Activation by N-acetyl-L-aspartate of acutely dissociated hippocampal neurons in rats via metabotropic glutamate receptors

Epilepsia

Volumn 44, Issue 9, 2003, Pages 1153-1159

  Yan, Hai Dun ^a   Ishihara, Kumatoshi ^b   Serikawa, Tadao ^c   Sasa, Masashi ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Hippocampal neuron; Metabotropic glutamate receptor (mGluR); N Acetyl L aspartate (NAA); NAA induced current; Patch clamp

Indexed keywords

ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ASPARTOACYLASE; CADMIUM CHLORIDE; GUANOSINE 5' O (2 THIODIPHOSPHATE); METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; N ACETYLASPARTIC ACID; TETRODOTOXIN; TETRYLAMMONIUM CHLORIDE;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL STIMULATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SEIZURE; TREMOR; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; ASPARTIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; HIPPOCAMPUS; NEURONS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0041413364     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2003.49402.x     Document Type: Article

References (25)

1. Tsai G, Coyle JT. N-Acetylaspartate in neuropsychiatric disorders. Prog Neurobiol 1995;46:531-40.
2. Baslow MH. A review of phylogenetic and metabolic relationships between the acylamino acids, N-acetyl-L-aspartic acid and N-acetyl-L-histidine, in the vertebrate nervous system. J Neurochem 1997;68:1335-44.
3. Miyake M, Kakimoto Y, Sorimachi M. A gas chromatographic method for determination of N-acetyl-L-aspartic acid, N-acetyl-β-aspartyl-glutamic acid and α-citryl-L-glutamic acid and their distributions in the brain and other organs of various species of animals. J Neurochem 1981;36:804-10.
4. Dunlop DS, McHale DM, Lajtha A. Decrease brain N-acetylaspartate in Huntington's disease. Brain Res 1992;580:44-8.
5. Plaitakis A, Constantakakis E. Altered metabolism of excitatory amino acids, N-acetyl-aspartate, and N-acetyl-aspartyl-glutamate in amyotrophic lateral sclerosis. Brain Res Bull 1993;30:381-6.
6. Richards TL. Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy. Am J Roentgenol 1991;157:1073-8.
7. Klunk WE, Panchalingam K, Moossy J, et al. N-Acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study. Neurology 1992;42:1578-85.
8. Hugg JW, Laxer KD, Matson GB, et al. Neuron loss localizes human temporal lobe epilepsy by in vivo proton magnetic resonance spectroscopic imaging. Ann Neurol 1993;34:788-94.
9. 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 1989;13:23-31.
10. Peden CJ, Rutherford MA, Sargentoni J, et al. Proton spectroscopy of the neonatal brain following hypoxic-ischaemic injury. Dev Med Child Neurol 1993;35:502-10.
11. 1H NMR spectroscopy in Canavan's disease: a report of two cases. Magn Reson Med 1991;19:439-45.
12. Paulus W, Peiffer J. Intracerebral distribution of mitochondrial abnormalities in 21 cases of infantile spongy dystrophy. J Neurol Sci 1990;95:49-62.
13. Sasa M, Ohno Y, Ujihara H, et al. Effects of antiepileptic drugs on absence-like and tonic seizures in the spontaneously epileptic rat, a double mutant rat. Epilepsia 1988;29:505-13.
14. Serikawa T, Ohno Y, Sasa M, et al. A new model of petit mal epilepsy: spontaneous spike and wave discharges in tremor rats. Lab Anim 1987;21:68-71.
15. Serikawa T, Yamada J. Epileptic seizures in rats homozygous for two mutants, zitter and tremor. J Hered 1987;77:441-4.
16. Hanaya R, Sasa M, Ujihara H, et al. Effect of antiepileptic drugs on absence-like seizures in the tremor rat. Epilepsia 1995;36:938-42.
17. Yamada J, Serikawa T, Ishiko J, et al. Rats with congenital tremor and curled whiskers and hair. Exp Anim 1985:34:183-8.
18. Kuramoto T, Mori M, Yamada J, et al. Tremor and zitter, causative mutant genes for epilepsy with spongiform encephalopathy in spontaneously epileptic rat (SER), are tightly linked to synaptobrevin-2 and prion protein genes, respectively. Biochem Biophys Res Commun 1994;200:1161-8.
19. Kitada K, Akimitsu T, Shigematsu Y, et al. Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. J Neurochem 2000;74:2512-9.
20. Akimitsu T, Kurisu K, Hanaya R, et al. Epileptic seizures induced by N-acetyl-L-aspartate in rats: in vivo and in vitro studies. Brain Res 2000;861:143-50.
21. Tsujiyama S, Akaike A, Ujihara H, et al. Potentiation by ethanol of GABA-induced current and facilitation of its desensitization in cultured rat cortical neurons. Gen Pharmacol 1997;28:375-80.
22. Nakagawa T, Shirasaki T, Wakamori M, et al. Excitatory amino acid response in isolated nucleus tractus solitarii neurons of the rat. Neurosci Res 1990;8:114-23.
23. 2+ activated nonspecific cationic current in CA1 hippocampal neurons. J Neurophysiol 1994;72:1561-9.
24. Lee K, Boden PR. Characterization of the inward current induced by metabotropic glutamate receptor stimulation in rat ventromedial hypothalamic neurones. J Physiol 1997;504:649-63.
25. Guérineau NC, Bossu J-L, Gähwiller BH, et al. Activation of nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus. J Neurosci 1995;15:4395-407.