Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors

Neuropharmacology

Volumn 42, Issue 5, 2002, Pages 593-602

  Krupp, Johannes J ^a,c   Vissel, Bryce ^b   Thomas, Christopher G ^a   Heinemann, Stephen F ^b   Westbrook, Gary L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Calcineurin; Desensitization; Mutagenesis; NMDA receptors; Patch clamp; Tyrosine phosphatases

Indexed keywords

ALANINE; CALCINEURIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PHOSPHATASE; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; SERINE; TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNAPSE;

EID: 0036236357     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00031-X     Document Type: Article

References (46)

1. Peroxovanadium compounds: Biological actions and mechanisms of insulin-mimesis
2. Protein tyrosine kinase-mediated potentiation of currents from cloned NMDA receptors
3. Tyrosine phosphorylation modulates the interaction of calmodulin with its target proteins
4. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation
5. AKAP signaling complexes at the cytoskeleton
6. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting
7. Zinc potentiates agonist-induced currents at certain splice variants of the NMDA receptor
8. Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
9. CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus
10. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits
11. The impact of receptor desensitization on fast synaptic transmission
12. Protein kinase recognition sequence motifs
13. Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family
14. N-terminal domains in the NR2 subunit control desensitization of NMDA receptors
15. 2+-dependent inactivation of NMDA receptors
16. Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium
17. 2+-dependent phosphatase
18. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1
19. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
20. G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
21. Role of AMPA receptor cycling in synaptic transmission and plasticity
22. Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin
23. Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization
24. Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine
25. NMDA receptor structure and function
26. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
27. Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinase
28. Molecular determinants of NMDA receptor internalization
29. Calcium-induced actin depolymerization reduces NMDA channel activity
30. Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons
31. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo
32. C-terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors
33. Potentiation of insulin-related signal transduction by a novel protein-phosphatase inhibitor, Et-3,4-dephostatin, on cultured 3T3-L1 apidocytes
34. Regulation of ligand-gated ion channels by protein phosphorylation
35. Regulation of glycine-insensitive desensitization of the NMDA receptor in outside-out patches
36. Synaptic desensitization of NMDA receptors by calcineurin
37. Glutamate receptor desensitization and its role in synaptic transmission
38. Desensitization of AMPA receptors upon multiquantal neurotransmitter release
39. Glycine-independent NMDA receptor desensitization: Localization of structural determinants
40. A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux
41. Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin
42. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex
43. Competitive binding of alpha-actinin and calmodulin to the NMDA receptor
44. Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors
45. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition
46. Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity