJ, Wittmann M, Lemaire W, Conn PJ (2003) The glycine transporter type 1 inhibitor N-[3-(4′-fluorophenyl)-3-(4″-phenyl-phnoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci 23:7586-7591
    • (2003) J Neurosci , vol.23 , pp. 7586-7591
    • Kinney, G.G.1    Sur, C.2    Burno, M.3    Mallorga, P.J.4    Williams, J.B.5    Figueros, D.J.6    Wittmann, M.7    Lemaire, W.8    Conn, P.J.9
  • 164
    • 2442702848 scopus 로고    scopus 로고
    • Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant NMDA receptors
    • Kloda A, Clements JD, Lewis RJ, Adams DJ (2004) Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant NMDA receptors. Mol Pharmacol 65:1386-1396
    • (2004) Mol Pharmacol , vol.65 , pp. 1386-1396
    • Kloda, A.1    Clements, J.D.2    Lewis, R.J.3    Adams, D.J.4
  • 165
    • 0037305349 scopus 로고    scopus 로고
    • Molecular aspects of glutamate dysregulation: Implications for schizophrenia and its treatment
    • Konradi C, Heckers S (2003) Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther 97:153-179
    • (2003) Pharmacol Ther , vol.97 , pp. 153-179
    • Konradi, C.1    Heckers, S.2
  • 167
    • 0031963928 scopus 로고    scopus 로고
    • Ligands of the NMDA receptor-associated glycine recognition site and motor behavior
    • Kretschmer BD (1998) Ligands of the NMDA receptor-associated glycine recognition site and motor behavior. Amino Acids 14:227-234
    • (1998) Amino Acids , vol.14 , pp. 227-234
    • Kretschmer, B.D.1
  • 168
    • 0032490655 scopus 로고    scopus 로고
    • The ventral pallidum mediates disruption of prepulse inhibition of the acoustic startle response induced by dopamine agonists, but not by NMDA antagonists
    • Kretschmer BD, Koch M (1998) The ventral pallidum mediates disruption of prepulse inhibition of the acoustic startle response induced by dopamine agonists, but not by NMDA antagonists. Brain Res 798:204-210
    • (1998) Brain Res , vol.798 , pp. 204-210
    • Kretschmer, B.D.1    Koch, M.2
  • 169
  • 170
    • 0029005597 scopus 로고
    • Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases
    • Kumashiro S, Hashimoto A, Nishikawa T (1995) Free D-serine in post-mortem brains and spinal cords of individuals with and without neuropsychiatric diseases. Brain Res 681:117-125
    • (1995) Brain Res , vol.681 , pp. 117-125
    • Kumashiro, S.1    Hashimoto, A.2    Nishikawa, T.3
  • 172
    • 0347091932 scopus 로고    scopus 로고
    • Glutamate, dopamine, and schizophrenia from pathophysiology to treatment
    • Laruelle M, Kegeles LS, Abi-Dargham A (2003) Glutamate, dopamine, and schizophrenia from pathophysiology to treatment. Ann NY Acad Sci 1003:138-158
    • (2003) Ann NY Acad Sci , vol.1003 , pp. 138-158
    • Laruelle, M.1    Kegeles, L.S.2    Abi-Dargham, A.3
  • 173
    • 0035903772 scopus 로고    scopus 로고
    • Asymmetrical reduction of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses
    • Law AJ, Deakin JFW (2001) Asymmetrical reduction of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses. NeuroReport 12:2971-2974
    • (2001) NeuroReport , vol.12 , pp. 2971-2974
    • Law, A.J.1    Deakin, J.F.W.2
  • 175
    • 0242653685 scopus 로고    scopus 로고
    • Role of NR2B-containing NMDA receptors in haloperidol-induced c-FOS in striatum and nucleus accumbens
    • Lee J, Rajakumar N (2003) Role of NR2B-containing NMDA receptors in haloperidol-induced c-FOS in striatum and nucleus accumbens. Neuroscience 122:739-745
    • (2003) Neuroscience , vol.122 , pp. 739-745
    • Lee, J.1    Rajakumar, N.2
  • 177
    • 0030032401 scopus 로고    scopus 로고
    • Preliminary investigation of high-dose oral glycine on serum levels and negative symptoms in schizophrenia: An open-label trial
    • Leiderman E, Zylberman I, Zukin SR, Cooper TB, Javitt DC (1996) Preliminary investigation of high-dose oral glycine on serum levels and negative symptoms in schizophrenia: an open-label trial. Biol Psychiatry 39:213-215
    • (1996) Biol Psychiatry , vol.39 , pp. 213-215
    • Leiderman, E.1    Zylberman, I.2    Zukin, S.R.3    Cooper, T.B.4    Javitt, D.C.5
  • 178
    • 0344430085 scopus 로고    scopus 로고
    • Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: Reversal by glycine and glycine transporter inhibitor
    • Le Pen G, Kew J, Alberati D, Borroni E, Heitz MP, Moreau JL (2003) Prepulse inhibition deficits of the startle reflex in neonatal ventral hippocampal-lesioned rats: reversal by glycine and glycine transporter inhibitor. Biol Psychiatry 54:1162-1170
    • (2003) Biol Psychiatry , vol.54 , pp. 1162-1170
    • Le Pen, G.1    Kew, J.2    Alberati, D.3    Borroni, E.4    Heitz, M.P.5    Moreau, J.L.6
  • 180
    • 0038645198 scopus 로고    scopus 로고
    • Clozapine inhibits isolated NMDA receptors expressed in Xenopus oocytes in a subunit specific manner
    • Levine JB, Martin G, Wilson A, Treistman SN (2003) Clozapine inhibits isolated NMDA receptors expressed in Xenopus oocytes in a subunit specific manner. Neurosci Lett 346:125-128
    • (2003) Neurosci Lett , vol.346 , pp. 125-128
    • Levine, J.B.1    Martin, G.2    Wilson, A.3    Treistman, S.N.4
  • 181
    • 0036308284 scopus 로고    scopus 로고
    • Schizophrenia as a disorder of neurodevelopment
