Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 359, Issue 4, 1999, Pages 280-287

  Ossowska, Krystyna ^a   Pietraszek, Małgorzata ^a   Wardas, Jadwiga ^a   Nowak, Gabriel ^a   Wolfarth, Stanisław ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Autoradiography; Chronic treatment; Clozapine; Cortex; Haloperidol; NMDA receptors

Indexed keywords

CLOZAPINE; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SPIPERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; CAUDATE NUCLEUS; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC SYSTEM; DRUG RECEPTOR BINDING; FRONTAL LOBE; INSULA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARIETAL LOBE; RAT;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; ANTIPSYCHOTIC AGENTS; AUTORADIOGRAPHY; CEREBRAL CORTEX; CLOZAPINE; CORPUS STRIATUM; DIZOCILPINE MALEATE; HALOPERIDOL; MALE; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; RECEPTORS, N-METHYL-D-ASPARTATE; SPIPERONE; TRITIUM;

EID: 0032924740     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005353     Document Type: Article

References (54)

1. Baldessarini RJ, Centorrino F, Flood JG, Volpicelli SA, Huston-Lyons D, Cohen BM (1993) Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 9:117-124
2. Banerjee SP, Zuck LG, Yablonsky-Alter E, Lidsky TI (1995) Glutamate agonist activity: Implications for antipsychotic drug action and schizophrenia. NeuroReport 6:2500-2504
3. Bunney BG, Bunney WE Jr, Carlsson A (1995) Schizophrenia and glutamate. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, pp 1205-1214
4. 3H]-CGP39653 mapping of glutamatergic N-methyl-D-aspartate receptors in the brain of aged rats. Neurosci Res Commun 12:31-39
5. Cohen BM, Tsuneizumi T, Baldessarini RJ, Campbell A, Babb SM (1992) Differences between antipsychotic drugs in persistence of brain levels and behavioral effects. Psychopharmacology 108:338-344
6. 3H]ifenprodil binding in rat brain membranes. J Pharmacol Exp Ther 280:584-592
7. Deakin JFW, Slater P, Simpson MDC, Gilchrist AC, Skan WJ, Royston MC, Reynolds GP, Cross AJ (1989) Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J Neurochem 52:1781-1786
8. DeBiasi S, Minelli A, Melone M, Conti F (1996) Presynaptic NMDA receptors in the neocortex are both auto- and heteroreceptors. NeuroReport 7:2773-2776
9. DeLisi LE, Buchsbaum MS, Holcomb HH, Langston KC, King AC, Kessler R, Pickar D, Carpenter WT, Morihisa JM, Margolin R, Weinberger DR (1989) Increased temporal lobe glucose use in chronic schizophrenic patients. Biol Psychiatry 25:835-851
10. Fletcher EJ, MacDonald JF (1993) Haloperidol interacts with the strychnine-insensitive glycine site at the NMDA receptor in cultured mouse hippocampal neurones. Eur J Pharmacol 235:291-295
11. Gandolfi O, Dall'Olio R (1996) Modulatory role of dopamine on excitatory amino acid receptors. Prog Neuropsychopharmacol Biol Psychiatry 20:659-671
12. Głazewski S, Skangiel-Kramska J, Kossut M (1993) Development of NMDA receptor-channel complex and L-type calcium channels in mouse hippocampus. J Neurosci Res 35:199-206
13. Gur RE, Resnick SM, Alavi A, Gur R, Caroff S, Dann R, Saykin AJ, Chawluk JB, Kushner M, Reivich M (1987) Regional brain function in schizophrenia, I: A positron emission tomography study. Arch Gen Psychiatry 44:119-125
14. 3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site. Brain Res 489:185-189
15. Huntley GW, Vichers JC, Janssen W, Brose N, Heinemann SF, Morrison JH (1994) Distribution and synaptic localization of immunocytochemically identified NMDA receptor subunit proteins in sensori-motor and visual cortices of monkey and human. J Neurosci 14:3603-3619
16. Ilyin VI, Whittemore ER, Guastella J, Weber E, Woodward RM (1996) Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. Mol Pharmacol 50:1541-1550
17. Ishimaru M, Kurumaji A, Toru M (1992) NMDA-associated glycine binding site increases in schizophrenic brains. Biol Psychiatry 32:379-381
18. Johansson C, Jackson DM, Svensson L (1994) The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat. Psychopharmacology 116:437-442
19. Kahn RS, Davis KL (1995) New developments in dopamine and schizophrenia. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, pp 1193-1201
20. Keck PE Jr, Cowen BM, Baldessarini RJ, McElroy SL (1989) Time course of antipsychotic effects of neuroleptic drugs. Am J Psychiatry 146:1289-1292
21. Keith VA, Mansbach RS, Geyer MA (1991) Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle. Biol Psychiatry 30:557-566
