-
1
-
-
0035066332
-
Alzheimer's Disease: Genes, Proteins and Therapy
-
81:741-766, 2001
-
Selkoe D.J., Alzheimer's Disease: Genes, Proteins and Therapy, Phys. Rev., 81:741-766, 2001
-
Phys. Rev.
-
-
Selkoe, D.J.1
-
2
-
-
0032899712
-
A full genome scan for late onset Alzheimer's disease
-
8:237-45, 1999
-
Kehoe P., Wavrant-De Vrieze .F, Crook R., Wu W.S., Holmans P., Fenton L, Spurlock G., Norton N., Williams H., Williams N., Lovestone S., PerezTur J., Hutton M., Chartier-Harlin M.C., Shears S., Roehl K., Booth J., Van Voorst W, Ramie D., Williams J., Goate A., Hardy J., Owen M J., A full genome scan for late onset Alzheimer's disease, Hum. Mol. Genet., 8:237-45, 1999
-
Hum. Mol. Genet.
-
-
Kehoe, P.1
Crook R, W.V.F.2
Wu, W.S.3
Holmans, P.4
Spurlock G, F.L.5
Norton, N.6
Williams, H.7
Williams, N.8
Lovestone, S.9
Pereztur, J.10
Hutton, M.11
Chartier-Harlin, M.C.12
Shears, S.13
Roehl, K.14
Booth, J.15
Van Ramie D, V.W.16
Williams, J.17
Goate, A.18
Hardy, J.19
Owen, M.J.20
more..
-
3
-
-
0031800003
-
The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease
-
27:119-142, 1998
-
Beffert U., Danik M., Krzykowski P., Ramassamy C., Berrada F., Poirier J., The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease, Brain Res. Rev., 27:119-142, 1998
-
Brain Res. Rev.
-
-
Beffert, U.1
Danik, M.2
Krzykowski, P.3
Ramassamy, C.4
Berrada, F.5
Poirier, J.6
-
4
-
-
0029844205
-
Human apolipoprotein E: The Alzheimer's Disease connection
-
10:1485-1494, 1996
-
Weisgraber K.H. and Mahley R.W., Human apolipoprotein E: the Alzheimer's Disease connection, FASEB J., 10:1485-1494, 1996
-
FASEB J.
-
-
Weisgraber, K.H.1
Mahley, R.W.2
-
5
-
-
0031149081
-
Altered apolipoprotein E secretion in cytokine treated human astrocyte cultures
-
148:15-8, 1997
-
Baskin F., Smith G.M., Fosmire J.A., Rosenberg R.N, Altered apolipoprotein E secretion in cytokine treated human astrocyte cultures, J. Neural. Sei, 148:15-8, 1997
-
J. Neural. Sei
-
-
Baskin, F.1
Smith, G.M.2
Fosmire, J.A.3
Rosenberg, R.N.4
-
6
-
-
0031079601
-
Astrocytes and microglia respond to estrogen with increased apoE mRNA HI vivo and HI vi'rro
-
143: 3138, 1997
-
Stone D.J., Rozovsky I., Morgan T.E., Anderson C.P., Hajian H., Finch C.E., Astrocytes and microglia respond to estrogen with increased apoE mRNA HI vivo and HI vi'rro, Exp. Neural., 143: 3138, 1997
-
Exp. Neural.
-
-
Stone, D.J.1
Rozovsky, I.2
Morgan, T.E.3
Anderson, C.P.4
Hajian, H.5
Finch, C.E.6
-
7
-
-
0035881730
-
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures
-
105:651-661,2001
-
Cedazo-Minguez A., Hamker U., Veh H., Meske V., Albert F., Cowburn R.F., Ohm T.G, Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures, Neuroscience, 105:651-661,2001
-
Neuroscience
-
-
Cedazo-Minguez, A.1
Hamker, U.2
Veh, H.3
Meske, V.4
Albert, F.5
Cowburn, R.F.6
Ohm, T.G.7
-
8
-
-
0033230490
-
Carboxyl-terminal domain of human apolipoprotein E: Expression, purification, and crystallization
-
17:267-272, 1999
-
Forstner M., Peters-Libeu C., Contreras-Forrest E., Newhouse Y., Knapp M., Rupp B., Weisgraber K. H., Carboxyl-terminal domain of human apolipoprotein E: expression, purification, and crystallization, Protein Expr. Purif., 17:267-272, 1999
-
Protein Expr. Purif.