    • Lewis DA, Levitt P (2002) Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 25:409-432
    • (2002) Annu Rev Neurosci , vol.25 , pp. 409-432
    • Lewis, D.A.1    Levitt, P.2
  • 182
    • 4444316217 scopus 로고    scopus 로고
    • Using animal models to test a neurodevelopmental hypothesis of schizophrenia
    • Lipska BK (2004) Using animal models to test a neurodevelopmental hypothesis of schizophrenia. J Psychiatry Neurosci 29:282
    • (2004) J Psychiatry Neurosci , vol.29 , pp. 282
    • Lipska, B.K.1
  • 183
    • 0347722473 scopus 로고    scopus 로고
    • Genomics and variation of ionotropic glutamate receptors
    • Lipsky RH, Goldman D (2003) Genomics and variation of ionotropic glutamate receptors. Ann NY Acad Sci 1003:22-35
    • (2003) Ann NY Acad Sci , vol.1003 , pp. 22-35
    • Lipsky, R.H.1    Goldman, D.2
  • 186
    • 1242317638 scopus 로고    scopus 로고
    • Sodium-coupled neutral amino acid (system N/A) transporters of the SLC38 gene family
    • Mackenzie S, Erickson JD (2004) Sodium-coupled neutral amino acid (system N/A) transporters of the SLC38 gene family. Pflugers Arch 447:784-795
    • (2004) Pflugers Arch , vol.447 , pp. 784-795
    • Mackenzie, S.1    Erickson, J.D.2
  • 187
    • 0036483593 scopus 로고    scopus 로고
    • The structure and function of glutamate receptor ion channels
    • Madden DR (2002) The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 3:91-101
    • (2002) Nat Rev Neurosci , vol.3 , pp. 91-101
    • Madden, D.R.1
  • 189
    • 4344621634 scopus 로고    scopus 로고
    • Role of glial amino acid transporters in synaptic transmission and brain energetics
    • Marcaggi P, Attwell D (2004) Role of glial amino acid transporters in synaptic transmission and brain energetics. Glia 47:217-225
    • (2004) Glia , vol.47 , pp. 217-225
    • Marcaggi, P.1    Attwell, D.2
  • 191
    • 0038798022 scopus 로고    scopus 로고
    • Direct and indirect modulation of the NMDA receptor: Potential for the development of novel antipsychotic therapies
    • Marino MJ, Conn PJ (2002) Direct and indirect modulation of the NMDA receptor: potential for the development of novel antipsychotic therapies. Curr Drug Targets 1:1-16
    • (2002) Curr Drug Targets , vol.1 , pp. 1-16
    • Marino, M.J.1    Conn, P.J.2
  • 192
    • 0032032540 scopus 로고    scopus 로고
    • Non-NMDA excitatory amino acid receptors in the ventral tegmental area mediate systemic dizocilpine (MK-801) induced hyperlocomotion and dopamine release in the nucleus accumbens
    • Mathé JM, Nomikos GG, Schilström B, Svensson TH (1998) Non-NMDA excitatory amino acid receptors in the ventral tegmental area mediate systemic dizocilpine (MK-801) induced hyperlocomotion and dopamine release in the nucleus accumbens. J Neurosci Res 51:583-592
    • (1998) J Neurosci Res , vol.51 , pp. 583-592
    • Mathé, J.M.1    Nomikos, G.G.2    Schilström, B.3    Svensson, T.H.4
  • 194
    • 13544263608 scopus 로고    scopus 로고
    • Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenia
    • Matute C, Melone M, Vallejo-Illarramendi A, Conti F (2005) Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenia. Glia 49:451-455
    • (2005) Glia , vol.49 , pp. 451-455
    • Matute, C.1    Melone, M.2    Vallejo-Illarramendi, A.3    Conti, F.4
  • 195
    • 0034094628 scopus 로고    scopus 로고
    • Glutamate receptor expression in schizophrenia brain
    • Meador-Woodruff JH, Healy DJ (2000) Glutamate receptor expression in schizophrenia brain. Brain Res Interactive 31:288-294
    • (2000) Brain Res Interactive , vol.31 , pp. 288-294
    • Meador-Woodruff, J.H.1    Healy, D.J.2
  • 197
    • 0035189584 scopus 로고    scopus 로고
    • Probing the human hippocampus using rCBF: Contrasts in schizophrenia
    • Medoff DR, Holcomb HH, Lahti AC, Tamminga CA (2001) Probing the human hippocampus using rCBF: contrasts in schizophrenia. Hippocampus 11:543-550
    • (2001) Hippocampus , vol.11 , pp. 543-550
    • Medoff, D.R.1    Holcomb, H.H.2    Lahti, A.C.3    Tamminga, C.A.4
  • 198
    • 0037272236 scopus 로고    scopus 로고
    • Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1
    • Melone M, Gragina L, Conti F (2003) Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1. Mol Psychiatry 8:12-13
    • (2003) Mol Psychiatry , vol.8 , pp. 12-13
    • Melone, M.1    Gragina, L.2    Conti, F.3
  • 199
    • 0030993243 scopus 로고    scopus 로고
    • Modulation of dopamine neuronal activity by glutamate receptor subtypes
    • Meltzer LT, Christoffersen CL, Serpa KA (1997) Modulation of dopamine neuronal activity by glutamate receptor subtypes. Neurosci Biobehav Rev 21:511-518
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 511-518
    • Meltzer, L.T.1    Christoffersen, C.L.2    Serpa, K.A.3
  • 200
    • 0034077277 scopus 로고    scopus 로고
    • Clozapine inhibits synaptic transmission at GABAergic synapses established ventral tegmental area neurones in culture
    • Michel FJ, Trudeau LE (2000) Clozapine inhibits synaptic transmission at GABAergic synapses established ventral tegmental area neurones in culture. Neuropharmacology 39:1536-1543
    • (2000) Neuropharmacology , vol.39 , pp. 1536-1543
