메뉴 건너뛰기




Volumn 11, Issue 1, 1999, Pages 19-22

Recognition of Gram-negative bacteria and endotoxin by the innate immune system

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; ENDOTOXIN;

EID: 0032997542     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)80004-1     Document Type: Review
Times cited : (501)

References (37)
  • 3
    • 0022462376 scopus 로고
    • Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum
    • Tobias P, Soldau K, Ulevitch R Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med. 164:1986;777-793.
    • (1986) J Exp Med , vol.164 , pp. 777-793
    • Tobias, P.1    Soldau, K.2    Ulevitch, R.3
  • 4
    • 0024464813 scopus 로고
    • Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages
    • Wright SD, Tobias PS, Ulevitch RJ, Ramos RA Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J Exp Med. 170:1989;1231-1241.
    • (1989) J Exp Med , vol.170 , pp. 1231-1241
    • Wright, S.D.1    Tobias, P.S.2    Ulevitch, R.J.3    Ramos, R.A.4
  • 6
    • 0025166114 scopus 로고
    • CD14 serves as the cellular receptor for complexes of lipopolysaccharide with lipopolysaccharide binding protein
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC CD14 serves as the cellular receptor for complexes of lipopolysaccharide with lipopolysaccharide binding protein. Science. 249:1990;1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 7
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • This paper describes the cloning and some characteristics of the first human toll-like receptor. A link between the innate immune system of Drosophila and man is provided by the data of this report; signalling from the cell surface to the nucleus is shown to be a property of this receptor.
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:1997;394-397. This paper describes the cloning and some characteristics of the first human toll-like receptor. A link between the innate immune system of Drosophila and man is provided by the data of this report; signalling from the cell surface to the nucleus is shown to be a property of this receptor.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway C.A., Jr.3
  • 8
    • 0031905311 scopus 로고    scopus 로고
    • A family of human receptors structurally related to Drosophila toll
    • A description of a family of human Toll-like receptors is presented in this report. The first hint that Toll-like-receptor 4 might be related to LPS responses can be inferred from this paper because of the chromosomal localization of human Toll-like-receptor 4 (on chromosome 9), corresponding to a region of mouse chromosome 4 near to the location of the Lps gene.
    • Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF A family of human receptors structurally related to Drosophila toll. Proc Natl Acad Sci USA. 95:1998;588-593. A description of a family of human Toll-like receptors is presented in this report. The first hint that Toll-like-receptor 4 might be related to LPS responses can be inferred from this paper because of the chromosomal localization of human Toll-like-receptor 4 (on chromosome 9), corresponding to a region of mouse chromosome 4 near to the location of the Lps gene.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 588-593
    • Rock, F.L.1    Hardiman, G.2    Timans, J.C.3    Kastelein, R.A.4    Bazan, J.F.5
  • 9
    • 0024327707 scopus 로고
    • Cloning of the cDNA of a human neutrophil bactericidal protein. Structure and functional correlations
    • Gray PW, Flaggs G, Leong SR, Gumina RJ, Weiss J, Ooi CE, Elsbach P Cloning of the cDNA of a human neutrophil bactericidal protein. Structure and functional correlations. J Biol Chem. 264:1989;9505-9509.
    • (1989) J Biol Chem , vol.264 , pp. 9505-9509
    • Gray, P.W.1    Flaggs, G.2    Leong, S.R.3    Gumina, R.J.4    Weiss, J.5    Ooi, C.E.6    Elsbach, P.7
  • 11
    • 0029057864 scopus 로고
    • Point mutagenesis of positively charged amino acids of cholesteryl ester transfer protein: Conserved residues within the lipid transfer/lipopolysaccharide binding protein gene family essential for function
    • Jiang X-C, Bruce C, Cocke T, Wang S, Boguski M, Tall AR Point mutagenesis of positively charged amino acids of cholesteryl ester transfer protein: conserved residues within the lipid transfer/lipopolysaccharide binding protein gene family essential for function. Biochemistry. 34:1995;7258-7263.
