The Drosophila atypical protein kinase C-Ref(2)P complex constitutes a conserved module for signaling in the toll pathway

Molecular and Cellular Biology

Volumn 22, Issue 24, 2002, Pages 8787-8795

  Avila, Antonia ^a   Silverman, Neal ^b   Diaz Meco, María T ^a   Moscat, Jorge ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTACIN; ATYPICAL PROTEIN KINASE C; DROSOMYCIN; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PROTEIN KINASE C; PROTEIN P62; PROTEIN RELISH; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; CELL FRACTIONATION; CELL LINE; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENES, REPORTER; INSECT PROTEINS; LIPOPOLYSACCHARIDES; MOLECULAR SEQUENCE DATA; NF-KAPPA B; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; PROTEINS; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA; MELANOGASTER;

EID: 18744372992     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.24.8787-8795.2002     Document Type: Article

References (43)

1. Bergmann, A., D. Stein, R. Geisler, S. Hagenmaier, B. Schmid, N. Fernandez, B. Schnell, and C. Nusslein-Volhard. 1996. A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila. Mech. Dev. 60:109-123.
2. Bonnard, M., C. Mirtsos, S. Suzuki, K. Graham, J. Huang, M. Ng, A. Itie, A. Wakeham, A. Shahinian, W. J. Henzel, A. J. Elia, W. Shillinglaw, T. W. Mak, Z. Cao, and W. C. Yeh. 2000. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J. 19:4976-4985.
3. Cao, Y., G. Bonizzi, T. N. Seagroves, F. R. Greten, R. Johnson, E. V. Schmidt, and M. Karin. 2001. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107:763-775.
4. Cao, Z., J. Xiong, M. Takeuchi, T. Kurama, and D. V. Goeddel. 1996. TRAF6 is a signal transducer for interleukin-1. Nature 383:443-446.
5. Contamine, D., A. M. Petitjean, and M. Ashburner. 1989. Genetic resistance to viral infection: The molecular cloning of a Drosophila gene that restricts infection by the rhabdovirus sigma. Genetics 123:525-533.
6. Dezelee, S., F. Bras, D. Contamine, M. Lopez-Ferber, D. Segretain, and D. Teninges. 1989. Molecular analysis of ref(2)P, a Drosophila gene implicated in sigma rhabdovirus multiplication and necessary for male fertility. EMBO J. 8:3437-3446.
7. Diaz-Meco, M. T., and J. Moscat. 2001. MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Mol. Cell. Biol. 21:1218-1227.
8. Drier, E. A., S. Govind, and R. Steward. 2000. Cactus-independent regulation of Dorsal nuclear import by the ventral signal. Curr. Biol. 10:23-26.
9. Dushay, M. S., B. Asling, and D. Hultmark. 1996. Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc. Natl. Acad. Sci. USA 93:10343-10347.
10. Fernandez, N. Q., J. Grosshans, J. S. Goltz, and D. Stein. 2001. Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation. Development 128:2963-2974.
11. Hoeflich, K. P., J. Luo, E. A. Rubie, M. S. Tsao, O. Jin, and J. R. Woodgett. 2000. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406:86-90.
12. Horng, T., and R. Medzhitov. 2001. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc. Natl. Acad. Sci. USA 98:12654-12658.
13. Hu, Y., V. Baud, T. Oga, K. I. Kim, K. Yoshida, and M. Karin. 2001. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature 410:710-714.
14. Imler, J. L., and J. A. Hoffmann. 2001. Toll receptors in innate immunity. Trends Cell Biol. 11:304-311.
15. Jefferies, C., A. Bowie, G. Brady, E.-L. Cooke, X. Li, and L. A. J. O'Neill. 2001. Transactivation by the p65 subunit of NF-κB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1. Mol. Cell. Biol. 21:4544-4552.
16. Joberty, G., C. Petersen, L. Gao, and I. G. Macara. 2000. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat. Cell Biol. 2:531-539.
17. Karin, M. 1999. The beginning of the end: Ikappab kinase (IKK) and NF-kappaB activation. J. Biol. Chem. 274:27339-27342.
18. Khush, R. S., F. Leulier, and B. Lemaitre. 2001. Drosophila immunity: Two paths to NF-kappaB. Trends Immunol. 22:260-264.
19. Lallena, M.-J., M. T. Diaz-Meco, G. Bren, C. V. Payá, and J. Moscat. 1999. Activation of IκB kinase β by protein kinase C isoforms. Mol. Cell. Biol. 19:2180-2188.
