Genomics and Variation of Ionotropic Glutamate Receptors

Annals of the New York Academy of Sciences

Volumn 1003, Issue , 2003, Pages 22-35

  Lipsky, Robert H ^a   Goldman, David ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Genomics; Ionotropic glutamate receptor genes; Missense variant; Polymorphism

Indexed keywords

AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; GLUTAMATE RECEPTOR; IONOTROPIC RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN SUBUNIT; SEROTONIN TRANSPORTER;

ADDICTION; ADRENERGIC TRANSMISSION; AMINO ACID SEQUENCE; ANXIETY DISORDER; BEHAVIOR; BEHAVIOR DISORDER; BRAIN DISEASE; BRAIN INJURY; CANONICAL ANALYSIS; CHROMOSOMAL LOCALIZATION; COGNITION; CONFERENCE PAPER; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DYSPHORIA; EPILEPSY; GENE FUNCTION; GENE LOCATION; GENETIC CONSERVATION; GENETIC CORRELATION; GENETIC SCREENING; GENETIC VARIABILITY; GENOMICS; GENOTYPE PHENOTYPE CORRELATION; GRIA2 GENE; GRIA3 GENE; GRIK1 GENE; GRIN2B GENE; GRIN3B GENE; HUMAN; LEARNING; MISSENSE MUTATION; MOLECULAR PHYLOGENY; MULTIGENE FAMILY; NEUROBIOLOGY; NEUROPATHOLOGY; NEUROPHARMACOLOGY; NOCICEPTION; NONHUMAN; PHARMACOGENOMICS; PROTEIN FUNCTION; RECEPTOR GENE; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SEQUENCE DATABASE; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SPECIES COMPARISON; SPECIES DIFFERENCE;

PROTEA;

EID: 0347722473     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1300.003     Document Type: Conference Paper

References (34)