    • (1995) Biochemistry , vol.34 , pp. 7258-7263
    • Jiang, X.-C.1    Bruce, C.2    Cocke, T.3    Wang, S.4    Boguski, M.5    Tall, A.R.6
  • 12
    • 0027291534 scopus 로고
    • Recognition of bacterial endotoxins by receptor-dependent mechanisms
    • Ulevitch RJ Recognition of bacterial endotoxins by receptor-dependent mechanisms. Adv Immunol. 53:1993;267-289.
    • (1993) Adv Immunol , vol.53 , pp. 267-289
    • Ulevitch, R.J.1
  • 13
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Here, positional cloning demonstrates that the Lps gene is homologous to human Toll-like-receptor 4. The mutation responsible for the defect in C3H/HeJ mice is identified and data are provided showing that there is a null muation in this gene in another LPS-nonresponsive mouse strain, C56BL/10ScCr.
    • Poltorak A, He X, Smirnova I, Liu M-Y, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos Cet al. Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:1998;2085-2088. Here, positional cloning demonstrates that the Lps gene is homologous to human Toll-like-receptor 4. The mutation responsible for the defect in C3H/HeJ mice is identified and data are provided showing that there is a null muation in this gene in another LPS-nonresponsive mouse strain, C56BL/10ScCr.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.-Y.4    Van Huffel, C.5    Du, X.6    Birdwell, D.7    Alejos, E.8    Silva, M.9    Galanos, C.10
  • 15
    • 0027446922 scopus 로고
    • Lipopolysaccharide (LPS) activation of human endothelial and epithelial cells is mediated by LPS binding protein and soluble CD14
    • Pugin J, Schurer-Maly CC, Leturcq D, Moriarty A, Ulevitch RJ, Tobias PS Lipopolysaccharide (LPS) activation of human endothelial and epithelial cells is mediated by LPS binding protein and soluble CD14. Proc Natl Acad Sci USA. 90:1993;2744-2748.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2744-2748
    • Pugin, J.1    Schurer-Maly, C.C.2    Leturcq, D.3    Moriarty, A.4    Ulevitch, R.J.5    Tobias, P.S.6
  • 16
    • 0030760314 scopus 로고    scopus 로고
    • Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution
    • Beamer LJ, Carroll SF, Eisenberg D Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Science. 276:1997;1861-1864.
    • (1997) Science , vol.276 , pp. 1861-1864
    • Beamer, L.J.1    Carroll, S.F.2    Eisenberg, D.3
  • 17
    • 0023761244 scopus 로고
    • A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis
    • Tobias PS, Mathison JC, Ulevitch RJ A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem. 263:1988;13479-13481.
    • (1988) J Biol Chem , vol.263 , pp. 13479-13481
    • Tobias, P.S.1    Mathison, J.C.2    Ulevitch, R.J.3
  • 18
    • 0030588577 scopus 로고    scopus 로고
    • Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation
    • Lamping N, Hoess A, Yu B, Park TC, Kirschning C-J, Pfeil D, Reuter D, Wright SD, Herrmann F, Schumann RR Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation. J Immunol. 157:1996;4648-4656.
    • (1996) J Immunol , vol.157 , pp. 4648-4656
    • Lamping, N.1    Hoess, A.2    Yu, B.3    Park, T.C.4    Kirschning, C.-J.5    Pfeil, D.6    Reuter, D.7    Wright, S.D.8    Herrmann, F.9    Schumann, R.R.10
  • 19
    • 0030855108 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-binding proteins BPI and LBP form different types of complexes with LPS
    • Tobias PS, Soldau K, Iovine NM, Elsbach P, Weiss J Lipopolysaccharide (LPS)-binding proteins BPI and LBP form different types of complexes with LPS. J Biol Chem. 272:1997;18682-18685.
    • (1997) J Biol Chem , vol.272 , pp. 18682-18685
    • Tobias, P.S.1    Soldau, K.2    Iovine, N.M.3    Elsbach, P.4    Weiss, J.5
  • 20
    • 0031569527 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: Preferential interaction with particular classes of lipid
    • This provides evidence that LBP and soluble CD14 have a function of lipid-transfer proteins.
