메뉴 건너뛰기




Volumn 75, Issue 1, 2004, Pages 18-26

Biology of Toll receptors: Lessons from insects and mammals

Author keywords

Drosophila; Innate immunity

Indexed keywords

MEMBRANE PROTEIN; TOLL LIKE RECEPTOR;

EID: 0842304592     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0403160     Document Type: Review
Times cited : (133)

References (107)
  • 2
    • 0037184995 scopus 로고    scopus 로고
    • Pattern recognition receptors: Doubling up for the innate immune response
    • Gordon, S. (2002) Pattern recognition receptors: doubling up for the innate immune response. Cell 111, 927-930.
    • (2002) Cell , vol.111 , pp. 927-930
    • Gordon, S.1
  • 3
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J., Hoffmann, J. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.4    Hoffmann, J.5
  • 4
    • 0037083557 scopus 로고    scopus 로고
    • The Toll pathway is required for resistance to gram-positive bacterial infections in Drosophila
    • Rutschmann, S., Kilinc, A., Ferrandon, D. (2002) The Toll pathway is required for resistance to gram- positive bacterial infections in Drosophila. J. Immunol. 168, 1542-1546.
    • (2002) J. Immunol. , vol.168 , pp. 1542-1546
    • Rutschmann, S.1    Kilinc, A.2    Ferrandon, D.3
  • 5
    • 0034708614 scopus 로고    scopus 로고
    • The Drosophila genome sequence: Implications for biology and medicine
    • Komberg, T. B., Krasnow, M. A. (2000) The Drosophila genome sequence: implications for biology and medicine. Science 287, 2218-2220.
    • (2000) Science , vol.287 , pp. 2218-2220
    • Komberg, T.B.1    Krasnow, M.A.2
  • 6
    • 0036167107 scopus 로고    scopus 로고
    • Drosophila innate immunity: An evolutionary perspective
    • Hoffmann, J. A., Reichhart, J. M. (2002) Drosophila innate immunity: an evolutionary perspective. Nat. Immunol. 3, 121-126.
    • (2002) Nat. Immunol. , vol.3 , pp. 121-126
    • Hoffmann, J.A.1    Reichhart, J.M.2
  • 7
    • 0037290892 scopus 로고    scopus 로고
    • Drosophila immunity: Paths and patterns
    • Hultmark, D. (2003) Drosophila immunity: paths and patterns. Curr. Opin. Immunol. 15, 12-19.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 12-19
    • Hultmark, D.1
  • 8
    • 0036160153 scopus 로고    scopus 로고
    • How Drosophila combats microbial infection: A model to study innate immunity and host-pathogen interactions
    • Tzou, P., De Gregorio, E., Lemaitre, B. (2002) How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions. Curr. Opin. Microbiol. 5, 102-110.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 102-110
    • Tzou, P.1    De Gregorio, E.2    Lemaitre, B.3
  • 10
    • 0037378655 scopus 로고    scopus 로고
    • Cutting edge: A toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
    • Bochud, P. Y., Hawn, T. R., Aderem, A. (2003) Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J. Immunol. 170, 3451-3454.
    • (2003) J. Immunol. , vol.170 , pp. 3451-3454
    • Bochud, P.Y.1    Hawn, T.R.2    Aderem, A.3
  • 12
    • 0033794461 scopus 로고    scopus 로고
    • A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection
    • Lorenz, E., Mira, J. P., Cornish, K. L., Arbour, N. C., Schwartz, D. A. (2000) A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect. Immun. 68, 6398-6401.
    • (2000) Infect. Immun. , vol.68 , pp. 6398-6401
    • Lorenz, E.1    Mira, J.P.2    Cornish, K.L.3    Arbour, N.C.4    Schwartz, D.A.5
  • 13
    • 0037465251 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
    • Dunne, A., O'Neill, L. A. (2003) The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE 2003, re3.
    • (2003) Sci STKE , vol.2003
    • Dunne, A.1    O'Neill, L.A.2
  • 14
    • 0035399769 scopus 로고    scopus 로고
    • Toll receptors in innate immunity
    • Imler, J., Hoffmann, J. A. (2001) Toll receptors in innate immunity. Trends Cell Biol. 11, 304-311.
