Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation

FASEB Journal

Volumn 10, Issue 11, 1996, Pages 1241-1248

  Johnson, Eric F ^a   Palmer, Colin N A ^a   Griffin, Keith J ^a   Hsu, Mei Hui ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

CYP4A; fatty acid hydroxylase; PPAR

Indexed keywords

CYTOCHROME P450; THYROID HORMONE; TRANSCRIPTION FACTOR;

BINDING SITE; CATABOLISM; DNA FLANKING REGION; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; MULTIGENE FAMILY; PEROXISOME; PRIORITY JOURNAL; RECOGNITION; REVIEW;

EID: 0029796038     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.11.8836037     Document Type: Review

References (67)

1. Reddy, J. K., and Mannaerts, G. P. (1994) Peroxisomal lipid metabolism. Annu. Rev. Nutr. 14, 343-370
2. Lock, E. A., Mitchell, A. M., and Elcombe, C. R. (1989) Biochemical mechanisms of induction of hepatic peroxisome proliferation. Annu. Rev. Pharmacol. Toxicol. 29, 145-163
3. Sharma, R., Lake, B. G., and Gibson, G. G. (1988) Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid β-oxidation pathway in the rat by elofibrate and di-(2-ethylhexyl)phthalate. Biochem. Pharmacol. 37, 1203-1206
4. Hardwick, J. P., Song, B., Huberman, E., and Gonzalez, F. J. (1987) Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid ω̄-hydroxylase (cytochrome P-450LAω̄). J. Biol. Chem. 262, 80-810
5. Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., Gunsalus, I. C., Gotoh, O., Okuda, K., and Nebert, D. W. (1993) The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12, 1-51
6. Lee, S. S.-T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H., and Gonzalez, F. J. (1995) Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15, 3012-3022
7. Issemann, I., and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (London) 347, 645-650
8. Göttlicher, M., Widmark, E., Li, Q., and Gustafsson, J.-Å. (1992) Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 89, 4653-4657
9. Sher, T., Yi, H.-F., McBride, O. W., and Gonzalez, F. J. (1993) cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32, 5598-5604
10. Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., and Evans, R. M. (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (London) 358, 771-774
11. Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., and Wahli, W. (1992) Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68, 879-887
12. Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., and Green, S. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 11, 433-439
13. Issemann, I., Prince, R., Tugwood, J., and Green, S. (1992) A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation. Biochem. Soc. Trans. 20, 824-827
14. Marcus, S. L., Miyata, K. S., Zhang, B., Subramani, S., Rachubinski, R. A., and Capone, J. P. (1993) Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Proc. Natl. Acad. Sci. USA 90, 5723-5727
15. Muerhoff, A. S., Griffin, K. J., and Johnson, E. F. (1992) The peroxisome proliferator activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid ω̄-hydroxylase, by clofibric acid. J. Biol. Chem. 267, 1905-19053
16. Aldridge, T. C., Tugwood, J. D., and Green, S. (1995) Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem. J. 306, 473-479
17. Chen, F., Law, S. W., and O'Malley, B. W. (1993) Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem. Biophys. Res. Commun. 196, 671-677
18. Zhu, Y., Alvares, K., Huang, Q., Rao, M. S., and Reddy, J. K. (1993) Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 268, 26817-26820
19. Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994) mPPARγ2: Tissue-specific regulator of an adipocyte enhancer. Genes & Dev. 8, 1224-1234
20. Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., and Evans, R. M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91, 7355-7359
21. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79, 1147-1156
22. Jones, P. S., Savory, R., Barratt, P., Bell, A. R., Gray, T. J. B., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Bell, D. R. (1995) Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes. Eur. J. Biochem. 233, 219-226