    • Michel, F.J.1    Trudeau, L.E.2
  • 201
    • 0013085913 scopus 로고    scopus 로고
    • B receptors in the pathogenesis and treatment of schizophrenia: A critical review
    • B receptors in the pathogenesis and treatment of schizophrenia: a critical review. Curr Drug Targets 1:191-213
    • (2002) Curr Drug Targets , vol.1 , pp. 191-213
    • Millan, M.J.1
  • 204
    • 4344575913 scopus 로고    scopus 로고
    • D-Serine as a glial modulator of nerve cells
    • Miller RF (2004) D-Serine as a glial modulator of nerve cells. Glia 47:275-283
    • (2004) Glia , vol.47 , pp. 275-283
    • Miller, R.F.1
  • 207
    • 9644265272 scopus 로고    scopus 로고
    • Amphetamine-induced fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction
    • Miyamoto S, Snouwaert JN, Koller BH, Moy SS, Lieberman JA, Duncan GE (2004) Amphetamine-induced fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction. Neuropsychopharmacology:1-9
    • (2004) Neuropsychopharmacology , pp. 1-9
    • Miyamoto, S.1    Snouwaert, J.N.2    Koller, B.H.3    Moy, S.S.4    Lieberman, J.A.5    Duncan, G.E.6
  • 208
    • 12244289624 scopus 로고    scopus 로고
    • Identification of a novel variant of the human NR2B gene promoter regions and its possible association with schizophrenia
    • Miyatake R, Furukawa A, Suwaki H (2002) Identification of a novel variant of the human NR2B gene promoter regions and its possible association with schizophrenia. Mol Psychiatry 7:1101-1106
    • (2002) Mol Psychiatry , vol.7 , pp. 1101-1106
    • Miyatake, R.1    Furukawa, A.2    Suwaki, H.3
  • 209
    • 0037093781 scopus 로고    scopus 로고
    • Stress activation of glutamate neurotransmission in the prefrontal cortex: Implications for dopamine-associated psychiatric disorders
    • Moghaddam B (2002) Stress activation of glutamate neurotransmission in the prefrontal cortex: implications for dopamine-associated psychiatric disorders. Biol Psychiatry 51:775-787
    • (2002) Biol Psychiatry , vol.51 , pp. 775-787
    • Moghaddam, B.1
  • 210
    • 0346367105 scopus 로고    scopus 로고
    • Bringing order to the glutamate chaos in schizophrenia
    • Moghaddam B (2003) Bringing order to the glutamate chaos in schizophrenia. Neuron 40:881-884
    • (2003) Neuron , vol.40 , pp. 881-884
    • Moghaddam, B.1
  • 211
    • 0347091934 scopus 로고    scopus 로고
    • Glutamatergic animal models of schizophrenia
    • Moghaddam B, Jackson ME (2003) Glutamatergic animal models of schizophrenia. Ann NY Acad Sci 1003:131-137
    • (2003) Ann NY Acad Sci , vol.1003 , pp. 131-137
    • Moghaddam, B.1    Jackson, M.E.2
  • 212
    • 0033588176 scopus 로고    scopus 로고
    • Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
    • Mohn AR, Gainetdinov RR, Caron MG, Koller BH (1999) Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98:427-436
    • (1999) Cell , vol.98 , pp. 427-436
    • Mohn, A.R.1    Gainetdinov, R.R.2    Caron, M.G.3    Koller, B.H.4
  • 213
    • 1642355796 scopus 로고    scopus 로고
    • Vesicular glutamate transporter-dependent glutamate release from astrocytes
    • Montana V, Ni Y, Sunjura V, Hua X, Parpura V (2004) Vesicular glutamate transporter-dependent glutamate release from astrocytes. J Neurosci 24:2633-2642
    • (2004) J Neurosci , vol.24 , pp. 2633-2642
    • Montana, V.1    Ni, Y.2    Sunjura, V.3    Hua, X.4    Parpura, V.5
  • 217
    • 1242283944 scopus 로고    scopus 로고
    • Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia
    • Mueller HT, Haroutunian V, Davis KL, Meador-Woodruff JH (2004) Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia. Mol Brain Res 121:60-69
    • (2004) Mol Brain Res , vol.121 , pp. 60-69
    • Mueller, H.T.1    Haroutunian, V.2    Davis, K.L.3    Meador-Woodruff, J.H.4
  • 218
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • Muir KW, Lees KR (1995) Clinical experience with excitatory amino acid antagonist drugs. Stroke 26:503-513
    • (1995) Stroke , vol.26 , pp. 503-513
    • Muir, K.W.1    Lees, K.R.2
  • 221
    • 0033943840 scopus 로고    scopus 로고
    • N-Acetylaspartyl-glutamate: Most abundant peptide neurotransmitter in mammalian central nervous system
    • Neale JH, Bzdega T, Wroblewska B (2000) N-Acetylaspartyl-glutamate: most abundant peptide neurotransmitter in mammalian central nervous system. J Neurochem 75:443-452
    • (2000) J Neurochem , vol.75 , pp. 443-452
    • Neale, J.H.1    Bzdega, T.2    Wroblewska, B.3
  • 222
    • 0036718797 scopus 로고    scopus 로고
    • Beyond the role of glutamate as a neurotransmitter
    • Nedergaard M, Takano T, Hansen AJ (2002) Beyond the role of glutamate as a neurotransmitter. Nat Rev Neurosci 3:748-755
    • (2002) Nat Rev Neurosci , vol.3 , pp. 748-755
    • Nedergaard, M.1    Takano, T.2    Hansen, A.J.3
  • 223
    • 0037445064 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells
    • Ninan I, Jardemark KE, Liang X, Wang RY (2003a) Calcium/ calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells. Synapse 47:285-294
    • (2003) Synapse , vol.47 , pp. 285-294
    • Ninan, I.1    Jardemark, K.E.2    Liang, X.3    Wang, R.Y.4
  • 224
    • 0037333394 scopus 로고    scopus 로고
    • Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of NMDA receptors in pyramidal cells of the rat medial prefrontal cortex
