Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices

Toxicology

Volumn 161, Issue 1-2, 2001, Pages 53-66

  Lupp, A ^a   Danz, M ^a   Muller D ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

naphthoflavone; Cytochrome P450; Dexamethasone; Glycogen; Histology; Liver slices; Phenobarbital; Precision cut

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 3A2; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; ENZYME INDUCING AGENT; GLYCOGEN; PHENOBARBITAL; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL VACUOLE; CENTRAL VEIN; CONTROLLED STUDY; ENZYME STRUCTURE; LIVER CELL; LIVER CELL DAMAGE; LIVER SLICE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE SECTION; VESSEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICONVULSANTS; BETA-NAPHTHOFLAVONE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; ENZYME INDUCTION; ENZYME INHIBITORS; GLYCOGEN; ISOENZYMES; LIVER; MALE; PHENOBARBITAL; RATS;

EID: 0035925660     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00333-X     Document Type: Article

References (25)

1. Culture of precision-cut liver slices: Effect of some peroxisome proliferators
2. Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP 1A1 and CYP 1A2 induction
3. Short-term maintenance of phase I and II metabolism in precision-cut liver slices in dynamic organ culture
4. Ethoxycoumarin O-deethylation activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro
5. Use of fresh and cryopreserved human liver slices in toxicology with special reference to in vitro induction of cytochrome P450
6. Cytochrome P-450 1A1/1A2 induction, albumin secretion, and histological changes in cultured rat liver slices
7. Cytochrome P450 isoenzyme activities in cultured rat and mouse liver slices
8. A new instrument for the rapid preparation of tissue slices
9. Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin
10. Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices
11. Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices
12. Induction of CYP 3A isoforms in cultured precision-cut human liver slices
13. Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: Effects of β-naphthoflavone, phenobarbital and dexamethasone on cytochrome P450 isoforms expression and on glycogen storage
14. Predictive value of liver slices for metabolism and toxicity in vivo: Use of acetaminophen as a model hepatotoxicant
15. Monooxygenation, cytochrome P450 1A1 and P450 1A1-mRNA in rat liver slices exposed to beta-naphthoflavone and dexamethasone in vitro
16. Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slices
17. Induction of cytochrome P450 2B1 m-RNA and pentoxyresorufin O-depentylation after exposure of precision-cut rat liver slices to phenobarbital
18. Immunohistochemical localization of cytochrome P450 1A1 in precision-cut rat liver slices after in vitro exposure to β-naphthoflavone
19. Zonation of hepatic cytochrome P-450 expression and regulation
20. Precision-cut tissue slices: Applications in pharmacology and toxicology
21. Benzo(a)pyrene-induced alterations in growth-related gene expression and signalling in precision-cut adult rat liver and kidney slices
22. Dynamic organ culture of precision liver slices for in vitro toxicology
23. Maintenance of adult rat liver slices in dynamic organ culture
24. Immunohistochemical localization of cytochrome P-450 1A1 induced by 3,3′,4,4′-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzofuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup)
25. Morphological and functional integrity of precision-cut rat liver slices in rotating organ culture and multiwell plate culture: Effects of oxygen tension