-
1
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S.I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R. et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275, 1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
-
2
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davis, T. et al. (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15, 356-362.
-
(1997)
Nat. Genet.
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
-
3
-
-
0031001041
-
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
-
Li, D.M. and Sun, H. (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res., 57, 2124-2129.
-
(1997)
Cancer Res.
, vol.57
, pp. 2124-2129
-
-
Li, D.M.1
Sun, H.2
-
4
-
-
0030837555
-
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
-
Myers, M.P., Stolarov, J.P., Eng, C., Li, J., Wang, S.I., Wigler, M.H., Parsons, R. and Tonks, N.K. (1997) P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl Acad. Sci. USA, 94, 9052-9057.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9052-9057
-
-
Myers, M.P.1
Stolarov, J.P.2
Eng, C.3
Li, J.4
Wang, S.I.5
Wigler, M.H.6
Parsons, R.7
Tonks, N.K.8
-
5
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama, T. and Dixon, J.E. (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 273, 13375-13378.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
6
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
-
Myers, M.P., Pass, I., Batty, I.H., Van der Kaay, J., Stolarov, J.R, Hemmings, B.A., Wigler, M.H., Downes, C.P. and Tonks, N.K. (1998) The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl Acad. Sci. USA, 95, 13513-13518.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
Pass, I.2
Batty, I.H.3
Van der Kaay, J.4
Stolarov, J.R.5
Hemmings, B.A.6
Wigler, M.H.7
Downes, C.P.8
Tonks, N.K.9
-
7
-
-
0034912744
-
PTEN and myotubularin: Novel phosphoinositide phosphatases
-
Maehama, T., Taylor, G.S. and Dixon, J.E. (2001) PTEN and myotubularin: novel phosphoinositide phosphatases. A. Rev. Biochem., 70, 247-279.
-
(2001)
A. Rev. Biochem.
, vol.70
, pp. 247-279
-
-
Maehama, T.1
Taylor, G.S.2
Dixon, J.E.3
-
8
-
-
0033957661
-
The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
-
1470
-
Vazquez, F. and Sellers, W.R. (2000) The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim. Biophys. Acta, 1470, M21-35.
-
(2000)
Biochim. Biophys. Acta
-
-
Vazquez, F.1
Sellers, W.R.2
-
9
-
-
0031004088
-
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
-
Liaw, D., Marsh, D.J., Li, J., Dahia, P.L., Wang, S.I., Zheng, Z., Bose, S., Call, K.M., Tsou, H.C., Peacocke, M. et al. (1997) Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet., 16, 64-67.
-
(1997)
Nat. Genet.
, vol.16
, pp. 64-67
-
-
Liaw, D.1
Marsh, D.J.2
Li, J.3
Dahia, P.L.4
Wang, S.I.5
Zheng, Z.6
Bose, S.7
Call, K.M.8
Tsou, H.C.9
Peacocke, M.10
-
10
-
-
0032853452
-
PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
-
Marsh, D.J., Kum, J.B., Lunetta, K.L., Bennett, M.J., Gorlin, R.J., Ahmed, S.F., Bodurtha, J., Crowe, C., Curtis, M.A., Dasouki, M. et al. (1999) PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Hum. Mol. Genet., 8, 1461-1472.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1461-1472
-
-
Marsh, D.J.1
Kum, J.B.2
Lunetta, K.L.3
Bennett, M.J.4
Gorlin, R.J.5
Ahmed, S.F.6
Bodurtha, J.7
Crowe, C.8
Curtis, M.A.9
Dasouki, M.10
-
11
-
-
8544247944
-
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease
-
Nelen, M.R., van Staveren, W.C., Peeters, E.A., Hassel, M.B., Gorlin, R.J., Hamm, H., Lindboe, C.F., Fryns, J.P., Sijmons, R.H., Woods, D.G. et al. (1997) Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. Hum. Mol. Genet., 6, 1383-1387.
-
(1997)
Hum. Mol. Genet.
, vol.6
, pp. 1383-1387
-
-
Nelen, M.R.1
van Staveren, W.C.2
Peeters, E.A.3
Hassel, M.B.4
Gorlin, R.J.5
Hamm, H.6
Lindboe, C.F.7
Fryns, J.P.8
Sijmons, R.H.9
Woods, D.G.10
-
12
-
-
0034701247
-
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis
-
Zhou, X.P., Marsh, D.J., Hampel, H., Mulliken, J.B., Gimm, O. and Eng, C. (2000) Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Hum. Mol. Genet., 9, 765-768.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 765-768
-
-
Zhou, X.P.1
Marsh, D.J.2
Hampel, H.3
Mulliken, J.B.4
Gimm, O.5
Eng, C.6
-
13
-
-
0035895042
-
PTEN mutations and Proteus syndrome
-
Eng, C., Thiele, H., Zhou, X.P., Gorlin, R.J., Hennekam, R.C. and Winter, R.M. (2001) PTEN mutations and Proteus syndrome. Lancet, 358, 2079-2080.
-
(2001)
Lancet
, vol.358
, pp. 2079-2080
-
-
Eng, C.1
Thiele, H.2
Zhou, X.P.3
Gorlin, R.J.4
Hennekam, R.C.5
Winter, R.M.6
-
14
-
-
0035928416
-
Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes
-
Zhou, X., Hampel, H., Thiele, H., Gorlin, R.J., Hennekam, R.C., Parisi, M., Winter, R.M. and Eng, C. (2001) Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes. Lancet, 358, 210-211.