-
-
Forstner, M.1
Peters-Libeu, C.2
Contreras-Forrest, E.3
Newhouse, Y.4
Knapp, M.5
Rupp, B.6
Weisgraber, K.H.7
-
9
-
-
0034100794
-
Apolipoprotein E4: An allele associated with many diseases
-
32:118-127, 2000
-
Smith J.D., Apolipoprotein E4: an allele associated with many diseases, Ann. Med., 32:118-127, 2000
-
Ann. Med.
-
-
Smith, J.D.1
-
10
-
-
0025735884
-
Linkage studies in familial Alzheimer disease: Evidence for chromosome 19 linkage
-
48:1034-50, 1991
-
Pericak-Vance M.A., Bebout J.L., Gaskell P.CJr., Yamaoka L.H., Hung W.Y., Alberts M.J., Walker A.P., Bartlett RJ., Haynes C.A., Welsh K.A., Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage, Am. J. Hum. Genet., 48:1034-50, 1991
-
Am. J. Hum. Genet.
-
-
Pericak-Vance, M.A.1
Bebout, J.L.2
P.cjr, G.3
Yamaoka, L.H.4
Hung, W.Y.5
Alberts, M.J.6
Walker, A.P.7
Bartlett, R.J.8
Haynes, C.A.9
Welsh, K.A.10
-
11
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
261:921-923, 1993
-
Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small GW., Roses A.D., Haines J.L., Pericak-Vance M.A., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, 261:921-923, 1993
-
Science
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
12
-
-
0032926539
-
Apolipoprotein E genetic variation and Alzheimer's disease. a metaanalysis
-
10:199209, 1999
-
Rubinsztein D.C, Easton D.F., Apolipoprotein E genetic variation and Alzheimer's disease. A metaanalysis, Dement. Geriatr. Cogn. Disord., 10:199209, 1999
-
Dement. Geriatr. Cogn. Disord.
-
-
Rubinsztein, D.C.1
Easton, D.F.2
-
13
-
-
17344374322
-
A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia
-
18:69-71, 1998
-
Bullido M.J., Artiga M.J., Recuero M., Sastre I., Garcia M.A., Aldudo J., Lendon C., Han S.W., Morris J.C., Frank A., Va/quez J., Goate A., Valdivieso F., A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia, Nat. Genet., 18:69-71, 1998
-
Nat. Genet.
-
-
Bullido, M.J.1
Artiga, M.J.2
Recuero, M.3
Sastre, I.4
Garcia, M.A.5
Aldudo, J.6
Lendon, C.7
Han, S.W.8
Morris, J.C.9
Frank, A.10
Vaquez, J.11
Goate, A.12
Valdivieso, F.13
-
14
-
-
0031911596
-
A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease
-
7:533-40, 1998
-
Lambert J.C., Pasquier F., Cottel D., Frigard B., Amouyel P., Chartier-Harlin M.C. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease, Hum. Mol. Genet., 7:533-40, 1998
-
Hum. Mol. Genet.
-
-
Lambert, J.C.1
Pasquier, F.2
Cottel, D.3
Frigard, B.4
Amouyel, P.5
Chartier-Harlin, M.C.6
-
15
-
-
0025971426
-
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
-
541:163-6, 1991
-
Namba Y., Tomonaga M., Kawasaki H., Otomo E., Ikeda K., Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease, Brain Res., 541:163-6, 1991
-
Brain Res.
-
-
Namba, Y.1
Tomonaga, M.2
Kawasaki, H.3
Otomo, E.4
Ikeda, K.5
-
16
-
-
0026542786
-
Apolipoprotein E: A patohological chaperone protein with cerebral and systemic amyloid
-
135:235-238, 1992
-
Wisniewski T., Frangione B., Apolipoprotein E: a patohological chaperone protein with cerebral and systemic amyloid, Nenrosci Lett., 135:235-238, 1992
-
Nenrosci Lett.
-
-
Wisniewski, T.1
Frangione, B.2
-
17
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease
-
90:1977-1981, 1993.
-
Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., Roses A.D., Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease, Proc. Natl. Acad. Sci. USA, 90:1977-1981, 1993.
