-
1
-
-
0024955886
-
Approaching the asymptote? Evolution and revolution in immunology
-
Janeway C.A. Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54:1989;1-13.
-
(1989)
Cold Spring Harbor Symp. Quant. Biol.
, vol.54
, pp. 1-13
-
-
Janeway C.A., Jr.1
-
5
-
-
0030991499
-
Drosophila cellular immunity against parasitoids
-
Carton Y., Nappi A.J. Drosophila cellular immunity against parasitoids. Parasitol. Today. 13:1997;218-227.
-
(1997)
Parasitol. Today
, vol.13
, pp. 218-227
-
-
Carton, Y.1
Nappi, A.J.2
-
6
-
-
0035133118
-
Immunogenetic aspects of the cellular immune response of Drosophila against parasitoids
-
Carton Y., Nappi A.J. Immunogenetic aspects of the cellular immune response of Drosophila against parasitoids. Immunogenetics. 52:2001;157-164.
-
(2001)
Immunogenetics
, vol.52
, pp. 157-164
-
-
Carton, Y.1
Nappi, A.J.2
-
8
-
-
0000926038
-
Recent advances in research on the insect prophenoloxidase cascade
-
Edited by Brey PT, Hultmark D. London: Chapman & Hall
-
Ashida M, Brey PT: Recent advances in research on the insect prophenoloxidase cascade. In Molecular Mechanisms of Immune Responses in Insects. Edited by Brey PT, Hultmark D. London: Chapman & Hall; 1998:135-172.
-
(1998)
Molecular Mechanisms of Immune Responses in Insects
, pp. 135-172
-
-
Ashida, M.1
Brey, P.T.2
-
9
-
-
0032005367
-
Role of the prophenoloxidase-activating system in invertebrate immunity
-
Söderhäll K., Cerenius L. Role of the prophenoloxidase-activating system in invertebrate immunity. Curr. Opin. Immunol. 10:1998;23-28.
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 23-28
-
-
Söderhäll, K.1
Cerenius, L.2
-
10
-
-
0028865526
-
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
-
Lemaitre B., Kromer-Metzger E., Michaut L., Nicolas E., Meister M., Georgel P., Reichhart J.M., Hoffmann J.A. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc. Natl. Acad. Sci. U.S.A. 92:1995;9465-9469.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 9465-9469
-
-
Lemaitre, B.1
Kromer-Metzger, E.2
Michaut, L.3
Nicolas, E.4
Meister, M.5
Georgel, P.6
Reichhart, J.M.7
Hoffmann, J.A.8
-
11
-
-
0021603716
-
Information for the dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA
-
Anderson K.V., Nusslein-Volhard C. Information for the dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature. 311:1984;223-227.
-
(1984)
Nature
, vol.311
, pp. 223-227
-
-
Anderson, K.V.1
Nusslein-Volhard, C.2
-
12
-
-
0035940499
-
Drosophila MyD88 is an adapter in the Toll signaling pathway
-
Horng T., Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 98:2001;12654-12658.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 12654-12658
-
-
Horng, T.1
Medzhitov, R.2
-
13
-
-
0036141954
-
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
-
Tauszig-Delamasure S., Bilak H., Capovilla M., Hoffmann J.A., Imler J.L. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat. Immunol. 3:2002;91-97.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 91-97
-
-
Tauszig-Delamasure, S.1
Bilak, H.2
Capovilla, M.3
Hoffmann, J.A.4
Imler, J.L.5
-
14
-
-
0035902486
-
Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
-
Shen B., Liu H., Skolnik E.Y., Manley J.L. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation. Proc. Natl. Acad. Sci. U.S.A. 98:2001;8596-8601.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 8596-8601
-
-
Shen, B.1
Liu, H.2
Skolnik, E.Y.3
Manley, J.L.4
-
15
-
-
0034695443
-
Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells
-
Kim Y.S., Han S.J., Ryu J.H., Choi K.H., Hong Y.S., Chung Y.H., Perrot S., Raibaud A., Brey P.T., Lee W.J. Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells. J. Biol. Chem. 275:2000;2071-2079.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2071-2079
-
-
Kim, Y.S.1
Han, S.J.2
Ryu, J.H.3
Choi, K.H.4
Hong, Y.S.5
Chung, Y.H.6
Perrot, S.7
Raibaud, A.8
Brey, P.T.9
Lee, W.J.10
-
16
-
-
0035187882
-
The antibacterial arm of the Drosophila innate immune response requires an IκB kinase
-
Lu Y., Wu L.P., Anderson K.V. The antibacterial arm of the Drosophila innate immune response requires an IκB kinase. Genes Dev. 15:2001;104-110.