    • Ninan I, Jardemark KE, Wang RY (2003b) Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of NMDA receptors in pyramidal cells of the rat medial prefrontal cortex. Neuropharmacology 44:462-472
    • (2003) Neuropharmacology , vol.44 , pp. 462-472
    • Ninan, I.1    Jardemark, K.E.2    Wang, R.Y.3
  • 226
    • 0034727878 scopus 로고    scopus 로고
    • Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus
    • Ohnuma T, Tessler G, Arai H, Faull RL, McKenna PJ, Emson PC (2000) Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Brain Res Mol Brain Res 85:24-31
    • (2000) Brain Res Mol Brain Res , vol.85 , pp. 24-31
    • Ohnuma, T.1    Tessler, G.2    Arai, H.3    Faull, R.L.4    McKenna, P.J.5    Emson, P.C.6
  • 229
    • 0036839191 scopus 로고    scopus 로고
    • Modulating sensory gating in healthy volunteers: The effects of ketamine and haloperidol
    • Oranje B, Gispen-de Wied CC, Verbaten MN, Kahn RS (2002) Modulating sensory gating in healthy volunteers: the effects of ketamine and haloperidol. Biol Psychiatry 52:557-895
    • (2002) Biol Psychiatry , vol.52 , pp. 557-895
    • Oranje, B.1    Gispen-de Wied, C.C.2    Verbaten, M.N.3    Kahn, R.S.4
  • 230
  • 231
    • 2442549046 scopus 로고    scopus 로고
    • Mechanisms of glutamate release from astrocytes: Gap junction "hemichannels", purinergic receptors and exocytotic release
    • Parpura V, Scemes E, Spray DC (2004) Mechanisms of glutamate release from astrocytes: gap junction "hemichannels", purinergic receptors and exocytotic release. Neurochem Int 45:259-264
    • (2004) Neurochem Int , vol.45 , pp. 259-264
    • Parpura, V.1    Scemes, E.2    Spray, D.C.3
  • 232
    • 0346461630 scopus 로고    scopus 로고
    • Glutamate and depression clinical and preclinical studies
    • Paul IA, Skolnick P (2003) Glutamate and depression clinical and preclinical studies. Ann NY Acad Sci 1003:250-272
    • (2003) Ann NY Acad Sci , vol.1003 , pp. 250-272
    • Paul, I.A.1    Skolnick, P.2
  • 233
    • 0034670647 scopus 로고    scopus 로고
    • Schizophrenia patients demonstrate a dissociation on declarative and non-declarative memory tests
    • Perry W, Light GA, Davis H, Braff DL (2000) Schizophrenia patients demonstrate a dissociation on declarative and non-declarative memory tests. Schizophr Res 46:167-174
    • (2000) Schizophr Res , vol.46 , pp. 167-174
    • Perry, W.1    Light, G.A.2    Davis, H.3    Braff, D.L.4
  • 234
    • 0347161155 scopus 로고    scopus 로고
    • Expression of mRNAs related to the GABAergic and glutamatergic neurotransmitter systems in the human thalamus: Normal and schizophrenic
    • Popken GJ, Leggio MG (2002) Expression of mRNAs related to the GABAergic and glutamatergic neurotransmitter systems in the human thalamus: normal and schizophrenic. Thalamus Relat Syst 1:349-369
    • (2002) Thalamus Relat Syst , vol.1 , pp. 349-369
    • Popken, G.J.1    Leggio, M.G.2
  • 235
    • 0032955821 scopus 로고    scopus 로고
    • Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia
    • Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B (1999) Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 156:145-147
    • (1999) Am J Psychiatry , vol.156 , pp. 145-147
    • Potkin, S.G.1    Jin, Y.2    Bunney, B.G.3    Costa, J.4    Gulasekaram, B.5
  • 236
    • 0036343122 scopus 로고    scopus 로고
    • Cellular perspectives on the glutamate-monoamine interactions in limbic lobe structures and their relevance for some psychiatric disorders
    • Pralong E, Magistretti P, Stoop R (2002) Cellular perspectives on the glutamate-monoamine interactions in limbic lobe structures and their relevance for some psychiatric disorders. Prog Neurobiol 67:173-202
    • (2002) Prog Neurobiol , vol.67 , pp. 173-202
    • Pralong, E.1    Magistretti, P.2    Stoop, R.3
  • 238
    • 0037417238 scopus 로고    scopus 로고
    • Memantine in moderate to severe Alzheimer's disease
    • Reisberg B, Doody R, Stöffler A (2003) Memantine in moderate to severe Alzheimer's disease. N Engl J Med 348:1333-1341
    • (2003) N Engl J Med , vol.348 , pp. 1333-1341
    • Reisberg, B.1    Doody, R.2    Stöffler, A.3
  • 241
    • 0344418672 scopus 로고    scopus 로고
    • Enhancement of NMDA immunoreactivity in residual dendritic spines in the caudate-putamen nucleus after chronic haloperidol administration
    • Rodriguez JJ, Pickel VM (1999) Enhancement of NMDA immunoreactivity in residual dendritic spines in the caudate-putamen nucleus after chronic haloperidol administration. Synapse 33:289-303
    • (1999) Synapse , vol.33 , pp. 289-303
    • Rodriguez, J.J.1    Pickel, V.M.2
  • 243
    • 0345257315 scopus 로고    scopus 로고
    • D-Cycloserine facilitates synaptic plasticity but impairs glutamate neurotransmission in rat hippocampus slices
    • Rouaud T, Billard JM (2003) D-Cycloserine facilitates synaptic plasticity but impairs glutamate neurotransmission in rat hippocampus slices. Br J Pharmacol 140:1051-1056
    • (2003) Br J Pharmacol , vol.140 , pp. 1051-1056
    • Rouaud, T.1    Billard, J.M.2
  • 244
    • 0028791942 scopus 로고
    • The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons
    • Rubin Y, La Placa MC, Smith DH, Thibault LE, Lenkinski RE (1995) The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons. Neurosci Lett 198:209-212
    • (1995) Neurosci Lett , vol.198 , pp. 209-212
    • Rubin, Y.1    La Placa, M.C.2    Smith, D.H.3    Thibault, L.E.4    Lenkinski, R.E.5
  • 246
    • 0028988978 scopus 로고
    • D-Serine, an endogenous synaptic modulator: Localization to astrocytes and glutamate-stimulated release
    • Schell MJ, Molliver ME, Snyder SH (1995) D-Serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A 92:3948-3952
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3948-3952
    • Schell, M.J.1    Molliver, M.E.2    Snyder, S.H.3
  • 247
    • 0036130340 scopus 로고    scopus 로고
    • Glutamate receptor genes
    • Schiffer HH (2002) Glutamate receptor genes. Mol Neurobiol 25:191-212
    • (2002) Mol Neurobiol , vol.25 , pp. 191-212
    • Schiffer, H.H.1
  • 248
    • 0345415193 scopus 로고    scopus 로고
    • Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine
    • Schiffer WK, Logan J, Dewey SL (2003) Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine. Neuropsychopharmacology 28:2192-2198
    • (2003) Neuropsychopharmacology , vol.28 , pp. 2192-2198
    • Schiffer, W.K.1    Logan, J.2    Dewey, S.L.3
  • 249
    • 0030983284 scopus 로고    scopus 로고
    • Behavioural pharmacology of glutamate receptors in the basal ganglia
    • Schmidt WJ, Kretschmer BD (1997) Behavioural pharmacology of glutamate receptors in the basal ganglia. Neurosci Biobehav Rev 21:381-392
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 381-392
    • Schmidt, W.J.1    Kretschmer, B.D.2
  • 250
    • 0038641323 scopus 로고    scopus 로고
    • Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain
    • Schmidt A, Zink M, Petroianu G, May B, Braus DF, Henn FA (2003) Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain. Neurosci Lett 347:81-84
    • (2003) Neurosci Lett , vol.347 , pp. 81-84
    • Schmidt, A.1    Zink, M.2    Petroianu, G.3    May, B.4    Braus, D.F.5    Henn, F.A.6
  • 251
    • 0032484645 scopus 로고    scopus 로고
    • Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT-1 Mma in the striatum
    • Schneider J, Wade T, Lidsky T (1998) Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT-1 Mma in the striatum. NeuroReport 9:133-136
    • (1998) NeuroReport , vol.9 , pp. 133-136
    • Schneider, J.1    Wade, T.2    Lidsky, T.3
  • 252
    • 0011900802 scopus 로고    scopus 로고
    • Preclinical pharmacology of mGlu2/3 receptor agonists: Novel agents for schizophrenia?
    • Schoepp DD, Marek GJ (2002) Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia? Curr Drug Targets CNS Neurol Disord 1:215-225
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , pp. 215-225
    • Schoepp, D.D.1    Marek, G.J.2
  • 253
    • 0032810486 scopus 로고    scopus 로고
    • Alterations of the dopaminergic and glutamatergic neurotransmission in adult rats with postnatal ibotenic acid hippocampus lesion
    • Schroeder H, Greekseh G, Beeker A, Bogerts B, Hoellt V (1999) Alterations of the dopaminergic and glutamatergic neurotransmission in adult rats with postnatal ibotenic acid hippocampus lesion. Psychopharmacology 145:61-66
    • (1999) Psychopharmacology , vol.145 , pp. 61-66
    • Schroeder, H.1    Greekseh, G.2    Beeker, A.3    Bogerts, B.4    Hoellt, V.5
  • 255
    • 0036784518 scopus 로고    scopus 로고
    • Manipulation of brain kynurenines: Glial targets, neuronal effects, and clinical opportunities
    • Schwarcz R, Pellicciari R (2002) Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303:1-10
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1-10
    • Schwarcz, R.1    Pellicciari, R.2
  • 257
    • 0642308239 scopus 로고    scopus 로고
    • Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid
    • Schwieler L, Erhardt S (2003) Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid. Neuropsychopharmacology 28:1770-1777
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1770-1777
    • Schwieler, L.1    Erhardt, S.2
  • 258
    • 1842510585 scopus 로고    scopus 로고
    • Clozapine modulates mid-brain dopamine neuron firing via interaction with the NMDA receptor complex
    • Schwieler L, Engberg G, Erhardt S (2004) Clozapine modulates mid-brain dopamine neuron firing via interaction with the NMDA receptor complex. Synapse 52:114-122
    • (2004) Synapse , vol.52 , pp. 114-122
    • Schwieler, L.1    Engberg, G.2    Erhardt, S.3
  • 261
    • 0030601254 scopus 로고    scopus 로고
    • Duration-dependent increase in striatal glutamate following prolonged fluphenazine administration in rats
    • See RE, Lynch AM (1996) Duration-dependent increase in striatal glutamate following prolonged fluphenazine administration in rats. Eur J Pharmacol 302:279-282
    • (1996) Eur J Pharmacol , vol.302 , pp. 279-282
    • See, R.E.1    Lynch, A.M.2
  • 262
    • 0035309305 scopus 로고    scopus 로고
    • Identification of genes from a schizophrenia-linked translocation breakpoint region
    • Semple CAM, Devon RS, Le Hellard S, Porteous DJ (2001) Identification of genes from a schizophrenia-linked translocation breakpoint region. Genomics 73:123-126