22. Kendrick SJ, Lynch DR, Pritchett DB (1996) Characterization of glutamate binding sites in receptors assembled from transfected NMDA receptor subunits. J Neurochem 67:608-616
23. Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmüller B (1980) Low cerebral fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20:379-382
24. 3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients. J Neural Transm 77:231-236
25. Korpi ER, Kaufmann CA, Marnela KM, Weinberger DR (1987) Cerebrospinal fluid amino acid concentrations in chronic schizophrenia. Psychiatry Res 20:337-345
26. Laprade N, Soghomonian JJ (1995) MK-801 decreases striatal and cortical GAD65 mRNA levels. NeuroReport 6:1885-1889
27. Laurie DJ, Seeburg PH (1994) Ligand affinities at recombinant N-methyl-D-asparate receptors depend on subunit composition. Eur J Pharmacol 268:335-345
28. Lidsky TI, Yablonsky-Alter E, Zuck L, Banerjee SP (1993) Antiglutamatergic effects of clozapine. Neurosci Lett 163:155-158
29. Lidsky TI, Yablonsky-Alter E, Zuck LG, Banerjee SP (1997) Antipsychotic drug effects on glutamatergic activity. Brain Res 764:46-52
30. Luisada PV, Brown B I (1976) Clinical management of the phencyclidine psychosis. Clin Toxicol 9:539-545
31. Lynch DR, Gallagher MJ (1996) Inhibition of N-methyl-D-aspartate receptors by haloperidol: Developmental and pharmacological characterization in native and recombinant receptors. J Pharmacol Exp Ther 279:154-161
32. Mansbach RS, Geyer MA (1989) Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology 2:299-308
33. McCoy L, Richfield EK (1996) Chronic antipsychotic treatment alters glycine-stimulated NMDA receptor binding in rat brain. Neurosci Lett 213:137-141
34. Meltzer HY, Stahl SM (1976) The dopamine hypothesis of schizophrenia: A review. Schizophrenia Bull 2:19-76
35. Nowak G, Li Y, Paul IA (1996) Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment. Eur J Pharmacol 295:75-85
36. Paxinos G, Watson C (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York
37. Perry TL (1982) Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction. Neurosci Lett 28:81-85
38. Pietraszek M, Ossowska K (1998) Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats. Naunyn Schmiedebergs Arch Pharmacol 357:466-471
39. Roberts GW (1990) Schizophrenia: The cellular biology of a functional psychosis. Trends Neurosci 13:207-211
40. 3H]MK-801 binding in rat brain. J Neurochem 60:1344-1353
41. Schroeder J, Buchsbaum MS, Siegel BV, Geider FJ, Lohr J, Tang C, Wu J, Potkin SG (1996) Cerebral metabolic activity correlates of subsyndromes in chronic schizophrenia. Schizophrenia Res 19:41-53
42. 1 receptors. Life Sci 44:229-236
43. Seeman P (1987) Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1:133-152
44. Sherman AD, Davidson AT, Barnah S, Hegwood TS, Waziri R (1991) Evidence of glutamatergic deficiency in schizophrenia. Neurosci Lett 121:77-80
45. Siegel BV, Buchsbaum MS, Bunney WE, Gottschalk LA, Haier RJ, Lohr JB, Lottenberg S, Najafi A, Nuechterlein KH, Potkin SG, Wu JC (1993) Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. Am J Psychiatry 150:1325-1336
46. 3H]CGP-39653: A new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain. Eur J Pharmacol 192:19-24
47. Simpson MDC, Slater P, Royston MC, Deakin JFW (1992) Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effect of disease process and neuroleptic medication. Schizophr Res 6:41-48
48. Swerdlow NR, Bakshi V, Geyer MA (1996) Seroquel restores sensorimotor gating in phencyclidine-treated rats. J Pharmacol Exp Ther 279:1290-1299
49. Tarazi FI, Florijn WI, Creese I (1996) Regulation of ionotropic glutamate receptors following subchronic and chronic treatment with typical and atypical antipsychotics. Psychopharmacology 128:371-379
50. Toru M, Watanabe S, Shibuya H, Nishikawa T, Noda K, Mitsushio H, Ichikawa H, Kurumaji A, Takashima M, Mataga N, Ogawa A (1988) Neurotransmitters, receptors and neuropeptides in postmortem brains of chronic schizophrenic patients. Acta Psychiatr Scand 78:121-137
51. Toru M, Kurumaji A, Kumashiro S, Suga I, Tamashima M, Nishikawa T (1992) Excitatory amino acidergic neurons in chronic schizophrenic brain. Mol Neuropharmacol 2:241-243
52. Tsai G, Passani LA, Slusher BS, Carter R, Baer L, Kleinman JE, Coyle JT (1995) Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch Gen Psychiatry 52:829-836
53. Ułas J, Nguyen L, Cotman CW (1993) Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex. NeuroReport 4:1049-1051
54. Wolfarth S, Ossowska K (1989) Can the supersensitivity of rodents to dopamine be regarded as a model of tardive dyskinesia? Prog Neuropsychopharmacol Biol Psychiatry 13:799-840