    • (2001) Trends Cell Biol. , vol.11 , pp. 304-311
    • Imler, J.1    Hoffmann, J.A.2
  • 15
    • 0036467389 scopus 로고    scopus 로고
    • IL-1 and IL-18 receptors, and their extended family
    • Sims, J. E. (2002) IL-1 and IL-18 receptors, and their extended family. Curr. Opin. Immunol. 14, 117-122.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 117-122
    • Sims, J.E.1
  • 16
    • 0036793439 scopus 로고    scopus 로고
    • TIR-X and TIR-NBS proteins: Two new families related to disease resistance TIR-NBS-LRR proteins encoded in Arabidopsis and other plant genomes
    • Meyers, B. C., Morgante, M., Michelmore, R. W. (2002) TIR-X and TIR-NBS proteins: two new families related to disease resistance TIR-NBS-LRR proteins encoded in Arabidopsis and other plant genomes. Plant J. 32, 77-92.
    • (2002) Plant J. , vol.32 , pp. 77-92
    • Meyers, B.C.1    Morgante, M.2    Michelmore, R.W.3
  • 17
    • 0029347064 scopus 로고
    • The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 and the tobacco viral resistance gene N
    • Lawrence, G. J., Finnegan, E. J., Ayliffe, M. A., Ellis, J. G. (1995) The L6 gene for flax rust resistance is related to the Arabidopsis bacterial resistance gene RPS2 and the tobacco viral resistance gene N. Plant Cell 7, 1195-1206.
    • (1995) Plant Cell , vol.7 , pp. 1195-1206
    • Lawrence, G.J.1    Finnegan, E.J.2    Ayliffe, M.A.3    Ellis, J.G.4
  • 18
    • 0034098633 scopus 로고    scopus 로고
    • Independent evolution of Toll and related genes in insects and mammals
    • Luo, C., Zheng, L. (2000) Independent evolution of Toll and related genes in insects and mammals. Immunogenetics 51, 92-98.
    • (2000) Immunogenetics , vol.51 , pp. 92-98
    • Luo, C.1    Zheng, L.2
  • 19
    • 0036166242 scopus 로고    scopus 로고
    • The Drosophila Toll-9 activates a constitutive antimicrobial defense
    • Ooi, J. Y., Yagi, Y., Hu, X., Ip, Y. T. (2002) The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep. 3, 82-87.
    • (2002) EMBO Rep. , vol.3 , pp. 82-87
    • Ooi, J.Y.1    Yagi, Y.2    Hu, X.3    Ip, Y.T.4
  • 20
    • 0034641738 scopus 로고    scopus 로고
    • Toll-related receptors and the control of antimicrobial peptide expression in drosophila
    • Tauszig, S., Jouanguy, E., Hoffmann, J. A., Imler, J. L. (2000) Toll-related receptors and the control of antimicrobial peptide expression in drosophila. Proc. Natl. Acad. Sci. USA 97, 10520-10525.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10520-10525
    • Tauszig, S.1    Jouanguy, E.2    Hoffmann, J.A.3    Imler, J.L.4
  • 23
    • 0036453721 scopus 로고    scopus 로고
    • Evolution of the TIR, tolls and TLRs: Functional inferences from computational biology
    • Beutler, B., Rehli, M. (2002) Evolution of the TIR, tolls and TLRs: functional inferences from computational biology. Curr. Top. Microbiol. Immunol. 270, 1-21.
    • (2002) Curr. Top. Microbiol. Immunol. , vol.270 , pp. 1-21
    • Beutler, B.1    Rehli, M.2
  • 24
    • 0036712463 scopus 로고    scopus 로고
    • Characterization of four Toll related genes during development and immune responses in Anopheles gambiae
    • Luna, C., Wang, X., Huang, Y., Zhang, J., Zheng, L. (2002) Characterization of four Toll related genes during development and immune responses in Anopheles gambiae. Insect Biochem. Mol. Biol. 32, 1171-1179.