23. Bell, D. R., Bars, R. G., and Elcombe, C. R. (1992) Differential tissue-specific expression and induction of cytochrome P450IVA1 and acyl-CoA oxidase. Eur. J. Biochem. 206, 979-986
24. Schmidt, A., Endo, N., Rutledge, S. J., Vogel, R., Shinar, D., and Rodan, G. A. (1992) Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6, 1634-1641
25. Beck, F., Plummer, S., Senior, P. V., Byrne, S., Green, S., and Brammar, W. J. (1992) The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat. Proc. R. Soc. Lond. [Biol.] 247, 83-87
26. Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956
27. Ibrahimi, A., Teboul, L., Gaillard, D., Amri, E.-Z., Ailhaud, G., Young, P., Cawthorne, M. A., and Grimaldi, P. A. (1994) Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells. Mol. Pharmacol. 46, 1070-1076
28. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812
29. 2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83, 813-819
30. Kimura, S., Hardwick, J. P., Kozak, C. A., and Gonzalez, F. J. (1989) The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes. DNA 8, 517-525
31. Roman, L. J., Palmer, C. N. A., Clark, J. E., Muerhoff, A. S., Griffin, K. J., Johnson, E. F., and Masters, B. S. S. (1993) Expression of rabbit cytochromes P4504A which catalyze the ω̄-hydroxylation of arachidonic acid, fatty acids, and prostaglandins. Arch. Biochem. Biophys. 307, 57-65
32. Yokotani, N., Bernhardt, R., Sogawa, K., Kusunose, E., Goloh, O., Kusunose, M., and Fujii-Kuriyama, Y. (1989) Two forms of ω̄-hydroxylase toward prostaglandin A and laurate. J. Biol. Chem. 264, 21665-21669
33. Bell, D. R., Plant, N. J., Rider, C. G., Na, L., Brown, S., Ateitalla, I., Acharya, S. K., Davies, M. H., Elias, E., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Elcombe, C. R. (1993) Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. Biochem. J. 294, 173-180
34. Harder, D. R., Campbell, W. B., and Roman, R. J. (1995) Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone J. Vasc. Res. 32, 79-92
35. Okita, R. T. (1994) Effect of peroxisome proliferators on microsomal P450 reactions. In Peroxisome Proliferators: Unique Inducers of Drug-Metabolizing Enzymes (Moody, D. E., ed) pp. 37-49, CRC Press, Boca Raton, Florida
36. Mortensen, P. B. (1992) Formation and degradation of dicarboxylic acids in relation to alterations in fatty acid oxidation in rats. Biochim. Biophys. Acta 1124, 71-79
37. Imaoka, S., Shimojo, N., and Funae, Y. (1988) Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats. Biochem. Biophys. Res. Commun. 152, 680-687
38. Barnett, C. R., Gibson, G. G., Wolf, C. R., Flatt, P. R., and Ioannides, C. (1990) Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes. Biochem. J. 268, 765-769
39. Ferguson, N. L., Donahue, B. S., Tenney, K. A., and Morgan, E. T. (1993) Pretranslational induction of CYP4A subfamily gene products in diabetic rats and reversal by oral vanadate treatment. Drug Metab. Dispos. 21, 745-746
40. Keller, H., Dreyer, C., Medin, J., Mahfoudi, A., Ozato, K., and Wahli, W. (1993) Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc. Natl. Acad. Sci. USA 90, 2160-2164
41. Kaikaus, R. M., Chan, W. K., Lysenko, N., Ray, R., Ortiz de Montellano, P. R., and Bass, N. M. (1993) Induction of peroxisomal fatty acid β-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 ω̄-hydroxylase pathway. J. Biol. Chem. 268, 9593-9603
42. Hsu, M., Palmer, C. N. A., Griffin, K. J., and Johnson, E. F. (1995) A single amino acid change in the mouse peroxisome proliferator activated receptor α alters transcriptional response to peroxisome proliferators. Mol. Pharmacol. 48, 559-567
43. Osumi, T., Wen, J.-K., and Hashimoto, T. (1991) Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene. Biochem. Biophys, Res. Commun. 175, 866-871
44. Palmer, C. N. A., Hsu, M.-H., Muerhoff, A. S., Griffin, K. J., and Johnson, E. F. (1994) Interaction of the peroxisome proliferator-activated receptor α with the retinoid X receptor α unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter. J. Biol. Chem. 269, 18083-18089