-
Proc. Natl. Acad. Sci. USA
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
Roses, A.D.7
-
18
-
-
0031587429
-
Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants
-
270:715-720, 1997
-
Permanne B., Perez C., Soto C., Frangione B., and Wisniewski T., Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants, Biochem. Biophys. Res. Commun., 270:715-720, 1997
-
Biochem. Biophys. Res. Commun.
-
-
Permanne, B.1
Perez, C.2
Soto, C.3
Frangione, B.4
Wisniewski, T.5
-
19
-
-
0027970307
-
Acceleration of Alzheimer's fibril formation by apolipoprotein E
-
145:1030-1035, 1994
-
Wisniewski T., Castano E., Golabek A., Vogel T., Fragione B., Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro, Am. J. Patlwl, 145:1030-1035, 1994
-
In Vitro, Am. J. Patlwl
-
-
Wisniewski, T.1
Castano, E.2
Golabek, A.3
Vogel, T.4
Fragione, B.5
-
20
-
-
0033593027
-
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease
-
96:5233-8, 1999
-
Bales K.R., Verina T., Cummins D.J., Du Y., Dodel R.C., Saura J., Fishman C.E., DeLong C.A., Piccardo P., Petegnief V., Ghetti B., Paul S.M., Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease, Proc. Nat. Acad. Sci. USA, 96:5233-8, 1999
-
Proc. Nat. Acad. Sci. USA
-
-
Bales, K.R.1
Verina, T.2
Cummins, D.J.3
Du, Y.4
Dodel, R.C.5
Saura, J.6
Fishman, C.E.7
Delong, C.A.8
Piccardo, P.9
Petegnief, V.10
Ghetti, B.11
Paul, S.M.12
-
21
-
-
0027931854
-
Isoformspecific binding of apolipoprotein E to betaamyloid
-
269:23403-23406, 1994
-
LaDu, M.J., Falduto, M.T., Manelli, A.M., Reardon, C.A., Getz, GS., Frail, D.E., Isoformspecific binding of apolipoprotein E to betaamyloid, J. Biol. Chem., 269:23403-23406, 1994
-
J. Biol. Chem.
-
-
Ladu, M.J.1
Falduto, M.T.2
Manelli, A.M.3
Reardon, C.A.4
Getz, G.S.5
Frail, D.E.6
-
22
-
-
0033559412
-
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease
-
103:R15R21, 1999
-
Holtzman D.M., Bales K.R., Wu S., Bhat P., Parsadanian M., Fagan A.M., Chang L.K., Sun Y., Paul S.M., Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease, J. Clin. Invest., 103:R15R21, 1999
-
J. Clin. Invest.
-
-
Holtzman, D.M.1
Bales, K.R.2
Wu, S.3
Bhat, P.4
Parsadanian, M.5
Fagan, A.M.6
Chang, L.K.7
Sun, Y.8
Paul, S.M.9
-
23
-
-
0034183020
-
Elevated a beta and apolipoprotein E in a betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease
-
6:430-9, 2000
-
Kuo Y.M., Crawford F., Mullan M., Kokjohn T.A., Emmerling M.R., Weller R.O., Roher A.E., Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease, Mol. Med., 6:430-9, 2000
-
Mol. Med.
-
-
Kuo, Y.M.1
Crawford, F.2
Mullan, M.3
Kokjohn, T.A.4
Emmerling, M.R.5
Weller, R.O.6
Roher, A.E.7
-
24
-
-
0033850407
-
-
33:95-130, 2000
-
Buée L., Bussiere T., Buée-Scherrer V., Delacourte A., Hof P.R., Tau protein isoforms, phosphorylation and role in neurodegenerative disorders, Brain Res. Rev., 33:95-130, 2000
-
Tau Protein Isoforms, Phosphorylation and Role in Neurodegenerative Disorders, Brain Res. Rev.
-
-
Buée, L.1
Bussiere, T.2
Buée-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
25
-
-
0028269666
-
Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimers disease brain are related to apolipoprotein E genotype
-
125: 163-171, 1994
-
Strittmatter W.J., WeisgraberK.H., Goedert M., Saunders A.M., Huang D., Corder E.H., Dong L.M., Jakes R., Alberts M.J., Gilbert J.R., Han S.H., Hulette C., Einstein G, Schmechel D., Pericak-Vance M.A., Roses A.D., Hypothesis: microtubule instability and paired helical filament formation in the Alzheimers disease brain are related to apolipoprotein E genotype, Exp. Neurol., 125: 163-171, 1994
-
Exp. Neurol.