-
(2001)
Lancet
, vol.358
, pp. 210-211
-
-
Zhou, X.1
Hampel, H.2
Thiele, H.3
Gorlin, R.J.4
Hennekam, R.C.5
Parisi, M.6
Winter, R.M.7
Eng, C.8
-
15
-
-
0034933494
-
PTEN mutations are uncommon in Proteus syndrome
-
Barker, K., Martinez, A., Wang, R., Bevan, S., Murday, V., Shipley, J., Houlston, R. and Harper, J. (2001) PTEN mutations are uncommon in Proteus syndrome. J. Med. Genet., 38, 480-481.
-
(2001)
J. Med. Genet.
, vol.38
, pp. 480-481
-
-
Barker, K.1
Martinez, A.2
Wang, R.3
Bevan, S.4
Murday, V.5
Shipley, J.6
Houlston, R.7
Harper, J.8
-
16
-
-
0033572644
-
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
-
Goberdhan, D.C., Paricio, N., Goodman, E.C., Mlodzik, M. and Wilson, C. (1999) Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev., 13, 3244-3258.
-
(1999)
Genes Dev.
, vol.13
, pp. 3244-3258
-
-
Goberdhan, D.C.1
Paricio, N.2
Goodman, E.C.3
Mlodzik, M.4
Wilson, C.5
-
17
-
-
0033376684
-
PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
-
Huang, H., Potter, C.J., Tao, W., Li, D.M., Brogiolo, W., Hafen, E., Sun, H. and Xu, T. (1999) PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development, 126, 5365-5372.
-
(1999)
Development
, vol.126
, pp. 5365-5372
-
-
Huang, H.1
Potter, C.J.2
Tao, W.3
Li, D.M.4
Brogiolo, W.5
Hafen, E.6
Sun, H.7
Xu, T.8
-
18
-
-
0036801311
-
PTEN function in mammalian cell size regulation
-
Backman, S., Stambolic, V. and Mak, T. (2002) PTEN function in mammalian cell size regulation. Curr. Opin. Neurobiol., 12, 516-522.
-
(2002)
Curr. Opin. Neurobiol.
, vol.12
, pp. 516-522
-
-
Backman, S.1
Stambolic, V.2
Mak, T.3
-
19
-
-
0037310664
-
Physiological functions of Pten in mouse tissues
-
Kishimoto, H., Hamada, K., Saunders, M., Backman, S., Sasaki, T., Nakano, T., Mak, T.W. and Suzuki, A. (2003) Physiological functions of Pten in mouse tissues. Cell Struct. Funct., 28, 11-21.
-
(2003)
Cell Struct. Funct.
, vol.28
, pp. 11-21
-
-
Kishimoto, H.1
Hamada, K.2
Saunders, M.3
Backman, S.4
Sasaki, T.5
Nakano, T.6
Mak, T.W.7
Suzuki, A.8
-
20
-
-
0033615538
-
Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
-
Lee, J.O., Yang, H., Georgescu, M.M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J.E., Pandolfi, P. and Pavletich, N.P. (1999) Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell, 99, 323-334.
-
(1999)
Cell
, vol.99
, pp. 323-334
-
-
Lee, J.O.1
Yang, H.2
Georgescu, M.M.3
Di Cristofano, A.4
Maehama, T.5
Shi, Y.6
Dixon, J.E.7
Pandolfi, P.8
Pavletich, N.P.9
-
21
-
-
0343183328
-
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
-
Liliental, J., Moon, S.Y., Lesche, R., Mamillapalli, R., Li, D., Zheng, Y., Sun, H. and Wu, H. (2000) Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr. Biol., 10, 401-404.
-
(2000)
Curr. Biol.
, vol.10
, pp. 401-404
-
-
Liliental, J.1
Moon, S.Y.2
Lesche, R.3
Mamillapalli, R.4
Li, D.5
Zheng, Y.6
Sun, H.7
Wu, H.8
-
22
-
-
0032486198
-
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
-
Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. and Yamada, K.M. (1998) Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science, 280, 1614-1617.
-
(1998)
Science
, vol.280
, pp. 1614-1617
-
-
Tamura, M.1
Gu, J.2
Matsumoto, K.3
Aota, S.4
Parsons, R.5
Yamada, K.M.6
-
23
-
-
0035253503
-
Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death
-
Weng, L.P., Gimm, O., Kum, J.B., Smith, W.M., Zhou, X.P., Wynford-Thomas, D., Leone, G. and Eng, C. (2001) Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. Hum. Mol. Genet, 10, 251-258.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 251-258
-
-
Weng, L.P.1
Gimm, O.2
Kum, J.B.3
Smith, W.M.4
Zhou, X.P.5
Wynford-Thomas, D.6
Leone, G.7
Eng, C.8
-
24
-
-
0032583122
-
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways
-
Gu, J., Tamura, M. and Yamada, K.M. (1998) Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J. Cell. Biol., 143, 1375-1383.
-
(1998)
J. Cell. Biol.
, vol.143
, pp. 1375-1383
-
-
Gu, J.1
Tamura, M.2
Yamada, K.M.3
-
25
-
-
0033606767
-
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
-
Gu, J., Tamura, M., Pankov, R., Danen, E.H., Takino, T., Matsumoto, K. and Yamada, K.M. (1999) Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J. Cell Biol., 146, 389-403.