-
(2001)
Genes Dev.
, vol.15
, pp. 104-110
-
-
Lu, Y.1
Wu, L.P.2
Anderson, K.V.3
-
17
-
-
0034303573
-
Role of Drosophila IKKγ in a Toll-independent antibacterial immune response
-
Rutschmann S., Jung A.C., Zhou R., Silverman N., Hoffmann J.A., Ferrandon D. Role of Drosophila IKKγ in a Toll-independent antibacterial immune response. Nat. Immunol. 1:2000;342-347.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 342-347
-
-
Rutschmann, S.1
Jung, A.C.2
Zhou, R.3
Silverman, N.4
Hoffmann, J.A.5
Ferrandon, D.6
-
18
-
-
0034287444
-
A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity
-
Silverman N., Zhou R., Stöven S., Pandey N., Hultmark D., Maniatis T. A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev. 14:2000;2461-2471.
-
(2000)
Genes Dev.
, vol.14
, pp. 2461-2471
-
-
Silverman, N.1
Zhou, R.2
Stöven, S.3
Pandey, N.4
Hultmark, D.5
Maniatis, T.6
-
19
-
-
0034303480
-
Activation of the Drosophila NF-κB factor Relish by rapid endoproteolytic cleavage
-
Stöven S., Ando I., Kadalayil L., Engström Y., Hultmark D. Activation of the Drosophila NF-κB factor Relish by rapid endoproteolytic cleavage. EMBO Rep. 1:2000;347-352.
-
(2000)
EMBO Rep.
, vol.1
, pp. 347-352
-
-
Stöven, S.1
Ando, I.2
Kadalayil, L.3
Engström, Y.4
Hultmark, D.5
-
20
-
-
0034613376
-
DFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
-
Hu S., Yang X. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. J. Biol. Chem. 275:2000;30761-30764.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30761-30764
-
-
Hu, S.1
Yang, X.2
-
21
-
-
0037172656
-
Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults
-
Leulier F., Vidal S., Saigo K., Ueda R., Lemaitre B. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Curr. Biol. 12:2002;996-1000.
-
(2002)
Curr. Biol.
, vol.12
, pp. 996-1000
-
-
Leulier, F.1
Vidal, S.2
Saigo, K.3
Ueda, R.4
Lemaitre, B.5
-
22
-
-
0035423794
-
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses
-
This paper shows the unexpected involvement of a TAK1 homolog in the activation of Relish.
-
Vidal S., Khush R.S., Leulier F., Tzou P., Nakamura M., Lemaitre B. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses. Genes Dev. 15:2001;1900-1912 This paper shows the unexpected involvement of a TAK1 homolog in the activation of Relish.
-
(2001)
Genes Dev.
, vol.15
, pp. 1900-1912
-
-
Vidal, S.1
Khush, R.S.2
Leulier, F.3
Tzou, P.4
Nakamura, M.5
Lemaitre, B.6
-
23
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang C., Deng L., Hong M., Akkaraju G.R., Inoue J., Chen Z.J. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 412:2001;346-351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
24
-
-
18044400563
-
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
-
This is the long-awaited molecular characterization of the imd gene, which originally defined the imd/Relish pathway. It has a Death domain that is closely related to the one present in RIP, but it is not a kinase.
