Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics

Journal of Neural Transmission

Volumn 104, Issue 6-7, 1997, Pages 761-766

  Evins, A E ^a   Amico, E T ^a   Shih, V ^a   Goff, D C ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Freedom Trail Clinic   (United States)

Author keywords

Amino acid; Aspartate,; Clozapine; Glutamate; Glycine; Negative symptoms; Psychopharmacology; Schizophrenia

Indexed keywords

ASPARTIC ACID; CLOZAPINE; GLUTAMIC ACID; GLYCINE; NEUROLEPTIC AGENT;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG MECHANISM; FEMALE; HUMAN; MALE; NEGATIVE SYNDROME; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; ASPARTIC ACID; CLOZAPINE; FEMALE; GLUTAMIC ACID; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; SCHIZOPHRENIA;

EID: 0030665569     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01291892     Document Type: Article

References (19)

1. Alfredsson G, Wiesel FA (1990) Relationships between clinical effects and monoamine metabolites and amino acids in sulpiride-treated schizophrenia patients. Psychopharmacology 101: 324-331
2. Alfredsson G, Wiesel FA, Tylec A (1988) Relationships between glutamate and monoamine metabolites in cerebrospinal fluid and serum in healthy volunteers. Biol Psychiatry 23: 689-697
3. Alfredsson G, Wiesel FA, Lindberg M (1988) Glutamate and glutamine in cerebrospinal fluid and serum from healthy volunteers-analytical aspects. J Chromatogr 424: 378-384
4. Bakshi VP, Swerdlow NR, Geyer MA (1994) Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271:787-794
5. Corbett R, Camacho R, Woods AT, Kerman LL, Fishkin RJ, Brooks K, Dunn RW (1995) Antipsychotic agents antagonize non-competitive N-methyl-d-aspartate antagonist-induced behaviors. Psychopharmacology 120: 67-74
6. Coyle JT (1996) The glutamatergic dysfunction hypothesis for schizophrenia. Harvard Rev Psychiatry 3: 241-253
7. Daly DA, Moghaddam B (1993) Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats. Neurosci Lett 152: 61-64
8. Farber NB, Price MT, Labruyere J, Nemnich J, St. Peter H, Wozniak DF, Olney JW (1993) Antipsychotic drugs blocks phencyclidine induced neurotoxicity. Biol Psychiatry 34: 119-121
9. Goff DC, Tsai G, Manoach DS, Coyle JT (1995) Dose-finding trial of d-cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am J Psychiatry 152: 1213-1215
10. Goff DC, Tsai G, Manoach DS, Flood J, Darby DG, Coyle JT (1996) D-cycloserine added to clozapine for patients with schizophrenia. Am J Psychiatry 153: 1628-1630
11. Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmuller B (1980) Low cerebrospinal glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20: 379-382
12. Korpi ER, Kaufmann CA, Marnela KM, Weinberger DR (1987) Cerebrospinal fluid amino acid concentrations in chronic schizophrenia. Psychiatry Res 20: 337-345
13. Lang A, Soosar A, Harro J (1992) The involvement of sigma and phencyclidine receptors in the action of antipsychotic drugs. Pharmacol Toxicol 71: 132-138
14. McGale EHF, Pye IF, Stonier C, Hutchinson EC, Aber GM (1977) Studies of the interrelationship between cerebrospinal fluid and plasma amino acid concentrations in normal individuals. J Neurochem 29: 291-297
15. Olney JW, Farber NB (1994) Efficacy of clozapine compared with other antipsychotics in preventing NMDA-antagonist neurotoxicity. J Clin Psychiatry 55: 43-46
16. Olney JW, Farber NB (1995) Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52: 998-1007
17. Tiedtke PI, Bischoff C, Schmidt WJ (1990) MK-801-induced stereotypy and its antagonism by neuroleptic drugs. J Neural Transm 81: 173-182
18. Watson GB, Bolanowski MA, Baganoff MP, Deppeler CL, Lanthorn TH (1990) D-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes. Brain Res 510: 158-160
19. Yamamoto BK, Pehek EA, Meltzer HY (1994) Brain region effects of clozapine on amino acid and monoamine transmission. J Clin Psychiatry 55: 8-14