Evaluation of NMDA Receptors in Vivo in Schizophrenic Patients with [ 123I]CNS 1261 and SPET: Preliminary Findings

Annals of the New York Academy of Sciences

Volumn 1003, Issue , 2003, Pages 364-367

  Bressan, Rodrigo A ^a   Erlandsson, Kjell ^b   Mulligan, Rachel S ^b   Gunn, Roger N ^d   Cunningham, Vincent J ^c   Owens, Jonathan ^e   Ell, Peter J ^b   Pilowsky, Lyn S ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d MCGILL UNIVERSITY   (Canada)

^e West of Scotland Radionuclide Dispensary   (United Kingdom)

Author keywords

NMDA receptor dysfunction; Schizophrenia; SPET technique

Indexed keywords

1 (1 NAPHTHYL) N' (3 IODOPHENYL) N' METHYLGUANIDINE I 123; CLOZAPINE; CNS 1261; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; TRACER; UNCLASSIFIED DRUG;

BLOOD ANALYSIS; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BINDING SITE; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; MENTAL PATIENT; NEUROIMAGING; SCHIZOPHRENIA; SCINTISCANNING; STATISTICAL ANALYSIS;

EID: 0347091911     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1300.027     Document Type: Conference Paper

References (5)

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2. 123I]CNS 1261 - A potential SPET tracer for the NMDA receptor. Nucl. Med. Biol. 30: 441-454.
3. 123I]CNS 1261. Nucl. Med. Biol. In press.
4. 123I]epidepride SPET study of amisulpride-treated patients. Am. J. Psychiatry 160: 1413-1420.
5. LARUELLE, M. 2000. Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J. Cereb. Blood Flow Metab. 20: 423-451.