Molecular Abnormalities of the Glutamate Synapse in the Thalamus in Schizophrenia

Annals of the New York Academy of Sciences

Volumn 1003, Issue , 2003, Pages 75-93

  Meador Woodruff, James H ^a   Clinton, Sarah M ^a   Beneyto, Monica ^a   McCullumsmith, Robert E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Excitatory amino acid transporters; Glutamate synapse; Phencyclidine; Schizophrenia; Thalamic anatomy

Indexed keywords

AMINO ACID TRANSPORTER; AMPA RECEPTOR; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; IONOTROPIC RECEPTOR; KAINIC ACID RECEPTOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 6; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR 8; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER RECEPTOR; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN SUBUNIT; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT;

AUTOPSY; AUTORADIOGRAPHY; BRAIN MAPPING; BRAIN SIZE; CELL ADHESION; CONFERENCE PAPER; CORRELATION ANALYSIS; CYTOPATHOLOGY; FUNCTIONAL ANATOMY; HUMAN; IN SITU HYBRIDIZATION; IN VIVO STUDY; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN VARIANT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYNAPSE; SYNAPTIC EFFICACY; SYNAPTIC TRANSMISSION; THALAMUS;

EID: 0346461649     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1300.005     Document Type: Conference Paper

References (104)

1. KRYSTAL, J.H. et al. 1994. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Psychiatry 51: 199-214.
2. JAVITT, D.C. & S.R. ZUKIN. 1991. Recent advances in the phencyclidine model of schizophrenia. Am. J. Psychiatry 148: 1301-1308.
3. LAHTI, A.C. et al. 1995. Ketamine activates psychosis and alters limbic blood flow in schizophrenia. Neuroreport 6: 869-872.
4. LUBY, E. et al. 1962. Model psychoses and schizophrenia. Am. J. Psychiatry 119: 61-67.
5. ITIL, T. et al. 1967. Effect of phencyclidine in chronic schizophrenics. Can. Psychiatr. Assoc. J. 12: 209-212.
6. AANONSEN, L.M. & G.L. WILCOX. 1986. Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice. Neurosci. Lett. 67: 191-197.
7. JENTSCH, J.D. & R.H. ROTH. 1999. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20: 201-225.
8. HERESCO-LEVY, U. et al. 2002. Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia. Am. J. Psychiatry 159: 480-482.
9. HERESCO-LEVY, U. et al. 1998. Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia. Int. J. Neuropsychopharmcol. 1: 131-135.
10. HERESCO-LEVY, U. et al. 1999. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch. Gen. Psychiatry 56: 29-36.
11. EVINS, A.E. et al. 2002. D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia. Schizophr. Res. 56: 19-23.
12. GREENE, R. et al. 2000. Short-term and long-term effects of N-methyl-D-aspartate receptor hypofunction. Arch. Gen. Psychiatry 57: 1180-1181.
13. FARBER, N.B., J.W. NEWCOMER & J.W. OLNEY. 1999. Glycine agonists: what can they teach us about schizophrenia? Arch. Gen. Psychiatry 56: 13-17.
14. DANBOLT, N.C. 2001. Glutamate uptake. Prog. Neurobiol. 65: 1-105.
15. MASSON, J. et al. 1999. Neurotransmitter transporters in the central nervous system. Pharmacol. Rev. 51: 439-464.
16. KANAI, Y., C.P. SMITH & M.A. HEDIGER. 1993. A new family of neurotransmitter transporters: the high-affinity glutamate transporters. FASEB J. 7: 1450-1459.
17. TAKAMORI, S. et al. 2000. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Nature 407: 189-194.
18. FREMEAU, R.T., JR. et al. 2001. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 31: 247-260.
19. BELLOCCHIO, E.E. et al. 2000. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science 289: 957-960.
20. AIHARA, Y. et al. 2000. Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. J. Neurochem. 74: 2622-2625.
21. BELLOCCHIO, E.E. et al. 1998. The localization of the brain-specific inorganic phosphate transporter suggests a specific presynaptic role in glutamatergic transmission. J. Neurosci. 18: 8648-8659.