    • (2002) Insect Biochem. Mol. Biol. , vol.32 , pp. 1171-1179
    • Luna, C.1    Wang, X.2    Huang, Y.3    Zhang, J.4    Zheng, L.5
  • 25
    • 0036023960 scopus 로고    scopus 로고
    • Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila
    • Ligoxygakis, P., Bulet, P., Reichhart, J. M. (2002) Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila. EMBO Rep. 3, 666-673.
    • (2002) EMBO Rep. , vol.3 , pp. 666-673
    • Ligoxygakis, P.1    Bulet, P.2    Reichhart, J.M.3
  • 26
    • 0036141954 scopus 로고    scopus 로고
    • Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
    • Tauszig-Delamasure, S., Bilak, H., Capovilla, M., Hoffmann, J. A., Imler, J. L. (2002) Drosophila MyD88 is required for the response to fungal and Gram- positive bacterial infections. Nat. Immunol. 3, 91-97.
    • (2002) Nat. Immunol. , vol.3 , pp. 91-97
    • Tauszig-Delamasure, S.1    Bilak, H.2    Capovilla, M.3    Hoffmann, J.A.4    Imler, J.L.5
  • 28
    • 0034777255 scopus 로고    scopus 로고
    • Tehao functions in the Toll pathway in Drosophila melanogaster: Possible roles in development and innate immunity
    • Luo, C., Shen, B., Manley, J. L., Zheng, L. (2001) Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Insect Mol. Biol. 10, 457-464.
    • (2001) Insect Mol. Biol. , vol.10 , pp. 457-464
    • Luo, C.1    Shen, B.2    Manley, J.L.3    Zheng, L.4
  • 29
    • 0036952124 scopus 로고    scopus 로고
    • Tissue and stage-specific expression of the Tolls in Drosophila embryos
    • Kambris, Z., Hoffmann, J. A., Imler, J. L., Capovilla, M. (2002) Tissue and stage-specific expression of the Tolls in Drosophila embryos. Gene Expr. Patterns 2, 311-317.
    • (2002) Gene Expr. Patterns , vol.2 , pp. 311-317
    • Kambris, Z.1    Hoffmann, J.A.2    Imler, J.L.3    Capovilla, M.4
  • 30
    • 0029730738 scopus 로고    scopus 로고
    • A conserved signaling pathway: The Drosophila toll-dorsal pathway
    • Belvin, M. P., Anderson, K. V. (1996) A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu. Rev. Cell Dev. Biol. 12, 393-416.
    • (1996) Annu. Rev. Cell Dev. Biol. , vol.12 , pp. 393-416
    • Belvin, M.P.1    Anderson, K.V.2
  • 31
    • 0028038271 scopus 로고
    • Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
    • Chiang, C., Beachy, P. A. (1994) Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila. Mech. Dev. 47, 225-239.
    • (1994) Mech. Dev. , vol.47 , pp. 225-239
    • Chiang, C.1    Beachy, P.A.2
  • 32
    • 0028326047 scopus 로고
    • The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll
    • Eldon, E., Kooyer, S., D'Evelyn, D., Duman, M., Lawinger, P., Botas, J., Bellen, H. (1994) The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll. Development 120, 885-899.
    • (1994) Development , vol.120 , pp. 885-899
    • Eldon, E.1    Kooyer, S.2    D'Evelyn, D.3    Duman, M.4    Lawinger, P.5    Botas, J.6    Bellen, H.7
  • 33
    • 0037383779 scopus 로고    scopus 로고
    • Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells
    • Seppo, A., Matani, P., Sharrow, M., Tiemeyer, M. (2003) Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Development 130, 1439-1448.
    • (2003) Development , vol.130 , pp. 1439-1448
    • Seppo, A.1    Matani, P.2    Sharrow, M.3    Tiemeyer, M.4
  • 35
    • 0345561540 scopus 로고    scopus 로고
    • Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
    • see comments
    • Qureshi, S. T., Lariviere, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., Malo, D. (1999) Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189, 615-625 (see comments) (published erratum appears in J Exp Med 1999 May 3;189(9):following 1518).
