Functional and pharmacological differences between recombinant N- methyl-D-aspartate receptors

Journal of Neurophysiology

Volumn 79, Issue 2, 1998, Pages 555-566

  Vicini, Stefano ^a   Wang, Jian Feng ^a   Li, Jin Hong ^a   Zhu, Wei Jian ^a   Wang, Yue Hua ^a   Luo, Jian Hong ^a   Wolfe, Barry B ^a   Grayson, Dennis R ^b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALLEGHENY SINGER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ARTICLE; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; MAMMAL; NONHUMAN; PLASMID; PRIORITY JOURNAL; RECEPTOR BINDING; RNA SPLICING; STRUCTURE ACTIVITY RELATION;

EID: 2642598047     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.79.2.555     Document Type: Article

References (40)

1. ANANTHARAM, V., PANCHAL, R. G., WILSON, A., KOLTCHIN, V. V., TREISTMAN, S. N., AND BAYLEY, H. Combinatorial RNA splicing alters the surface charge on the NMDA receptor. FEBS Lett. 305: 27-30, 1992.
2. CARMIGNOTO, G. AND VICINI, S. Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science 258: 1007-1011, 1992.
3. CHAZOT, P. L., COLEMAN, S. K., CIK, M., AND STEPHENSON, F. A. Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269: 24403-24409, 1994.
4. EBRALIDZE, A. K., ROSSI, D. J., TONEGAWA, S., AND SLATER, N. T. Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J. Neurosci. 16: 5014-5025, 1996.
5. EHLERS, M. D., ZHANG, S., BERNHADT, J. P., AND HUGANIR, R. L. Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell 84: 745-755, 1996.
6. FLINT, A. C., MAISCH, U. S., WEISHAUPT, J. H., KRIEGSTEIN, A. R., AND MONYER, H. NR2A subunit expression shortens NMDA receptor synaptic currents in developing neocortex. J. Neurosci. 17: 2469-2476, 1997.
7. HESTRIN, S. Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse. Nature 357: 686-689, 1992.
8. HOLLMANN, M., BOULTER, J., MARON, C., BEASLY, L., SULLIVAN, J., PECHT, G., AND HEINEMANN, S. Zinc potentiates agonist induced currents at certain splice variants of the NMDA receptor. Neuron 10: 943-954, 1993.
9. ILYIN, V., WITTERMORE, E. R., GUASTELLA, J., WEBER, E., AND WOODWARD, R. M. Subtypes-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. Mol. Pharmacol. 50: 1541-1550, 1996.
10. A channels response to brief agonist pulses. Neuron 15: 181-191, 1995.
11. KIRSON, E. H. AND YAARI, Y. Synaptic NMDA receptors in developing mouse hippocampal neurones: functional properties and sensitivity to ifenprodil. J. Physiol. (Lond.) 497: 437-455, 1996.
12. KOHR, G., ECKARDT, S., LUDDENS, H., MONYER, H., AND SEEBURG, P. H. NMDA receptor channels: subunit-specific potentiation by reducing agents. Neuron 12: 1031-1040, 1994.
13. KOHR, G. AND SEEBURG, P. H. Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J. Physiol. (Lond.) 492: 445-452, 1996.
14. KRUPP, J. J., VISSEL, B., HEINEMANN, S. F., AND WESTBROOK, G. L. Calcium-dependent inactivation of recombinant NMDA receptors is NR2-subunit specific. Mol. Pharmacol. 50: 1680-1688, 1996.
15. LAU, L. F. AND HUGANIR, R. L. Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 270: 20036-20041, 1995.
16. LAURIE, D. J., PUTZKE, J., ZIEGLGANSBERGER, W., SEEBURG, P. H., AND TOLLE, T. R. The distribution of splice variants of the NMDAR1 subunit mRNA in adult brain. Mol. Brain Res. 32: 94-108, 1995.
17. LAURIE, D. J. AND SEEBURG, P. H. Ligand affinities at recombinant N-methyl-D-aspartate receptors depends on subunit composition. Eur. J. Pharmacol. 268: 335-345, 1994a.
18. LAURIE, D. J. AND SEEBURG, P. H. Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J. Neurosci. 14: 3180-3194, 1994b.