-
(1999)
J. Cell Biol.
, vol.146
, pp. 389-403
-
-
Gu, J.1
Tamura, M.2
Pankov, R.3
Danen, E.H.4
Takino, T.5
Matsumoto, K.6
Yamada, K.M.7
-
26
-
-
0034921007
-
Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
-
Yamada, K.M. and Araki, M. (2001) Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J. Cell Sci., 114, 2375-2382.
-
(2001)
J. Cell Sci.
, vol.114
, pp. 2375-2382
-
-
Yamada, K.M.1
Araki, M.2
-
27
-
-
0034671221
-
Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor
-
Georgescu, M.M., Kirsch, K.H., Kaloudis, P., Yang, H., Pavletich, N.P., and Hanafusa, H. (2000) Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res., 60, 7033-7038.
-
(2000)
Cancer Res.
, vol.60
, pp. 7033-7038
-
-
Georgescu, M.M.1
Kirsch, K.H.2
Kaloudis, P.3
Yang, H.4
Pavletich, N.P.5
Hanafusa, H.6
-
28
-
-
0036181869
-
PTEN: The down side of PI 3-kinase signalling
-
Leslie, N.R. and Downes, C.P. (2002) PTEN: The down side of PI 3-kinase signalling. Cell Signal., 14, 285-295.
-
(2002)
Cell Signal.
, vol.14
, pp. 285-295
-
-
Leslie, N.R.1
Downes, C.P.2
-
29
-
-
0034657764
-
Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
-
Gao, X., Neufeld, T.P. and Pan, D. (2000) Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev. Biol., 221, 404-418.
-
(2000)
Dev. Biol.
, vol.221
, pp. 404-418
-
-
Gao, X.1
Neufeld, T.P.2
Pan, D.3
-
30
-
-
0036713481
-
The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
-
Oldham, S., Stocker, H., Laffargue, M., Wittwer, F., Wymann, M. and Hafen, E. (2002) The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels. Development, 129, 4103-4109.
-
(2002)
Development
, vol.129
, pp. 4103-4109
-
-
Oldham, S.1
Stocker, H.2
Laffargue, M.3
Wittwer, F.4
Wymann, M.5
Hafen, E.6
-
31
-
-
12444284168
-
The biological functions of insulin receptor signalling: Size isn't everything, even in Drosophila
-
(in press)
-
Goberdhan, D.C., Wilson, C. (2003) The biological functions of insulin receptor signalling: size isn't everything, even in Drosophila. Differentiation, (in press).
-
(2003)
Differentiation
-
-
Goberdhan, D.C.1
Wilson, C.2
-
32
-
-
0035805162
-
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
-
Potter, C.J., Huang, H. and Xu, T. (2001) Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell, 105, 357-368.
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
Huang, H.2
Xu, T.3
-
33
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
Tapon, N., Ito, N., Dickson, B.J., Treisman, J.E. and Hariharan, I.K. (2001) The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell, 105, 345-355.
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
34
-
-
0034982971
-
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
-
Gao, X. and Pan, D. (2001) TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev., 15, 1383-1392.
-
(2001)
Genes Dev.
, vol.15
, pp. 1383-1392
-
-
Gao, X.1
Pan, D.2
-
35
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signalling network
-
Saucedo, L.J., Gao, X., Chiarelli, D.A., Li, L., Pan, D. and Edgar, B.A. (2003) Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol., 5, 566-571.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
Li, L.4
Pan, D.5
Edgar, B.A.6
-
36
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker, H., Radimerski, T., Schindelbolz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G. and Hafen, E. (2003) Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol., 5, 559-566.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-566
-
-
Stocker, H.1
Radimerski, T.2
Schindelbolz, B.3
Wittwer, F.4
Belawat, P.5
Daram, P.6
Breuer, S.7
Thomas, G.8
Hafen, E.9
-
37
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Zhang, Y., Gao, X., Saucedo, L.J., Ru, B., Edgar, B.A. and Pan, D. (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol., 5, 578-581.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
-
38
-
-
0037086001
-
Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
Stocker, H., Andjelkovic, M., Oldham, S., Laffargue, M., Wymann, M.P., Hemmings, B.A. and Hafen, E. (2002) Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science, 295, 2088-2091.
-
(2002)
Science
, vol.295
, pp. 2088-2091
-
-
Stocker, H.1
Andjelkovic, M.2
Oldham, S.3
Laffargue, M.4
Wymann, M.P.5
Hemmings, B.A.6
Hafen, E.7
-
39
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter, C.J., Pedraza, L.G. and Xu, T. (2002) Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol., 4, 658-665.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
40
-
-
0036119219
-
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
-
Radimerski, T., Montagne, J., Rintelen, F., Stocker, H., van der Kaay, J., Downes, C.P., Hafen, E. and Thomas, G. (2002) dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat. Cell Biol., 4, 251-255.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 251-255
-
-
Radimerski, T.1
Montagne, J.2
Rintelen, F.3
Stocker, H.4
van der Kaay, J.5
Downes, C.P.6
Hafen, E.7
Thomas, G.8
-
41
-
-
0037108151
-
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
-
Radimerski, T., Montagne, J., Hemmings-Mieszczak, M. and Thomas, G. (2002) Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. Genes Dev., 16, 2627-2632.
-
(2002)
Genes Dev.