-
-
Strittmatter, W.J.1
Weisgraber, K.H.2
Goedert, M.3
Saunders, A.M.4
Huang, D.5
Corder, E.H.6
Dong, L.M.7
Jakes, R.8
Alberts, M.J.9
Gilbert, J.R.10
Han, S.H.11
Hulette, C.12
Schmechel D, E.G.13
Pericak-Vance, M.A.14
Roses, A.D.15
-
26
-
-
0032512634
-
A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins
-
273:4206-4212, 1998
-
DeMattos R.B., Curtiss L.K., Williams D.L., A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins, J. Biol. Chem., 273:4206-4212, 1998
-
J. Biol. Chem.
-
-
Demattos, R.B.1
Curtiss, L.K.2
Williams, D.L.3
-
27
-
-
0032935789
-
-
72:206-13, .1999
-
Genis I., Fisher A., Michaelson D.M., Site-specific dephosphorylation of tau of apolipoprotein Edeficient and control mice by Ml muscarinic agonist treatment, J. Neurochein., 72:206-13, .1999
-
Tau of Apolipoprotein Edeficient and Control Mice by Ml Muscarinic Agonist Treatment, J. Neurochein.
-
-
Genis, I.1
Fisher, A.2
Michaelson, D.M.3
Of, S.-S.D.4
-
28
-
-
0033889344
-
Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein
-
156:951-64, 2000
-
Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, Van Leuven F., Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tan in the brains of transgenic mice, Am. J. Pathol., 156:951-64, 2000
-
Tan in the Brains of Transgenic Mice, Am. J. Pathol.
-
-
Tesseur, I.1
Van Dorpe, J.2
Spittaels, K.3
Van Den Haute, C.4
Van Leuven F, M.D.5
-
29
-
-
0029989760
-
The intracellular Fate of apolipoprotein E is
-
7:1005-1008, 1996
-
Lovestone S., Anderton B.H., Hartley C., Jensen T.G, Jorgensen A.L., The intracellular Fate of apolipoprotein E is tan dependent and apoE allele specific, NenroReport, 7:1005-1008, 1996
-
Tan Dependent and ApoE Allele Specific, NenroReport
-
-
Lovestone, S.1
Anderton, B.H.2
Hartley, C.3
Jensen, T.G.4
Jorgensen, A.L.5
-
30
-
-
0033119820
-
A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic,J
-
19:2464-73, 1999
-
DeMattos R.B., Thorngate F.E., Williams D.L., A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic,J. Neurosci., 19:2464-73, 1999
-
Neurosci.
-
-
Demattos, R.B.1
Thorngate, F.E.2
Williams, D.L.3
-
31
-
-
0031662182
-
Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel
-
8:641-653, 1998
-
Muller W., Meske V., Berlin K., Scharnagl H., März W., Ohm T.G, Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel, Brain Pathol., 8:641-653, 1998
-
Brain Pathol.
-
-
Muller, W.1
Meske, V.2
Berlin, K.3
Scharnagl, H.4
März, W.5
Ohm, T.G.6
-
32
-
-
0032031784
-
Apolipoprotein E (ApoE) peptide regulates
-
7. Neurosci. Res.
-
Wang X., Luebbe P., Gruenstein E., Zemlan, F., Apolipoprotein E (ApoE) peptide regulates tau phosphorylation via two different signaling pathways, 7. Neurosci. Res., 51:658-665, 1998
-
Tau Phosphorylation via Two Different Signaling Pathways
-
-
Wang, X.1
Luebbe, P.2
Gruenstein, E.3
Zemlan, F.4
-
33
-
-
0032938625
-
Assembly of paired helical filaments from mouse
-
451:3944,1999
-
Kampers T., Pangalos M., Geerts H., Wiech H., Mandelkow, E., Assembly of paired helical filaments from mouse tan: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease, FEBS Lett., 451:3944,1999
-
Tan: Implications for the Neurofibrillary Pathology in Transgenic Mouse Models for Alzheimer's Disease, FEBS Lett.
