D-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices

British Journal of Pharmacology

Volumn 140, Issue 6, 2003, Pages 1051-1056

  Rouaud, E ^a   Billard, J M ^a  

^a INSERM   (France)

Author keywords

Glutamate; Glycine binding site; Hippocampus; Learning; Long term depression; Schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; BICUCULLINE; CYCLOSERINE; GLYCINE RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; RECEPTOR SUBTYPE; STRYCHNINE;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN SLICE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; EXCITATORY POSTSYNAPTIC POTENTIAL; GLUTAMATERGIC NEUROTRANSMISSION; HIPPOCAMPUS; LONG TERM DEPRESSION; MALE; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; CYCLOSERINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; MALE; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 0345257315     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705541     Document Type: Article

References (26)

1. ABEL, T. & LATTAL, M. (2001). Molecular mechanisms of memory acquisition, consolidation and retrieval. Curr. Opin. Neurobiol., 11, 180-187.
2. AURA, J. & RIEKKINEN JR, P. (2000). Pre-training blocks the improving effect of tetrahydroaminoacridine and D-cycloserine on spatial navigation performance in aged rats. Eur. J. Pharmacol., 390, 313-318.
3. BALLARD, T.M., PAULY-EVERS, M., HIGGINS, G.A., OUAGAZZA, A.M., MUTEL, V., BORRONI, E., KEMP, J.A., BLUETHMANN, H. & KEW, J.N. (2002). Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity. J. Neurosci., 22, 6713-6723.
4. BAXTER, M.G., LANTHORN, T.H., FRICK, K.M., GOLSKI, S., WAN., R-Q. & OLTON, D.S. (1994). D-Cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiol. Aging, 15, 207-213.
5. BLISS, T.V.P. & COLLINGRIDGE, G.L. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature, 361, 31-39.
6. CHATTIPAKORN, S.C. & MCMAHON, L.L. (2002). Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. J. Neurophysiol., 87, 1515-1525.
7. CREAGER, R., DUNWIDDIE, T. & LYNCH, G. (1980). Paired-pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus. J. Physiol (Lond)., 299, 409-424.
8. DANYSZ, W. & PARSONS, C.G. (1998). Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol. Rev., 50, 598-664.
9. GOFF, D.C., TSAI, G.C., MANOACH, D.S., FLOOD, J., DARBY, G.C. & COYLE, J.T. (1996). D-Cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am. J. Psychiatry, 153, 1628-1630.
10. HOOD, W.F., COMPTON, R.P. & MONAHAN, J.B. (1989). D-Cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neurosci. Lett., 98, 91-95.
11. ISHIMARU, M. & TORU, M. (1997). The glutamate hypothesis of schizophrenia: therapeutic implications. CNS Drugs, 7, 47-67.
12. JAVITT, D.C. (2002). Glycine modulators in schizophrenia. Curr. Opin. Invest. Drugs, 3, 1067-1072.
13. KESSLER, M., BAUDRY, M. & LYNCH, G. (1989). Quinoxaline derivatives are high-affinity antagonist of the NMDA-associated glycine sites. Brain Res., 489, 377-382.
14. KEW, J.N., KOESTER, A., MOREAU, J.L., JENK, F., OUAGAZZA, A.M., MUTEL, V., RICHARDS, J.G., TRUBE, G., FISCHER, G., MONTKOWSKI, A., HUNDT, W., REINSCHEID, R.K., PAULY-EVERS, M., KEMP, J.A. & BLUETHMANN, H. (2000). Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site. J. Neurosci., 20, 4037-4049.
15. LELONG, V., DAUPHIN, F. & BOULOUARD, M. (2001). RS 67333 and D-cycloserine accelerate learning acquisition in the rat. Neuropharmacology, 41, 517-522.
16. MOHR, E., KNOTT, V., SAMPSON, M., WESNES, K., HERTING, R. & MENDIS, T. (1995). Cognitive and quantified electroencephalographic correlates of cycloserine tratment in Alzheimer's disease. Clin. Neuropharmacol., 18, 28-38.
17. MORI, M., GAHWILER, B.H. & GERBER, U. (2002). Beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro. J. Physiol (Lond)., 539, 191-200.
18. PITKÄNEN, M., SIRVÏO, J., LAHTINEN, H., KOIVISTO, E. & RIEKKINEN, P. (1994). D-Cycloserine, a partial agonist at the glycine site, enhances the excitability of dentate granule cells in vivo in rats. Eur. J. Pharmacol., 253, 125-129.
19. PRIESTLEY, T., LAUGHTON, P., MYERS, J., LEBOURDELLES, B., KERBY, J. & WHITING, P.J. (1995). Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2a and NR1a/NR2b subunits assemblies expressed in permanently transfected mouse fibroplast cells. Mol. Pharmacol., 48, 841-848.
20. QUATERMAIN, D., MOWER, J., RAFFERTY, M.F., HERTING, R.L. & LANTHORN, T.H. (1994). Acute but not chronic activation of NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention. Eur. J. Pharmacol., 257, 7-12.
21. ROGAWSKI, M.A. (2000). Low affinity channel blocking (uncompetitive) NMDA receptor antagonists as therapeutic agents: toward an understanding of heir favorable tolerabiliy. Amino Acids, 19, 133-149.
22. SHEININ, A., SHAVIT, S. & BENVENISTE, M. (2001). Subunit specificity and mechanism of action of NMDA partial agonist D-serine. Neuropharmacology, 41, 151-158.
23. THOMPSON, L.T., MOSKAL, J.R. & DISTERHOFT, J.F. (1992). Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine. Nature, 359, 638-641.
24. WATSON, G.B., BOLANOWSKI, M.A., BAGANOFF, M.P., DEPPELER, C.J. & LANTHORN, H. (1990). D-Cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes. Brain Res., 510, 158-160.
25. WATANABE, Y., HIMI, T., SAITO, H. & ABE, K. (1992). Involvement of glycine site associated with the NMDA receptor in hippocampal long-term potentiation and acquisition of spatial memory in rats. Brain Res., 582, 58-64.
26. YOON, K.W., WOTRING, V.E. & FUSE, T. (1998). Multiple picrotoxinin effect on glycine channels in rat hippocampal neurons. Neuroscience, 87, 807-815.