, vol.16
, pp. 2627-2632
-
-
Radimerski, T.1
Montagne, J.2
Hemmings-Mieszczak, M.3
Thomas, G.4
-
43
-
-
0036943458
-
Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size
-
Goberdhan, D.C. and Wilson, C. (2002) Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size. Dev. Genes Evol., 212, 196-202.
-
(2002)
Dev. Genes Evol.
, vol.212
, pp. 196-202
-
-
Goberdhan, D.C.1
Wilson, C.2
-
44
-
-
0035815445
-
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
-
Tatar, M., Kopelman, A., Epstein, D., Tu, M.P., Yin, C.M. and Garofalo, R.S. (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science, 292, 107-110.
-
(2001)
Science
, vol.292
, pp. 107-110
-
-
Tatar, M.1
Kopelman, A.2
Epstein, D.3
Tu, M.P.4
Yin, C.M.5
Garofalo, R.S.6
-
45
-
-
0035815414
-
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
-
Clancy, D.J., Gems, D., Harshman, L.G., Oldham, S., Stocker, H., Hafen, E., Leevers, S.J. and Partridge, L. (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science, 292, 104-106.
-
(2001)
Science
, vol.292
, pp. 104-106
-
-
Clancy, D.J.1
Gems, D.2
Harshman, L.G.3
Oldham, S.4
Stocker, H.5
Hafen, E.6
Leevers, S.J.7
Partridge, L.8
-
46
-
-
0037052544
-
Ablation of insulin-producing neurons in flies: Growth and diabetic phenotypes
-
Rulifson, E.J., Kim, S.K. and Nusse, R. (2002) Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science, 296, 1118-1120.
-
(2002)
Science
, vol.296
, pp. 1118-1120
-
-
Rulifson, E.J.1
Kim, S.K.2
Nusse, R.3
-
47
-
-
0037031147
-
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
-
Ikeya, T., Galic, M., Belawat, P., Nairz, K. and Hafen, E. (2002) Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol., 12, 1293-1300.
-
(2002)
Curr. Biol.
, vol.12
, pp. 1293-1300
-
-
Ikeya, T.1
Galic, M.2
Belawat, P.3
Nairz, K.4
Hafen, E.5
-
48
-
-
0032238299
-
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
-
Ogg, S. and Ruvkun, G. (1998) The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell, 2, 887-893.
-
(1998)
Mol. Cell
, vol.2
, pp. 887-893
-
-
Ogg, S.1
Ruvkun, G.2
-
49
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Geloen, A., Even, P.C., Cervera, P. and Le Bouc, Y. (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature, 421, 182-187.
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Geloen, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
50
-
-
0034680008
-
The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
-
Scanga, S.E., Ruel, L., Binari, R.C., Snow, B., Stambolic, V., Bouchard, D., Peters, M., Calvieri, B., Mak, T.W., Woodgett, J.R. et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene, 19, 3971-3977.
-
(2000)
Oncogene
, vol.19
, pp. 3971-3977
-
-
Scanga, S.E.1
Ruel, L.2
Binari, R.C.3
Snow, B.4
Stambolic, V.5
Bouchard, D.6
Peters, M.7
Calvieri, B.8
Mak, T.W.9
Woodgett, J.R.10
-
51
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki, A., de la Pompa, J.L., Stambolic, V., Elia, A.J., Sasaki, T., del Barco Barrantes, I., Ho, A., Wakeham, A., Itie, A., Khoo, W. et al. (1998) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol., 8, 1169-1178.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1169-1178
-
-
Suzuki, A.1
de la Pompa, J.L.2
Stambolic, V.3
Elia, A.J.4
Sasaki, T.5
del Barco Barrantes, I.6
Ho, A.7
Wakeham, A.8
Itie, A.9
Khoo, W.10
-
52
-
-
0031870959
-
Pten is essential for embryonic development and tumour suppression
-
Di Cristofano, A., Pesce, B., Cordon-Cardo, C. and Pandolfi, P.P. (1998) Pten is essential for embryonic development and tumour suppression. Nat. Genet., 19, 348-355.
-
(1998)
Nat. Genet.
, vol.19
, pp. 348-355
-
-
Di Cristofano, A.1
Pesce, B.2
Cordon-Cardo, C.3
Pandolfi, P.P.4
-
53
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
Podsypanina, K., Ellenson, L.H., Nemes, A., Gu, J., Tamura, M., Yamada, K.M., Cordon-Cardo, C., Catoretti, G., Fisher, P.E. and Parsons, R. (1999) Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl Acad. Sci. USA, 96, 1563-1568.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
54
-
-
0034234268
-
+/- mice
-
+/- mice. Cancer Res., 60, 3605-3611.
-
(2000)
Cancer Res.
, vol.60
, pp. 3605-3611
-
-
Stambolic, V.1
Tsao, M.S.2
Macpherson, D.3
Suzuki, A.4
Chapman, W.B.5
Mak, T.W.6
-
55
-
-
0035733762
-
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
-
Backman, S.A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J., Tsao, M.S., Shannon, P., Bolon, B., Ivy, G.O. et al. (2001) Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet., 29, 396-403.
-
(2001)
Nat. Genet.
, vol.29
, pp. 396-403
-
-
Backman, S.A.1
Stambolic, V.2
Suzuki, A.3
Haight, J.4
Elia, A.5
Pretorius, J.6
Tsao, M.S.7
Shannon, P.8
Bolon, B.9
Ivy, G.O.10
-
56
-
-
0035734381
-
Pten regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
-
Kwon, C.H., Zhu, X., Zhang, J., Knoop, L.L., Tharp, R., Smeyne, R.J., Eberhart, C.G., Burger, P.C. and Baker, S.J. (2001) Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat. Genet., 29, 404-411.
-
(2001)
Nat. Genet.
, vol.29
, pp. 404-411
-
-
Kwon, C.H.1
Zhu, X.2
Zhang, J.3
Knoop, L.L.4
Tharp, R.5
Smeyne, R.J.6
Eberhart, C.G.7
Burger, P.C.8
Baker, S.J.9
-
57
-
-
0035824396
-
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
-
Groszer, M., Erickson, R., Scripture-Adams, D.D., Lesche, R., Trumpp, A., Zack, J.A., Komblum, H.I., Liu, X. and Wu, H. (2001) Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science, 294, 2186-2189.
-
(2001)
Science
, vol.294
, pp. 2186-2189
-
-
Groszer, M.1
Erickson, R.2
Scripture-Adams, D.D.3
Lesche, R.4
Trumpp, A.5
Zack, J.A.6
Komblum, H.I.7
Liu, X.8
Wu, H.9
-
58
-
-
0036279763
-
PTEN in neural precursor cells: Regulation of migration, apoptosis, and proliferation
-
Li, L., Liu, F., Salmonsen, R.A., Turner, T.K., Litofsky, N.S., Di Cristofano, A., Pandolfi, P.P., Jones, S.N., Recht, L.D. and Ross, A.H. (2002) PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol. Cell Neurosci., 20, 21-29.
-
(2002)
Mol. Cell Neurosci.
, vol.20
, pp. 21-29
-
-
Li, L.1
Liu, F.2
Salmonsen, R.A.3
Turner, T.K.4
Litofsky, N.S.5
Di Cristofano, A.6
Pandolfi, P.P.7
Jones, S.N.8
Recht, L.D.9
Ross, A.H.10
-
59
-
-
0036637660
-
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum
-
Marino, S., Krimpenfort, P., Leung, C., van der Korput, H.A., Trapman, J., Camenisch, I., Berns, A. and Brandner, S. (2002) PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development, 129, 3513-3522.
-
(2002)
Development
, vol.129
, pp. 3513-3522
-
-
Marino, S.1
Krimpenfort, P.2
Leung, C.3
van der Korput, H.A.4
Trapman, J.5
Camenisch, I.6
Berns, A.7
Brandner, S.8
-
60
-
-
0034213075
-
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
-
Shioi, T., Kang, P.M., Douglas, P.S., Harape, J., Yballe, C.M., Lawitts, J., Cantley, L.C. and Izumo, S. (2000) The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J., 19, 2537-2548.
-
(2000)
EMBO J.
, vol.19
, pp. 2537-2548
-
-
Shioi, T.1
Kang, P.M.2
Douglas, P.S.3
Harape, J.4
Yballe, C.M.5
Lawitts, J.6
Cantley, L.C.7
Izumo, S.8
-
61
-
-
0035736260
-
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
-
Bodine, S.C., Stitt, T.N., Gonzalez, M., Kline, W.O., Stover, G.L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J.C., Glass, D.J. et al. (2001) Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol., 3, 1014-1019.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1014-1019
-
-
Bodine, S.C.1
Stitt, T.N.2
Gonzalez, M.3
Kline, W.O.4
Stover, G.L.5
Bauerlein, R.6
Zlotchenko, E.7
Scrimgeour, A.8
Lawrence, J.C.9
Glass, D.J.10
-
62
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar, D.C., Salama, S., Tsou, C., Harlow, E. and Blenis, J. (2002) Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev., 16, 1472-1487.
-
(2002)
Genes Dev.
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
Harlow, E.4
Blenis, J.5
-
63
-
-
0032843540
-
+/- mice
-
+/- mice. Science, 285, 2122-2125.
-
(1999)
Science
, vol.285
, pp. 2122-2125
-
-
Di Cristofano, A.1
Kotsi, P.2
Peng, Y.F.3
Cordon-Cardo, C.4
Elkon, K.B.5
Pandolfi, P.P.6
-
64
-
-
0034995242
-
T cell-specific loss of Pten leads to defects in central and peripheral tolerance
-
Suzuki, A., Yamaguchi, M.T., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A., Higuchi, T., Fukumoto, M. et al. (2001) T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity, 14, 523-534.
-
(2001)
Immunity
, vol.14
, pp. 523-534
-
-
Suzuki, A.1
Yamaguchi, M.T.2
Ohteki, T.3
Sasaki, T.4
Kaisho, T.5
Kimura, Y.6
Yoshida, R.7
Wakeham, A.8
Higuchi, T.9
Fukumoto, M.10
-
65
-
-
0036201223
-
Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN
-
Seminario, M.C. and Wange, R.L. (2002) Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN. Semin. Immunol., 14, 27-36.
-
(2002)
Semin. Immunol.
, vol.14
, pp. 27-36
-
-
Seminario, M.C.1
Wange, R.L.2
-
66
-
-
0037416216
-
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination
-
Suzuki, A., Kaisho, T., Ohishi, M., Tsukio-Yamaguchi, M., Tsubata, T., Koni, P.A., Sasaki, T., Mak, T.W. and Nakano, T. (2003) Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J. Exp. Med., 197, 657-667.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 657-667
-
-
Suzuki, A.1
Kaisho, T.2
Ohishi, M.3
Tsukio-Yamaguchi, M.4
Tsubata, T.5
Koni, P.A.6
Sasaki, T.7
Mak, T.W.8
Nakano, T.9
-
67
-
-
0035656273
-
Regulation of Drosophila tracheal system development by protein kinase B
-
Jin, J., Anthopoulos, N., Wetsch, B., Binari, R.C., Isaac, D.D., Andrew, D.J., Woodgett, J.R. and Manoukian, A.S. (2001) Regulation of Drosophila tracheal system development by protein kinase B. Dev. Cell, 1, 817-827.
