Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

American Journal of Pathology

Volumn 157, Issue 4, 2000, Pages 1097-1103

  Perren, Aurel ^a,b,c   Komminoth, Paul ^a,c   Saremaslani, Parvin ^a,c   Matter, Claudia ^a,c   Feurer, Seraina ^a,c   Lees, Jacqueline A ^c,d   Heitz, Philipp U ^a,c   Eng, Charis ^b,c,e  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CELLULAR DISTRIBUTION; CHROMOSOME 10Q; COWDEN SYNDROME; EXON; FEMALE; GENE EXPRESSION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MALIGNANT TRANSFORMATION; PANCREAS ISLET CELL TUMOR; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

EID: 0033809990     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64624-X     Document Type: Article

References (31)

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2. Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms
3. Identification of p53 gene mutations in gastrointestinal and pancreatic carcinoids by nonradioisotopic SSCA
4. Oncogene expression in endocrine pancreatic tumors
5. Genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization
6. Localization of the gene for Cowden disease to 10q22-23
7. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer
8. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
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11. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
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13. Germline and germline mosaic mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arterio-venous malformations and lipomatosis
14. PTEN1 is frequently mutated in primary endometrial carcinomas
15. PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma
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17. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
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20. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
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28. Phospholipid signalling in the nucleus
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30. Phosphotidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocyte differentiation