-
Georgel P., Naitza S., Kappler C., Ferrandon D., Zachary D., Swimmer C., Kopczynski C., Duyk G., Reichhart J.M., Hoffmann J.A. Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev. Cell. 1:2001;503-514 This is the long-awaited molecular characterization of the imd gene, which originally defined the imd/Relish pathway. It has a Death domain that is closely related to the one present in RIP, but it is not a kinase.
-
(2001)
Dev. Cell
, vol.1
, pp. 503-514
-
-
Georgel, P.1
Naitza, S.2
Kappler, C.3
Ferrandon, D.4
Zachary, D.5
Swimmer, C.6
Kopczynski, C.7
Duyk, G.8
Reichhart, J.M.9
Hoffmann, J.A.10
-
25
-
-
0037151118
-
Genetic evidence for the essential role of β-transducin repeat-containing protein in the inducible processing of NF-κB2/p100
-
Fong A., Sun S.C. Genetic evidence for the essential role of β-transducin repeat-containing protein in the inducible processing of NF-κB2/p100. J. Biol. Chem. 277:2002;22111-22114.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22111-22114
-
-
Fong, A.1
Sun, S.C.2
-
26
-
-
0022881454
-
β-1,3-glucan receptor and peptidoglycan receptor are present as separate entities within insect prophenoloxidase activating system
-
Yoshida H., Ochiai M., Ashida M. β-1,3-glucan receptor and peptidoglycan receptor are present as separate entities within insect prophenoloxidase activating system. Biochem. Biophys. Res. Commun. 141:1986;1177-1184.
-
(1986)
Biochem. Biophys. Res. Commun.
, vol.141
, pp. 1177-1184
-
-
Yoshida, H.1
Ochiai, M.2
Ashida, M.3
-
27
-
-
0024297132
-
Purification of a β-1,3-glucan recognition protein in the prophenoloxidase activating system from hemolymph of the silkworm, Bombyx mori
-
Ochiai M., Ashida M. Purification of a β-1,3-glucan recognition protein in the prophenoloxidase activating system from hemolymph of the silkworm, Bombyx mori. J. Biol. Chem. 263:1988;12056-12062.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 12056-12062
-
-
Ochiai, M.1
Ashida, M.2
-
28
-
-
0029884417
-
Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx mori
-
Yoshida H., Kinoshita K., Ashida M. Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx mori. J. Biol. Chem. 271:1996;13854-13860.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13854-13860
-
-
Yoshida, H.1
Kinoshita, K.2
Ashida, M.3
-
29
-
-
0032544089
-
A peptidoglycan recognition protein in innate immunity conserved from insects to humans
-
Kang D., Liu G., Lundstrom A., Gelius E., Steiner H. A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc. Natl. Acad. Sci. U.S.A. 95:1998;10078-10082.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 10078-10082
-
-
Kang, D.1
Liu, G.2
Lundstrom, A.3
Gelius, E.4
Steiner, H.5
-
30
-
-
0034610370
-
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster
-
Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D. A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 97:2000;13772-13777.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 13772-13777
-
-
Werner, T.1
Liu, G.2
Kang, D.3
Ekengren, S.4
Steiner, H.5
Hultmark, D.6
-
31
-
-
0035856990
-
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
-
In this paper, a mutation called semmelweiss is found to block activation of the Toll pathway by Micrococcus cells without affecting induction of the same pathway by Beauveria. The mutation is mapped to the PGRP-SA gene. This shows for the first time that a PGRP is required for the immune reactions in Drosophila.
-
Michel T., Reichhart J.-M., Hoffmann J.A., Royet J. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature. 414:2001;756-759 In this paper, a mutation called semmelweiss is found to block activation of the Toll pathway by Micrococcus cells without affecting induction of the same pathway by Beauveria. The mutation is mapped to the PGRP-SA gene. This shows for the first time that a PGRP is required for the immune reactions in Drosophila.
