A family of proteins related to Spätzle, the Toll receptor ligand, are encoded in the Drosophila genome

Proteins: Structure, Function and Genetics

Volumn 45, Issue 1, 2001, Pages 71-80

  Parker, James ^a   Mizuguchi, Kenji ^a   Gay, N J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Conserved gene structure; Cystine knot fold; Embryonic development; Innate immunity

Indexed keywords

CYSTINE; LIGAND; TOLL LIKE RECEPTOR;

ADOLESCENT; ARTICLE; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE DUPLICATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE STRUCTURE; GENETIC CODE; GENETIC CONSERVATION; GENOME; IMMUNITY; INTRON; LARVA; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FOLDING;

DROSOPHILA;

EID: 0035479747     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.1125     Document Type: Article

References (34)

1. A conserved signaling pathway: Them Drosophila toll-dorsal pathway
2. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
3. Drosophila immunity
4. Phylogenetic perspectives in innate immunity
5. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
6. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
7. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
8. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
9. Regulated nuclear import of Rel proteins in the Drosophila immune response
10. A family of human receptors structurally related to Drosophila Toll
11. TLR6: A novel member of an expanding toll-like receptor family
12. Innate immunity: The virtues of a nonclonal system of recognition
13. Lipoproteins take their toll on the host
14. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
15. The genome sequence of Drosophila melanogaster
16. Getting knotted: A model for the structure and activation of Spatzle
17. Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity
18. Horseshoe crab coagulogen is an invertebrate protein with a nerve growth factor-like domain
19. Nerve growth factor revisited
20. Crystal structure of a coagulogen, the clotting protein from horseshoe crab: A structural homologue of nerve growth factor
21. The spatzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
22. Gapped Blast and PSI-Blast: A new generation of protein database search programs
23. Homstrad: A database of protein structure alignments for homologous families
24. Scop: A structural classification of proteins database for the investigation of sequences and structures
25. Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
26. Joy: Protein sequence-structure representation and analysis
27. Complementary DNA sequencing: Expressed sequence tags and human genome project
28. A Drosophila complementary DNA resource
29. Splicing signals in Drosophila: Intron size, information content, and consensus sequences
30. Prediction of complete gene structures in human genomic DNA
31. Psort: A program for detecting sorting signals in proteins and predicting their subcellular localization
32. On the predictive recognition of signal peptide sequences
33. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila