Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans

Molecular Endocrinology

Volumn 15, Issue 9, 2001, Pages 1571-1585

  Handschin, C ^a   Podvinec, M ^a   Stockli J ^a   Hoffmann, K ^a   Meyer, U A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1,9 DIDEOXYFORSKOLIN; ANDROSTANE RECEPTOR; BUCLADESINE; CELL NUCLEUS RECEPTOR; CYTOCHROME P450; FORSKOLIN; MESSENGER RNA; ORPHAN NUCLEAR RECEPTOR; PHENOBARBITAL; PREGNANE X RECEPTOR; RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL CELL; ARTICLE; BIRD; CONTROLLED STUDY; GENE ACTIVATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; RODENT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; XENOBIOTIC METABOLISM;

EID: 0034838324     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.15.9.0701     Document Type: Article

References (54)

1. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
2. Phenobarbital induction of cytochrome P-450 gene expression
3. Steroid hormone receptors: Many actors in search of a plot
4. Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers
5. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR and PPAR
6. Orphan nuclear receptors: Shifting endocrinology into reverse
7. Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors
8. Regulation of cytochrome P450 (CYP) genes by nuclear receptors
9. Regulation of cytochrome P450 gene transcription by phenobarbital
10. Extent and character of phenobarbital-mediated changes in gene expression in liver
11. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interaction
12. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
13. Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene
14. Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene
15. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2b10 Gene
16. The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness
17. Analysis of a phenobarbital-responsive enhancer sequence located in the 5′ flanking region of the chicken CYP2H1 gene: Identification and characterization of functional protein-binding sites
18. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
19. A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line
20. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
21. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
22. CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)
23. Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes
24. Heme biosynthesis in a chicken hepatoma cell line (LMH): Comparison with primary chick embryo liver cells (CELC)
25. Establishment and characterization of a chicken hepatocellular carcinoma cell line, LMH
26. Induction of heme oxygenase-1 in LMH cells. Comparison of LMH cells to primary cultures of chick embryo liver cells
27. Isolation and characterization of genomic clones for two chicken phenobarbital-inducible cytochrome P-450 genes
28. Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37)
29. Molecular regulation of heme biosynthesis in higher vertebrates
30. Induction of 5-aminolevulinate synthase by drugs is independent of increased apocytochrome P450 synthesis
31. Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes
32. Physiological and pathophysiological regulation of cytochrome P450
33. Ligand-independent activation of steroid hormone receptors
34. Modulating nuclear receptor function: May the phos be with you
35. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
36. Forskolin-mediated induction of CYP3A1 mRNA expression in primary rat hepatocytes is independent of elevated intracellular cyclic AMP
37. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures
38. Involvement of synthesis and phosphorylation of nuclear protein factors that bind to the positive cis-acting element in the transcriptional activation of the CYP2B1/B2 gene by phenobarbitone in vivo
39. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes
40. Lack of modulation by phenobarbital of cyclic AMP levels or protein kinase A activity in rat primary hepatocytes
41. Transcriptional regulation of the chicken CYP2H1 gene
42. Mutational analysis of the CYP2B2 phenobarbital response unit and inhibitory effect of the constitutive androstane receptor on phenobarbital responsiveness
43. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
44. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
45. The xenobiotic compound 1,4-bis[2-(3, 5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR
46. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
47. Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling
48. cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures
49. Humanized xenobiotic response in mice expressing nuclear receptor SXR
50. Nuclear orphan receptors control cholesterol catabolism
51. Don't know much bile-ology
52. Catabolites of cholesterol synthesis pathways and forskolin as activators of the farnesoid X-activated nuclear receptor
53. Drug-mediated induction of cytochrome(s) P-450 and drug metabolism in cultured hepatocytes maintained in chemically defined medium
54. Induction of δ-aminolevulinate synthase and cytochrome P-450 hemoproteins in hepatocyte culture. Effect of glucose and hormones