-
-
Kampers, T.1
Pangalos, M.2
Geerts, H.3
Wiech, H.4
Mandelkow, E.5
-
34
-
-
0035372336
-
Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) (1-42), and apoE/Aβ complexes on Protein Kinase C-cc (PKC-a) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
-
38:615-625,2001
-
Cedazo-Minguez A., Wiehager B., Huettinger M., Winblad B., Cowburn R.F., Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) (1-42), and apoE/Aβ complexes on Protein Kinase C-cc (PKC-a) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts, Nenrochem. Int., 38:615-625,2001
-
Nenrochem. Int.
-
-
Cedazo-Minguez, A.1
Wiehager, B.2
Huettinger, M.3
Winblad, B.4
Cowburn, R.F.5
-
35
-
-
0032850599
-
Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
-
58:1010-1019, 1999
-
Pei J-J., Braak E., Braak H., Grundke-Iqbal I., Iqbal, K., Winblad B., Cowburn R.F., Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes,/ Neuropath. Exp. Neural, 58:1010-1019, 1999
-
Neuropath. Exp. Neural
-
-
Pei, J.-J.1
Braak, E.2
Braak, H.3
Grundke-Iqbal, I.4
Iqbal, K.5
Winblad, B.6
Cowburn, R.F.7
-
36
-
-
0034711453
-
-
3βidentified by nano-electrospray mass spectrometry, FEBS Lett.
-
Gibb G, Pearce J., Betts J.C., Lovestone S., Hoffmann M.M., Maerz W, Blackstock W.P., Anderton, B.H. Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase3βidentified by nano-electrospray mass spectrometry, FEBS Lett., 485:99-103, 2001
-
Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase
-
-
Pearce J, G.G.1
Betts, J.C.2
Lovestone, S.3
Hoffmann, M.M.4
Maerz, W.5
Blackstock, W.P.6
Anderton, B.H.7
-
37
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate
-
95:9637-41, 1998
-
Takashima A., Murayama M., Murayama O., Kohno T., Honda T., Yasutake K., Nihonmatsu N., Mercken M., Yamaguchi H., Sugihara S., Wolozin B., Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau, Proc. Natl. Acad. Sci. USA, 95:9637-41, 1998
-
Tau, Proc. Natl. Acad. Sci. USA
-
-
Takashima, A.1
Murayama, M.2
Murayama, O.3
Kohno, T.4
Honda, T.5
Yasutake, K.6
Nihonmatsu, N.7
Mercken, M.8
Yamaguchi, H.9
Sugihara, S.10
Wolozin, B.11
-
38
-
-
0029781509
-
Functional interaction of beta-catenin with the transcription factor LEF-1
-
382:638-42, 1996
-
Behrens J., von Kries J.P., Kühl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W., Functional interaction of beta-catenin with the transcription factor LEF-1, Nature, 382:638-42, 1996
-
Nature
-
-
Behrens, J.1
Von Kries, J.P.2
Kühl, M.3
Bruhn, L.4
Wedlich, D.5
Grosschedl, R.6
Birchmeier, W.7
-
39
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
395:698702, 1998
-
Zhang Z., Hartmann H., Do V.M., Abramowski D., Sturchler-Pierrat C., Staufenbiel M., Sommer B., van de Wetering M., devers H., Saftig P., De Strooper B., He X., Yankner B.A., Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis, Nature, 395:698702, 1998
-
Nature
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
Abramowski, D.4
Sturchler-Pierrat, C.5
Staufenbiel, M.6
Sommer, B.7
Van De Wetering, M.8
Devers, H.9
Saftig, P.10
De Strooper, B.11
He, X.12
Yankner, B.A.13
-
40
-
-
0035793539
-
Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular kinase signal-regulated kinase pathway
-
276:3046-3053, 2001
-
Ohkubo N., Mitsuda N., Tamatini M., Yamaguchi A., Lee Y-D., Ogihara T., Vitek M.P., Tohyama, M., Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular kinase signal-regulated kinase pathway, J. Biol. Chem., 276:3046-3053, 2001
-
J. Biol. Chem.
-
-
Ohkubo, N.1
Mitsuda, N.2
Tamatini, M.3
Yamaguchi, A.4
Lee, Y.-D.5
Ogihara, T.6
Vitek, M.P.7
Tohyama, M.8
-
41
-
-
0028557128
-
Neurite degeneration elicited by apolipoprotein E peptides
-
130:120-126, 1994
-
Crutcher K.A., Clay M.A., Scott S.A., Tian X., Tolar M., Harmony J.A., Neurite degeneration elicited by apolipoprotein E peptides, Exp. Neural., 130:120-126, 1994
-
Exp. Neural.
