Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity

Protein Science

Volumn 13, Issue 6, 2004, Pages 1627-1635

  Barinka, Cyril ^a   Šácha, Pavel ^a,c   Sklenár, Jan ^b,c   Man, Petr ^b,c   Bezouška, Karel ^b,c   Slusher, Barbara S ^d   Konvalinka, Jan ^a,c  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

Enzyme kinetics; GCPII; Glycosylation; NAALADase; Proteolytic activity; PSMA

Indexed keywords

GAMMA GLUTAMYL HYDROLASE; GAMMA GLUTAMYL HYDROLASE 2; N ACETYLASPARTYLGLUTAMIC ACID; PEPTIDE DERIVATIVE; PROSTATE SPECIFIC MEMBRANE ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME KINETICS; GLYCOSYLATION; KIDNEY; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN TARGETING; SMALL INTESTINE; SYNAPTIC MEMBRANE; TUMOR; UPREGULATION; VALIDATION PROCESS;

ANIMALS; ANTIGENS, SURFACE; BINDING SITES; CATALYSIS; CELL LINE; GENE EXPRESSION; GLUTAMATE CARBOXYPEPTIDASE II; GLYCOSYLATION; HUMANS; HYDROLYSIS; INSECTS; KINETICS; MUTAGENESIS, SITE-DIRECTED;

EID: 2442663919     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.04622104     Document Type: Article

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