-
(2001)
Nature
, vol.414
, pp. 756-759
-
-
Michel, T.1
Reichhart, J.-M.2
Hoffmann, J.A.3
Royet, J.4
-
32
-
-
0037066464
-
Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
-
The authors isolate mutations in the PGRP-LC gene that block activation of the imd/Relish pathway. Overexpression of the same gene results in constitutive activation. PGRP-LC is required for signal-dependent processing of Relish. The authors also show that PGRP-LC mediates induction by lipopolysaccharide as well as by peptidoglycan.
-
Choe K.-M., Werner T., Stöven S., Hultmark D., Anderson K.V. Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science. 296:2002;359-362 The authors isolate mutations in the PGRP-LC gene that block activation of the imd/Relish pathway. Overexpression of the same gene results in constitutive activation. PGRP-LC is required for signal-dependent processing of Relish. The authors also show that PGRP-LC mediates induction by lipopolysaccharide as well as by peptidoglycan.
-
(2002)
Science
, vol.296
, pp. 359-362
-
-
Choe, K.-M.1
Werner, T.2
Stöven, S.3
Hultmark, D.4
Anderson, K.V.5
-
33
-
-
0037061450
-
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
-
In addition to showing the effect of a PGRP-LC mutant on the induction of antibacterial peptides, this study used epigenetic analysis to show that PGRP-LC acts upstream of imd.
-
Gottar M., Gobert V., Michel T., Belvin M., Duyk G., Hoffmann J.A., Ferrandon D., Royet J. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature. 416:2002;640-644 In addition to showing the effect of a PGRP-LC mutant on the induction of antibacterial peptides, this study used epigenetic analysis to show that PGRP-LC acts upstream of imd.
-
(2002)
Nature
, vol.416
, pp. 640-644
-
-
Gottar, M.1
Gobert, V.2
Michel, T.3
Belvin, M.4
Duyk, G.5
Hoffmann, J.A.6
Ferrandon, D.7
Royet, J.8
-
34
-
-
0037061482
-
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
-
Using RNA interference, PGRP-LC is found to affect the phagocytosis of E. coli. A mutant in the PGRP-LC gene is generated and found to be defective in the induction of antibacterial peptides.
-
Rämet M., Manfruelli P., Pearson A., Mathey-Prevot B., Ezekowitz R.A. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature. 416:2002;644-648 Using RNA interference, PGRP-LC is found to affect the phagocytosis of E. coli. A mutant in the PGRP-LC gene is generated and found to be defective in the induction of antibacterial peptides.
-
(2002)
Nature
, vol.416
, pp. 644-648
-
-
Rämet, M.1
Manfruelli, P.2
Pearson, A.3
Mathey-Prevot, B.4
Ezekowitz, R.A.5
-
35
-
-
0029846206
-
Purification and molecular cloning of an inducible Gram-negative bacteria-binding protein from the silkworm, Bombyx mori
-
Lee W.J., Lee J.D., Kravchenko V.V., Ulevitch R.J., Brey P.T. Purification and molecular cloning of an inducible Gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proc. Natl. Acad. Sci. U.S.A. 93:1996;7888-7893.
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 7888-7893
-
-
Lee, W.J.1
Lee, J.D.2
Kravchenko, V.V.3
Ulevitch, R.J.4
Brey, P.T.5
-
36
-
-
0343415656
-
A lipopolysaccharide- and β-1,3-glucan-binding protein from hemocytes of the freshwater crayfish Pacifastacus leniusculus. Purification, characterization, and cDNA cloning
-
Lee S.Y., Wang R., Söderhäll K. A lipopolysaccharide- and β-1,3-glucan-binding protein from hemocytes of the freshwater crayfish Pacifastacus leniusculus. Purification, characterization, and cDNA cloning. J. Biol. Chem. 275:2000;1337-1343.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1337-1343
-
-
Lee, S.Y.1
Wang, R.2
Söderhäll, K.3
-
37
-
-
0035824575
-
Distinct carbohydrate recognition domains of an invertebrate defense molecule recognize Gram-negative and Gram-positive bacteria
-
This paper analyses the functional domains that bind to bacteria in coelomic cytolytic factor, a member of the β-GRP family from an earthworm. A conserved β-GRP domain binds lipopolysaccharide and β-1,3-glucans; a second domain has affinity for peptidoglycan and chitin epitopes.
