Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of β-cleaved C-terminal APP fragments

Journal of Biological Chemistry

Volumn 277, Issue 39, 2002, Pages 36415-36424

  Mathews, Paul M ^a,b,c   Jiang, Ying ^a,b,c   Schmidt, Stephen D ^a,b,c   Grbovic, Olivera M ^a,b,c   Mercken, Marc ^a,b,c   Nixon, Ralph A ^a,b,c  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELLS; DRUG PRODUCTS; IMMUNOLOGY; METABOLITES; SURFACES;

IMMUNOLABELLING;

PHYSIOLOGY;

AMYLOID PRECURSOR PROTEIN; CALPAIN; CALPASTATIN; CALPEPTIN; EPITOPE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CONCENTRATION RESPONSE; ENDOSOME; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECRETION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CALPAIN; CELL LINE; CELL MEMBRANE; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOSOMES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MUTATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0037184127     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205208200     Document Type: Article

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