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Volumn 31, Issue 2-3, 2000, Pages 302-312

Serotonin model of schizophrenia: emerging role of glutamate mechanisms

Author keywords

5 HT(2A) receptor; Hallucinogen; Ketamine; Locus coeruleus; LSD; Metabotropic receptor; NMDA receptor; Phencylidine; Prefrontal cortex

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR ANTAGONIST; DECAHYDRO 6 [2 (1H TETRAZOL 5 YL)ETHYL] 3 ISOQUINOLINECARBOXYLIC ACID; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; INDOLEAMINE; KAINIC ACID RECEPTOR ANTAGONIST; KETAMINE; LYSERGIDE; MESCALINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; PHENETHYLAMINE; PSYCHEDELIC AGENT; SEROTONIN; SEROTONIN 2A RECEPTOR;

EID: 0034055690     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(99)00046-6     Document Type: Conference Paper
Times cited : (411)

References (90)
  • 1
    • 0031875396 scopus 로고    scopus 로고
    • The NMDA antagonist model for schizophrenia: Promise and pitfalls
    • Abi-Saab W.M., D'Souza D.C., Moghaddam B., Krystal J.H. The NMDA antagonist model for schizophrenia: promise and pitfalls. Pharmacopsychiatry. 31(Suppl.):1998;104-109.
    • (1998) Pharmacopsychiatry , vol.31 , Issue.SUPPL. , pp. 104-109
    • Abi-Saab, W.M.1    D'Souza, D.C.2    Moghaddam, B.3    Krystal, J.H.4
  • 2
    • 0018855090 scopus 로고
    • Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli
    • Aghajanian G.K. Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli. Brain Res. 186:1980;492-498.
    • (1980) Brain Res. , vol.186 , pp. 492-498
    • Aghajanian, G.K.1
  • 3
    • 0002777541 scopus 로고
    • Electrophysiology of serotonin receptor subtypes and signal transduction mechanisms
    • in: F.E. Bloom and D.J. Kupfer (Eds.), Raven Press, New York
    • G.K. Aghajanian, Electrophysiology of serotonin receptor subtypes and signal transduction mechanisms, in: F.E. Bloom and D.J. Kupfer (Eds.), Psychopharmacology: the Fourth Generation of Progress, Raven Press, New York, 1995, pp. 451-460.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 451-460
    • Aghajanian, G.K.1
  • 4
    • 0014420460 scopus 로고
    • Lysergic acid diethylamide: Sensitive neuronal units in the midbrain raphe
    • Aghajanian G.K., Foote W.E., Sheard M.H. Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe. Science. 161:1968;706-708.
    • (1968) Science , vol.161 , pp. 706-708
    • Aghajanian, G.K.1    Foote, W.E.2    Sheard, M.H.3
  • 5
    • 0016633012 scopus 로고
    • Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors
    • Aghajanian G.K., Haigler H.J. Hallucinogenic indoleamines: preferential action upon presynaptic serotonin receptors. Psychopharmacology. 1:1975;619-629.
    • (1975) Psychopharmacology , vol.1 , pp. 619-629
    • Aghajanian, G.K.1    Haigler, H.J.2
  • 6
    • 0015362013 scopus 로고
    • Lysergic acid diethylamide and serotonin: Direct actions on serotonin-containing neurons in rat brain
    • Aghajanian G.K., Haigler H.J., Bloom F.E. Lysergic acid diethylamide and serotonin: direct actions on serotonin-containing neurons in rat brain. Life Sci. 11:1972;615-622.
    • (1972) Life Sci. , vol.11 , pp. 615-622
    • Aghajanian, G.K.1    Haigler, H.J.2    Bloom, F.E.3
  • 7
    • 0031006582 scopus 로고    scopus 로고
    • Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells
    • Aghajanian G.K., Marek G.J. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36:1997;589-599.
    • (1997) Neuropharmacology , vol.36 , pp. 589-599
    • Aghajanian, G.K.1    Marek, G.J.2
  • 8
    • 0033577494 scopus 로고    scopus 로고
    • 2A receptors increase EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release
    • in press
    • 2A receptors increase EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release, Brain Res. (1999) in press.