    • (2001) Genomics , vol.73 , pp. 123-126
    • Semple, C.A.M.1    Devon, R.S.2    Le Hellard, S.3    Porteous, D.J.4
  • 263
    • 1242284561 scopus 로고    scopus 로고
    • New antipsychotics and schizophrenia: A review on efficacy and side effects
    • Serretti A, De Ronchi D, Lorenzi C, Barardi D (2004) New antipsychotics and schizophrenia: a review on efficacy and side effects. Curr Med Chem 11:343-358
    • (2004) Curr Med Chem , vol.11 , pp. 343-358
    • Serretti, A.1    De Ronchi, D.2    Lorenzi, C.3    Barardi, D.4
  • 265
    • 0034898096 scopus 로고    scopus 로고
    • Subunit specificity and mechanism of action of NMDA partial agonist D-cycloserine
    • Sheinin A, Shavit S, Benveniste M (2001) Subunit specificity and mechanism of action of NMDA partial agonist D-cycloserine. Neuropharmacology 41:151-158
    • (2001) Neuropharmacology , vol.41 , pp. 151-158
    • Sheinin, A.1    Shavit, S.2    Benveniste, M.3
  • 267
    • 0037405733 scopus 로고    scopus 로고
    • Dendritic glutamate-induced bursting in the prefrontal cortex: Further characterization and effects of phencyclidine
    • Shi WX, Zhang XX (2003) Dendritic glutamate-induced bursting in the prefrontal cortex: further characterization and effects of phencyclidine. J Pharmacol Exp Ther 305:680-687
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 680-687
    • Shi, W.X.1    Zhang, X.X.2
  • 268
    • 1642338752 scopus 로고    scopus 로고
    • Glycine and D-cycloserine attenuate vacuous chewing movements in a rat model of tardive dyskinesia
    • Shoham S, Mazeh H, Javitt DC, Heresco-Levy U (2004) Glycine and D-cycloserine attenuate vacuous chewing movements in a rat model of tardive dyskinesia. Brain Res 1004:142-147
    • (2004) Brain Res , vol.1004 , pp. 142-147
    • Shoham, S.1    Mazeh, H.2    Javitt, D.C.3    Heresco-Levy, U.4
  • 269
    • 0034849588 scopus 로고    scopus 로고
    • Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia
    • Smith RE, Haroutunian V (2001a) Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia. Am J Psychiatry 158:1393-1399
    • (2001) Am J Psychiatry , vol.158 , pp. 1393-1399
    • Smith, R.E.1    Haroutunian, V.2
  • 270
    • 0035903814 scopus 로고    scopus 로고
    • Vesicular glutamate transporter transcript expression in the thalamus in schizophrenia
    • Smith RE, Haroutunian V (2001b) Vesicular glutamate transporter transcript expression in the thalamus in schizophrenia. NeuroReport 12:1-3
    • (2001) NeuroReport , vol.12 , pp. 1-3
    • Smith, R.E.1    Haroutunian, V.2
  • 272
    • 4544246380 scopus 로고    scopus 로고
    • Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition
    • Spooren W, Mombereau C, Maco M, Gill R, Kemp JA, Ozmen L, Nakanishi S, Higgins GA (2004) Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition. Psychopharmacology 175:99-105
    • (2004) Psychopharmacology , vol.175 , pp. 99-105
    • Spooren, W.1    Mombereau, C.2    Maco, M.3    Gill, R.4    Kemp, J.A.5    Ozmen, L.6    Nakanishi, S.7    Higgins, G.A.8
  • 276
    • 0032188850 scopus 로고    scopus 로고
    • Electrophysiological characterization of GABAergic neurons in ventral tegmental area
    • Stefensen SC, Svingos AL, Pickel VM, Henriksen SJ (1998) Electrophysiological characterization of GABAergic neurons in ventral tegmental area. J Neurosci 18:8003-8015
    • (1998) J Neurosci , vol.18 , pp. 8003-8015
    • Stefensen, S.C.1    Svingos, A.L.2    Pickel, V.M.3    Henriksen, S.J.4
  • 277
    • 0030057542 scopus 로고    scopus 로고
    • The behavioural and neurochemical effects of phencyclidine in humans and animals: Some implications for modelling psychosis
    • Steinpreis RE (1996) The behavioural and neurochemical effects of phencyclidine in humans and animals: some implications for modelling psychosis. Behav Brain Res 74:45-55
    • (1996) Behav Brain Res , vol.74 , pp. 45-55
    • Steinpreis, R.E.1
  • 278
    • 0036690151 scopus 로고    scopus 로고
    • Endogenous kynurenines as targets for drug discovery and development
    • Stone TW, Darlington LG (2002) Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 1:609-620
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 609-620
    • Stone, T.W.1    Darlington, L.G.2
  • 279
    • 2942529361 scopus 로고    scopus 로고
    • Effect of D-serine on a delayed match-to-place task for the water maze
    • Stouffer EM, Petri HL, Devan BD (2004) Effect of D-serine on a delayed match-to-place task for the water maze. Behav Brain Res 152:447-452
    • (2004) Behav Brain Res , vol.152 , pp. 447-452
    • Stouffer, E.M.1    Petri, H.L.2    Devan, B.D.3
  • 281
    • 1942539345 scopus 로고    scopus 로고
    • Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: Relation to negative symptoms
    • Sumiyoshi T, Anil AE, Jin D, Jayathilake K, Lee M, Meltzer HY (2004) Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms. Int J Neuropharmacol 7:1-8
    • (2004) Int J Neuropharmacol , vol.7 , pp. 1-8
    • Sumiyoshi, T.1    Anil, A.E.2    Jin, D.3    Jayathilake, K.4    Lee, M.5    Meltzer, H.Y.6
  • 283
    • 0042343859 scopus 로고    scopus 로고
    • Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine
    • Takahata R, Moghaddam B (2003) Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine. Neuropsychopharmacology 28:1117-1124
