The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP3 levels

Development

Volumn 129, Issue 17, 2002, Pages 4103-4109

  Oldham, Sean ^a   Stocker, Hugo ^a   Laffargue, Muriel ^a   Wittwer, Franz ^a   Wymann, Matthias ^a   Hafen, Ernst ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Cancer; Growth; Insulin; PI 3 kinase; PtdInsP3; Pten; Tumor suppressor

Indexed keywords

ADAPTOR PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INOSITOL PHOSPHATE; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE P60; RAS PROTEIN; SOMATOMEDIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOCHEMISTRY; BODY GROWTH; BODY SIZE; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; GENE ACTIVITY; GENE LOSS; GENE MUTATION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; BODY CONSTITUTION; CARRIER PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; RECEPTOR, INSULIN; RECEPTORS, SOMATOMEDIN; SECOND MESSENGER SYSTEMS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; HEXAPODA;

EID: 0036713481     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
2. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
3. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
4. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
5. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
6. Role of brain insulin receptor in control of body weight and reproduction
7. IRS-2 pathways integrate female reproduction and energy homeostasis
8. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
9. The Drosophila insulin receptor is required for normal growth
10. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
11. The Drosophila insulin receptor homolog: A gene essential for embryonic development encodes two receptor isoforms with different signaling potential
12. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
13. Genetic analysis of insulin signaling in Drosophila
14. Drosophila tumor suppressor PTFN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
15. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
16. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
17. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
18. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
19. The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
20. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
21. PTEN: A tumour suppressor that functions as a phospholipid phosphatase
22. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
23. Genetic control of size in Drosophila
24. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
25. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
26. Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha). Functions of lipid kinase-deficient P13Kalpha in signaling
27. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
28. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro
29. The function of GRB2 in linking the insulin receptor to Ras signaling pathways
30. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
31. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
32. IGF-1 receptor signalling in transformation and differentiation
33. Synthesis and function of 3-phosphorylated inositol lipids
34. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
35. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
36. The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis
37. The IRS-signalling system during insulin and cytokine action