19. LESTER, R.A.J., CLEMENTS, J. D., WESTBROOK, G. L., AND JAHR, C. E. Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature 346: 565-567, 1990.
20. LESTER, R.A.J. AND JAHR, C. E. NMDA channel behavior depends on agonist affinity. J. Neurosci. 12: 635-643, 1992.
21. LESTER, R.A.J., TONG, G., AND JAHR, C. E. Interactions between the glycine and glutamate binding sites of NMDA receptors. J. Neurosci. 13: 1088-1096, 1993.
22. LUO, J., WANG, Y. H., YASUDA, R. P., DUNAH, A., AND WOLFE, B. B. The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits. Mol. Pharmacol. 51: 79-86, 1997.
23. MCBAIN, C. J. AND MAYER, M. L. N-methyl-D-aspartic acid receptor structure and function. Physiol. Rev. 74: 723-760, 1994.
24. MEDINA, I., FILIPPOVA, N., CHARTON, G., ROUGEOLE, S., BEN-ARI, Y., KHRESTCHATISKY, M., AND BREGESTOVSKI, P. Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells. J. Physiol. (Lond.) 482: 567-573, 1995.
25. MONYER, H., BURNASHEV, H., LAURIE, D. J., SAKMANN, B., AND SEEBURG, P. H. Developmental and regional expression in the rat brain and functional properties of the four NMDA receptors. Neuron 12: 529-540, 1994.
26. MOON, I. S., APPERSON, M. L., AND KENNEDY, M. B. The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc. Natl. Acad. Sci. USA 91: 3954-3958, 1994.
27. PLANT, T., SCHIRRRA, C., GARASHUCK, O., ROSSIER, J., AND KONNERTH, A. Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain. J. Physiol. (Lond.) 499: 47-63, 1997.
28. PORTERA-CAILLIAU, C., PRICE, D. L., AND MARTIN, L. J. N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies. J. Neurochem. 66: 692-700, 1996.
29. PRIESTLEY, T., LAUGHTON, P., MYERS, J., LE BOURDELLES, B., KERBY, J., AND WHITING, P. J. Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Mol. Pharmacol. 48: 841-848, 1995.
30. SHEETZ, A. J. AND CONSTANTINE-PATON, M. Modulation of NMDA receptor function: implication for vertebrate neural development. FASEB J. 8: 745-752, 1994.
31. SHENG, M., CUMMINGS, L., ROLDAN, L. A., JAN, Y. N., AND JAN, L. Y. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368: 144-147, 1994.
32. SPRUSTON, N., JONAS, P., AND SAKMANN, B. Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. J. Physiol. (Lond.) 482: 325-352, 1995.
33. STERN, P., BEHE, P., SCHOEPFER, R., AND COLQUOUN, D. Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors. Proc. R. Soc. Lond. B Biol. Sci. 250: 271-277, 1992.
34. SUGIHARA, H., MORIYOSHI, K., ISHRI, T., MASU, M., AND NAKANISHI, S. Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem. Biophys. Res. Commun. 185: 826-832, 1992.
35. TAKAHASHI, T., FELDMEYER, D., SUZUKI, N., ONODERA, K., CULL-CANDY, S. G., SAKIMURA, K., AND MISHINA, M. Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum J. Neurosci. 16: 4376-4382, 1996.
36. VALLANO, M. L., LAMBOLEZ, B., AUDINAT, E., AND ROSSIER, J. Neuronal activity differentially regulates NMDA receptor subunit expression in cerebellar granule cells. J. Neurosci. 16: 631-639, 1996.
37. WANG, Y. H., BOSY, T. Z., YASUDA, R. P., GRAYSON, D.R., VICINI, S., PIZZORUSSO, T., AND WOLFE, B. B. Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum. J. Neurochem. 65: 176-183, 1995.
38. WATANABE, M., INOUE, Y., SAKIMURA, K., AND MISHINA M. Developmental changes in distribution of NMDA receptor channel subunit mRNAs. NeuroReport 3: 1138-1140, 1992.
39. WILLIAMS, K. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44: 851-859, 1993.
40. ZUKIN, R. S. AND BENNETT, M.L.V. Alternatively spliced isoforms of the NMDAR1 receptor subunit. Trends Neurosci. 18: 306-313, 1995.