-
(2001)
Dev. Cell
, vol.1
, pp. 817-827
-
-
Jin, J.1
Anthopoulos, N.2
Wetsch, B.3
Binari, R.C.4
Isaac, D.D.5
Andrew, D.J.6
Woodgett, J.R.7
Manoukian, A.S.8
-
68
-
-
18644372367
-
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
-
Crackower, M.A., Oudit, G.Y., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J. et al. (2002) Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell, 110, 737-749.
-
(2002)
Cell
, vol.110
, pp. 737-749
-
-
Crackower, M.A.1
Oudit, G.Y.2
Kozieradzki, I.3
Sarao, R.4
Sun, H.5
Sasaki, T.6
Hirsch, E.7
Suzuki, A.8
Shioi, T.9
Irie-Sasaki, J.10
-
69
-
-
0037205230
-
Tumor suppressor PTEN mediates sensing of chemoattractant gradients
-
Iijima, M. and Devreotes, P. (2002) Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell, 109, 599-610.
-
(2002)
Cell
, vol.109
, pp. 599-610
-
-
Iijima, M.1
Devreotes, P.2
-
70
-
-
0037205265
-
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
-
Funamoto, S., Meili, R., Lee, S., Party, L. and Firtel, R.A. (2002) Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell, 109, 611-623.
-
(2002)
Cell
, vol.109
, pp. 611-623
-
-
Funamoto, S.1
Meili, R.2
Lee, S.3
Party, L.4
Firtel, R.A.5
-
71
-
-
0034635513
-
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
-
Servant, G., Weiner, O.D., Herzmark, P., Balla, T., Sedat, J.W. and Bourne, H.R. (2000) Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science, 287, 1037-1040.
-
(2000)
Science
, vol.287
, pp. 1037-1040
-
-
Servant, G.1
Weiner, O.D.2
Herzmark, P.3
Balla, T.4
Sedat, J.W.5
Bourne, H.R.6
-
72
-
-
0037133606
-
Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis
-
Hannigan, M., Zhan, L., Li, Z., Ai, Y., Wu, D. and Huang, C.K. (2002) Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc. Natl Acad. Sci. USA, 99, 3603-3608.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 3603-3608
-
-
Hannigan, M.1
Zhan, L.2
Li, Z.3
Ai, Y.4
Wu, D.5
Huang, C.K.6
-
73
-
-
0036308458
-
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
-
Wang, F., Herzmark, P., Weiner, O.D., Srinivasan, S., Servant, G. and Bourne, H.R. (2002) Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat. Cell Biol., 4, 513-518.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 513-518
-
-
Wang, F.1
Herzmark, P.2
Weiner, O.D.3
Srinivasan, S.4
Servant, G.5
Bourne, H.R.6
-
74
-
-
0036308972
-
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
-
Weiner, O.D., Neilsen, P.O., Prestwich, G.D., Kirschner, M.W., Cantley, L.C. and Bourne, H.R. (2002) A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat. Cell Biol., 4, 509-513.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 509-513
-
-
Weiner, O.D.1
Neilsen, P.O.2
Prestwich, G.D.3
Kirschner, M.W.4
Cantley, L.C.5
Bourne, H.R.6
-
75
-
-
0037428076
-
Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity
-
Shi, S.H., Jan, L.Y. and Jan, Y.N. (2003) Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell, 112, 63-75.
-
(2003)
Cell
, vol.112
, pp. 63-75
-
-
Shi, S.H.1
Jan, L.Y.2
Jan, Y.N.3
-
76
-
-
0031892814
-
Single neuron mosaics of the Drosaphila gigas mutant project beyond normal targets and modify behavior
-
Canal, I., Acebes, A. and Ferrus, A. (1998) Single neuron mosaics of the Drosaphila gigas mutant project beyond normal targets and modify behavior. J Neurosci., 18, 999-1008.
-
(1998)
J. Neurosci.
, vol.18
, pp. 999-1008
-
-
Canal, I.1
Acebes, A.2
Ferrus, A.3
-
77
-
-
0036714316
-
Invasive cell migration is initiated by guided growth of long cellular extensions
-
Fulga, T.A. and Rorth, P. (2002) Invasive cell migration is initiated by guided growth of long cellular extensions. Nat. Cell Biol., 4, 715-719.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 715-719
-
-
Fulga, T.A.1
Rorth, P.2
-
78
-
-
0035878707
-
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
-
Leslie, N.R., Bennett, D., Gray, A., Pass, I., Hoang-Xuan, K. and Downes, C.P. (2001) Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem. J., 357, 427-435.
-
(2001)
Biochem. J.