    • (1999) Brain Res.
    • Aghajanian, G.K.1    Marek, G.J.2
  • 10
    • 0022922681 scopus 로고
    • Typical and atypical antipsychotic occupancy of D2 and S2 receptors: An autoradiographic analysis in rat brain
    • Altar C.A., Wasley A.M., Neale R.F., Stone G.A. Typical and atypical antipsychotic occupancy of D2 and S2 receptors: an autoradiographic analysis in rat brain. Brain Res. Bull. 16:1986;517-525.
    • (1986) Brain Res. Bull. , vol.16 , pp. 517-525
    • Altar, C.A.1    Wasley, A.M.2    Neale, R.F.3    Stone, G.A.4
  • 11
    • 0030941817 scopus 로고    scopus 로고
    • Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients
    • Andreasen N.C., O'Leary D.S., Flaun M., Nopoulos P., Watkins G.L., Boles Ponto L.L. Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients. Lancet. 349:1997;1730-1734.
    • (1997) Lancet , vol.349 , pp. 1730-1734
    • Andreasen, N.C.1    O'Leary, D.S.2    Flaun, M.3    Nopoulos, P.4    Watkins, G.L.5    Boles Ponto, L.L.6
  • 12
    • 0025924342 scopus 로고
    • 1A receptors mediate opposing responses on membrane excitability in rat association cortex
    • 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience. 40:1991;399-412.
    • (1991) Neuroscience , vol.40 , pp. 399-412
    • Araneda, R.1    Andrade, R.2
  • 13
    • 0025921604 scopus 로고
    • Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients
    • R.C. Arora, H.Y. Meltzer, Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients, J. Neural. Transm. Gen. Sect. 85 (1991).
    • (1991) J. Neural. Transm. Gen. Sect. , vol.85
    • Arora, R.C.1    Meltzer, H.Y.2
  • 15
    • 0019732445 scopus 로고
    • Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
    • Aston-Jones G., Bloom F.E. Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J. Neurosci. 1:1981;887-900.
    • (1981) J. Neurosci. , vol.1 , pp. 887-900
    • Aston-Jones, G.1    Bloom, F.E.2
  • 16
    • 0005194025 scopus 로고
    • Enzymatic formation of psychotomimetic metabolites from naturally occurring compounds
    • Axelrod J. Enzymatic formation of psychotomimetic metabolites from naturally occurring compounds. J. Pharmacol. Exp. Ther. 138:1962;28-33.
    • (1962) J. Pharmacol. Exp. Ther. , vol.138 , pp. 28-33
    • Axelrod, J.1
  • 17
    • 0008631917 scopus 로고
    • Acquired and crossed tolerance to mescaline, LSD-25, and BOL-148
    • Balestrieri A., Fontanari D. Acquired and crossed tolerance to mescaline, LSD-25, and BOL-148. Arch. Gen. Psychiatry. 1:1959;279-282.
    • (1959) Arch. Gen. Psychiatry , vol.1 , pp. 279-282
    • Balestrieri, A.1    Fontanari, D.2
  • 20
    • 0030174848 scopus 로고    scopus 로고
    • Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans
    • Bonson K.R., Buckholtz J.W., Murphy D.L. Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans. Neuropsychopharmacology. 14:1996;125-436.
    • (1996) Neuropsychopharmacology , vol.14 , pp. 125-436
    • Bonson, K.R.1    Buckholtz, J.W.2    Murphy, D.L.3
  • 21
    • 0030966452 scopus 로고    scopus 로고
    • Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers
    • Breier A., Malhotra A.K., Pinals D.A., Weisenfeld N.I., Pickar D. Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers. Am. J. Psychiatry. 154:1997;805-811.
    • (1997) Am. J. Psychiatry , vol.154 , pp. 805-811
    • Breier, A.1    Malhotra, A.K.2    Pinals, D.A.3    Weisenfeld, N.I.4    Pickar, D.5
  • 22
    • 0030273870 scopus 로고    scopus 로고
    • 2A receptor mRNAs and binding site densities are differentially altered in schizophrenia
    • 2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology. 15:1996;442-445.