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1117-1124
    • Takahata, R.1    Moghaddam, B.2
  • 286
    • 0028301264 scopus 로고
    • Stereoselective antagonism by enantiomers of alanine and serine of phencyclidine-induced hyperactivity, stereotypy and ataxia in the rat
    • Tanii Y, Nishikawa T, Hashimoto A, Takahashi K (1994) Stereoselective antagonism by enantiomers of alanine and serine of phencyclidine-induced hyperactivity, stereotypy and ataxia in the rat. J Pharmacol Exp Ther 269:1040-1048
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 1040-1048
    • Tanii, Y.1    Nishikawa, T.2    Hashimoto, A.3    Takahashi, K.4
  • 287
    • 0041430707 scopus 로고    scopus 로고
    • Long-term effects of olanzapine, risperidone, and quetiapine on ionotropic glutamate receptor types: Implications for antipsychotic drug treatment
    • Tarazi FI, Baldessarini RJ, Kula NS, Zhang H (2003) Long-term effects of olanzapine, risperidone, and quetiapine on ionotropic glutamate receptor types: implications for antipsychotic drug treatment. J Pharmacol Exp Ther 306:1145-1151
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 1145-1151
    • Tarazi, F.I.1    Baldessarini, R.J.2    Kula, N.S.3    Zhang, H.4
  • 288
    • 1442351172 scopus 로고    scopus 로고
    • Peptide transporters: Structure, function, regulation and application for drug delivery
    • Terada T, Inui K (2004) Peptide transporters: structure, function, regulation and application for drug delivery. Curr Drug Metab 5:85-94
    • (2004) Curr Drug Metab , vol.5 , pp. 85-94
    • Terada, T.1    Inui, K.2
  • 290
    • 7244220611 scopus 로고    scopus 로고
    • Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS
    • Théberge J, Al-Semann Y, Williamson PC, Menon RS, Neufeld RWJ, Rajakumar N, Schaefer B, Densmore M, Drost DJ (2003) Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS. Am J Psychiatry 160:2231-2233
    • (2003) Am J Psychiatry , vol.160 , pp. 2231-2233
    • Théberge, J.1    Al-Semann, Y.2    Williamson, P.C.3    Menon, R.S.4    Neufeld, R.W.J.5    Rajakumar, N.6    Schaefer, B.7    Densmore, M.8    Drost, D.J.9
  • 291
    • 2942558677 scopus 로고    scopus 로고
    • 3-T proton MRS investigation of glutamate and glutamine in adolescents at high genetic risk for schizophrenia
    • Tibbo P, Hanstock C, Valiakalayil A, Allen P (2004) 3-T proton MRS investigation of glutamate and glutamine in adolescents at high genetic risk for schizophrenia. Am J Psychiatry 161:1116-1118
    • (2004) Am J Psychiatry , vol.161 , pp. 1116-1118
    • Tibbo, P.1    Hanstock, C.2    Valiakalayil, A.3    Allen, P.4
  • 293
    • 0022611408 scopus 로고
    • Antagonism of phencyclidine induced hyperactivity by glycine in mice
    • Toth E, Lajtha A (1986) Antagonism of phencyclidine induced hyperactivity by glycine in mice. Neurochem Res 11:393-400
    • (1986) Neurochem Res , vol.11 , pp. 393-400
    • Toth, E.1    Lajtha, A.2
  • 294
    • 4444229475 scopus 로고    scopus 로고
    • Glutamate co-transmission as an emerging concept in monoamine neuron function
    • Trudeau LE (2004) Glutamate co-transmission as an emerging concept in monoamine neuron function. Rev Psychiatr Neurosci 29:296-310
    • (2004) Rev Psychiatr Neurosci , vol.29 , pp. 296-310
    • Trudeau, L.E.1
  • 296
    • 0032403626 scopus 로고    scopus 로고
    • D-Serine added to antipsychotics for the treatment of schizophrenia
    • Tsai G, Yang P, Chung LC, Lange N, Coyle JT (1998) D-Serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 44:1081-1089
    • (1998) Biol Psychiatry , vol.44 , pp. 1081-1089
    • Tsai, G.1    Yang, P.2    Chung, L.C.3    Lange, N.4    Coyle, J.T.5
  • 298
    • 1542617755 scopus 로고    scopus 로고
    • Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia
    • Tsai G, Lane HY, Yang P, Chong MY, Lang N (2004a) Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 55:452-456
    • (2004) Biol Psychiatry , vol.55 , pp. 452-456
    • Tsai, G.1    Lane, H.Y.2    Yang, P.3    Chong, M.Y.4    Lang, N.5
  • 300
    • 2642566270 scopus 로고    scopus 로고
    • Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signalling mechanisms
    • Tseng KY, O'Donnell P (2004) Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signalling mechanisms. J Neurosci 24:5131-5139
    • (2004) J Neurosci , vol.24 , pp. 5131-5139
    • Tseng, K.Y.1    O'Donnell, P.2
  • 301
    • 9244243064 scopus 로고    scopus 로고
    • Glutamatergic drugs for schizophrenia: A systematic review and meta-analysis
    • Tuominen HJ, Tiihonen J, Wahlbeck K (2005) Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophr Res 72:225-234
    • (2005) Schizophr Res , vol.72 , pp. 225-234
    • Tuominen, H.J.1    Tiihonen, J.2    Wahlbeck, K.3
  • 303
    • 0037123710 scopus 로고    scopus 로고
    • Gene expression of D-amino acid oxidase in cultured rat astrocytes regional and cell type specific expression
    • Urai Y, Jinnouchi O, Kwak KT, Suzue A, Nagahiro S, Fukui K (2002) Gene expression of D-amino acid oxidase in cultured rat astrocytes regional and cell type specific expression. Neurosci Lett 324:101-104
    • (2002) Neurosci Lett , vol.324 , pp. 101-104