-
Bilej M., De Baetselier P., Van Dijck E., Stijlemans B., Colige A., Beschin A. Distinct carbohydrate recognition domains of an invertebrate defense molecule recognize Gram-negative and Gram-positive bacteria. J. Biol. Chem. 276:2001;45840-45847 This paper analyses the functional domains that bind to bacteria in coelomic cytolytic factor, a member of the β-GRP family from an earthworm. A conserved β-GRP domain binds lipopolysaccharide and β-1,3-glucans; a second domain has affinity for peptidoglycan and chitin epitopes.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45840-45847
-
-
Bilej, M.1
De Baetselier, P.2
Van Dijck, E.3
Stijlemans, B.4
Colige, A.5
Beschin, A.6
-
38
-
-
0034693324
-
Gram-negative bacteria binding protein, a pattern recognition receptor for lipopolysaccharide and β-1,3-glucan, which mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells
-
Kim Y.-S., Ryu J.-H., Han S.-J., Choi K.-H., Nam K., Jang I., Lemaitre B., Brey P.T., Lee W.-J. Gram-negative bacteria binding protein, a pattern recognition receptor for lipopolysaccharide and β-1,3-glucan, which mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. J. Biol. Chem. 275:2000;32721-32727.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32721-32727
-
-
Kim, Y.-S.1
Ryu, J.-H.2
Han, S.-J.3
Choi, K.-H.4
Nam, K.5
Jang, I.6
Lemaitre, B.7
Brey, P.T.8
Lee, W.-J.9
-
39
-
-
0035940514
-
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
-
De Gregorio E., Spellman P.T., Rubin G.M., Lemaitre B. Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc. Natl. Acad. Sci. U.S.A. 98:2001;12590-12595 This is the first microarray study of immune-inducible genes in Drosophila. The data are also available online at http://www.fruitfly.org/expression/immunity/.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 12590-12595
-
-
De Gregorio, E.1
Spellman, P.T.2
Rubin, G.M.3
Lemaitre, B.4
-
40
-
-
0035909905
-
A genome-wide analysis of immune responses in Drosophila
-
•].
-
•].
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 15119-15124
-
-
Irving, P.1
Troxler, L.2
Heuer, T.S.3
Belvin, M.4
Kopczynski, C.5
Reichhart, J.M.6
Hoffmann, J.A.7
Hetru, C.8
-
41
-
-
0028922245
-
Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line
-
Rosetto M., Engström Y., Baldari C.T., Telford J.L., Hultmark D. Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line. Biochem. Biophys. Res. Commun. 209:1995;111-116.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.209
, pp. 111-116
-
-
Rosetto, M.1
Engström, Y.2
Baldari, C.T.3
Telford, J.L.4
Hultmark, D.5
-
42
-
-
0030595339
-
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
Lemaitre B., Nicolas E., Michaut L., Reichhart J.-M., Hoffmann J.A. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86:1996;973-983.
