Role of Pin2/TRF1 in telomere maintenance and cell cycle control

Journal of Cellular Biochemistry

Volumn 89, Issue 1, 2003, Pages 19-37

  Zhou, Xiao Zhen ^a,b   Perrem, Kilian ^a   Lu, Kun Ping ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Pin2 TRF1; Pin2 TRF1 interacting proteins; Telomerase inhibitor; Telomeres; The cell cycle

Indexed keywords

ATM PROTEIN; DNA; KU ANTIGEN; PROTEIN; PROTEIN PIN 2; PROTEIN TRF 1; TANKYRASE; TELOMERASE; UNCLASSIFIED DRUG;

AGING; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHROMOSOME SIZE; CHROMOSOME STRUCTURE; DEREGULATION; DNA DAMAGE; GENETIC STABILITY; GENOMICS; HUMAN; MITOSIS; MOLECULAR MODEL; MOLECULE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; REGULATORY MECHANISM; TELOMERE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NUCLEAR; CELL CYCLE; CELL CYCLE PROTEINS; DNA DAMAGE; DNA HELICASES; DNA-BINDING PROTEINS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SUBCELLULAR FRACTIONS; TELOMERASE; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEINS;

EID: 0037405046     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10496     Document Type: Article

References (156)

1. Abraham RT. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177-2196.
2. Ahmad K, Golic KG. 1999. Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis. [In process citation.] Genetics 151:1041-1051.
3. Aragona M, Buda CA, Panetta S, Morelli M, Giudice A, Campagna FL, Pontoriero A, Cascinu S, La Torre F. 2000. Immunohistochemical telomeric-repeat binding factor-1 expression in gastrointestinal tumors. Oncol Rep 7:987-990.
4. Artandi SE, DePinho RA. 2000. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev 10:39-46.
5. Baffa R, Santoro R, Bullrich F, Mandes B, Ishii H, Croce CM. 2000. Definition and refinement of chromosome 8p regions of loss of heterozygosity in gastric cancer. Clin Cancer Res 6:1372-1377.
6. Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, Collins F, Shiloh Y, Crawley JN, Ried T, Tagle D, Wynshaw BA. 1996. Atm-deficient mice: A paradigm of ataxia telangiectasia. Cell 86:159-171.
7. Beamish H, Khanna KK, Lavin MF. 1994. Ionizing radiation and cell cycle progression in ataxia telangiectasia. Radiat Res 138:S130-S133.
8. Beamish H, Williams R, Chen P, Lavin MF. 1996. Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J Biol Chem 271:20486-20493.
9. Bianchi A, Smith S, Chong L, Elias P, de Lange T. 1997. TRF1 is a dimer and bends telomeric DNA. EMBO J 16:1785-1794.
10. Bianchi A, Stansel RM, Fairall L, Griffith JD, Rhodes D, de Lange T. 1999. TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J 18:5735-5744.
11. Bilaud T, Koering CE, Binet BE, Ancelin K, Pollice A, Gasser SM, Gilson E. 1996. The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants, and human. Nucleic Acids Res 24:1294-1303.
12. Blackburn EH. 2001. Switching and signaling at the telomere. Cell 106:661-673.
13. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34.
14. Bockmuhl U, Ishwad CS, Ferrell RE, Gollin SM. 2001. Association of 8p23 deletions with poor survival in head and neck cancer. Otolaryngol Head Neck Surg 124:451-455.
15. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352.
16. Broccoli D, Young JW, de Lange T. 1995. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 92:9082-9086.
17. Bryan TM, Cech TR. 1999. Telomerase and the maintenance of chromosome ends. Curr Opin Cell Biol 11:318-324.
18. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14:4240-4248.
19. Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, Yates JR, Hays L, Morgan WF, Petrini JH. 1998. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response. Cell 93:477-486.
20. Chen P, Gatei M, O'Connell MJ, Khanna KK, Bugg SJ, Hogg A, Scott SP, Hobson K, Lavin MF. 1999. Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells. Oncogene 18:249-256.
21. Chikashige Y, Ding DQ, Funabiki H, Haraguchi T, Mashiko S, Yanagida M, Hiraoka Y. 1994. Telomere-led premeiotic chromosome movement in fission yeast. Science 264:270-273.
22. Chong L, van SB, Broccoli D, Erdjument BH, Hanish J, Tempst P, de Lange T. 1995. A human telomeric protein. Science 270:1663-1667.
23. Cohn M, Blackburn EH. 1995. Telomerase in yeast. Science 269:396-400.
24. Cook BD, Dynek JN, Chang W, Shostak G, Smith S. 2002. Role for the related poly(ADP-ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol 22:332-342.
25. Cooke HJ, Smith BA. 1986. Variability at the telomeres of the human X/Y pseudoautosomal region. Cold Spring Harb Symp Quant Biol 51(Pt 1):213-219.
26. Cooper JP, Nimmo ER, Allshire RC, Cech TR. 1997. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385:744-747.
27. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells, which express telomerase activity. EMBO J 11:1921-1929.
28. Counter CM, Meyerson M, Eaton EN, Weinberg RA. 1997. The catalytic subunit of yeast telomerase. Proc Natl Acad Sci USA 94:9202-9207.
29. De Divitiis O, La Torre D. 2001. Inverse correlation of TRF1 expression and cell proliferation in human primary intracranial tumors. J Neurosurg Sci 45:1-6.
30. Digweed M, Reis A, Sperling K. 1999. Nijmegen breakage syndrome: Consequences of defective DNA double strand break repair. Bioessays 21:649-656.
31. Elson A, Wang Y, Daugherty CJ, Morton CC, Zhou F, Campos-Torres J, Leder P. 1996. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci USA 93:13084-13089.
32. Emi M, Fujiwara Y, Nakajima T, Tsuchiya E, Tsuda H, Hirohashi S, Maeda Y, Tsuruta K, Miyaki M, Nakamura Y. 1992. Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer. Cancer Res 52:5368-5372.