20. Leitges, M., L. Sanz, P. Martin, A. Duran, U. Braun, J. F. Garcia, F. Camacho, M. T. Diaz-Meco, P. D. Rennert, and J. Moscat. 2001. Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol. Cell 8:771-780.
21. Li, Q., G. Estepa, S. Memet, A. Israel, and I. M. Verma. 2000. Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation. Genes Dev. 14:1729-1733.
22. Lin, D., A. S. Edwards, J. P. Fawcett, G. Mbamalu, J. D. Scott, and T. Pawson. 2000. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat. Cell Biol. 2:540-547.
23. Lomaga, M. A., W. C. Yeh, I. Sarosi, G. S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, A. van der Heiden, A. Itie, A. Wakeham, W. Khoo, T. Sasaki, Z. Cao, J. M. Penninger, C. J. Paige, D. L. Lacey, C. R. Dunstan, W. J. Boyle, D. V. Goeddel, and T. W. Mak. 1999. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13:1015-1024.
24. Moscat, J., and M. T. Diaz-Meco. 2000. The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep. 1:399-403.
25. Nishizuka, Y. 1995. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9:484-496.
26. Ponting, C. P., T. Ito, J. Moscat, M. T. Diaz-Meco, F. Inagaki, and H. Sumimoto. 2002. OPR, PC and AID: All in the PB1 family. Trends Biochem. Sci. 27:10.
27. Qiu, R. G., A. Abo, and G. Steven Martin. 2000. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr. Biol. 10:697-707.
28. Sanchez, P., G. De Career, I. V. Sandoval, J. Moscat, and M. T. Diaz-Meco. 1998. Localization of atypical protein kinase C isoforms into lysosometargeted endosomes through interaction with p62. Mol. Cell. Biol. 18:3069-3080.
29. Sanz, L., M. T. Diaz-Meco, H. Nakano, and J. Moscat. 2000. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J. 19:1576-1586.
30. Sanz, L., P. Sanchez, M. J. Lallena, M. T. Diaz-Meco, and J. Moscat. 1999. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J. 18:3044-3053.
31. Schmitz, M. L., S. Bacher, and M. Kracht. 2001. I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations. Trends Biochem. Sci. 26:186-190.
32. Shen, B., H. Liu, E. Y. Skolnik, and J. L. Manley. 2001. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation. Proc. Natl. Acad. Sci. USA 98:8596-8601.
33. Silverman, N., and T. Maniatis. 2001. NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15:2321-2342.
34. Silverman, N., R. Zhou, S. Stoven, N. Pandey, D. Hultmark, and T. Maniatis. 2000. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev. 14:2461-2471.
35. Sizemore, N., N. Lerner, N. Dombrowski, H. Sakurai, and G. R. Stark. 2002. Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B. J. Biol. Chem. 277:3863-3869.
36. Stoven, S., I. Ando, L. Kadalayil, Y. Engstrom, and D. Hultmark. 2000. Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage. EMBO Rep. 1:347-352.
37. Suzuki, A., T. Yamanaka, T. Hirose, N. Manabe, K. Mizuno, M. Shimizu, K. Akimoto, Y. Izumi, T. Ohnishi, and S. Ohno. 2001. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J. Cell Biol. 152:1183-1196.
38. Tauszig-Delamasure, S., H. Bilak, M. Capovilla, J. A. Hoffmann, and J. L. Imler. 2002. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat. Immunol. 3:91-97.
39. Wayne, M. L., D. Contamine, and M. Kreitman. 1996. Molecular population genetics of ref(2)P, a locus which confers viral resistance in Drosophila. Mol. Biol. Evol. 13:191-199.
40. Wodarz, A., A. Ramrath, A. Grimm, and E. Knust. 2000. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J. Cell Biol. 150:1361-1374.
41. Wooten, M. W., M. L. Seibenhener, V. Mamidipudi, M. T. Diaz-Meco, P. A. Barker, and J. Moscat. 2001. The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J. Biol. Chem. 276:7709-7712.
42. Wyers, F., A. M. Petitjean, P. Dru, P. Gay, and D. Contamine. 1995. Localization of domains within the Drosophila Ref(2)P protein involved in the intracellular control of sigma rhabdovirus multiplication. J. Virol. 69:4463-4470.
43. Yin, L., L. Wu, H. Wesche, C. D. Arthur, J. M. White, D. V. Goeddel, and R. D. Schreiber. 2001. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 291:2162-2165.