-
(1996)
Cell
, vol.86
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
Reichhart, J.-M.4
Hoffmann, J.A.5
-
43
-
-
0035877718
-
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2
-
da Silva Correia J., Soldau K., Christen U., Tobias P.S., Ulevitch R.J. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276:2001;21129-21135.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21129-21135
-
-
Da Silva Correia, J.1
Soldau, K.2
Christen, U.3
Tobias, P.S.4
Ulevitch, R.J.5
-
44
-
-
0037025399
-
The extracellular Toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus
-
Iwaki D., Mitsuzawa H., Murakami S., Sano H., Konishi M., Akino T., Kuroki Y. The extracellular Toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 277:2002;24315-24320.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 24315-24320
-
-
Iwaki, D.1
Mitsuzawa, H.2
Murakami, S.3
Sano, H.4
Konishi, M.5
Akino, T.6
Kuroki, Y.7
-
45
-
-
0036467392
-
Toll-like receptors: Key mediators of microbe detection
-
Underhill D.M., Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr. Opin. Immunol. 14:2002;103-110.
-
(2002)
Curr. Opin. Immunol.
, vol.14
, pp. 103-110
-
-
Underhill, D.M.1
Ozinsky, A.2
-
46
-
-
0037025213
-
Activation of Drosophila Toll during fungal infection by a blood serine protease
-
The first serine protease shown to be involved in the immune response in Drosophila.
-
Ligoxygakis P., Pelte N., Hoffmann J.A., Reichhart J.M. Activation of Drosophila Toll during fungal infection by a blood serine protease. Science. 297:2002;114-116 The first serine protease shown to be involved in the immune response in Drosophila.
-
(2002)
Science
, vol.297
, pp. 114-116
-
-
Ligoxygakis, P.1
Pelte, N.2
Hoffmann, J.A.3
Reichhart, J.M.4
-
47
-
-
0033578917
-
Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila
-
Levashina E.A., Langley E., Green C., Gubb D., Ashburner M., Hoffmann J.A., Reichhart J.M. Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila. Science. 285:1999;1917-1919.
-
(1999)
Science
, vol.285
, pp. 1917-1919
-
-
Levashina, E.A.1
Langley, E.2
Green, C.3
Gubb, D.4
Ashburner, M.5
Hoffmann, J.A.6
Reichhart, J.M.7
-
49
-
-
0030663332
-
The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
-
Williams M.J., Rodriguez A., Kimbrell D.A., Eldon E.D. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 16:1997;6120-6130.
-
(1997)
EMBO J.
, vol.16
, pp. 6120-6130
-
-
Williams, M.J.1
Rodriguez, A.2
Kimbrell, D.A.3
Eldon, E.D.4
-
50
-
-
0034641738
-
Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
-
Tauszig S., Jouanguy E., Hoffmann J.A., Imler J.-L. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 97:2000;10520-10525.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 10520-10525
-
-
Tauszig, S.1
Jouanguy, E.2
Hoffmann, J.A.3
Imler, J.-L.4
-
51
-
-
0034777255
-
Tehao functions in the Toll pathway in Drosophila melanogaster: Possible roles in development and innate immunity
-
Luo C., Shen B., Manley J.L., Zheng L. Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Insect Mol. Biol. 10:2001;457-464.
-
(2001)
Insect Mol. Biol.
, vol.10
, pp. 457-464
-
-
Luo, C.1
Shen, B.2
Manley, J.L.3
Zheng, L.4
-
52
-
-
0036023960
-
Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila
-
Ligoxygakis P., Bulet P., Reichhart J.M. Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila. EMBO Rep. 3:2002;666-673.
-
(2002)
EMBO Rep.
, vol.3
, pp. 666-673
-
-
Ligoxygakis, P.1
Bulet, P.2
Reichhart, J.M.3
-
53
-
-
0031446642
-
Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
-
Lemaitre B., Reichhart J.M., Hoffmann J.A. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc. Natl. Acad. Sci. U.S.A. 94:1997;14614-14619.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 14614-14619
-
-
Lemaitre, B.1
Reichhart, J.M.2
Hoffmann, J.A.3
-
55
-
-
0033231556
-
Relish, a central factor in the control of humoral, but not cellular immunity in Drosophila
-
Hedengren M., Åsling B., Dushay M.S., Ando I., Ekengren S., Wihlborg M., Hultmark D. Relish, a central factor in the control of humoral, but not cellular immunity in Drosophila. Mol. Cell. 4:1999;827-837.