    • (1999) J. Exp. Med. , vol.189 , pp. 615-625
    • Qureshi, S.T.1    Lariviere, L.2    Leveque, G.3    Clermont, S.4    Moore, K.J.5    Gros, P.6    Malo, D.7
  • 36
    • 0345561540 scopus 로고    scopus 로고
    • (published erratum appears, May 3; following 1518)
    • Qureshi, S. T., Lariviere, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., Malo, D. (1999) Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189, 615-625 (see comments) (published erratum appears in J Exp Med 1999 May 3;189(9):following 1518).
    • (1999) J Exp Med , vol.189 , Issue.9
  • 37
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., Akira, S. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 40
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R. L., Akira, S. (2002) Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10-14.
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5    Dong, Z.6    Modlin, R.L.7    Akira, S.8
  • 41
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll- like receptor 3
    • Alexopoulou, L., Holt, A. C., Medzhitov, R., Flavell, R. A. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll- like receptor 3. Nature 413, 732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 45
    • 0037036469 scopus 로고    scopus 로고
    • TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells
    • Abreu, M. T., Arnold, E. T., Thomas, L. S., Gonsky, R., Zhou, Y., Hu, B., Arditi, M. (2002) TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J. Biol. Chem. 277, 20431-20437.
    • (2002) J. Biol. Chem. , vol.277 , pp. 20431-20437
    • Abreu, M.T.1    Arnold, E.T.2    Thomas, L.S.3    Gonsky, R.4    Zhou, Y.5    Hu, B.6    Arditi, M.7
  • 46
    • 0034703072 scopus 로고    scopus 로고
    • CD14-dependent lipopolysaccharide-induced beta -defensin-2 expression in human tracheobronchial epithelium
    • Becker, M. N., Diamond, G., Verghese, M. W., Randell, S. H. (2000) CD14-dependent lipopolysaccharide-induced beta -defensin-2 expression in human tracheobronchial epithelium. J. Biol. Chem. 275, 29731-29736.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29731-29736
    • Becker, M.N.1    Diamond, G.2    Verghese, M.W.3    Randell, S.H.4
  • 47
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., Madara, J. L. (2001) Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167, 1882-1885.
    • (2001) J. Immunol. , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 48
    • 0037018107 scopus 로고    scopus 로고
    • Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells
    • Hornef, M. W., Frisan, T., Vandewalle, A., Normark, S., Richter-Dahlfors, A. (2002) Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J. Exp. Med. 195, 559-570.
    • (2002) J. Exp. Med. , vol.195 , pp. 559-570
    • Hornef, M.W.1    Frisan, T.2    Vandewalle, A.3    Normark, S.4    Richter-Dahlfors, A.5
  • 52
    • 0032997542 scopus 로고    scopus 로고
    • Recognition of gram-negative bacteria and endotoxin by the innate immune system
    • Ulevitch, R. J., Tobias, P. S. (1999) Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr. Opin. Immunol. 11, 19-22.
    • (1999) Curr. Opin. Immunol. , vol.11 , pp. 19-22
    • Ulevitch, R.J.1    Tobias, P.S.2
  • 54
    • 0037097672 scopus 로고    scopus 로고
    • Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4
    • Guillot, L., Balloy, V., McCormack, F. X., Golenbock, D. T., Chignard, M., Si-Tahar, M. (2002) Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J. Immunol. 168, 5989-5992.
    • (2002) J. Immunol. , vol.168 , pp. 5989-5992
    • Guillot, L.1    Balloy, V.2    McCormack, F.X.3    Golenbock, D.T.4    Chignard, M.5    Si-Tahar, M.6
  • 55
    • 0037094084 scopus 로고    scopus 로고
    • Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
    • Johnson, G. B., Brunn, G. J., Kodaira, Y., Platt, J. L. (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J. Immunol. 168, 5233-5239.
    • (2002) J. Immunol. , vol.168 , pp. 5233-5239
    • Johnson, G.B.1    Brunn, G.J.2    Kodaira, Y.3    Platt, J.L.4
  • 57
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley, S. T., King, J. A., Hancock, W. W. (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J. Immunol. 167, 2887-2894.
