Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder

Archives of General Psychiatry

Volumn 61, Issue 7, 2004, Pages 649-657

  Woo, Tsung Ung W ^a,b,c   Walsh, John P ^a   Benes, Francine M ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS MENTAL HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALPRAZOLAM; AMITRIPTYLINE; BENZATROPINE; CARBAMAZEPINE; CHLORPROMAZINE; CLONAZEPAM; DESIPRAMINE; DIGOXIGENIN; FLUPHENAZINE; FLUPHENAZINE DECANOATE; GABAPENTIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 67; HYDROXYZINE; LITHIUM; MESSENGER RNA; METHYLPHENIDATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PERPHENAZINE; PSYCHOTROPIC AGENT; QUETIAPINE; RECEPTOR SUBUNIT; RISPERIDONE; SULFUR 35; TRAZODONE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROATE SEMISODIUM;

ARTICLE; AUTOPSY; BIPOLAR DISORDER; BRAIN CORTEX; CELL DENSITY; CELL SUBPOPULATION; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IN SITU HYBRIDIZATION; INTERNEURON; MALE; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SCHIZOPHRENIA;

ADULT; AGED; BIPOLAR DISORDER; CELL COUNT; DIGOXIGENIN; FEMALE; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION; GLUTAMATE DECARBOXYLASE; GYRUS CINGULI; HUMANS; IN SITU HYBRIDIZATION; INTERNEURONS; ISOENZYMES; MALE; MIDDLE AGED; PYRAMIDAL CELLS; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SCHIZOPHRENIA;

EID: 3042782805     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.61.7.649     Document Type: Article

References (57)