    • Wurfel MM, Wright SD Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid. J Immunol. 158:1997;3925-3934. This provides evidence that LBP and soluble CD14 have a function of lipid-transfer proteins.
    • (1997) J Immunol , vol.158 , pp. 3925-3934
    • Wurfel, M.M.1    Wright, S.D.2
  • 21
    • 0032544343 scopus 로고    scopus 로고
    • Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide
    • The authors show that phosphoinositides bind to CD14 and occupy a site that is either very close to, or identical to, that which binds LPS.
    • Wang PY, Kitchens RL, Munford RS Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide. J Biol Chem. 273:1998;24309-24313. The authors show that phosphoinositides bind to CD14 and occupy a site that is either very close to, or identical to, that which binds LPS.
    • (1998) J Biol Chem , vol.273 , pp. 24309-24313
    • Wang, P.Y.1    Kitchens, R.L.2    Munford, R.S.3
  • 22
    • 0024402277 scopus 로고
    • Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins
    • Flegel WA, Wolpl A, Mannel DN, Northoff H Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins. Infect Immun. 57:1989;2237-2245.
    • (1989) Infect Immun , vol.57 , pp. 2237-2245
    • Flegel, W.A.1    Wolpl, A.2    Mannel, D.N.3    Northoff, H.4
  • 24
    • 0031440937 scopus 로고    scopus 로고
    • Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact
    • Wurfel MM, Monks BG, Ingalls RR, Dedrick RL, Delude R, Zhou D, Lamping N, Schumann RR, Thieringer R, Fenton MJet al. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med. 186:1997;2051-2056.
    • (1997) J Exp Med , vol.186 , pp. 2051-2056
    • Wurfel, M.M.1    Monks, B.G.2    Ingalls, R.R.3    Dedrick, R.L.4    Delude, R.5    Zhou, D.6    Lamping, N.7    Schumann, R.R.8    Thieringer, R.9    Fenton, M.J.10
  • 28
    • 0030745310 scopus 로고    scopus 로고
    • Molecules and mechanisms operating in septic shock: Lessions from knockout mice
    • Gutierrez-Ramos JC, Bluethmann H Molecules and mechanisms operating in septic shock: lessions from knockout mice. Immunol Today. 8:1997;329-334.
    • (1997) Immunol Today , vol.8 , pp. 329-334
    • Gutierrez-Ramos, J.C.1    Bluethmann, H.2
  • 29
    • 0030910681 scopus 로고    scopus 로고
    • Strategies for the treatment of sepsis
    • Warren HS Strategies for the treatment of sepsis. New Engl J Med. 336:1997;952-953.
    • (1997) New Engl J Med , vol.336 , pp. 952-953
    • Warren, H.S.1
  • 30
    • 0031606321 scopus 로고    scopus 로고
    • Animal models of sepsis and shock: A review and lessons learned
    • This is a critical evaluation of the strengths and weaknesses of animal models used to study endotoxin-mediated and septic shock.
    • Deitch EA Animal models of sepsis and shock: a review and lessons learned. Shock. 9:1998;1-11. This is a critical evaluation of the strengths and weaknesses of animal models used to study endotoxin-mediated and septic shock.
    • (1998) Shock , vol.9 , pp. 1-11
    • Deitch, E.A.1
  • 32
    • 0032506137 scopus 로고    scopus 로고
    • Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin
    • This paper reports the first demonstration that the blockade of LPS binding to CD14 in an animal model provides a therapeutic window for treatment of endotoxic shock. Treatment may begin after initial exposure to LPS and still have a marked therapeutic benefit.
    • Schimke J, Mathison J, Morgiewicz J, Ulevitch RJ Anti-CD14 mAb treatment provides therapeutic benefit after in vivo exposure to endotoxin. Proc Natl Acad Sci USA. 95:1998;13875-13880. This paper reports the first demonstration that the blockade of LPS binding to CD14 in an animal model provides a therapeutic window for treatment of endotoxic shock. Treatment may begin after initial exposure to LPS and still have a marked therapeutic benefit.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13875-13880
    • Schimke, J.1    Mathison, J.2    Morgiewicz, J.3    Ulevitch, R.J.4
  • 33
    • 0032100444 scopus 로고    scopus 로고
    • Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multigene receptor family in humans
    • The authors report on the cloning of members of the human Toll-like-receptor family.