    • (2001) J. Immunol. , vol.167 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 60
    • 0037414787 scopus 로고    scopus 로고
    • Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages
    • Gao, B., Tsan, M. F. (2003) Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages. J. Biol. Chem. 278, 174-179.
    • (2003) J. Biol. Chem. , vol.278 , pp. 174-179
    • Gao, B.1    Tsan, M.F.2
  • 61
    • 0035877718 scopus 로고    scopus 로고
    • Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2
    • da Silva Correia, J., Soldau, K., Christen, U., Tobias, P. S., Ulevitch, R. J. (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276, 21129-21135.
    • (2001) J. Biol. Chem. , vol.276 , pp. 21129-21135
    • Da Silva Correia, J.1    Soldau, K.2    Christen, U.3    Tobias, P.S.4    Ulevitch, R.J.5
  • 63
    • 0034007076 scopus 로고    scopus 로고
    • Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
    • Poltorak, A., Ricciardi-Castagnoli, P., Citterio, S., Beutler, B. (2000) Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation. Proc. Natl. Acad. Sci. USA 97, 2163-2167.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2163-2167
    • Poltorak, A.1    Ricciardi-Castagnoli, P.2    Citterio, S.3    Beutler, B.4
  • 64
    • 0032033030 scopus 로고    scopus 로고
    • Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity
    • DeLotto, Y., DeLotto, R. (1998) Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity. Mech. Dev. 72, 141-148.
    • (1998) Mech. Dev. , vol.72 , pp. 141-148
    • DeLotto, Y.1    DeLotto, R.2
  • 66
    • 0035479747 scopus 로고    scopus 로고
    • A family of proteins related to Spatzle, the toll receptor ligand, are encoded in the Drosophila genome
    • Parker, J. S., Mizuguchi, K., Gay, N. J. (2001) A family of proteins related to Spatzle, the toll receptor ligand, are encoded in the Drosophila genome. Proteins 45, 71-80.
    • (2001) Proteins , vol.45 , pp. 71-80
    • Parker, J.S.1    Mizuguchi, K.2    Gay, N.J.3
  • 67
    • 0035856990 scopus 로고    scopus 로고
    • Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
    • Michel, T., Reichhart, J. M., Hoffmann, J. A., Royet, J. (2001) Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414, 756-759.
    • (2001) Nature , vol.414 , pp. 756-759
    • Michel, T.1    Reichhart, J.M.2    Hoffmann, J.A.3    Royet, J.4
  • 68
    • 0037025213 scopus 로고    scopus 로고
    • Activation of Drosophila Toll during fungal infection by a blood serine protease
    • Ligoxygakis, P., Pelte, N., Hoffmann, J. A., Reichhart, J. M. (2002) Activation of Drosophila Toll during fungal infection by a blood serine protease. Science 297, 114-116.
    • (2002) Science , vol.297 , pp. 114-116
    • Ligoxygakis, P.1    Pelte, N.2    Hoffmann, J.A.3    Reichhart, J.M.4
  • 69
    • 0037218616 scopus 로고    scopus 로고
    • By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide
    • Liu, L., Roberts, A. A., Ganz, T. (2003) By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide. J. Immunol. 170, 575-580.
    • (2003) J. Immunol. , vol.170 , pp. 575-580
    • Liu, L.1    Roberts, A.A.2    Ganz, T.3
  • 71
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov, R. (2001) Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1, 135-145.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 72
    • 0036709969 scopus 로고    scopus 로고
    • A universal role for MyD88 in TLR/IL-1R-mediated signaling
    • Janssens, S., Beyaert, R. (2002) A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem. Sci. 27, 474-482.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 474-482
    • Janssens, S.1    Beyaert, R.2
  • 73
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., Adachi, O., Ogawa, T., Takeda, K., Akira, S. (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122.
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 74
    • 0033968625 scopus 로고    scopus 로고
    • Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
    • In Process Citation
    • Takeuchi, O., Takeda, K., Hoshino, K., Adachi, O., Ogawa, T., Akira, S. (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12, 113-117 (In Process Citation).
