메뉴 건너뛰기




Volumn 1003, Issue , 2003, Pages 94-101

Glutamate Receptors and Transporters in the Hippocampus in Schizophrenia

Author keywords

AMPA receptor; Gene expression; Kainate receptor; Lateralization; Medial temporal lobe; mRNA; NMDA receptor

Indexed keywords

AMINO ACID TRANSPORTER; AMPA RECEPTOR; BIOLOGICAL MARKER; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; IONOTROPIC RECEPTOR; KAINIC ACID RECEPTOR; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT; VESICULAR TRANSPORT PROTEIN;

EID: 0141532459     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1300.006     Document Type: Conference Paper
Times cited : (123)

References (43)
  • 1
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • OLNEY, J.W. & N.B. FARBER. 1995. Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry 52: 998-1007.
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 2
    • 0031979134 scopus 로고    scopus 로고
    • Schizophrenia and glutamatergic transmission
    • TAMMINGA, C.A. 1998. Schizophrenia and glutamatergic transmission. Crit. Rev. Neurobiol. 12: 21-36.
    • (1998) Crit. Rev. Neurobiol. , vol.12 , pp. 21-36
    • Tamminga, C.A.1
  • 3
    • 0036174640 scopus 로고    scopus 로고
    • Glutamatergic mechanisms in schizophrenia
    • TSAI, G. & J.T. COYLE. 2002. Glutamatergic mechanisms in schizophrenia. Annu. Rev. Pharmacol. Toxicol. 42: 165-179.
    • (2002) Annu. Rev. Pharmacol. Toxicol. , vol.42 , pp. 165-179
    • Tsai, G.1    Coyle, J.T.2
  • 4
    • 0035028512 scopus 로고    scopus 로고
    • Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence
    • CARLSSON, A., N. WATERS, S. HOLM-WATERS, et al. 2001. Interactions between monoamines, glutamate, and GABA in schizophrenia: New evidence. Annu. Rev. Pharmacol. Toxicol. 41: 237-260.
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 237-260
    • Carlsson, A.1    Waters, N.2    Holm-Waters, S.3
  • 5
    • 0033754407 scopus 로고    scopus 로고
    • Imaging the glutamatergic system in vivo - Relevance to schizophrenia
    • BRESSAN, R.A. & L.S. PILOWSKY. 2000. Imaging the glutamatergic system in vivo - relevance to schizophrenia. Eur. J. Nucl. Med. 27: 1723-1731.
    • (2000) Eur. J. Nucl. Med. , vol.27 , pp. 1723-1731
    • Bressan, R.A.1    Pilowsky, L.S.2
  • 6
    • 0029736547 scopus 로고    scopus 로고
    • Advances in post mortem molecular neurochemistry and neuropathology: Examples from schizophrenia research
    • HARRISON, P.J. 1996. Advances in post mortem molecular neurochemistry and neuropathology: examples from schizophrenia research. Br. Med. Bull. 52: 527-538.
    • (1996) Br. Med. Bull. , vol.52 , pp. 527-538
    • Harrison, P.J.1
  • 7
    • 0347791241 scopus 로고    scopus 로고
    • Laser-assisted microdissection: Methods for the molecular analysis of psychiatric disorders at a cellular resolution
    • In press
    • BURNET, P.W.J., S.L. EASTWOOD & P.J. HARRISON. 2003. Laser-assisted microdissection: methods for the molecular analysis of psychiatric disorders at a cellular resolution. Biol. Psychiatry. In press.
    • (2003) Biol. Psychiatry
    • Burnet, P.W.J.1    Eastwood, S.L.2    Harrison, P.J.3
  • 8
    • 0034094628 scopus 로고    scopus 로고
    • Glutamate receptor expression in schizophrenic brain
    • MEADOR-WOODRUFF, J.H. & D.J. HEALY. 2000. Glutamate receptor expression in schizophrenic brain. Brain Res. Rev. 31: 288-294.
    • (2000) Brain Res. Rev. , vol.31 , pp. 288-294
    • Meador-Woodruff, J.H.1    Healy, D.J.2
  • 9
    • 0037305349 scopus 로고    scopus 로고
    • Molecular aspects of glutamate dysfunction: Implications for schizophrenia and its treatment
    • KONRADI, C. & S. HECKERS. 2003. Molecular aspects of glutamate dysfunction: implications for schizophrenia and its treatment. Pharmacol. Therap. 97: 153-179.
    • (2003) Pharmacol. Therap. , vol.97 , pp. 153-179
    • Konradi, C.1    Heckers, S.2
  • 10
    • 0025221418 scopus 로고
    • Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem
    • KERWIN, R.W., S. PATEL & B. MELDRUM. 1990. Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience 39: 25-32.
    • (1990) Neuroscience , vol.39 , pp. 25-32
    • Kerwin, R.W.1    Patel, S.2    Meldrum, B.3
  • 11
    • 0033914752 scopus 로고    scopus 로고
    • Iontropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: Effects of schizophrenia
    • GAO, X-M., K. SAKAI, R.C. ROBERTS, et al. 2000. Iontropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. Am J. Psychiatry 157: 1141-1149.
    • (2000) Am J. Psychiatry , vol.157 , pp. 1141-1149
    • Gao, X.-M.1    Sakai, K.2    Roberts, R.C.3
  • 12
    • 0035903772 scopus 로고    scopus 로고
    • Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses
    • LAW, A.J. & J.F.W. DEAKIN. 2001. Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses. Neuroreport 12: 2971-2974.
    • (2001) Neuroreport , vol.12 , pp. 2971-2974
    • Law, A.J.1    Deakin, J.F.W.2
  • 13
    • 0025967753 scopus 로고
    • Decreased hippocampal expression of a glutamate receptor gene in schizophrenia
    • HARRISON, P.J., D. MCLAUGHLIN & R.W. KERWIN. 1991. Decreased hippocampal expression of a glutamate receptor gene in schizophrenia. Lancet 337: 450-452.
    • (1991) Lancet , vol.337 , pp. 450-452
    • Harrison, P.J.1    McLaughlin, D.2    Kerwin, R.W.3
  • 14
    • 0028907468 scopus 로고
    • Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia
    • EASTWOOD, S.L., B. MCDONALD, P.W.J. BURNET, et al. 1995. Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluR1 and GluR2 in medial temporal lobe neurons in schizophrenia. Mol. Brain Res. 29: 211-223.
    • (1995) Mol. Brain Res. , vol.29 , pp. 211-223
    • Eastwood, S.L.1    Mcdonald, B.2    Burnet, P.W.J.3
  • 15
    • 0031004644 scopus 로고    scopus 로고
    • Immuno-autoradiographic evidence for a loss of α-amino-3-hydroxy-5- methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia
    • EASTWOOD, S.L., R.W. KERWIN & P.J. HARRISON. 1997. Immuno-autoradiographic evidence for a loss of α-amino-3-hydroxy-5-methyl- 4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia. Biol. Psychiatry 41: 636-643.
    • (1997) Biol. Psychiatry , vol.41 , pp. 636-643
    • Eastwood, S.L.1    Kerwin, R.W.2    Harrison, P.J.3
  • 16
    • 0031017606 scopus 로고    scopus 로고
    • GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: A reverse transcriptase-polymerase chain reaction (RT-PCR) study
    • EASTWOOD, S.L., P.W.J. BURNET & P.J. HARRISON. 1997. GluR2 glutamate receptor subunit flip and flop isoforms are decreased in the hippocampal formation in schizophrenia: a reverse transcriptase-polymerase chain reaction (RT-PCR) study. Mol. Brain Res. 44: 92-98.
    • (1997) Mol. Brain Res. , vol.44 , pp. 92-98
    • Eastwood, S.L.1    Burnet, P.W.J.2    Harrison, P.J.3
  • 17
    • 0030933984 scopus 로고    scopus 로고
    • Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia
    • PORTER, R.H.P., S.L. EASTWOOD & P.J. HARRISON. 1997. Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. Brain Res. 751: 217-231.
    • (1997) Brain Res. , vol.751 , pp. 217-231
    • Porter, R.H.P.1    Eastwood, S.L.2    Harrison, P.J.3
  • 18
    • 0034747123 scopus 로고    scopus 로고
    • 5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic-depressives
    • 5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic-depressives. Hippocampus 11: 482-491.
    • (2001) Hippocampus , vol.11 , pp. 482-491
    • Benes, F.M.1    Todtenkopf, M.S.2    Kostoulakos, P.3
  • 19
    • 0034727878 scopus 로고    scopus 로고
    • Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus
    • OHNUMA, T., S. TESSLER, H. ARAI, et al. 2000. Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Mol. Brain Res. 85: 24-31.
    • (2000) Mol. Brain Res. , vol.85 , pp. 24-31
    • Ohnuma, T.1    Tessler, S.2    Arai, H.3
  • 20
    • 0027985445 scopus 로고