    • (1996) Neuropsychopharmacology , vol.15 , pp. 442-445
    • Burnet, P.W.J.1    Harrison, P.J.2
  • 23
    • 0024247522 scopus 로고
    • The current status of the dopamine hypothesis of schizophrenia
    • Carlsson A. The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology. 1:1988;179-186.
    • (1988) Neuropsychopharmacology , vol.1 , pp. 179-186
    • Carlsson, A.1
  • 24
    • 0030943091 scopus 로고    scopus 로고
    • Neurotransmitter aberrations in schizophrenia: New perspectives and therapeutic implications
    • Carlsson A., Hansson L.O., Waters N., Carlsson M.L. Neurotransmitter aberrations in schizophrenia: new perspectives and therapeutic implications. Life Sci. 61:1997;75-94.
    • (1997) Life Sci. , vol.61 , pp. 75-94
    • Carlsson, A.1    Hansson, L.O.2    Waters, N.3    Carlsson, M.L.4
  • 25
    • 0028980787 scopus 로고
    • 2A receptor antagonist MDL 100, 907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse - implications for psychosis
    • 2A receptor antagonist MDL 100, 907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse - implications for psychosis. J. Neural Transm. 100:1995;225-237.
    • (1995) J. Neural Transm. , vol.100 , pp. 225-237
    • Carlsson, M.L.1
  • 26
    • 0018080923 scopus 로고
    • Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism
    • Cedarbaum J.M., Aghajanian G.K. Activation of locus coeruleus neurons by peripheral stimuli: modulation by a collateral inhibitory mechanism. Life Sci. 23:1978;1383-1392.
    • (1978) Life Sci. , vol.23 , pp. 1383-1392
    • Cedarbaum, J.M.1    Aghajanian, G.K.2
  • 28
    • 0027335524 scopus 로고
    • 2 agonist augments γ-aminobutyric acid and excitatory amino acid inputs to noradrenergic locus coeruleus neurons
    • 2 agonist augments γ-aminobutyric acid and excitatory amino acid inputs to noradrenergic locus coeruleus neurons. Neuroscience. 54:1993;409-420.
    • (1993) Neuroscience , vol.54 , pp. 409-420
    • Chiang, C.1    Aston-Jones, G.2
  • 30
    • 0001989283 scopus 로고
    • Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons
    • Dahlstrom A., Fuxe K. Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol. Scand. 62(Suppl. 232):1964;1-55.
    • (1964) Acta Physiol. Scand. , vol.62 , Issue.SUPPL. 232 , pp. 1-55
    • Dahlstrom, A.1    Fuxe, K.2
  • 31
    • 0032561707 scopus 로고    scopus 로고
    • Differential effects of clozapine and haloperidol on ketamine-induced metabolic activation
    • Duncan G.E., Leipzig J.N., Mailman R.B., Lieberman J.A. Differential effects of clozapine and haloperidol on ketamine-induced metabolic activation. Brain Res. 812:1998;65-75.
    • (1998) Brain Res. , vol.812 , pp. 65-75
    • Duncan, G.E.1    Leipzig, J.N.2    Mailman, R.B.3    Lieberman, J.A.4
  • 33
    • 0343399209 scopus 로고
    • Effects of LSD-25 on brain serotonin
    • Freedman D.X. Effects of LSD-25 on brain serotonin. J. Pharmacol. Exp. Ther. 134:1961;160-166.
    • (1961) J. Pharmacol. Exp. Ther. , vol.134 , pp. 160-166
    • Freedman, D.X.1
  • 34
    • 84959069373 scopus 로고
    • Drugs which antagonize 5-hydroxytryptamine
    • Gaddum J.H., Hammeed K.A. Drugs which antagonize 5-hydroxytryptamine. Br. J. Pharmacol. 9:1954;240-248.
    • (1954) Br. J. Pharmacol. , vol.9 , pp. 240-248
    • Gaddum, J.H.1    Hammeed, K.A.2
  • 35
    • 0025602917 scopus 로고
    • Do classical hallucinogens act as 5-HT2 agonists or antagonists?
    • Glennon R.A. Do classical hallucinogens act as 5-HT2 agonists or antagonists? Neuropsychopharmacology. 3:1990;509-517.