45. Palmer, C. N. A., Hsu, M., Griffin, K. J., and Johnson, E. F. (1995) Novel sequence determinants in peroxisome proliferator signaling. J. Biol. Chem. 270, 16114-16121
46. Krey, C., Mahfoudi, A., and Wahli, W. (1995) Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Sp1 in the transcriptional regulation of the acyl-coenzyme-A oxidase promoter. Mol. Endocrinol. 9, 219-231
47. Vu-Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J.-C., Staels, B., and Auwerx, J. (1995) Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J. Clin. Invest. 96, 741-750
48. Rodrïguez, J. C., Gil-Gómez, G., Hegardt, F. G., and Haro, D. (1994) Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids. J. Biol. Chem. 269, 18767-18772
49. Castelein, H., Gulick, T., Declercq, P. E., Mannaerts, G. P., Moore, D. D., and Baes, M. I. (1994) The peroxisome proliferator activated receptor regulates malic enzyme gene expression. J. Biol. Chem. 269, 26754-26758
50. Tontonoz, P., Hu, E., Devine, J., Beale, E. G., and Spiegelman, B. M. (1995) PPARγ2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15, 351-357
51. Schoonjans, K., Watanabe, M., Suzuki, H., Mahfoudi, A., Krey, G., Wahli, W., Grimaldi, P., Staels, B., Yamamoto, T., and Auwerx, J. (1995) Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J. Biol. Chem. 270, 19269-19276
52. Gulick, T., Cresci, S., Caira, T., Moore, D. D., and Kelly, D. P. (1994) The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. USA 91, 11012-11016
53. Huan, B., Kosovsky, M. J., and Siddiqui, A. (1995) Retinoid X receptor α transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor. J. Virol. 69, 547-551
54. Glass, C. K. (1994) Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocr. Rev. 15, 391-407
55. Miyata, K. S., Zhang, B., Marcus, S. L., Capone, J. P., and Rachubinski, R. A. (1993) Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling. J. Biol. Chem. 268, 19169-19172
56. Hertz, R., Bishara-Shieban, J., and Bar-Tana, J. (1995) Mode of action of peroxisome proliferates as hypolipidemic drugs, suppression of apolipoprotein C-III. J. Biol. Chem. 270, 13470-13475
57. Gearing, K. L., Göttlicher, M., Teboul, M., Widmark, E., and Gustafsson, J.-Å. (1993) Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc. Natl. Acad. Sci. USA 90, 1440-1444
58. Issemann, I., Prince, R. A., Tugwood, J. D., and Green, S. (1993) The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J. Mol. Endocrinol. 11, 37-47
59. Harding, H. P., and Lazar, M. A. (1993) The orphan receptor Rev-ErbA α activates transcription via a novel response element. Mol. Cell Biol. 13, 3113-3121
60. Giguëre, V., Tini, M., Flock, G., Ong, E., Evans, R. M., and Otulakowski, G. (1994) Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan hormone nuclear receptors. Genes & Dev. 8, 538-553
61. Becker-André, M., Wiesenberg, I., Schaeren-Wiemers, N., André, E., Missbach, M., Saurat, J.-H., and Carlberg, C. (1994) Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J. Biol. Chem. 269, 28531-28534
62. Wiesenberg, I., Missbach, M., Kahlen, J.-P., Schräder, M., and Carlberg, C. (1995) Transcriptional activation of the nuclear receptor RZRα by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res. 23, 327-333
63. Wilson, T. E., Paulsen, R. E., Padgett, K. A., and Milbrandt, J. (1992) Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Science 256, 107-110
64. Giguere, V., McBroom, L. D., and Flock, G. (1995) Determinants of target gene specificity for ROR α1: monomeric DNA binding by an orphan nuclear receptor. Mol. Cell Biol. 15, 2517-2526
65. Rastinejad, F., Perlmann, T., Evans, R. M., and Sigler, P. B. (1995) Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature (London) 375, 203-211
66. Kurokawa, R., Yu, V. C., Näär, A., Kyakumoto, S., Han, Z., Silverman, S., Rosenfeld, M. G., and Glass, C. K. (1993) Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers. Genet & Dev. 7, 1423-1435
67. Gronemeyer, H., and Moras, D. (1995) How to finger DNA. Nature (London) 375, 190-191