, vol.357
, pp. 427-435
-
-
Leslie, N.R.1
Bennett, D.2
Gray, A.3
Pass, I.4
Hoang-Xuan, K.5
Downes, C.P.6
-
79
-
-
0034652102
-
A role for nuclear PTEN in neuronal differentiation
-
Lachyankar, M.B., Sultana, N., Schonhoff, C.M., Mitra, P., Poluha, W., Lambert, S., Quesenberry, P.J., Litofsky, N.S., Recht, L.D., Nabi, R. et al. (2000) A role for nuclear PTEN in neuronal differentiation. J. Neurosci., 20, 1404-1413.
-
(2000)
J. Neurosci.
, vol.20
, pp. 1404-1413
-
-
Lachyankar, M.B.1
Sultana, N.2
Schonhoff, C.M.3
Mitra, P.4
Poluha, W.5
Lambert, S.6
Quesenberry, P.J.7
Litofsky, N.S.8
Recht, L.D.9
Nabi, R.10
-
80
-
-
0033843623
-
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
-
Gimm, O., Perren, A., Weng, L.P., Marsh, D.J., Yeh, J.J., Ziebold, U., Gil, E., Hinze, R., Delbridge, L., Lees, J.A. et al. (2000) Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am. J. Pathol., 156, 1693-1700.
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 1693-1700
-
-
Gimm, O.1
Perren, A.2
Weng, L.P.3
Marsh, D.J.4
Yeh, J.J.5
Ziebold, U.6
Gil, E.7
Hinze, R.8
Delbridge, L.9
Lees, J.A.10
-
81
-
-
0033809990
-
Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells
-
Perren, A., Komminoth, P., Saremaslani, P., Matter, C., Feurer, S., Lees, J.A., Heitz, P.U. and Eng, C. (2000) Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. Am. J. Pathol., 157, 1097-1103.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1097-1103
-
-
Perren, A.1
Komminoth, P.2
Saremaslani, P.3
Matter, C.4
Feurer, S.5
Lees, J.A.6
Heitz, P.U.7
Eng, C.8
-
82
-
-
0034743127
-
Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing
-
Osborne, S.L., Thomas, C.L., Gschmeissner, S. and Schiavo, G. (2001) Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. J. Cell. Sci., 114, 2501-2511.
-
(2001)
J. Cell. Sci.
, vol.114
, pp. 2501-2511
-
-
Osborne, S.L.1
Thomas, C.L.2
Gschmeissner, S.3
Schiavo, G.4
-
83
-
-
0037057801
-
The nuclear phosphoinositide 3-kinase/AKT pathway: A new second messenger system
-
1584
-
Neri, L.M., Borgatti, P., Capitani, S. and Martelli, A.M. (2002) The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim. Biophys. Acta, 1584, 73-80.
-
(2002)
Biochim. Biophys. Acta
, pp. 73-80
-
-
Neri, L.M.1
Borgatti, P.2
Capitani, S.3
Martelli, A.M.4
-
84
-
-
0035966127
-
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
-
Vazquez, F., Grossman, S.R., Takahashi, Y., Rokas, M.V., Nakamura, N. and Sellers, W.R. (2001) Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J. Biol. Chem., 276, 48627-48630.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48627-48630
-
-
Vazquez, F.1
Grossman, S.R.2
Takahashi, Y.3
Rokas, M.V.4
Nakamura, N.5
Sellers, W.R.6
-
85
-
-
0033946740
-
Phosphorylation of the PTEN tail regulates protein stability and function
-
Vazquez, F., Ramaswamy, S., Nakamura, N. and Sellers, W.R. (2000) Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell. Biol., 20, 5010-5018.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5010-5018
-
-
Vazquez, F.1
Ramaswamy, S.2
Nakamura, N.3
Sellers, W.R.4
-
86
-
-
0038272084
-
Membrane-binding and activation mechanism of PTEN
-
Das, S., Dixon, J.E. and Cho, W. (2003) Membrane-binding and activation mechanism of PTEN. Proc. Natl Acad. Sci. USA, 100, 7491-7496.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 7491-7496
-
-
Das, S.1
Dixon, J.E.2
Cho, W.3
-
87
-
-
0035847102
-
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
-
Torres, J. and Pulido, R. (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem., 276, 993-998.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 993-998
-
-
Torres, J.1
Pulido, R.2
-
88
-
-
0037174166
-
Direct identification of PTEN phosphorylation sites
-
Miller, S.J., Lou, D.Y., Seldin, D.C., Lane, W.S. and Neel, B.G. (2002) Direct identification of PTEN phosphorylation sites. FEBS Lett., 528, 145-153.
-
(2002)
FEBS Lett.
, vol.528
, pp. 145-153
-
-
Miller, S.J.1
Lou, D.Y.2
Seldin, D.C.3
Lane, W.S.4
Neel, B.G.5
-
89
-
-
0036644058
-
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation
-
Birle, D., Bottini, N., Williams, S., Huynh, H., deBelle, I., Adamson, E. and Mustelin, T. (2002) Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J. Immunol., 169, 286-291.
-
(2002)
J. Immunol.
, vol.169
, pp. 286-291
-
-
Birle, D.1
Bottini, N.2
Williams, S.3
Huynh, H.4
deBelle, I.5
Adamson, E.6
Mustelin, T.7
-
90
-
-
0037444213
-
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels
-
Waite, K.A. and Eng, C. (2003) BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum. Mol. Genet., 12, 679-684.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 679-684
-
-
Waite, K.A.1
Eng, C.2
-
91
-
-
0036843937
-
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
-
Kurose, K., Gilley, K., Matsumoto, S., Watson, P.H., Zhou, X.P. and Eng, C. (2002) Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat. Genet., 32, 355-357.