    • (1990) Neuropsychopharmacology , vol.3 , pp. 509-517
    • Glennon, R.A.1
  • 36
    • 0021646446 scopus 로고
    • 2 involvement in the mechanism of action of hallucinogenic agents
    • 2 involvement in the mechanism of action of hallucinogenic agents. Life Sci. 35:1984;2502-2511.
    • (1984) Life Sci. , vol.35 , pp. 2502-2511
    • Glennon, R.A.1    Titeler, M.2    McKenney, J.D.3
  • 37
    • 0028587383 scopus 로고
    • Two components of transmitter release at a central synapse
    • Goda Y., Stevens C.F. Two components of transmitter release at a central synapse. Proc. Natl. Acad. Sci. USA. 91:1994;12942-12946.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12942-12946
    • Goda, Y.1    Stevens, C.F.2
  • 38
    • 0031856738 scopus 로고    scopus 로고
    • History, rationale and potential of human experimental hallucinogenic drug research in psychiatry
    • Gouzoulis-Mayfrank E., Hermle L., Thelen B., Sass H. History, rationale and potential of human experimental hallucinogenic drug research in psychiatry. Pharmacopsychiatry. 31(Suppl.):1998;63-68.
    • (1998) Pharmacopsychiatry , vol.31 , Issue.SUPPL. , pp. 63-68
    • Gouzoulis-Mayfrank, E.1    Hermle, L.2    Thelen, B.3    Sass, H.4
  • 39
    • 0030825125 scopus 로고    scopus 로고
    • Alterations in the cortical serotonergic system in schizophrenia: A postmortem study
    • Gurevich E.V., Joyce J.N. Alterations in the cortical serotonergic system in schizophrenia: a postmortem study. Biol. Psychiatry. 42:1997;529-545.
    • (1997) Biol. Psychiatry , vol.42 , pp. 529-545
    • Gurevich, E.V.1    Joyce, J.N.2
  • 40
    • 0015537765 scopus 로고
    • Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain
    • Haigler H.J., Aghajanian G.K. Mescaline and LSD: direct and indirect effects on serotonin-containing neurons in brain. Eur. J. Pharmacol. 21:1973;53-60.
    • (1973) Eur. J. Pharmacol. , vol.21 , pp. 53-60
    • Haigler, H.J.1    Aghajanian, G.K.2
  • 41
    • 0032032619 scopus 로고    scopus 로고
    • Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken
    • Hamada S., Senzaki K., Hamaguchi-Hamada K., Tabuchi K., Yamamoto H., Yamamoto T., Yoshikawa S., Okano H., Okado N. Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. Mol. Brain Res. 54:1998;199-211.
    • (1998) Mol. Brain Res. , vol.54 , pp. 199-211
    • Hamada, S.1    Senzaki, K.2    Hamaguchi-Hamada, K.3    Tabuchi, K.4    Yamamoto, H.5    Yamamoto, T.6    Yoshikawa, S.7    Okano, H.8    Okado, N.9
  • 43
    • 0031933951 scopus 로고    scopus 로고
    • Anxiolytic and side-effect profile of LY354740: A potent, highly selective, orally active agonist for group II metabotropic glutamate receptors
    • Helton D.R., Tizzano J.P., Monn J.A., Schoepp D.D., Kallman J. Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J. Pharmacol. Exp. Ther. 284:1998;651-660.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 651-660
    • Helton, D.R.1    Tizzano, J.P.2    Monn, J.A.3    Schoepp, D.D.4    Kallman, J.5
  • 44
    • 0027102864 scopus 로고
    • Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: Experimental psychosis as a tool for psychiatric research
    • Hermle L., Funfgeld M., Oepen G., Botsch H., Borchardt D., Gouzoulis E., Fehrenbach R.A., Spitzer M. Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Biol. Psychiatry. 32:1992;976-991.