22. ZHOU, M. & H.K. KIMELBERG. 2001. Freshly isolated hippocampal CA1 astrocytes comprise two populations differing in glutamate transporter and AMPA receptor expression. J. Neurosci. 21: 7901-7908.
23. BLEAKMAN, D. & D. LODGE. 1998. Neuropharmacology of AMPA and kainate receptors. Neuropharmacology 37: 1187-1204.
24. HOLLMANN, M. & S. HEINEMANN. 1994. Cloned glutamate receptors. Annu. Rev. Neurosci. 17: 31-108.
25. NAKANISHI, S. 1992. Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603.
26. NAGAO, S., S. KWAK & I. KANAZAWA. 1997. EAAT4, a glutamate transporter with properties of a chloride channel, is predominantly localized in Purkinje cell dendrites, and forms parasagittal compartments in rat cerebellum. Neuroscience 78: 929-933.
27. BAR-PELED, O. et al. 1997. Distribution of glutamate transporter subtypes during human brain development. J. Neurochem. 69: 2571-2580.
28. MILTON, I.D. et al. 1997. Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study. Brain Res. Mol. Brain Res. 52: 17-31.
29. LEHRE, K.P. et al. 1995. Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J. Neurosci. 15: 1835-1853.
30. ROTHSTEIN, J.D. et al. 1994. Localization of neuronal and glial glutamate transporters. Neuron 13: 713-725.
31. FURUTA, A., J.D. ROTHSTEIN & L.J. MARTIN. 1997. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. J. Neurosci. 17: 8363-8375.
32. FURUTA, A. et al. 1997. Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4. Neuroscience 81: 1031-1042.
33. YAMADA, K. et al. 1996. EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. Neuroreport 7: 2013-2017.
34. YAMADA, K. et al. 1997. Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells. Neurosci. Res. 27: 191-198.
35. LAAKE, J.H. et al. 1999. Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum. Neuroscience 88: 1137-1151.
36. MARAGAKIS, N.J. & J.D. ROTHSTEIN. 2001. Glutamate transporters in neurologic disease. Arch. Neurol. 58: 365-370.
37. MARIE, H. et al. 2002. The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol. Cell. Neurosci. 19: 152-164.
38. LIN, C.I. et al. 2001. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature 410: 84-88.
39. JACKSON, M. et al. 2001. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature 410: 89-93.
40. MEADOR-WOODRUFF, J.M., A.J. HOGG, et al. 2001. Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder. Brain Res. Bull. 55(5): 631-640.
41. ANDREASEN, N.C., S. PARADISO, et al. 1998. "Cognitive dysmetria" as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry? Schizophr. Bull. 24(2): 203-218.
42. JONES, E.G. 1997. Cortical development and thalamic pathology in schizophrenia. Schizophr. Bull. 23(3): 483-501.
43. OKE, A.F. & R.N. ADAMS. 1987. Elevated thalamic dopamine: possible link to sensory dysfunctions in schizophrenia. Schizophr. Bull. 13(4): 589-604.
44. SCHEIBEL, A.B. 1997. The thalamus and neuropsychiatric illness. J. Neuropsychiatry Clin. Neurosci. 9(3): 342-353.
45. STERIADE, M., E.G. JONES, et al. 1997. Thalamus: Organization and Function. Elsevier. Amsterdam.
46. JONES, E.G. 1998. The thalamus of primates. In The Primate Nervous System, Part II. F.E. Bloom, A. Bjorklund & T. Hokfelt, Eds.: 14: 1-246. Elsevier. New York.
47. SALT, T.E. & S.A. EATON. 1996. Functions of ionotropic and metabotropic glutamate receptors in sensory transmission in the mammalian thalamus. Prog. Neurobiol. 48(1): 55-72.
48. PAKKENBERG, B. 1990. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch. Gen. Psychiatry 47(11): 1023-1028.
49. PAKKENBERG, B. 1992. The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics. Schizophr. Res. 7(2): 95-100.
50. PAKKENBERG, B. 1993. Leucotomized schizophrenics lose neurons in the mediodorsal thalamic nucleus. Neuropathol. Appl. Neurobiol. 19(5): 373-380.
51. POPKEN, G.J., W.E. BUNNEY, JR., et al. 2000. Subnucleus-specific loss of neurons in medial thalamus of schizophrenics. Proc. Natl. Acad. Sci. USA 97(16): 9276-9780.
52. YOUNG, K., K. MANAYE, et al. 2000. Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia. Biol. Psychiatry 47(11): 944-953.
53. BYNE, W., M.S. BUCHSBAUM, et al. 2002. Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia. Am. J. Psychiatry 159(1): 59-65.
54. LEWIS, D.A., D.A. CRUZ, et al. 2001. Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamus. Am. J. Psychiatry 158(9): 1411-1422.
55. DANOS, P., B. BAUMANN, et al. 2002. The ventral lateral posterior nucleus of the thalamus in schizophrenia: a post-mortem study. Psychiatry Res. 114(1): 1-9.
56. ANDREASEN, N.C., J.C. EHRHARDT, et al. 1990. Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. Arch. Gen. Psychiatry 47(1): 35-44.
57. ANDREASEN, N.C., S. ARNDT, et al. 1994. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 266(5183): 294-298.
58. BUCHSBAUM, M.S. & E.A. HAZLETT. 1998. Positron emission tomography studies of abnormal glucose metabolism in schizophrenia. Schizophr. Bull. 24(3): 343-364.
59. DASARI, M., L. FRIEDMAN, et al. 1999. A magnetic resonance imaging study of thalamic area in adolescent patients with either schizophrenia or bipolar disorder as compared to healthy controls. Psychiatry Res. 91(3): 155-162.
60. FLAUM, M., V.W. SWAYZE, 2ND, et al. 1995. Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. Am. J. Psychiatry 152(5): 704-714.
61. GILBERT, A.R., D.R. ROSENBERG, et al. 2001. Thalamic volumes in patients with first-episode schizophrenia. Am. J. Psychiatry 158(4): 618-624.
62. GUR, R.E., V. MAANY, et al. 1998. Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Am. J. Psychiatry 155(12): 1711-1717.
63. STAAL, W.G., H.E. HULSHOFF POL, et al. 1998. Partial volume decrease of the thalamus in relatives of patients with schizophrenia. Am. J. Psychiatry 155(12): 1784-1786.
64. ETTINGER, U., X.A. CHITNIS, et al. 2001. Magnetic resonance imaging of the thalamus in first-episode psychosis. Am. J. Psychiatry 158(1): 116-118.
65. KONICK, L.C. & L. FRIEDMAN. 2001. Meta-analysis of thalamic size in schizophrenia. Biol. Psychiatry 49(1): 28-38.
66. BYNE, W., M.S. BUCHSBAUM, et al. 2001. Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder. Arch. Gen. Psychiatry 58(2): 133-140.
67. BUCHSBAUM, M.S., T. SOMEYA, et al. 1996. PET and MRI of the thalamus in never-medicated patients with schizophrenia. Am. J. Psychiatry 153(2): 191-199.
68. HAZLETT, E.A., M.S. BUCHSBAUM, et al. 1999. Three-dimensional analysis with MRI and PET of the size, shape, and function of the thalamus in the schizophrenia spectrum. Am. J. Psychiatry 156(8): 1190-1199.
69. RESNICK, S.M., R.E. GUR, et al. 1988. Positron emission tomography and subcortical glucose metabolism in schizophrenia. Psychiatry Res. 24(1): 1-11.
70. TAMMINGA, C.A., G.K. THAKER, et al. 1992. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch. Gen. Psychiatry 49(7): 522-530.
71. VITA, A., S. BRESSI, et al. 1995. High-resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenic patients. Am. J. Psychiatry 152(6): 876-882.
72. ANDREASEN, N.C., D.S. O'LEARY, et al. 1996. Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc. Natl. Acad. Sci. USA 93(18): 9985-9990.
73. HECKERS, S., S.L. RAUCH, et al. 1998. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat. Neurosci. 1(4): 318-323.
74. SILBERSWEIG, D.A., E. STERN, et al. 1995. A functional neuroanatomy of hallucinations in schizophrenia. Nature 378(6553): 176-179.
75. BURNASHEV, N., H. MONYER, et al. 1992. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron 8: 189-198.
76. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron 15: 193-204.
77. 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252: 851-853.
78. 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron 12: 1281-1289.