    • (2000) Int. Immunol. , vol.12 , pp. 113-117
    • Takeuchi, O.1    Takeda, K.2    Hoshino, K.3    Adachi, O.4    Ogawa, T.5    Akira, S.6
  • 75
    • 0035339861 scopus 로고    scopus 로고
    • Endotoxin-induced maturation of MyD88-deficient dendritic cells
    • Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K., Akira, S. (2001) Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166, 5688-5694.
    • (2001) J. Immunol. , vol.166 , pp. 5688-5694
    • Kaisho, T.1    Takeuchi, O.2    Kawai, T.3    Hoshino, K.4    Akira, S.5
  • 77
    • 0035889228 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    • Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Muhlradt, P. F., Sato, S., Hoshino, K., Akira, S. (2001) Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167, 5887-5894.
    • (2001) J. Immunol. , vol.167 , pp. 5887-5894
    • Kawai, T.1    Takeuchi, O.2    Fujita, T.3    Inoue, J.4    Muhlradt, P.F.5    Sato, S.6    Hoshino, K.7    Akira, S.8
  • 78
    • 0037153130 scopus 로고    scopus 로고
    • The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
    • Horng, T., Barton, G. M., Flavell, R. A., Medzhitov, R. (2002) The adaptor molecule TIRAP provides signalling specificity for Toll- like receptors. Nature 420, 329-333.
    • (2002) Nature , vol.420 , pp. 329-333
    • Horng, T.1    Barton, G.M.2    Flavell, R.A.3    Medzhitov, R.4
  • 80
    • 0037307766 scopus 로고    scopus 로고
    • Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo
    • Charatsi, I., Luschnig, S., Bartoszewski, S., Nusslein-Volhard, C., Moussian, B. (2003) Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo. Mech. Dev. 120, 219-226.
    • (2003) Mech. Dev. , vol.120 , pp. 219-226
    • Charatsi, I.1    Luschnig, S.2    Bartoszewski, S.3    Nusslein-Volhard, C.4    Moussian, B.5
  • 81
    • 0035940499 scopus 로고    scopus 로고
    • Drosophila MyD88 is an adapter in the Toll signaling pathway
    • Horng, T., Medzhitov, R. (2001) Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc. Natl. Acad. Sci. USA 98, 12654-12658.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12654-12658
    • Horng, T.1    Medzhitov, R.2
  • 83
    • 0037320451 scopus 로고    scopus 로고
    • TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-β induction
    • Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., Seya, T. (2003) TICAM-1, an adapter molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nat. Immunol. 4, 161-167.
    • (2003) Nat. Immunol. , vol.4 , pp. 161-167
    • Oshiumi, H.1    Matsumoto, M.2    Funami, K.3    Akazawa, T.4    Seya, T.5
  • 84
    • 0037114185 scopus 로고    scopus 로고
    • Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-beta Promoter in the Toll-Like Receptor Signaling
    • Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., Akira, S. (2002) Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-beta Promoter in the Toll-Like Receptor Signaling. J. Immunol. 169, 6668-6672.
    • (2002) J. Immunol. , vol.169 , pp. 6668-6672
    • Yamamoto, M.1    Sato, S.2    Mori, K.3    Hoshino, K.4    Takeuchi, O.5    Takeda, K.6    Akira, S.7
  • 85
    • 0037454946 scopus 로고    scopus 로고
    • Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
    • Burns, K., Janssens, S., Brissoni, B., Olivos, N., Beyaert, R., Tschopp, J. (2003) Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197, 263-268.
    • (2003) J. Exp. Med. , vol.197 , pp. 263-268
    • Burns, K.1    Janssens, S.2    Brissoni, B.3    Olivos, N.4    Beyaert, R.5    Tschopp, J.6
  • 87
    • 0037292275 scopus 로고    scopus 로고
    • Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members
    • Janssens, S., Beyaert, R. (2003) Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 11, 293-302.