-
-
Crutcher, K.A.1
Clay, M.A.2
Scott, S.A.3
Tian, X.4
Tolar, M.5
Harmony, J.A.6
-
42
-
-
0030804828
-
Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E related synthetic peptides is receptor mediated
-
17:56785686, 1997
-
Tolar M., Marques M., Harmony J., Crutcher K., Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E related synthetic peptides is receptor mediated, J. NeuroscL, 17:56785686, 1997
-
J. NeuroscL
-
-
Tolar, M.1
Marques, M.2
Harmony, J.3
Crutcher, K.4
-
43
-
-
0031836724
-
Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype
-
57:415-25, 1997
-
Montine K.S., Reich E., Neely M.D., Sidell K.R., Oison S.J., Markesbery W.R., Montine, T.J., Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype, J. Neuropathol. Exp. Neural., 57:415-25, 1997
-
J. Neuropathol. Exp. Neural.
-
-
Montine, K.S.1
Reich, E.2
Neely, M.D.3
Sidell, K.R.4
Oison, S.J.5
Markesbery, W.R.6
Montine, T.J.7
-
44
-
-
0034052607
-
Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain
-
7:23-37. 2000
-
Ramassamy C., Averill D., Beffert U., Theroux L., Lussier-Cacan S., Cohn J. S., Christen Y., Schoofs A., Davignon J., Poirier, J., Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain, Neurobiol. Dis., 7:23-37. 2000
-
Neurobiol. Dis.
-
-
Ramassamy, C.1
Averill, D.2
Beffert, U.3
Theroux, L.4
Lussier-Cacan, S.5
Cohn, J.S.6
Christen, Y.7
Schoofs, A.8
Davignon, J.9
Poirier, J.10
-
45
-
-
0000448998
-
Alzheimer a beta neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by a beta-related peptides
-
17:773-80, 1996
-
Ma J., Brewer H.B. Jr., Potter H., Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides, Neurobiol. Aging, 17:773-80, 1996
-
Neurobiol. Aging
-
-
Ma, J.1
Brewer Jr., H.B.2
Potter, H.3
-
46
-
-
0028237778
-
Attenuation of the neurotoxic effect of a beta amyloid peptide by apolipoprotein E
-
199:163-70, 1994
-
Whitson J.S., Mims M.P., Strittmatter W.J., Yamaki T., Morrisett J.D., Appel S.H., Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E, Biochem. Biophys. Res. Commun., 199:163-70, 1994
-
Biochem. Biophys. Res. Commun.
-
-
Whitson, J.S.1
Mims, M.P.2
Strittmatter, W.J.3
Yamaki, T.4
Morrisett, J.D.5
Appel, S.H.6
-
47
-
-
0029765553
-
Apolipoprotein E allelespecific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
-
14:55-61, 1996
-
Miyata M. and Smith J.D. Apolipoprotein E allelespecific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides, Nat. Genet., 14:55-61, 1996
-
Nat. Genet.
-
-
Miyata, M.1
Smith, J.D.2
-
48
-
-
0034063728
-
A mechanism for the neuroprotective effect of apolipoprotein E: Isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal
-
74: 1426-33, 2000
-
Pedersen W.A., Chan S.L., Mattson M.P., A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal, J. Neurochem., 74: 1426-33, 2000
-
J. Neurochem.
-
-
Pedersen, W.A.1
Chan, S.L.2
Mattson, M.P.3
-
49
-
-
0034055035
-
Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease
-
97:207-10, 2000
-
Buttini M, Akeefe H, Lin C, Mahley R.W., Pitas R.E., Wyss-Coray T., Mucke L., Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease, Neitroscience, 97:207-10, 2000
-
Neitroscience
-
-
Buttini, M.1
Akeefe, H.2
Lin, C.3
Mahley, R.W.4
Pitas, R.E.5
Wyss-Coray, T.6
Mucke, L.7
-
50
-
-
0034668838
-
Neuronal apoptosis by apolipoprotein E4 through low-density lipopprotein receptorrelated protein and heterotrimeric GTPases
-
15:8401-8409, 2000
-
Hashimoto Y., Jiang H., Niikura T., Ito Y., Hagiwara A., Umezawa K., Abe Y., Mutuyama Y., Nishimoto I., Neuronal apoptosis by apolipoprotein E4 through low-density lipopprotein receptorrelated protein and heterotrimeric GTPases, J. NeuroscL, 15:8401-8409, 2000
-
J. NeuroscL
-
-
Hashimoto, Y.1
Jiang, H.2
Niikura, T.3
Ito, Y.4
Hagiwara, A.5
Umezawa, K.6
Abe, Y.7
Mutuyama, Y.8
Nishimoto, I.9
-
51
-
-
0032971798
-
Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein Ederived peptide
-
72:1069-80, 1999
-
Moulder K.L., Narita M., Chang L.K., Bu G, Johnson E.M. Jr., Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein Ederived peptide, J. Nenrochein., 72:1069-80, 1999