79. SWANSON, G.T., S.K. KAMBOJ, et al. 1997. Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. J. Neurosci. 17: 58-69.
80. ANDERSSON, O., A. STENQVIST, et al. 2001. Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. Genomics 78(3): 178-184.
81. DURAND, G.M., M.V.L. BENNETT, et al. 1993. Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation of polyamines and protein kinase C. Proc. Natl. Acad. Sci. USA 90: 6731-6735.
82. BOECKMAN, F.A. & E. AIZENMAN. 1994. Stable transfection of the NMDAR1 subunit in Chinese hamster ovary cells fails to produce a functional N-methyl-D-aspartate receptor. Neurosci. Lett. 173: 189-192.
83. GALLAGHER, M.J., H. HUANG, et al. 1996. Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 271: 9603-9611.
84. GRIMWOOD, S., B. LEBOURDELLES, et al. 1995. Recombinant human NMDA homomeric NMDAR1 receptors expressed in mammalian cells form a high-affinity glycine antagonist binding site. J. Neurochem. 64: 525-530.
85. LYNCH, D.R., N.J. ANEGAWA, et al. 1994. N-methyl-D-Aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents. Mol. Pharmacol. 45: 540-545.
86. MONYER, H.R. R. SPRENGEL, et al. 1992. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256: 1217-1220.
87. RODRIGUEZ-PAZ, J.M., Y. ANANTHARAM, et al. 1995. Block of the N-methyl-D-aspartate receptor by phencyclidine-like drugs is influenced by alternative splicing. Neurosci. Lett. 190: 147-150.
88. IBRAHIM, H., A. HOGG, et al. 2000. Ionotropic glutamate receptor binding and subunit mRNA expression in thalamic nuclei in schizophrenia. Am. J. Psychiatry 157: 1811-1823.
89. CLINTON, S.M., V. HAROUTUNIAN, et al. 2003. Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia. Am. J. Psychiatry 160(6): 1100-1109.
90. POPKEN, G.J., M.G. LEGGIO, et al. 2002. Expression of mRNAs related to the GABAergic and glutamatergic neurotransmitter systems in the human thalamus: normal and schizophrenic. Thalamus & Related Systems 1: 349-369.
91. RICHARDSON-BURNS, S.M., V. HAROUTUNIAN, et al. 2000. Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus. Biol. Psychiatry 47: 22-28.
92. SHENG, M. & D. PAK. 2000. Ligand-gated ion channel interactions with cytoskeletal and signaling proteins. Annu. Rev. Physiol. 62: 755-778.
93. EHLERS, M., E. FUNG, et al. 1998. Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments. J. Neurosci. 18(2): 720-730.
94. LIN, J., M. WYSZYNSKI, et al. 1998. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J. Neurosci. 18(6): 2017-2027.
95. XU, Z., D.L. DONG, et al. 1994. Neuronal intermediate filaments: new progress on an old subject. Curr. Opin. Neurobiol. 4(5): 655-661.
96. EHLERS, M.D., W.G. TINGLEY, et al. 1995. Regulated subcellular distribution of the NR1 subunit of the NMDA receptor. Science 269(5231): 1734-1737.
97. SHENOLIKAR, S. 1994. Protein serine/threonine phosphatases - new avenues for cell regulation. Annu. Rev. Cell Biol. 10: 55-86.
98. TERRY-LORENZO, R., M. INOUE, et al. 2000. Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. J. Biol. Chem. 275(4): 2139-2446.
99. DRACHEVA, S., S.A. MARRAS, et al. 2001. N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am. J. Psychiatry 158(9): 1400-1410.
100. OHNUMA, T., H. KATO, et al. 2000. Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia. NeuroReport 11(14): 3133-3137.
101. SMITH, R.E., V. HAROUTUNIAN, et al. 2001. Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia. Am. J. Psychiatry 158(9): 1393-1399.
102. SMITH, R.E., V. HAROUTUNIAN, et al. 2001. Vesicular glutamate transporter transcript expression in the thalamus in schizophrenia. Neuroreport 12(13): 1-3.
103. MCCULLUMSMITH, R.E., V. HAROUTUNIAN, et al. 2002. Expression of glutaminase transcripts in the thalamus of subjects with schizophrenia. Biol. Psychiatry 51: 25.
104. GLUCK, M.R. et al. 2002. Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients. Am. J. Psychiatry 159: 1165-1173.