The antibacterial arm of the Drosophila innate immune response requires an IκB kinase

Genes and Development

Volumn 15, Issue 1, 2001, Pages 104-110

  Lu, Yiran ^a,b   Wu, Louisa P ^a,c   Anderson, Kathryn V ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

Antimicrobial peptide; Drosophila; I B kinase; Innate immunity; NF B; Relish

Indexed keywords

GENE PRODUCT; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRD5 PROTEIN; PHOSPHOTRANSFERASE; RELISH PROTEIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; DROSOPHILA; ESCHERICHIA COLI; GENE INDUCTION; GENE MUTATION; GENE SEQUENCE; IMMUNE RESPONSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTI-BACTERIAL AGENTS; BETA-GALACTOSIDASE; CROSSES, GENETIC; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ESCHERICHIA COLI; FEMALE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; I-KAPPA B KINASE; LARVA; MALE; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

ANIMALIA; ESCHERICHIA COLI; MAMMALIA;

EID: 0035187882     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.856901     Document Type: Article

References (40)

1. Toll signaling pathways in the innate immune response
2. Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product
3. Tlr4: Central component of the sole mammalian LPS sensor
4. Targeted gene expression as a means of altering cell rates and generating dominant phenotypes
5. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
6. Characterization of an immunodeficiency mutant in Drosophila
7. mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila
8. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
9. Origins of immunity: Relish, a compound Rel-like gene in the antibacterJal defense of Drosophila
10. Interactions between the cellular and humoral immune responses in Drosophila
11. Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects
12. Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
13. Innate Jmmunity of Jnsects
14. Immune reactions in Drosophila and other insects: A model for innate immunJty
15. Dif, a dorsal-related gene that mediates an immune response in Drosophila
16. Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells
17. A recessive mutation, immune deficJency (imd), defines two distinct control pathways in the Drosophila host defense
18. Functional analysis and regulation of nuclear import of Dorsal during the immune response in Drosophila
19. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
20. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
21. The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection
22. Two distinet pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin
23. Severe liver degeneratJon in mice lacking the IκB kinase 2 gene
24. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor KB activation and prevention of apoptosis
25. A mosaic analysis in Drosophila far body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
26. Innate immune recognition: Mechanisms and pathways
27. Toll receptor mediated Drosophila immune response requires Dif, an NF-κB factor
28. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
29. Identffication and characterization of an IκB kinase
30. The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
31. A Drosophila IκB kJnase complex required for Relish cleavage and antibacterial immunity
32. P element-mediated transformation
33. Genetic analysis of protein kinase B (AKT) in Drosophila
34. Activation of the Drosophila NF-κB factor Relish by rapid endoproteolytic cleavage
35. Differential roles of TLR2 and TLR4 in recognition of gram-negative and grampositive bacterial cell wall components
36. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
37. The Lps gene, Insights into the genetic and molecular basis of LPS responsiveness and macrophage differentiation
38. Looking at embryos
39. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
40. Regulated nuclear import of Rel proteins in the Drosophila immune response