    • (1992) Biol. Psychiatry , vol.32 , pp. 976-991
    • Hermle, L.1    Funfgeld, M.2    Oepen, G.3    Botsch, H.4    Borchardt, D.5    Gouzoulis, E.6    Fehrenbach, R.A.7    Spitzer, M.8
  • 46
    • 0031594813 scopus 로고    scopus 로고
    • 2A serotonin receptors in the primate cerbral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
    • 2A serotonin receptors in the primate cerbral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc. Natl. Acad. Sci. USA. 95:1998;735-740.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 735-740
    • Jakab, R.L.1    Goldman-Rakic, P.S.2
  • 47
    • 0025678665 scopus 로고
    • Catecholaminergic, GABAergic, and hippocamposeptal innervation of GABAergic 'somatospiny' neurons in the rat lateral septal area.
    • Jakab R.L., Leranth C. Catecholaminergic, GABAergic, and hippocamposeptal innervation of GABAergic 'somatospiny' neurons in the rat lateral septal area. J. Comp. Neurol. 302:1990;305-321.
    • (1990) J. Comp. Neurol. , vol.302 , pp. 305-321
    • Jakab, R.L.1    Leranth, C.2
  • 48
    • 0032402417 scopus 로고    scopus 로고
    • The molecular biology of serotonin receptors: Therapeutic implications for the interface of mood and psychosis
    • Kroeze W.K., Roth G.L. The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis. Biol. Psychiatry. 44:1998;1128-1142.
    • (1998) Biol. Psychiatry , vol.44 , pp. 1128-1142
    • Kroeze, W.K.1    Roth, G.L.2
  • 49
    • 0028943849 scopus 로고
    • Ketamine activates psychosis and alters limbic blood flow in schizophrenia
    • Lahti A.C., Holcomb H.H., Medoff D.R., Tamminga C.A. Ketamine activates psychosis and alters limbic blood flow in schizophrenia. Neuroreport. 6:1995;869-872.
    • (1995) Neuroreport , vol.6 , pp. 869-872
    • Lahti, A.C.1    Holcomb, H.H.2    Medoff, D.R.3    Tamminga, C.A.4
  • 52
    • 0030750142 scopus 로고    scopus 로고
    • Differential effects of single and repeated ketamine administration on dopamine, serotonin and GABA transmission in rat medial prefrontal cortex
    • Lindefors N., Barati S., O'Connor W.T. Differential effects of single and repeated ketamine administration on dopamine, serotonin and GABA transmission in rat medial prefrontal cortex. Brain Res. 759:1997;205-212.
    • (1997) Brain Res. , vol.759 , pp. 205-212
    • Lindefors, N.1    Barati, S.2    O'Connor, W.T.3
  • 55
    • 0032100675 scopus 로고    scopus 로고
    • 5-HT-induced EPSCs in neocortical layer V pyramidal cell of prefrontal cortex: Suppression by μ opiate receptor activation
    • Marek G.J., Aghajanian G.K. 5-HT-induced EPSCs in neocortical layer V pyramidal cell of prefrontal cortex: Suppression by μ opiate receptor activation. Neuroscience. 86:1998;485-497.
    • (1998) Neuroscience , vol.86 , pp. 485-497
    • Marek, G.J.1    Aghajanian, G.K.2
  • 56
    • 0008052472 scopus 로고    scopus 로고
    • 2A receptor-induced EPSCs in layer V pyramidal cells of prefrontal cortex: Block by group II/III metabotropic glutamate agonists
    • 2A receptor-induced EPSCs in layer V pyramidal cells of prefrontal cortex: block by group II/III metabotropic glutamate agonists. Soc. Neurosci. Abs. 24:1998;1366.
    • (1998) Soc. Neurosci. Abs. , vol.24 , pp. 1366
    • Marek, G.J.1    Aghajanian, G.K.2
  • 57
    • 0032587892 scopus 로고    scopus 로고
    • 1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex
    • in press
    • 1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex, Eur. J. Pharmacol. (1999) in press.
    • (1999) Eur. J. Pharmacol.
    • Marek, G.J.1    Aghajanian, G.K.2
  • 58
    • 0343399202 scopus 로고    scopus 로고
    • Systemic PCP treatment elevated brain extracellular 5-HT: A microdialysis study
    • in press
    • P. Martin, M.L. Carlsson, S. Hjorth, Systemic PCP treatment elevated brain extracellular 5-HT: a microdialysis study, Neuroreport (1999) in press.