-
J. Nenrochein.
-
-
Moulder, K.L.1
Narita, M.2
Chang, L.K.3
Bu, G.4
Johnson Jr., E.M.5
-
52
-
-
0035847650
-
Beta-VLDL protects against Aβ(l-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells
-
12:201-206, 2001
-
Cedazo-Mînguez A., Huettinger M., Cowburn R.F., Beta-VLDL protects against Aβ(l-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells, NeuroRepon, 12:201-206, 2001
-
NeuroRepon
-
-
Cedazo-Mînguez, A.1
Huettinger, M.2
Cowburn, R.F.3
-
53
-
-
0033968648
-
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
-
74:1008-16,2000
-
Michikawa M., Fan Q.W., Isobe I., Yanagisawa K., Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture, J. Nenrochein., 74:1008-16,2000
-
J. Nenrochein.
-
-
Michikawa, M.1
Fan, Q.W.2
Isobe, I.3
Yanagisawa, K.4
-
54
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme a inhibitors
-
57:1439-43, 2000
-
Wolozin B., Kellman W., Ruosseau P., Celesia GG, Siegel G, Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A inhibitors, Arch. Neural., 57:1439-43, 2000
-
Arch. Neural.
-
-
Wolozin, B.1
Kellman, W.2
Ruosseau, P.3
Celesia, G.G.4
Siegel, G.5
-
55
-
-
0001504829
-
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta40
-
98:5856-61, 2001
-
Fassbender K., Simons M., Bergmann C., Stroick M., Lutjohann D., Keller P., Runz H., Kühl S., Bertsch T., von Bergmann K., Hennerici M., Beyreuther K., Hartmann T., Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta40 in vitro and HI vivo, Proc. Natl. Acad. Sci. USA, 98:5856-61, 2001
-
In Vitro and HI Vivo, Proc. Natl. Acad. Sci. USA
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
Stroick, M.4
Lutjohann, D.5
Keller, P.6
Runz, H.7
Kühl, S.8
Bertsch, T.9
Von Bergmann, K.10
Hennerici, M.11
Beyreuther, K.12
Hartmann, T.13
-
56
-
-
0034515763
-
Apolipoprotein E and Alzheimer's disease. a role in amyloid catabolism
-
924: 81-90, 2000
-
Poirier J., Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism, Ann. NY Acad. Sci., 924: 81-90, 2000
-
Ann. NY Acad. Sci.
-
-
Poirier, J.1
-
57
-
-
0035142852
-
Cholesterol-dependent modulation of tau phosphorylation in cultured neurons
-
76:391-400, 2001
-
Fan Q.W., Yu W., Senda T., Yanagisawa K., Michikawa M., Cholesterol-dependent modulation of tau phosphorylation in cultured neurons, J. Neurochem., 76:391-400, 2001
-
J. Neurochem.
-
-
Fan, Q.W.1
Yu, W.2
Senda, T.3
Yanagisawa, K.4
Michikawa, M.5
-
58
-
-
0035042440
-
Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
-
19:231-45, 2001
-
Arendt T., Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease, Int. J. Dev. NeuroscL, 19:231-45, 2001
-
Int. J. Dev. NeuroscL
-
-
Arendt, T.1
-
59
-
-
0028232662
-
Differential effects of apolipoproteins E3 and E4 on neuronal growth
-
264:850-2, 1994
-
Nathan B.P., Bellosta S., Sanan D.A., Weisgraber K.H., Mahley R.W., Pitas R.E., Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro, Science, 264:850-2, 1994
-
In Vitro, Science
-
-
Nathan, B.P.1
Bellosta, S.2
Sanan, D.A.3
Weisgraber, K.H.4
Mahley, R.W.5
Pitas, R.E.6
-
60
-
-
0033597195
-
Differential neurotrophic effects of apolipoprotein E in aged transgenic mice
-
265:218-22, 1999
-
Veinbergs L, Mallory M., Mante M., Rockenstein E., Gilbert J.R., Masliah E., Differential neurotrophic effects of apolipoprotein E in aged transgenic mice, Neurosci. Lett., 265:218-22, 1999
-
Neurosci. Lett.