-
(1999)
Mol. Cell
, vol.4
, pp. 827-837
-
-
Hedengren, M.1
Åsling, B.2
Dushay, M.S.3
Ando, I.4
Ekengren, S.5
Wihlborg, M.6
Hultmark, D.7
-
56
-
-
0031748547
-
A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis
-
Qiu P., Pan P.C., Govind S. A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Development. 125:1998;1909-1920.
-
(1998)
Development
, vol.125
, pp. 1909-1920
-
-
Qiu, P.1
Pan, P.C.2
Govind, S.3
-
57
-
-
0037013856
-
The Toll and Imd pathways are the major regulators of the immune response in Drosophila
-
include a wealth of information
-
De Gregorio E., Spellman P.T., Tzou P., Rubin G.M., Lemaitre B. The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J. 21:2002;2568-2579 By using microarrays, the authors provide the first genome-wide overview of the genes that are affected by the imd/Relish and Toll/Dif pathways. The data, which are also available online at http://www.fruitfly.org/expression/immunity/, include a wealth of information.
-
(2002)
EMBO J.
, vol.21
, pp. 2568-2579
-
-
De Gregorio, E.1
Spellman, P.T.2
Tzou, P.3
Rubin, G.M.4
Lemaitre, B.5
-
59
-
-
0036532316
-
Intracellular vs extracellular recognition of pathogens - Common concepts in mammals and flies
-
Girardin S.E., Sansonetti P.J., Philpott D.J. Intracellular vs extracellular recognition of pathogens - common concepts in mammals and flies. Trends Microbiol. 10:2002;193-199.
-
(2002)
Trends Microbiol.
, vol.10
, pp. 193-199
-
-
Girardin, S.E.1
Sansonetti, P.J.2
Philpott, D.J.3
-
60
-
-
18744372992
-
The Drosophila atypical PKC-Ref(2)P complex constitutes a conserved module for signaling in the Toll pathway
-
in press
-
Avila A, Silverman N, Diaz-Meco MT, Moscat J: The Drosophila atypical PKC-Ref(2)P complex constitutes a conserved module for signaling in the Toll pathway. Mol Cell Biol 2002, in press.
-
(2002)
Mol Cell Biol
-
-
Avila, A.1
Silverman, N.2
Diaz-Meco, M.T.3
Moscat, J.4
-
61
-
-
0036166242
-
The Drosophila Toll-9 activates a constitutive antimicrobial defense
-
Ooi J.Y., Yagi Y., Hu X., Ip Y.T. The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep. 3:2002;82-87.
-
(2002)
EMBO Rep.
, vol.3
, pp. 82-87
-
-
Ooi, J.Y.1
Yagi, Y.2
Hu, X.3
Ip, Y.T.4
-
62
-
-
0037108754
-
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
-
Takehana A., Katsuyama T., Yano T., Oshima Y., Takada H., Aigaki T., Kurata S. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc. Natl. Acad. Sci. U.S.A. 99:2002;13705-13710.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 13705-13710
-
-
Takehana, A.1
Katsuyama, T.2
Yano, T.3
Oshima, Y.4
Takada, H.5
Aigaki, T.6
Kurata, S.7
-
63
-
-
0037083557
-
Cutting edge: The Toll pathway is required for resistance to Gram-positive bacterial infections in Drosophila
-
Rutschmann S., Kilinc A., Ferrandon D. Cutting edge: The Toll pathway is required for resistance to Gram-positive bacterial infections in Drosophila. J. Immunol. 168:2002;1542-1546.
-
(2002)
J. Immunol.
, vol.168
, pp. 1542-1546
-
-
Rutschmann, S.1
Kilinc, A.2
Ferrandon, D.3
|