    • Differential changes in glutamate receptor subunit messenger RNAs in rat brain after haloperidol treatment
    • EASTWOOD, S.L., P. STORY, P.W.J. BURNET, et al. 1994. Differential changes in glutamate receptor subunit messenger RNAs in rat brain after haloperidol treatment. J. Psychopharmacol. 80: 196-203.
    • (1994) J. Psychopharmacol. , vol.80 , pp. 196-203
    • Eastwood, S.L.1    Story, P.2    Burnet, P.W.J.3
  • 21
    • 0028947052 scopus 로고
    • Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs
    • FITZGERALD, L.W., A.Y. DEUTCH, G. GASIC, et al. 1995. Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J. Neurosci. 15: 2453-2461.
    • (1995) J. Neurosci. , vol.15 , pp. 2453-2461
    • Fitzgerald, L.W.1    Deutch, A.Y.2    Gasic, G.3
  • 22
    • 0030593497 scopus 로고    scopus 로고
    • The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain
    • EASTWOOD, S.L., R.H.P. PORTER & P.J. HARRISON. 1996. The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain. Neurosci. Lett. 212: 163-166.
    • (1996) Neurosci. Lett. , vol.212 , pp. 163-166
    • Eastwood, S.L.1    Porter, R.H.P.2    Harrison, P.J.3
  • 23
    • 0013198358 scopus 로고    scopus 로고
    • The expression of vesicular glutamate transporters defines two classes of excitatory synapse
    • FREMEAU, R.T., JR., M.D. TROVER, I. PAHNER, et al. 2001. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 31: 247-260.
    • (2001) Neuron , vol.31 , pp. 247-260
    • Fremeau Jr., R.T.1    Trover, M.D.2    Pahner, I.3
  • 24
    • 56249085714 scopus 로고    scopus 로고
    • The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons
    • HERZOG, E., G.C. BELLENCHI, C. GRAS, et al. 2001. The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J. Neurosci. 21: 1-6.
    • (2001) J. Neurosci. , vol.21 , pp. 1-6
    • Herzog, E.1    Bellenchi, G.C.2    Gras, C.3
  • 25
    • 0346530779 scopus 로고    scopus 로고
    • Vesicular glutamate transporter (VGLUT) gene expression provides further evidence for glutamatergic synaptic pathology in the hippocampus in schizophrenia
    • HARRISON, P.J. & S.L. EASTWOOD. 2003. Vesicular glutamate transporter (VGLUT) gene expression provides further evidence for glutamatergic synaptic pathology in the hippocampus in schizophrenia [Abstract]. Schizophr. Res. 60: 62-63.
    • (2003) Schizophr. Res. , vol.60 , pp. 62-63
    • Harrison, P.J.1    Eastwood, S.L.2
  • 26
    • 0032556365 scopus 로고    scopus 로고
    • Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia
    • HARRISON, P.J. & S.L. EASTWOOD. 1998. Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. Lancet 352: 1669-1673.
    • (1998) Lancet , vol.352 , pp. 1669-1673
    • Harrison, P.J.1    Eastwood, S.L.2
  • 27
    • 0008024807 scopus 로고    scopus 로고
    • Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: A study of complexin mRNAs
    • EASTWOOD, S.L. & P.J. HARRISON. 2000. Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs. Mol. Psychiatry 5: 425-432.
    • (2000) Mol. Psychiatry , vol.5 , pp. 425-432
    • Eastwood, S.L.1    Harrison, P.J.2
  • 28
    • 0346530781 scopus 로고    scopus 로고
    • Complexins I and II in hippocampus in schizophrenia
    • SAWADA, K., A. BARR, S. TAKAHASHI, et al. 2003. Complexins I and II in hippocampus in schizophrenia [Abstract]. Schizophr. Res. 60: 74-75.
    • (2003) Schizophr. Res. , vol.60 , pp. 74-75
    • Sawada, K.1    Barr, A.2    Takahashi, S.3
  • 30
    • 0035510713 scopus 로고    scopus 로고
    • Restless AMPA receptors: Implications for synaptic neurotransmission and plasticity
    • LÜSCHER, C. & M. FRERKING. 2001. Restless AMPA receptors: implications for synaptic neurotransmission and plasticity. Trends Neurosci. 24: 665-670.
    • (2001) Trends Neurosci. , vol.24 , pp. 665-670
    • Lüscher, C.1    Frerking, M.2
  • 32
    • 0032975940 scopus 로고    scopus 로고
    • Decreased hippocampal (CA3) NMDA receptors in schizophrenia
