In Silico Approaches, and In Vitro and In Vivo Experiments to Predict Induction of Drug Metabolism

Drug News and Perspectives

Volumn 16, Issue 7, 2003, Pages 423-434

  Handschin, Christoph ^a   Podvinec, Michael ^b,c   Meyer, Urs A ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF BASEL   (Switzerland)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANE RECEPTOR; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 3A4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PREGNANE X RECEPTOR; STEROID RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

COMPUTER MODEL; DNA POLYMORPHISM; DRUG DESIGN; DRUG METABOLISM; DRUG TRANSPORT; ENZYME INDUCTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PREDICTION; REGULATORY MECHANISM; REVIEW;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; ENZYME INDUCTION; HUMANS; LIVER; MODELS, BIOLOGICAL; TECHNOLOGY, PHARMACEUTICAL;

EID: 0344442328     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2003.16.7.829354     Document Type: Review

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