-
(2002)
Nat. Genet.
, vol.32
, pp. 355-357
-
-
Kurose, K.1
Gilley, K.2
Matsumoto, S.3
Watson, P.H.4
Zhou, X.P.5
Eng, C.6
-
92
-
-
0041450058
-
PTEN tumor suppressor regulates P53 protein levels and activity through phosphatase-dependent and -independent mechanisms
-
Freeman, D.J., Li, A.G., Wei, G., Li, H.H., Kertesz, N., Lesche, R., Whale, A.D., Martinez-Diaz, H., Rozengurt, N., Cardiff, R.D. et al. (2003) PTEN tumor suppressor regulates P53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell, 3, 117-130.
-
(2003)
Cancer Cell
, vol.3
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.H.4
Kertesz, N.5
Lesche, R.6
Whale, A.D.7
Martinez-Diaz, H.8
Rozengurt, N.9
Cardiff, R.D.10
-
93
-
-
0141955349
-
PTEN and P53: Who will get the upper hand?
-
Trotman, L.C. and Pandolfi, P.P. (2003) PTEN and P53: Who will get the upper hand? Cancer Cell, 3, 97-9.
-
(2003)
Cancer Cell
, vol.3
, pp. 97-99
-
-
Trotman, L.C.1
Pandolfi, P.P.2
-
94
-
-
0037067656
-
P53: Good cop/bad cop
-
Sharpless, N.E. and DePinho, R.A. (2002) P53: good cop/bad cop. Cell, 110, 9-12.
-
(2002)
Cell
, vol.110
, pp. 9-12
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
95
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo, L.D. and Donner, D.B. (2001) A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl Acad. Sci. USA, 98, 11598-11603.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
96
-
-
0035865399
-
A role for P53 in base excision repair
-
Zhou, J., Ahn, J., Wilson, S.H. and Prives, C. (2001) A role for P53 in base excision repair. EMBO J., 20, 914-923.
-
(2001)
EMBO J.
, vol.20
, pp. 914-923
-
-
Zhou, J.1
Ahn, J.2
Wilson, S.H.3
Prives, C.4
-
97
-
-
0034854091
-
Regulation of PTEN transcription by P53
-
Stambolic, V., MacPherson, D., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S. and Mak, T.W. (2001) Regulation of PTEN transcription by P53. Mol. Cell, 8, 317-325.
-
(2001)
Mol. Cell
, vol.8
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
Benchimol, S.7
Mak, T.W.8
-
98
-
-
0037085271
-
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
-
Mayo, L.D., Dixon, J.E., Durden, D.L., Tonks, N.K. and Donner, D.B. (2002) PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J. Biol. Chem., 277, 5484-5489.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5484-5489
-
-
Mayo, L.D.1
Dixon, J.E.2
Durden, D.L.3
Tonks, N.K.4
Donner, D.B.5
-
99
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
Hidalgo, M. and Rowinsky, E.K. (2000) The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene, 19, 6680-6686.
-
(2000)
Oncogene
, vol.19
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
100
-
-
0035199914
-
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
-
Virolle, T., Adamson, E.D., Baron, V., Birle, D., Mercola, D., Mustelin, T. and de Belle, I. (2001) The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat. Cell Biol., 3, 1124-1128.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1124-1128
-
-
Virolle, T.1
Adamson, E.D.2
Baron, V.3
Birle, D.4
Mercola, D.5
Mustelin, T.6
de Belle, I.7
-
101
-
-
0036094861
-
Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN
-
Huang, J. and Kontos, C.D. (2002) Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. Arterioscler. Thromb. Vasc. Biol., 22, 745-751.
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 745-751
-
-
Huang, J.1
Kontos, C.D.2
-
102
-
-
0036231778
-
Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice
-
Butler, M., McKay, R.A., Popoff, I.J., Gaude, W.A., Witchell, D., Murray, S.F., Dean, N.M., Bhanot, S. and Monia, B.P. (2002) Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes, 51, 1028-1034.
-
(2002)
Diabetes
, vol.51
, pp. 1028-1034
-
-
Butler, M.1
McKay, R.A.2
Popoff, I.J.3
Gaude, W.A.4
Witchell, D.5
Murray, S.F.6
Dean, N.M.7
Bhanot, S.8
Monia, B.P.9
-
103
-
-
0036741622
-
An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye
-
Tseng, A.S. and Hariharan, I.K. (2002) An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. Genetics, 162, 229-243.
-
(2002)
Genetics
, vol.162
, pp. 229-243
-
-
Tseng, A.S.1
Hariharan, I.K.2
-
104
-
-
0036670695
-
The bantam gene regulates Drosophila growth
-
Hipfher, D.R., Weigmann, K. and Cohen, S.M. (2002) The bantam gene regulates Drosophila growth. Genetics, 161, 1527-1537.
-
(2002)
Genetics
, vol.161
, pp. 1527-1537
-
-
Hipfher, D.R.1
Weigmann, K.2
Cohen, S.M.3
-
105
-
-
0037418839
-
Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosaphila
-
Brennecke, J., Hipfher, D.R., Stark, A., Russell, R.B. and Cohen, S.M. (2003) bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosaphila. Cell, 113, 25-36.
-
(2003)
Cell
, vol.113
, pp. 25-36
-
-
Brennecke, J.1
Hipfher, D.R.2
Stark, A.3
Russell, R.B.4
Cohen, S.M.5
|