    • Urai, Y.1    Jinnouchi, O.2    Kwak, K.T.3    Suzue, A.4    Nagahiro, S.5    Fukui, K.6
  • 304
    • 0033167970 scopus 로고    scopus 로고
    • Facilitated NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 area of dystrophin-deficient mice
    • Vaillend C, Ungerer A, Billard JM (1999) Facilitated NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 area of dystrophin-deficient mice. Synapse 33:59-70
    • (1999) Synapse , vol.33 , pp. 59-70
    • Vaillend, C.1    Ungerer, A.2    Billard, J.M.3
  • 309
    • 4744365205 scopus 로고    scopus 로고
    • Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies
    • Vieira AR, Devlin AM (2004) Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies. Am J Med Gen 130A:329-330
    • (2004) Am J Med Gen , vol.130 A , pp. 329-330
    • Vieira, A.R.1    Devlin, A.M.2
  • 312
    • 0035985470 scopus 로고    scopus 로고
    • Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the NMDA glutamate receptor
    • Williams NM, Bowen T, Spurlock G, Norton N, Williams HJ, Hoogendoom B, Owen MJ, O'Donovan MC (2002) Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the NMDA glutamate receptor. Mol Psychiatry 7:508-514
    • (2002) Mol Psychiatry , vol.7 , pp. 508-514
    • Williams, N.M.1    Bowen, T.2    Spurlock, G.3    Norton, N.4    Williams, H.J.5    Hoogendoom, B.6    Owen, M.J.7    O'Donovan, M.C.8
  • 315
    • 1642410058 scopus 로고    scopus 로고
    • Serotonergic/glutamatergic interactions: The effects of mGlu (2/3) receptor ligands in rats trained with LSD and PCP as discriminative stimuli
    • Winter JC, Eckler JR, Rabin RA (2003) Serotonergic/glutamatergic interactions: the effects of mGlu (2/3) receptor ligands in rats trained with LSD and PCP as discriminative stimuli. Psychopharmacology 172:233-240
    • (2003) Psychopharmacology , vol.172 , pp. 233-240
    • Winter, J.C.1    Eckler, J.R.2    Rabin, R.A.3
  • 316
    • 2342523931 scopus 로고    scopus 로고
    • Non-opioid actions of opioid peptides
    • Wollemann M, Benyhe S (2004) Non-opioid actions of opioid peptides. Life Sci 75:257-270
    • (2004) Life Sci , vol.75 , pp. 257-270
    • Wollemann, M.1    Benyhe, S.2
  • 317
    • 0033539510 scopus 로고    scopus 로고
    • Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
    • Wolosker H, Blackshaw S, Snyder SH (1999) Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A 96:13409-13414
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13409-13414
    • Wolosker, H.1    Blackshaw, S.2    Snyder, S.H.3
  • 318
    • 3042782805 scopus 로고    scopus 로고
    • 2A in the anterior cingulate cortex in schizophrenia and bipolar disorder
    • 2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch Gen Psychiatry 61:649-657
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 649-657
    • Woo, T.U.W.1    Walsh, J.P.2    Benes, F.M.3
  • 320
    • 0032790229 scopus 로고    scopus 로고
    • Subunit- and site-specific pharmacology of the NMDA receptor channel
    • Yamakura T, Shimoh K (1999) Subunit- and site-specific pharmacology of the NMDA receptor channel. Prog Neurobiol 59:279-298
    • (1999) Prog Neurobiol , vol.59 , pp. 279-298
    • Yamakura, T.1    Shimoh, K.2
  • 321
    • 0028004050 scopus 로고
    • Brain region effects of clozapine on amino acid and monoamine transmission
    • Yamamoto BK, Pehek EA, Meltzer HY (1994) Brain region effects of clozapine on amino acid and monoamine transmission. J Clin Psychiatry 55:8-14
    • (1994) J Clin Psychiatry , vol.55 , pp. 8-14
    • Yamamoto, B.K.1    Pehek, E.A.2    Meltzer, H.Y.3
  • 322
    • 0041413364 scopus 로고    scopus 로고
    • Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors
    • Yan HD, Ishihara K, Serikawa T, Sasa M (2003) Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors. Epilepsia 44:1153-1159
    • (2003) Epilepsia , vol.44 , pp. 1153-1159
    • Yan, H.D.1    Ishihara, K.2    Serikawa, T.3    Sasa, M.4
  • 323
    • 2342636333 scopus 로고    scopus 로고
    • Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol
    • Yanahashi S, Hashimoto K, Hattori K, Yuasa S, Iyo M (2004) Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol. Brain Res 1011:84-93
    • (2004) Brain Res , vol.1011 , pp. 84-93
    • Yanahashi, S.1    Hashimoto, K.2    Hattori, K.3    Yuasa, S.4    Iyo, M.5
  • 325
    • 0037531231 scopus 로고    scopus 로고
    • Functional hemichannels in astrocytes: A novel mechanism of glutamate release
    • Ye ZC, Wyeth MS, Baltan-Tekkok S, Ransom BR (2003) Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J Neurosci 23:3588-3596
    • (2003) J Neurosci , vol.23 , pp. 3588-3596
    • Ye, Z.C.1    Wyeth, M.S.2    Baltan-Tekkok, S.3    Ransom, B.R.4
  • 327
    • 0036850510 scopus 로고    scopus 로고
    • Selective alterations in ionotropic glutamate receptors in the anterior cingulate cortex in schizophrenia
    • Zavitsanou K, Ward PB, Huang XF (2002) Selective alterations in ionotropic glutamate receptors in the anterior cingulate cortex in schizophrenia. Neuropsychopharmacology 27:826-833
    • (2002) Neuropsychopharmacology , vol.27 , pp. 826-833
    • Zavitsanou, K.1    Ward, P.B.2    Huang, X.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.