Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity

Journal of Neuroscience

Volumn 22, Issue 15, 2002, Pages 6713-6723

  Ballard, Theresa M ^a   Pauly Evers, Meike ^a   Higgins, Guy A ^a   Ouagazzal, Abdel Mouttalib ^a,c   Mutel, Vincent ^a   Borroni, Edilio ^a   Kemp, John A ^a   Bluethmann, Horst ^a   Kew, James N C ^a,b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b GLAXOSMITHKLINE   (United Kingdom)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Antipsychotics; Glycine site; Grin1; NMDA receptor; NMDAR1; Schizophrenia

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIZOCILPINE; GENE PRODUCT; GLYCINE; MONOAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; PROTEIN GRIN1; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE MODEL; DOPAMINERGIC SYSTEM; DRUG RECEPTOR BINDING; HABITUATION; HIPPOCAMPUS; LOCOMOTION; LONG TERM POTENTIATION; MAZE TEST; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BINDING; SCHIZOPHRENIA; SEROTONINERGIC SYSTEM; STARTLE REFLEX; STEREOTYPY; SYNAPTIC MEMBRANE;

EID: 0036703884     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-15-06713.2002     Document Type: Article

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