1. ZUBIETA, J.K., M.M. HEITZEG, Y.R. SMITH, et al. 2003. COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 299: 1240-1243.
2. HARIRI, A.R., V.S. MATTAY, A. TESSITORE, et al. 2002. Serotonin transporter genetic variation and the response of the human amygdala. Science 297: 400-4003.
3. EGAN, M.F., M. KOJIMA, J.H. CALLICOTT, et al. 2003. The BDNF va166met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112: 257-269.
4. RUDOLPH, J.G., S. WHITE, C. SOKOLSKY, et al. 2002. Determination of melting temperature for variant detection using dHPLC: a comparison between an empirical approach and DNA melting prediction software. Genet Test. 6: 169-176.
5. WILLIAMS, N.M., T. BOWEN, G. SPURLOCK, et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Mol. Psychiatry 7: 508-514.
6. RICE, S.R., N. NIU, D.B. BERMAN, et al. 2001. Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1 receptor gene in schizophrenic patients. Mol. Psychiatry 6: 274-284.
7. OHTSUKI, T., K. SAKURAI, H. DOU, et al. 2001. Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. Mol. Psychiatry 6: 211-216.
8. CARGILL, M., D. ALTSHULER, J. IRELAND, et al. 1999. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. 22: 231-238.
9. WU, W.R., N. LI & B. A. SORG. 2002. Regulation of medial prefrontal cortex dopamine by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptors. Neuroscience 114: 507-516.
10. THOMAS, M.J., C. BEURRIER, A. BONCI & R.C. MALENKA. 2001. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nat. Neurosci. 12: 1217-1223.
11. GHASEMZADEH, M.B., L.C. NELSON, X.Y. LU & P.W. KALIVAS. 1999. Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment. J. Neurochem. 72: 157-165.
12. MEAD, A.N., A. VASILAKI, C. SPYRAKI, et al. 1999. AMPA-receptor involvement in c-fos expression in the medial prefrontal cortex and amygdala dissociates neural substrates of conditioned activity and conditioned reward. Eur. J. Neurosci. 11: 4089-4098.
13. SUTTON, M.A., E.F. SCHMIDT, K.H. CHOI, et al. 2003. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature 421: 70-75.
14. SATO, M., C.C. CHEN, K. AKIYAMA & S. OTSUKI. 1983. Acute exacerbation of paranoid psychotic state after long-term abstinence in patients with previous methamphetamine psychosis. Biol. Psychiatry 18: 429-440.
15. WANG, J. & P. O'DONNELL. 2001. D(1) dopamine receptors potentiate NMDA-mediated excitability increase in layer V prefrontal cortical pyramidal neurons. Cereb. Cortex 11: 452-462.
16. VENTURA, R., S. CABIB & S. PUGLISI-ALLEGRA. 2001. Opposite genotype-dependent mesocorticolimbic dopamine response to stress. Neuroscience 104: 627-631.
17. MIZOGUCHI, K., M. YUZURIHARA, A. ISHIGE, et al. 2000. Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. J. Neurosci. 20: 1568-1574.
18. CABIB, S., C. ORSINI, M. LE MOAL & P.V. PIAZZA. 2000. Abolition and reversal of strain differences in behavioral responses to drug of abuse after a brief experience. Science 289: 463-465.
19. MOHN, A.R., R.R. GAINETDINOV, M.G. CARON & B.H. KOLLER. 1999. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 98: 427-436.
20. MIYAMOTO, Y., K. YAMADA, Y. NODA, et al. 2001. Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor ε1 subunit. J. Neurosci. 21: 750-757.
21. OHTSUKI, T., K. SAKURAI, H. DOU, M. TORU, et al. 2001. Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. Mol. Psychiatry 6: 211-216.
22. ITOKAWA, M., K. YAMADA, K. YOSHITSUGU, et al. 2003. A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia. Pharmacogenetics 13: 271-278.
23. SHIBATA, H., A. SHIBATA, H. NINOMIYA, et al. 2002. Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia. Psychiatry Res. 113: 59-67.
24. SCHIFFER, H.H., G.T. SWANSON, E. MASLIAH & S.F. HEINEMANN. 2000. Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. J. Neurosci. 20: 9025-9033.
25. BEGNI, S., M. POPOLI, S. MORASCHI, et al. 2002. Association between the ionotropic glutamate receptor kainte 3 (GRIK3) ser310ala polymorphism and schizophrenia. Mol. Psychiatry 7: 416-418.
26. MAKINO, C., Y. FUJII, R. KIKUTA, et al. 2003. Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region. Am. J. Med. Genet. 116B: 16-22.
27. SIEGFRIED, B. & R.L. NUNES DE SOUZA. 1989. NMDA receptor blockade in the periaqueductal grey prevents stress-induced analgesia in attacked mice. Eur. J. Pharmacol. 168: 239-242.
28. JACQUET, Y.F. 1988. The NMDA receptor: central role in pain inhibition in rat periaqueductal gray. Eur. J. Pharmacol. 154: 271-276.
29. CHAPLAN, S.R., A.B. MALMBERG & T.L. YAKSH. 1997. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J. Pharmacol. Exp. Ther. 280: 829-838.
30. AANONSEN, L.M. & G.L. WILCOX. 1987. Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists. J. Pharmacol. Exp. Ther. 243: 9-19.
31. WATANABE, M. 1997. Developmental dynamics of gene expression for NMDA receptor channel. In The Ionotropic Glutamate Receptors. D.T. Mogaghan & R.J. Wenthold, Eds.: 189-218.Humana Press. Totowa, NJ.
32. MINAMI, T., J. SUGATANI, K. SAKIMURA, et al. 1997. Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice. Br. J. Pharmacol. 120: 1522-1526.
33. WAINAI, T., T. TAKEUCHI, N. SEO & M. MISHINA. 2001. Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. Neuroreport 12: 3169-3172.
34. WEI, F., G.D. WANG, G.A. KERCHNER, et al. 2001. Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat. Neurosci. 4: 164-169.