By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharide

Journal of Immunology

Volumn 170, Issue 1, 2003, Pages 575-580

  Liu, Lide ^a   Roberts, Alice A ^a   Ganz, Tomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BETA DEFENSIN; BETA DEFENSIN 2; DNA; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; BONE MARROW CELL; CELL CULTURE; CONTROLLED STUDY; DNA MICROARRAY; EPIDERMIS; EPIDERMIS CELL; GENE EXPRESSION; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; KERATINOCYTE; LANGERHANS CELL; MONOCYTE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

EID: 0037218616     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.1.575     Document Type: Article

References (41)

1. Ganz, T. 2002. Epithelia: Not just physical barriers. Proc. Natl. Acad. Sci. USA 99:3357.
2. Harder, J., J. Bartels, E. Christophers, and J.-M. Schroeder. 1997. A peptide antibiotic from human skin. Nature 387:861.
3. Singh, P. K., H. P. Jia. K. Wiles, J. Hesselberth, L. Liu, B. D. Conway, E. P. Greenberg, E. V. Valore, M. J. Welsh, T. Ganz, et al. 1998. Production of β-defensins by human airway epithelia. Proc. Natl. Acad. Sci. USA 95:14961.
4. Liu, A. Y., D. Destoumieux, A. V. Wong, C. H. Park, E. V. Valore, L. Liu, and T. Ganz. 2002. Human β-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J. Invest. Dermatol. 118:275.
5. Liu, L., L. Wang, H. P. Jia, C. Zhao, H. H. Q. Heng, B. C. Schutte, P. B. J. McCray, and T. Ganz. 1998. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222:237.
6. Raetz, C. R., R. J. Ulevitch, S. D. Wright, C. H. Sibley, A. Ding, and C. F. Nathan. 1991. Gram-negative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J. 5:2652.
7. Beutler, B. 2000. Endotoxin. Toll-like receptor 4, and the afferent limb of innate immunity. Curr. Opin. Microbiol. 3:23.
8. Poltorak, A., X. He, I. Smimova, M. Y. Liu, C. V. Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282:2085.
9. Asai, Y., Y. Ohyama, K. Gen, and T. Ogawa. 2001. Bacterial fimbriae and their peptides activate human gingival epithelial cells through Toll-like receptor 2. Infect. Immun. 69:7387.
10. Cario, E., D. Brown, M. McKee, K. Lynch-Devaney, G. Gerken, and D. K. Podolsky. 2002. Commensal-associated molecular patterns induce selective Toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am. J. Pathol. 160:165.
11. Cario, E., and D. K. Podolsky. 2000. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 68:7010.
12. Fusunyan, R. D., N. N. Nanthakumar, M. E. Baldeon, and W. A. Walker. 2001. Evidence for an innate immune response in the immature human intestine: Toll-like receptors on fetal enterocytes. Pediatr. Res. 49:589.
13. Hornef, M. W., T. Frisan, A. Vandewalle, S. Normark. and A. Richter-Dahlfors. 2002. Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J. Exp. Med. 195:559.
14. Song, P. I., T. A. Abraham, Y. Park, A. S. Zivony. B. Harten, H. F. Edelhauser, S. L. Ward, C. A. Armstrong, and J. C. Ansel. 2001. The expression of functional LPS receptor proteins CD14 and Toll-like receptor 4 in human corneal cells. Invest. Ophthalmol. Visual Sci. 42:2867.
15. Wolfs, T. G., W. A. Buurman, A. van Schadewijk, B. de Vries, M. A. Daemen, P. S. Hiemstra, and C. van't Veer. 2002. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated up-regulation during inflammation. J. Immunol. 168:1286.
16. Dinarello, C. A. 1994. The biological properties of interieukin-1. Eur. Cytokine Network 5:517.
17. Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095.
18. Murphy, J. E., C. Robert, and T. S. Kupper. 2000. Interleukin-1 and cutaneous inflammation: A crucial link between innate and acquired immunity. J. Invest. Dermatol. 114:602.
19. Debets, R., J. P. Hegmans, P. Croughs, R. J. Troost, J. B. Prins, R. Benner, and E. P. Prens. 1997. The IL-1 system in psoriatic skin: IL-1 antagonist sphere of influence in lesional psoriatic epidermis. J. Immunol. 158:2955.
