Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor

Cancer Research

Volumn 60, Issue 24, 2000, Pages 7033-7038

  Georgescu, Maria Magdalena ^a   Kirsch, Kathrin H ^a   Kaloudis, Paul ^b   Yang, Haijuan ^b   Pavletich, Nikola P ^b   Hanafusa, Hidesaburo ^a,c  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; GENE INACTIVATION; GENE LOSS; GENE MUTATION; HUMAN; HUMAN CELL; MEMBRANE BINDING; MYRISTYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

BINDING SITES; CATALYTIC DOMAIN; CELL DIVISION; CELL MEMBRANE; GENE DELETION; HUMANS; IMMUNOBLOTTING; LIPID METABOLISM; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTATION; MYRISTIC ACIDS; PHOSPHORIC MONOESTER HYDROLASES; PLASMIDS; POINT MUTATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034671221     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
2. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
3. PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers
4. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
5. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
6. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
7. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
8. Structure and function of phosphoinositide 3-kinases
9. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
10. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
11. The PTEN/MMAC1 tumor suppressor induces cell death that is rescue by the AKT/protein kinase B oncogene
12. 1 growth arrest in glioma cells
13. 1 cell cycle arrest in human glioblastoma cells
14. Regulation of Akt/PKB activity, cellular growth and apoptosis in prostate carcinoma cells by MMAC/PTEN
15. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
16. 2+-binding domain
17. The six amino-terminal amino acids of p60src are to cause myristylation of p21v-ras
18. Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-κB
19. PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas
20. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
21. Alterations PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines
22. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21
23. PEST sequences and regulation by proteolysis
24. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
25. Crystal structure of a mammalian phosphoinositide-specific phospholipase C δ
26. 2+/phospholipid binding fold
27. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase
28. Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
29. Mutational analysis of the PTEN gene in gliomas: Molecular and pathological correlations
30. Loss of heterozygosity and mutational analysis of the: PTEN/MMAC1 gene in synchronous endometrial and ovariar carcinomas
31. Mutation analysis of the PTEN/MMAC1 gene in lung cancer
32. Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers
33. Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease
34. Phosphorylation of the PTEN tail regulates protein stability and function
35. Pharmacological rescue of mutant p53 conformation and function