    • DEAN B., E. SCARR, R. BRADBURY & D. COPOLOV. 1999. Decreased hippocampal (CA3) NMDA receptors in schizophrenia. Synapse 32: 67-69.
    • (1999) Synapse , vol.32 , pp. 67-69
    • Dean, B.1    Scarr, E.2    Bradbury, R.3    Copolov, D.4
  • 33
    • 0024392625 scopus 로고
    • Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia
    • DEAKIN, J.F.W., P. SLATER, M.D.C. SIMPSON, et al. 1989. Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J. Neurochem. 52: 1781-1786.
    • (1989) J. Neurochem. , vol.52 , pp. 1781-1786
    • Deakin, J.F.W.1    Slater, P.2    Simpson, M.D.C.3
  • 34
    • 0028928362 scopus 로고
    • Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers
    • BREESE, C.R., R. FREEDMAN & S. LEONARD. 1995. Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res. 674: 82-90.
    • (1995) Brain Res. , vol.674 , pp. 82-90
    • Breese, C.R.1    Freedman, R.2    Leonard, S.3
  • 35
    • 0035177944 scopus 로고    scopus 로고
    • Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia
    • HARRISON, P.J. & S.L. EASTWOOD. 2001. Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia. Hippocampus 11: 508-519.
    • (2001) Hippocampus , vol.11 , pp. 508-519
    • Harrison, P.J.1    Eastwood, S.L.2
  • 36
    • 0034098525 scopus 로고    scopus 로고
    • Emerging principles of altered neural circuitry in schizophrenia
    • BENES, F.M. 2000. Emerging principles of altered neural circuitry in schizophrenia. Brain Res. Rev. 31: 251-269.
    • (2000) Brain Res. Rev. , vol.31 , pp. 251-269
    • Benes, F.M.1
  • 37
    • 0026452868 scopus 로고
    • Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats
    • PELLEGRINI-GIAMPIETRO, D., R.S. ZUKIN, M.V.L. BENNETT, et al. 1992. Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats. Proc. Natl. Acad. Sci. USA 89: 10499-10503.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10499-10503
    • Pellegrini-Giampietro, D.1    Zukin, R.S.2    Bennett, M.V.L.3
  • 39
    • 0023853975 scopus 로고
    • Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia
    • KERWIN, R.W., S. PATEL, B.S. MELDRUM, et al. 1988. Asymmetrical loss of glutamate receptor subtype in left hippocampus in schizophrenia. Lancet I: 583-584.
    • (1988) Lancet , vol.1 , pp. 583-584
    • Kerwin, R.W.1    Patel, S.2    Meldrum, B.S.3
  • 40
    • 0345899865 scopus 로고    scopus 로고
    • Expression of vesicular glutamate transporters one and two in medial temporal lobe structures in schizophrenia, bipolar disorder, and major depressive disorder
    • MCCULLUM SMITH, R. & J. MEADOR-WOODRUFF. 2003. Expression of vesicular glutamate transporters one and two in medial temporal lobe structures in schizophrenia, bipolar disorder, and major depressive disorder [Abstract]. Schizophr. Res. 60 (suppl.): 65.
    • (2003) Schizophr. Res. , vol.60 , Issue.SUPPL. , pp. 65
    • McCullum Smith, R.1    Meador-Woodruff, J.2
  • 41
    • 0037105936 scopus 로고    scopus 로고
    • Further postmortem autoradiographic studies of AMPA receptor binding in schizophrenia
    • NOGA, T.J. & H. WANG. 2002. Further postmortem autoradiographic studies of AMPA receptor binding in schizophrenia. Synapse 45: 250-258.
    • (2002) Synapse , vol.45 , pp. 250-258
    • Noga, T.J.1    Wang, H.2
  • 42
    • 0032924127 scopus 로고    scopus 로고
    • The neuropathology of schizophrenia: A critical review of the data and their interpretation
    • HARRISON, P.J. 1999. The neuropathology of schizophrenia: a critical review of the data and their interpretation. Brain 122: 593-624.
    • (1999) Brain , vol.122 , pp. 593-624
    • Harrison, P.J.1
  • 43
    • 0037308528 scopus 로고    scopus 로고
    • Genes for schizophrenia? Recent findings and their pathophysiological implications
    • HARRISON, P.J. & M.J. OWEN. 2003. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361: 417-419.
    • (2003) Lancet , vol.361 , pp. 417-419
    • Harrison, P.J.1    Owen, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.