N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 23, 2003, Pages 13674-13679

  Sur, Cyrille ^a   Mallorga, Pierre J ^a   Wittmann, Marion ^a   Jacobson, Marlene A ^a   Pascarella, Danette ^a   Williams, Jacinta B ^a   Brandish, Philip E ^a   Pettibone, Douglas J ^a   Scolnick, Edward M ^a   Conn, P Jeffrey ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CLOZAPINE; G PROTEIN COUPLED RECEPTOR; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NORCLOZAPINE; PARTIAL AGONIST;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CHOLINERGIC ACTIVITY; CHOLINERGIC TRANSMISSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HUMAN; HUMAN CELL; IC 50; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SITE DIRECTED MUTAGENESIS;

ALLOSTERIC SITE; ANIMALS; BRAIN; CELL LINE; CLOZAPINE; CRICETINAE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HIPPOCAMPUS; HUMANS; INHIBITORY CONCENTRATION 50; MUTAGENESIS, SITE-DIRECTED; NEURONS; PROTEIN BINDING; RATS; RECEPTOR, MUSCARINIC M1; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

ANIMALIA;

EID: 10744223983     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1835612100     Document Type: Article

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