Tumor suppressor PTEN mediates sensing of chemoattractant gradients

Cell

Volumn 109, Issue 5, 2002, Pages 599-610

  Iijima, Miho ^a   Devreotes, Peter ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ACTIN POLYMERIZATION; ARTICLE; BINDING SITE; CHEMOTAXIS; CONTROLLED STUDY; DICTYOSTELIUM DISCOIDEUM; FEEDBACK SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; PROTOZOA;

EID: 0037205230     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00745-6     Document Type: Article

References (50)

1. Isolation of Dictyostelium discoideum cytokinesis mutants by restriction enzyme-mediated integration of the blasticidin S resistance marker
2. Chemokines in pathology and medicine
3. Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization
4. RNA in cytoplasmic and nuclear fractions of cellular slime mold amebas
5. Quantitative analysis of cyclic AMP waves mediating aggregation in Dictyostelium discoideum
6. Transmembrane signaling in Dictyostelium
7. Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
8. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
9. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC
10. Spatial sensing in fibroblasts mediated by 3′ phosphoinositides
11. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
12. Receptor-mediated activation of heterotrimeric G proteins in living cells
13. Localization of the G protein βγ complex in living cells during chemotaxis
14. Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses
15. Altered responsiveness to chemokines due to targeted disruption of SHIP
16. Microbiological assay of cyclic 3′,5′-AMP
17. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
18. Models of eukaryotic gradient sensing: Application to chemotaxis of amoebae and neutrophils
19. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
20. Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
21. Chemoattractant and GTP γ S-mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes
22. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
23. PTEN and myotubularin: Novel phosphoinositide phosphatases
24. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
25. The lipid phosphatase activity of PTEN is critical for its tumor supressor function
26. A membrane-permeant ester of phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) is an activator of human neutrophil migration
27. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
28. Molecular genetics of signal transduction in Dictyostelium
29. A cell's sense of direction
30. G protein signaling events are activated at the leading edge of chemotactic cells
31. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development
32. Leukocytes navigate by compass: Roles of PI3Kγ and its lipid products
33. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
34. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
35. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
36. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
37. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
38. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
39. Surface receptor-mediated activation of adenylate cyclase in Dictyostelium. Regulation by guanine nucleotides in wild-type cells and aggregation deficient mutants
40. Single-molecule analysis of chemotactic signaling in Dictyostelium cells
41. Molecular basis of localized responses during chemotaxis in amoebae and leukocytes
42. Signal transduction in the cellular slime molds
43. Synthesis and function of 3-phosphorylated inositol lipids
44. Eosinophils in asthma and other allergic diseases
45. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
46. Roles of phospholipid signaling in chemoattractant-induced responses
47. Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
48. Lipids on the move: Phosphoinositide 3-kinases in leukocyte function
49. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation
50. Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F actin distribution and impairs pinocytosis