    • Chaudhary PM, Ferguson C, Nguyen V, Nguyen O, Massa HF, Eby M, Jasmin A, Trask BJ, Hood L, Nelson PS Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multigene receptor family in humans. Blood. 91:1998;4020-4027. The authors report on the cloning of members of the human Toll-like-receptor family.
    • (1998) Blood , vol.91 , pp. 4020-4027
    • Chaudhary, P.M.1    Ferguson, C.2    Nguyen, V.3    Nguyen, O.4    Massa, H.F.5    Eby, M.6    Jasmin, A.7    Trask, B.J.8    Hood, L.9    Nelson, P.S.10
  • 34
    • 2642708378 scopus 로고    scopus 로고
    • The molecular mechanism of B cell activation by toll-like receptor protein RP-105
    • This describes the intracellular signalling pathways used by a Toll-like-receptor, RP-105.
    • Chan VW, Mecklenbrauker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med. 188:1998;93-101. This describes the intracellular signalling pathways used by a Toll-like-receptor, RP-105.
    • (1998) J Exp Med , vol.188 , pp. 93-101
    • Chan, V.W.1    Mecklenbrauker, I.2    Su, I.3    Texido, G.4    Leitges, M.5    Carsetti, R.6    Lowell, C.A.7    Rajewsky, K.8    Miyake, K.9    Tarakhovsky, A.10
  • 35
    • 0032526861 scopus 로고    scopus 로고
    • The human toll signaling pathway: Divergence of nuclear factor κb and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    • Data presented here suggest that signalling through human Toll-like-receptor 4 diverges upstream of TRAF6 insofar as activation of NF-κB and the stress pathways is concerned.
    • Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A The human toll signaling pathway: divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med. 187:1998;2097-2101. Data presented here suggest that signalling through human Toll-like-receptor 4 diverges upstream of TRAF6 insofar as activation of NF-κB and the stress pathways is concerned.
    • (1998) J Exp Med , vol.187 , pp. 2097-2101
    • Muzio, M.1    Natoli, G.2    Saccani, S.3    Levrero, M.4    Mantovani, A.5
  • 36
    • 0032541661 scopus 로고    scopus 로고
    • Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
    • The authors provide evidence that human toll-like-receptor 2 is involved in CD14-dependent responses to LPS. The involvement of signalling pathways used by IL-1 is also established.
    • Yang RB, Mark MR, Gray A, Huang A, Xie MH, Zhang H, Goddard A, Wood WI, Gurney AL, Godowski PJ Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 17:1998;284-288. The authors provide evidence that human toll-like-receptor 2 is involved in CD14-dependent responses to LPS. The involvement of signalling pathways used by IL-1 is also established.
    • (1998) Nature , vol.17 , pp. 284-288
    • Yang, R.B.1    Mark, M.R.2    Gray, A.3    Huang, A.4    Xie, M.H.5    Zhang, H.6    Goddard, A.7    Wood, W.I.8    Gurney, A.L.9    Godowski, P.J.10
  • 37
    • 0031774181 scopus 로고    scopus 로고
    • Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
    • This report links human toll-like-receptor 2 to CD14-dependent signalling initiated by LPS. Direct evidence supports the contention that LPS-mediated stimulation of human Toll-like-receptor 2 initiates an IL-1R-like NF-κB signalling cascade.
    • Kirschning CJ, Wesche H, Ayres TM, Rothe M Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med. 188:1998;2091-2097. This report links human toll-like-receptor 2 to CD14-dependent signalling initiated by LPS. Direct evidence supports the contention that LPS-mediated stimulation of human Toll-like-receptor 2 initiates an IL-1R-like NF-κB signalling cascade.
    • (1998) J Exp Med , vol.188 , pp. 2091-2097
    • Kirschning, C.J.1    Wesche, H.2    Ayres, T.M.3    Rothe, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.