1. Paus T. Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci. 2001;2:417-424,
2. Carter CS, Botvinick MM, Cohen JD. The contribution of the anterior cingulate cortex to executive processes in cognition. Rey Neurosci. 1999;10:49-57.
3. Carter CS, Braver TS, Barch DM, Botvinick MM, Noll D, Cohen JD. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science. 1998;280:747-749.
4. Falkenstein M, Hohnsbein J, Hoormann J, Blanke L. Effects of crossmodal divided attention on late ERP components, II: error processing in choice reaction tasks. Electroencephalogr Clin NeurophysioL 1991;78:447-455.
5. Gehring WJ, Knight RT. Prefrontal-cingulate interactions in action monitoring. Nat Neurosci. 2000;3:516-520.
6. Benes FM. Alterations of neural circuitry within layer II of anterior cingulate cortex in schizophrenia. J Psychiatr Res. 1999;33:511-512.
7. Benes FM, Vincent SL, Todtenkopf M. The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol Psychiatry. 2001;50:395-406.
8. Carter CS, MacDonald AW III, Ross LL, Stenger VA. Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study. Am J Psychiatry. 2001;158:1423-1428.
9. Eastwood SL, Harrison PJ. Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders: a review and a Western blot study of synaptophysin, GAP-43 and the complexins. Brain Res Bull. 2001;55:569-578.
10. Cotter D, Landau S, Beasley C, et al. The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia. Biol Psychiatry. 2002;51:377-386.
11. Chana G, Landau S, Beasley C, Everall IP, Cotter D. Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol Psychiatry. 2003;53:1086-1098.
12. Akbarian S, Kim JJ, Potkin SG, et al. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry. 1995;52:258-266.
13. Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA. Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical γ-aminobutyric acid neurons in subjects with schizophrenia. Arch Gen Psychiatry. 2000;57:237-245.
14. Volk D, Austin M, Pierri J, Sampson A, Lewis D. GABA transporter-1 mRNA in the prefrontal cortex in schizophrenia: decreased expression in a subset of neurons. Am J Psychiatry. 2001;158:256-265.
15. Benes FM, Vincent SL, Alsterberg G, Bird ED, SanGiovanni JP. Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics. J Neurosci. 1992;12:924-929.
16. Benes FM, Berretta S. GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology. 2001;25:1-27.
17. Costa E, Davis J, Grayson DR, Guidotti A, Pappas GD, Pesold C. Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability. Neurobiol Dis. 2001;8:723-742.
18. Lewis DA, Pierri JN, Volk DW, Melchitzky DS, Woo TU. Altered GABA neurotransmission and prefrontal cortical dysfunction in schizophrenia. Biol Psychiatry. 1999;46:616-626,
19. Woo TUW, Whitehead RE, Melchitzky DS, Lewis DA. A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia. Proc Natl Acad Sci U S A. 1998;95:5341-5346.
20. Benes FM, Kwok EW, Vincent SL, Todtenkopf MS. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry. 1998;44:88-97.
21. Benes FM, Todtenkopf MS, Logiotatos P, Williams M. Glutamate decarboxylase (65)-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain. J Chem Neuroanat. 2000;20:259-269.
22. Guidotti A, Auta J, Davis JM, et al. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a post-mortem brain study. Arch Gen Psychiatry. 2000;57:1061-1069,
23. Kromkamp M, Uylings HB, Smidt MP, Hellemons AJ, Burbach JP, Kahn RS. Decreased thalamic expression of the homeobox gene DLX1 in psychosis. Arch Gen Psychiatry. 2003;60:869-874.
24. Todtenkopf MS, Benes FM. Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain. Synapse. 1998;29:323-332.
25. Tamminga CA. Schizophrenia and glutamatergic transmission. Crit Rev Neurobiol. 1998;12:21-36.
26. Coyle JT. The glutamatergic dysfunction hypothesis for schizophrenia. Harv Rev Psychiatry. 1996;3:241-253.
27. Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry. 2001;158:1367-1377.
28. Carlsson A, Waters N, Holm-Waters S, Tedroff J, Nilsson M, Carlsson ML. Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence. Annu Rev Pharmacol Toxicol. 2001;41:237-260.
29. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991;148:1301-1308.
30. Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry. 1995;52:998-1007.
31. Olney JW, Newcomer JW, Farber NB. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res. 1999;33:523-533.
32. Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M, Nabeshima T. Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor ε1 subunit. J Neurosci. 2001;21:750-757.
33. Feighner JP, Robins E, Guze SB, Woodruff RA Jr, Winokur G, Munoz R. Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry. 1972;26:57-63.
34. Kingsbury AE, Foster OJ, Nisbet AP, et al. Tissue pH as an indicator of mRNA preservation in human post-mortem brain. Brain Res Mol Brain Res. 1995;28:311-318.
35. Harrison PJ, Heath PR, Eastwood SL, Burnet PW, McDonald B, Pearson RC. The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins. Neurosci Lett. 1995;200:151-154.
36. Eastwood SL, Kerwin RW, Harrison PJ. Immunoautoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-d-aspartate glutamate receptors within the medial temporal lobe in schizophrenia. Biol Psychiatry. 1997;41:636-643.
37. Benes FM. Altered glutamatergic and GABAergic mechanisms in the cingulate cortex of the schizophrenic brain. Arch Gen Psychiatry. 1995;52:1015-1024.
38. Lewis DA. GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia. Brain Res Brain Res Rev. 2000;31:270-276.
39. Reynolds GP, Beasley CL. GABAergic neuronal subtypes in the human frontal cortex: development and deficits in schizophrenia. J Chem Neuroanat. 2001;22:95-100.
40. Heckers S, Stone D, Walsh J, Shick J, Koul P, Benes FM. Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Arch Gen Psychiatry. 2002;59:521-529.
41. Constantinidis C, Williams GV, Goldman-Rakic PS. A role for inhibition in shaping the temporal flow of information in prefrontal cortex. Nat Neurosci. 2002;5:175-180.
42. Constantinidis C, Franowicz MN, Goldman-Rakic PS. Coding specificity in cortical microcircuits: a multiple-electrode analysis of primate prefrontal cortex. J Neurosci. 2001;21:3646-3655.
43. Rao SG, Williams GV, Goldman-Rakic PS. Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC. J Neurophysiol. 1999;81:1903-1916.
44. Stone DJ, Walsh J, Benes FM. Localization of cells preferentially expressing GAD (67) with negligible GAD(65) transcripts in the rat hippocampus: a double in situ hybridization study. Brain Res Mol Brain Res. 1999;71:201-209.
45. Benes FM. Emerging principles of altered neural circuitry in schizophrenia. Brain Res Brain Res Rev. 2000;31:251-269.
46. Barbas H, Pandya DN. Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. J Comp Neurol. 1989;286:353-375.
47. Barbas H, De Olmos J. Projections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey. J Comp Neurol. 1990;300:549-571.
48. Benes FM, Davidson J, Bird ED. Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiatry. 1986;43:31-35.
49. Benes FM, McSparren J, Bird ED, SanGiovanni JP, Vincent SL. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry. 1991;48:996-1001.
50. DeFelipe J. Types of neurons, synaptic connections and chemical characteristics of cells immunoreactive for calbindin-D28K, parvalbumin and calretinin in the neocortex. J Chem Neuroanat. 1997;14:1-19.
51. Conde F, Lund JS, Jacobowitz DM, Baimbridge KG, Lewis DA. Local circuit neurons immunoreactive for calretinin, calbindin D-28k or parvalbumin in monkey prefrontal cortex: distribution and morphology. J Comp Neurol. 1994;341:95-116.
52. Gabbott PL, Bacon SJ. Local circuit neurons in the medial prefrontal cortex (areas 24a,b,c, 25 and 32) in the monkey, II: quantitative areal and laminar distributions. J Comp Neurol. 1996;364:609-636.
53. Kawaguchi Y, Kondo S. Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex. J Neurocytol. 2002;31:277-287.
54. Benes FM, Walsh J, Bhattacharyya S, Sheth A, Berretta S. DNA fragmentation decreased in schizophrenia but not bipolar disorder. Arch Gen Psychiatry. 2003;60:359-364.
55. Kawaguchi Y, Kubota Y. GABAergic cell subtypes and their synaptic connections in rat frontal cortex. Cereb Cortex. 1997;7:476-486.
56. Somogyi P, Tamas G, Lujan R, Buhl EH. Salient features of synaptic organisation in the cerebral cortex. Brain Res Brain Res Rev. 1998;26:113-135.
57. Gupta A, Wang Y, Markram H. Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science. 2000;287:273-278.