-
-
Mallory M, V.L.1
Mante, M.2
Rockenstein, E.3
Gilbert, J.R.4
Masliah, E.5
-
61
-
-
0033564771
-
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- Mice: Isoform-specific effects on neurodegeneration
-
19:4867-80, 1999
-
Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration, J. Neurosci, 19:4867-80, 1999
-
J. Neurosci
-
-
Buttini, M.1
Orth, M.2
Bellosta, S.3
Akeefe, H.4
Pitas, R.E.5
Wyss-Coray, T.6
Mucke, L.7
Mahley, R.W.8
-
62
-
-
0031051353
-
Cholinergic activation of phosphoinositide signalling is impaired in Alzheimer's disease brain
-
18:111-120, 1997
-
Jope R.S., Song, L., Powers R.E., Cholinergic activation of phosphoinositide signalling is impaired in Alzheimer's disease brain, Nenrobio. Aging, 18:111-120, 1997
-
Nenrobio. Aging
-
-
Jope, R.S.1
Song, L.2
Powers, R.E.3
-
63
-
-
0028973318
-
Regional alterations in Ml muscarinic receptor-G protein coupling in Alzheimer's disease
-
54:783-9, 1995
-
Ladner C.J., Celesia G.G., Magnuson D.J., Lee J.M., Regional alterations in Ml muscarinic receptor-G protein coupling in Alzheimer's disease, J. Neuropathol. Exp. Neural., 54:783-9, 1995
-
J. Neuropathol. Exp. Neural.
-
-
Ladner, C.J.1
Celesia, G.G.2
Magnuson, D.J.3
Lee, J.M.4
-
64
-
-
0007691164
-
Apolipoprotein E allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease
-
92:12260-12264, 1995
-
Poirier J., Delisle M-C., Quirion R., Aubert I., Farlow M., Lahiri D., Hui S., Bertrand P.J. Nalbantoglu B., Gilfix M., Gauthier S., Apolipoprotein E allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease, Proc Natl. Acad. Sci. USA, 92:12260-12264, 1995
-
Proc Natl. Acad. Sci. USA
-
-
Poirier, J.1
Delisle, M.-C.2
Quirion, R.3
Aubert, I.4
Farlow, M.5
Lahiri, D.6
Hui, S.7
Nalbantoglu B, B.P.J.8
Gilfix, M.9
Gauthier, S.10
-
65
-
-
0028904432
-
A severe loss of choline acetyltranferase in the frontal cortex of Alzheimer patients carrying apolipoprotein 4 allele
-
187:79-82, 1995
-
Soininen H.O., Kosunen S., Helisalmi A., Mannermaa L., Paljarvi S., Talasniemi M., Ryynanen P., Riekkinen S., A severe loss of choline acetyltranferase in the frontal cortex of Alzheimer patients carrying apolipoprotein 4 allele, Neurosci. Lett., 187:79-82, 1995
-
Neurosci. Lett.
-
-
Soininen, H.O.1
Kosunen, S.2
Helisalmi, A.3
Mannermaa, L.4
Paljarvi, S.5
Talasniemi, M.6
Ryynanen, P.7
Riekkinen, S.8
-
66
-
-
0034029057
-
No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice
-
93:411-8,2000
-
Bronfman F.C, Tesseur L, Hofker M.H., Havekens L.M., Van Leuven R, No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice, Neuroscience, 93:411-8,2000
-
Neuroscience
-
-
Bronfman, F.C.1
Tesseur, L.2
Hofker, M.H.3
Havekens, L.M.4
Van Leuven, R.5
-
67
-
-
33747025797
-
Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: Protection by estrogen and glutathione
-
Cedazo-Mînguez A. and Cowburn R.F., Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis: protection by estrogen and glutathione, FEES left., In press
-
FEES Left.
-
-
Cedazo-Mînguez, A.1
Cowburn, R.F.2
Press, I.3
|