    • (1999) Neuroreport
    • Martin, P.1    Carlsson, M.L.2    Hjorth, S.3
  • 59
    • 0031950519 scopus 로고    scopus 로고
    • Rodent data and general hypothesis: Antipsychotic action exerted through 5-HT2A receptor antagonism is dependent on increased serotonergic tone
    • Martin P., Waters N., Schmidt C.J., Carlsson A., Carlsson M.L. Rodent data and general hypothesis: antipsychotic action exerted through 5-HT2A receptor antagonism is dependent on increased serotonergic tone. J. Neural Transm. 105:1998;365-396.
    • (1998) J. Neural Transm. , vol.105 , pp. 365-396
    • Martin, P.1    Waters, N.2    Schmidt, C.J.3    Carlsson, A.4    Carlsson, M.L.5
  • 60
    • 0032032540 scopus 로고    scopus 로고
    • Non-NMDA excitatory amino acid receptors in the ventral tegmental area mediate systemic dizocilpine (MK-801) induced hyperlocomotion and dopamine release in the nucleus accumbens
    • Mathe J.M., Nomikos G.G., Schilstrom B., Svensson T.H. Non-NMDA excitatory amino acid receptors in the ventral tegmental area mediate systemic dizocilpine (MK-801) induced hyperlocomotion and dopamine release in the nucleus accumbens. J. Neurosci. Res. 51:1998;583-592.
    • (1998) J. Neurosci. Res. , vol.51 , pp. 583-592
    • Mathe, J.M.1    Nomikos, G.G.2    Schilstrom, B.3    Svensson, T.H.4
  • 61
    • 0028870612 scopus 로고
    • Blockade of phencyclinine-induced hyperlocomotion by MDL 100,907
    • Maurel-Remy S., Bervoets K., Millan M.J. Blockade of phencyclinine-induced hyperlocomotion by MDL 100,907. Eur. J. Pharmacol. 180:1995;R9-R11.
    • (1995) Eur. J. Pharmacol. , vol.180
    • Maurel-Remy, S.1    Bervoets, K.2    Millan, M.J.3
  • 63
    • 0025124833 scopus 로고
    • 2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites
    • 2 receptor by in situ hybridization histochemistry. Correlation with the distribution of receptor sites. Brain Res. 524:1990;139-143.
    • (1990) Brain Res. , vol.524 , pp. 139-143
    • Mengod, G.1    Pompeiano, M.2    Martinez-Mir, M.I.3    Palacios, J.M.4
  • 65
    • 0032575715 scopus 로고    scopus 로고
    • Stimulation of group II metabotropic glutamate receptors normalizes the cognitive and motoric effects of phencylidine
    • Moghaddam B., Adams B. Stimulation of group II metabotropic glutamate receptors normalizes the cognitive and motoric effects of phencylidine. Science. 281:1998;1349-1352.
    • (1998) Science , vol.281 , pp. 1349-1352
    • Moghaddam, B.1    Adams, B.2
  • 66
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with prefrontal cortex
    • Moghaddam B., Adams B., Verma A., Daly D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with prefrontal cortex. J. Neurosci. 17:1997;2921-2927.
    • (1997) J. Neurosci. , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 67
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney J.W., Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry. 52:1995;998-1007.
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 68
    • 0001168945 scopus 로고
    • Schizophrenia: A new approach
    • Osmond H., Smythies J.R. Schizophrenia: a new approach. J. Ment. Sci. 98:1952;309-315.
    • (1952) J. Ment. Sci. , vol.98 , pp. 309-315
    • Osmond, H.1    Smythies, J.R.2
  • 70
    • 0022346190 scopus 로고
    • Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
    • Pazos A., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346:1985;205-230.
    • (1985) Brain Res. , vol.346 , pp. 205-230
    • Pazos, A.1    Palacios, J.M.2
  • 71
    • 0019366734 scopus 로고
    • Psychiatric and medical syndromes associated with phencyclidine (PC) abuse
    • Pearlson G.D. Psychiatric and medical syndromes associated with phencyclidine (PC) abuse. John Hopkins Med. J. 148:1981;25-33.