    • (2003) Mol. Cell , vol.11 , pp. 293-302
    • Janssens, S.1    Beyaert, R.2
  • 89
    • 0034655280 scopus 로고    scopus 로고
    • IL-1 receptor-associated kinase modulates host responsiveness to endotoxin
    • Swantek, J. L., Tsen, M. F., Cobb, M. H. Thomas, J. A. (2000) IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J. Immunol. 164, 4301-4306.
    • (2000) J. Immunol. , vol.164 , pp. 4301-4306
    • Swantek, J.L.1    Tsen, M.F.2    Cobb, M.H.3    Thomas, J.A.4
  • 92
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., Chen, Z. J. (2000) Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361.
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1    Wang, C.2    Spencer, E.3    Yang, L.4    Braun, A.5    You, J.6    Slaughter, C.7    Pickart, C.8    Chen, Z.J.9
  • 93
  • 94
    • 0035883151 scopus 로고    scopus 로고
    • NF-kappaB signaling pathways in mammalian and insect innate immunity
    • Silverman, N., Maniatis, T. (2001) NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15, 2321-2342.
    • (2001) Genes Dev. , vol.15 , pp. 2321-2342
    • Silverman, N.1    Maniatis, T.2
  • 95
    • 0035187882 scopus 로고    scopus 로고
    • The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase
    • Lu, Y., Wu, L. P., Anderson, K. V. (2001) The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase. Genes Dev. 15, 104-110.
    • (2001) Genes Dev. , vol.15 , pp. 104-110
    • Lu, Y.1    Wu, L.P.2    Anderson, K.V.3
  • 97
    • 18744372992 scopus 로고    scopus 로고
    • The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway
    • Avila, A., Silverman, N., Diaz-Meco, M. T., Moscat, J. (2002) The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Mol. Cell. Biol. 22, 8787-8795.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8787-8795
    • Avila, A.1    Silverman, N.2    Diaz-Meco, M.T.3    Moscat, J.4
  • 99
    • 0038701608 scopus 로고    scopus 로고
    • Double-stranded RNA Signaling by Toll-like Receptor 3 Requires Specific Tyrosine Residues in Its Cytoplasmic Domain
    • Sarkar, S. N., Smith, H. L., Rowe, T. M., Sen, G. C. (2003) Double-stranded RNA Signaling by Toll-like Receptor 3 Requires Specific Tyrosine Residues in Its Cytoplasmic Domain. J. Biol. Chem. 278, 4393-4396.
    • (2003) J. Biol. Chem. , vol.278 , pp. 4393-4396
    • Sarkar, S.N.1    Smith, H.L.2    Rowe, T.M.3    Sen, G.C.4
  • 101
    • 0037446651 scopus 로고    scopus 로고
    • Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response
    • Muraille, E., De Trez, C., Brait, M., De Baetselier, P., Leo, O., Carlier, Y. (2003) Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J. Immunol. 170, 4237-4241.
    • (2003) J. Immunol. , vol.170 , pp. 4237-4241
    • Muraille, E.1    De Trez, C.2    Brait, M.3    De Baetselier, P.4    Leo, O.5    Carlier, Y.6
  • 102
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, Toll-like Receptor 4-dependent T Helper Cell Type 2 Responses to Inhaled Antigen
    • Eisenbarth, S. C., Piggott, D. A., Huleatt, J. W., Visintin, I., Herrick, C. A., Bottomly, K. (2002) Lipopolysaccharide-enhanced, Toll-like Receptor 4-dependent T Helper Cell Type 2 Responses to Inhaled Antigen. J. Exp. Med. 196, 1645-1651.
    • (2002) J. Exp. Med. , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 103
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K. J., Powrie, F. (2001) Regulatory T cells in the control of immune pathology. Nat. Immunol. 2, 816-822.
    • (2001) Nat. Immunol. , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 104
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C., Medzhitov, R. (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 106
  • 107
    • 0031574072 scopus 로고    scopus 로고
    • The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools
    • Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., Higgins, D. G. (1997) The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25, 4876-4882.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 4876-4882
    • Thompson, J.D.1    Gibson, T.J.2    Plewniak, F.3    Jeanmougin, F.4    Higgins, D.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.