Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain

European Journal of Neuroscience

Volumn 18, Issue 8, 2003, Pages 2227-2238

  Helboe, Lone ^a   Egebjerg, Jan ^a   Møller, Morten ^b   Thomsen, Christian ^a  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

4F2hc associating transporter; D serine transporter; Schizophrenia; SLC 7 transporter

Indexed keywords

AMINO ACID TRANSPORTER; DEXTRO SERINE; POLYCLONAL ANTIBODY; SODIUM ION; TRITIUM;

AMYGDALOID NUCLEUS; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BRAIN; BRAIN STEM; BRAIN SYNAPTOSOME; CAUDATE NUCLEUS; CELL MEMBRANE; CELL ULTRASTRUCTURE; CINGULATE GYRUS; CONTROLLED STUDY; CORRELATION ANALYSIS; DENDRITIC CELL; DENTATE GYRUS; ELECTRON MICROSCOPY; EMBRYO; ENTOPEDUNCULAR NUCLEUS; ENZYME SPECIFICITY; FIBROBLAST; GENETIC TRANSFECTION; GLIA CELL; GLOBUS PALLIDUS; HIPPOCAMPUS; HUMAN; HUMAN CELL; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; ISOTOPE LABELING; KIDNEY CELL; MALE; MICROSCOPY; MOLECULAR CLONING; MOUSE; NEOCORTEX; NERVE ENDING; NONHUMAN; NUCLEUS ACCUMBENS; PERIKARYON; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PUTAMEN; RAT; RODENT; SODIUM TRANSPORT; STRIA TERMINALIS; THALAMUS; WESTERN BLOTTING; WHITE MATTER;

ALANINE; AMINO ACID TRANSPORT SYSTEM A; AMINO ACID TRANSPORT SYSTEM L; AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; ANTIGENS, CD98; BETA-ALANINE; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CELL LINE; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; GLYCINE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; MICE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; SODIUM; SYNAPTOSOMES; TRANSFECTION;

EID: 1542640509     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02966.x     Document Type: Article

References (31)

1. Arriza, J.L., Kavanaugh, M.P., Fairman, W.A., Wu, Y.N., Murdoch, G.H., North, R.A. & Amara, S.G. (1993) Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J. Biol. Chem., 268, 15329-15332.
2. Baranano, D.E., Ferris, C.D. & Snyder, S.H. (2001) Atypical neural messengers. Trends Neurosci., 24, 99-106.
3. Brauner-Osborne, H., Egebjerg, J., Nielsen, E.O., Madsen, U. & Krogsgaard-Larsen, P. (2000) Ligands for glutamate receptors: design and therapeutic prospects. J. Med. Chem., 43, 2609-2645.
4. Chairoungdua, A., Kanai, Y., Matsuo, H., Inatomi, J., Kim, D.K. & Endou, H. (2001) Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. J. Biol. Chem., 276, 49390-49399.
5. Christensen, H.N. (1990) Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev., 70, 43-77.
6. 3H]D-serine labels strychnine-insensitive glycine recognition sites of rat central nervous system. Life Sci., 46, 155-164.
7. Danysz, W. & Parsons, A.C. (1998) Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol. Rev., 50, 597-664.
8. Devés, R. & Boyd, C.A. (2000) Surface antigen CD98 (4F2): not a single membrane protein, but a family of proteins with multiple functions. J. Membr. Biol., 173, 165-177.
9. Dunlop, D.S. & Neidle, A. (1997) The origin and turnover of D-serine in brain. Biochem. Biophys. Res. Commun., 235, 26-30.
10. +-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D-and L-amino acids. J. Biol. Chem., 275, 9690-9698.
11. Hashimoto, A., Nishikawa, T., Oka, T. & Takahashi, K. (1993) Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. J. Neurochem., 60, 783-786.
12. Hashimoto, A. & Oka, T. (1997) Free D-aspartate and D-serine in the mammalian brain and periphery. Prog. Neurobiol., 52, 325-353.
13. Hashimoto, A., Oka, T. & Nishikawa, T. (1995a) Extracellular concentration of endogenous free D-serine in the rat brain as revealed by in vivo microdialysis. Neuroscience, 66, 635-643.
14. Hashimoto, A., Oka, T. & Nishikawa, T. (1995b) Anatomical distribution and postnatal changes in endogenous free D-aspartate and D-serine in rat brain and periphery. Eur. J. Neurosci., 7, 1657-1663.
15. Hayashi, F., Takahashi, K. & Nishikawa, T. (1997) Uptake of D-and L-serine in C6 glioma cells. Neurosci. Lett., 239, 85-88.
16. Horiike, K., Tojo, H., Arai, R., Nozaki, M. & Maeda, T. (1994) D-Amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes. Brain Res., 652, 297-303.
17. Javitt, D.C., Balla, A. & Sershen, H. (2002) A novel alanine-insensitive D-serine transporter in rat brain synaptosomal membranes. Brain Res., 941, 146-149.
18. Kanai, Y. & Endou, H. (2001) Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr. Drug Metab., 2, 339-354.
19. 3H]serine binding to synaptosomal fraction isolated from rat brain tissues. J. Neurochem., 69, 399-405.
20. Matsui, T., Sekiguchi, M., Hashimoto, A., Tomita, V., Nishikawa, T. & Wada, K. (1995) Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J. Neurochem., 65, 454-458.
21. Mothet, J.P., Parent, A.T., Wolosker, H., Brady, R.O., Linden, D.J., Ferris, C.D., Rogawski, M.A. & Snyder, S.H. (2000) D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc. Natl Acad. Sci. USA, 97, 4926-4931.
22. +-independent transporter for small neutral amino acids that transports D-serine with high affinity. Neurosci. Lett., 287, 231-235.
23. Ribeiro, C.S., Reis, M., Panizzutti, R., De Miranda, J. & Wolosker, H. (2002) Glial transport of the neuromodulator D-serine. Brain Res., 929, 202-209.
24. Schell, M.J., Brady, R.O., Molliver, M.E. & Snyder, S.H. (1997) D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J. Neurosci., 17, 1604-1615.
25. Schell, M.J., Molliver, M.E. & Snyder, S.H. (1995) D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc. Natl Acad. Sci. USA, 92, 3948-3952.
26. +-dependent neutral amino acid transporter. J. Biol. Chem., 271, 14883-14890.
27. Wagner, C.A., Lang, F. & Broer, S. (2001) Function and structure of heterodimeric amino acid transporters. Am. J. Physiol. Cell. Physiol., 281, 1077-1093.
28. Wako, K., Ma, N., Shiroyama, T. & Semba, R. (1995) Glial uptake of intracerebroventricularly injected D-serine in the rat brain: an immunocytochemical study. Neurosci. Lett., 185, 171-174.
29. Wolosker, H., Blackshaw, S. & Snyder, S.H. (1999) Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc. Natl Acad. Sci. USA, 96, 13409-13414.
30. Yamamoto, N., Tomita, U., Umino, A. & Nishikawa, T. (2001) Uptake of D-serine by synaptosomal P2 fraction isolated from rat brain. Synapse, 42, 84-86.
31. Yasuda, E., Ma, N. & Semba, R. (2001) Immunohistochemical evidences for localization and production of D-serine in some neurons in the rat brain. Neurosci. Lett., 299, 162-164.