    • (1981) John Hopkins Med. J. , vol.148 , pp. 25-33
    • Pearlson, G.D.1
  • 74
    • 0011761658 scopus 로고
    • LSD-25 action in normal subjects treated with a monoamine oxidase inhibitor
    • Resnick O., Krus D.M., Raskin M. LSD-25 action in normal subjects treated with a monoamine oxidase inhibitor. Life Sci. 3:1964;1207-1214.
    • (1964) Life Sci. , vol.3 , pp. 1207-1214
    • Resnick, O.1    Krus, D.M.2    Raskin, M.3
  • 75
    • 0023769782 scopus 로고
    • Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis
    • Sanders-Bush E., Burris K.D., Knoth K. Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis. J. Pharmacol. Exp. Therapeutics. 246:1988;924-928.
    • (1988) J. Pharmacol. Exp. Therapeutics , vol.246 , pp. 924-928
    • Sanders-Bush, E.1    Burris, K.D.2    Knoth, K.3
  • 77
    • 0001209293 scopus 로고
    • Some serotonin-like activities of lysergic acid diethylamide
    • Shaw E., Woolley D.W. Some serotonin-like activities of lysergic acid diethylamide. Science. 124:1956;121-123.
    • (1956) Science , vol.124 , pp. 121-123
    • Shaw, E.1    Woolley, D.W.2
  • 79
    • 34250567842 scopus 로고
    • Dimethyltryptamine: Its metabolism in man; The relation of its psychotic effect to serotonin metabolism
    • Szara S. Dimethyltryptamine: its metabolism in man; the relation of its psychotic effect to serotonin metabolism. Experientia. 12:1956;441-442.
    • (1956) Experientia , vol.12 , pp. 441-442
    • Szara, S.1
  • 80
    • 0032401099 scopus 로고    scopus 로고
    • Sertotonin and schizophrenia
    • Tamminga C.A. Sertotonin and schizophrenia. Biol. Psychiatry. 44:1998;1079-1080.
    • (1998) Biol. Psychiatry , vol.44 , pp. 1079-1080
    • Tamminga, C.A.1
  • 81
    • 0027311307 scopus 로고
    • Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex
    • Tanaka E., North R.A. Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex. J. Neurophys. 69:1993;1749-1757.
    • (1993) J. Neurophys. , vol.69 , pp. 1749-1757
    • Tanaka, E.1    North, R.A.2
  • 82
    • 0023882042 scopus 로고
    • 2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens
    • 2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology. 94:1988;213-216.
    • (1988) Psychopharmacology , vol.94 , pp. 213-216
    • Titeler, M.1    Lyon, R.A.2    Glennon, R.A.3
  • 85
    • 0030916849 scopus 로고    scopus 로고
    • Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis
    • Vollenweider F.X., Leenders K.L., Scharfetter C., Maguire P., Stadelmann O., Angst J. Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacology. 16:1997;357-372.
    • (1997) Neuropsychopharmacology , vol.16 , pp. 357-372
    • Vollenweider, F.X.1    Leenders, K.L.2    Scharfetter, C.3    Maguire, P.4    Stadelmann, O.5    Angst, J.6
  • 87
    • 0030612257 scopus 로고    scopus 로고
    • 2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
    • 2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse. 27:1997;32-79.
    • (1997) Synapse , vol.27 , pp. 32-79
    • Willins, D.L.1    Deutch, A.Y.2    Roth, B.L.3
  • 88
    • 0000358118 scopus 로고
    • A biochemical and pharmacological suggestion about certain mental disorders
    • Woolley D.W., Shaw E. A biochemical and pharmacological suggestion about certain mental disorders. Proc. Natl. Acad. Sci. USA. 40:1954;228-231.
    • (1954) Proc. Natl. Acad. Sci. USA , vol.40 , pp. 228-231
    • Woolley, D.W.1    Shaw, E.2
  • 89
    • 0000358118 scopus 로고
    • A biochemical and pharmacological suggestion about certain mental disorders
    • Woolley D.W., Shaw W. A biochemical and pharmacological suggestion about certain mental disorders. Proc. Natl. Acad. Sci. USA. 40:1954;228-231.
    • (1954) Proc. Natl. Acad. Sci. USA , vol.40 , pp. 228-231
    • Woolley, D.W.1    Shaw, W.2


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