20. Carter. D. B., M. R. Deibel, Jr., C. J. Dunn, C. S. Tomich, A. L. Laborde, J. L. Slightom, A. E. Berger, M. J. Bienkowski, F. F. Sun, R. N. McEwan, et al. 1990. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344:633.
21. Irikura, V. M., M. Lagraoui, and D. Hirsh. 2002. The epistatic interrelationships of IL-1, IL-1 receptor antagonist, and the type I IL-1 receptor. J. Immunol. 169:393.
22. Freeman, B. D., and T. G. Buchman. 2001. Interleukin-1 receptor antagonist as therapy for inflammatory disorders. Expert Opin. Biol. Ther. 1:301.
23. Schagger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochein. 166:368.
24. Diamond, G., J. P. Russell, and C. L. Bevins. 1996. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc. Natl. Acad. Sci. USA 93:5156.
25. Diamond, G., V. Kaiser. J. Rhodes, J. P. Russell, and C. L. Bevins. 2000. Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells. Infect. Immun. 68:113.
26. Schonwetter. B. S., E. D. Stolzenberg, and M. A. Zasloff. 1995. Epithelial antibiotics induced at sites of inflammation. Science 267:1645.
27. Gewirtz, A. T., T. A. Navas, S. Lyons, P. J. Godowski, and J. L. Madara. 2001. Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167:1882.
28. Abreu, M. T., P. Vora, E. Faure. L. S. Thomas, E. T. Arnold, and M. Arditi. 2001. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J. Immunol. 167:1609.
29. Watson, P. H., E. R. Leygue, and L. C. Murphy. 1998. Psoriasin (S100A7). Int. J. Biochem. Cell Biol. 30:567.
30. Cabral, A., P. Voskamp, A. M. Cleton-Jansen, A. South, D. Nizetic, and C. Baekendorf. 2001. Structural organization and regulation of the small proline-rich family of comified envelope precursors suggest a role in adaptive barrier function. J. Biol. Chem. 276:19231.
31. Sauder, D. N., C. A. Dinarello, and V. B. Morhenn. 1984. Langerhans cell production of interleukin-1. J. Invest. Dermatol. 82:605.
32. Mizutani, H., R. Black, and T. S. Kupper. 1991. Human keratinocytes produce but do not process pro-interleukin-1 (IL-1)β: Different strategies of IL-1 production and processing in monocytes and keratinocytes. J. Clin. Invest. 87:1066.
33. Lee, R. T., W. H. Briggs, G. C. Cheng, H. B. Rossiter, P. Libby, and T. Kupper. 1997. Mechanical deformation promotes secretion of IL-1α and IL-1 receptor antagonist. J. Immunol. 159:5084.
34. Cumberbatch, M., C. E. Griffiths, S. C. Tucker, R. J. Dearman, and I. Kimber. 1999. Tumour necrosis factor-α induces Langerhans cell migration in humans. Br. J. Dermatol. 141:192.
35. Rasanen, L., M. Lehto, C. Jansen, T. Reunala. and P. Leinikki. 1986. Human epidermal Langerhans cells and peripheral blood monocytes: Accessory cell function, autoactivating and alloactivating capacity and ETAF/IL-1 production. Scand. J. Immunol. 24:503.
36. Erdag, G., and J. R. Morgan. 2002. Interleukin-1α and interleukin-6 enhance the antibacterial properties of cultured composite keratinocyte grafts. Ann. Surg. 235:113.
37. Lehrer, R. I., A. K. Lichtenstein, and T. Ganz. 1993. Defensins: Antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. Immunol. 11:105.
38. Oren, A., T. Ganz, L. Liu, and T. Meerloo. In human epidermis, β-defensin-2 is packaged in lamellar bodies. Exp. Mol. Pathol. In press.
39. Nizet, V., T. Ohtake, X. Lauth, J. Trowbridge, J. Rudisill, R. A. Dorschner, V. Pestonjamasp, J. Piraino, K. Huttner, and R. L. Gallo. 2001. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454.
40. Christophers, E., and T. Henseler. 1987. Contrasting disease patterns in psoriasis and atopic dermatitis. Arch. Dermatol. Res. 279(Suppl.):S48.
41. Ong, P. Y., T. Ohtake, C. Brandt, I. Strickland, M. Boguniewicz, T. Ganz, R. L. Gallo, and D. Y. Leung. 2002. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347:1151.