33. Evans SK, Lundblad V. 2000. Positive and negative regulation of telomerase access to the telomere. J Cell Sci 113(Pt 19):3357-3364.
34. Fairall L, Chapman L, Moss H, de Lange T, Rhodes D. 2001. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol Cell 8:351-361.
35. Featherstone C, Jackson SP. 1998. DNA repair: The Nijmegen breakage syndrome protein. Curr Biol 8: R622-R625.
36. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, et al. 1995. The RNA component of human telomerase. Science 269:1236-1241.
37. Fritz E, Friedl AA, Zwacka RM, Eckardt-Schupp F, Meyn MS. 2000. The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis, and telomere shortening in A-T cells. Mol Biol Cell 11:2605-2616.
38. Fry AM. 2002. The Nek2 protein kinase: A novel regulator of centrosome structure. Oncogene 21:6184-6194.
39. Funabiki H, Hagan I, Uzawa S, Yanagida M. 1993. Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J Cell Biol 121:961-976.
40. Furnari B, Rhind N, Russell P. 1997. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase [see comments]. Science 277:1495-1497.
41. Gasser SM. 2000. A sense of the end. Science 288:1377-1379.
42. Gilley D, Tanaka H, Hande MP, Kurimasa A, Li GC, Oshimura M, Chen DJ. 2001. DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci USA 98:15084-15088.
43. Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, Jorcano JL, Blasco MA. 2001. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 20:2619-2630.
44. Gravel S, Larrivee M, Labrecque P, Wellinger RJ. 1998. Yeast Ku as a regulator of chromosomal DNA end structure. Science 280:741-744.
45. Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B, Petes TD. 1995. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82:823-829.
46. Greider CW, Blackburn EH. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413.
47. Greider CW, Blackburn EH. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337:331-337.
48. Griffith J, Bianchi A, de Lange T. 1998. TRF1 promotes parallel pairing of telomeric tracts in vitro. J Mol Biol 278:79-88.
49. Gustafson CE, Wilson PJ, Lukeis R, Baker E, Woollatt E, Annab L, Hawke L, Barrett JC, Chenevix-Trench G. 1996. Functional evidence for a colorectal cancer tumor suppressor gene at chromosome 8p22-23 by monochromosome transfer. Cancer Res 56:5238-5245.
50. Haber JE. 1998. The many interfaces of Mre11. Cell 95:583-586.
51. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. 1999a. Creation of human tumor cells with defined genetic elements. Nature 400:464-468.
52. Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M, Weinberg RA. 1999b. Inhibition of telomerase limits the growth of human cancer cells [see comments]. Nat Med 5:1164-1170.
53. Halvorsen TL, Leibowitz G, Levine F. 1999. Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol Cell Biol 19:1864-1870.
54. Harley CB. 1991. Telomere loss: Mitotic clock or genetic time bomb? Mutat Res 256:271-282.
55. Harley CB, Futcher AB, Greider CW. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460.
56. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866-868.
57. Herbert B, Pitts AE, Baker SI, Hamilton SE, Wright WE, Shay JW, Corey DR. 1999. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA 96:14276-14281.
58. Hsu HL, Gilley D, Blackburn EH, Chen DJ. 1999. Ku is associated with the telomere in mammals. Proc Natl Acad Sci USA 96:12454-12458.
59. Hsu HL, Gilley D, Galande SA, Hande MP, Allen B, Kim SH, Li GC, Campisi J, Kohwi-Shigematsu T, Chen DJ. 2000. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev 14:2807-2812.
60. Ishwad CS, Shuster M, Bockmuhl U, Thakker N, Shah P, Toomes C, Dixon M, Ferrell RE, Gollin SM. 1999. Frequent allelic loss and homozygous deletion in chromosome band 8p23 in oral cancer. Int J Cancer 80:25-31.
61. Kaminker PG, Kim SH, Taylor RD, Zebarjadian Y, Funk WD, Morin GB, Yaswen P, Campisi J. 2001. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem 276:35891-35899.
62. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. 1994. Specific association of human telomerase activity with immortal cells and cancer [see comments]. Science 266:2011-2015.
63. Kim SH, Kaminker P, Campisi J. 1999. TIN2, a new regulator of telomere length in human cells. Nat Genet 23:405-412.
64. King RW, Deshaies RJ, Peters JM, Kirschner MW. 1996. How proteolysis drives the cell cycle. Science 274:1652-1659.
65. Kirk KE, Harmon BP, Reichardt IK, Sedat JW, Blackburn EH. 1997. Block in anaphase chromosome separation caused by a telomerase template mutation. Science 275:1478-1481.
66. Kishi K, Lu KP. 2002. A critical role for Pin2/TRF1 in ATM-dependent regulation: Inhibition of Pin2/TRF1 function complements telomere shortening, the radiosensitivity, and G2/M checkpoint defect of ataxia-telangiectasia cells. J Biol Chem 277:7420-7429.
67. Kishi S, Wulf G, Nakamura M, Lu KP. 2001a. Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells containing short telomeres and is down-regulated in breast tumors. Oncogene 20:1497-1508.
68. Kishi S, Zhou XZ, Nakamura N, Ziv Y, Khoo C, Hill DE, Shiloh Y, Lu KP. 2001b. Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276:29282-29291.
69. Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. 1998. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396:84-88.
70. Krauskopf A, Blackburn EH. 1996. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383:354-357.
71. Krien MJ, Bugg SJ, Palatsides M, Asouline G, Morimyo M, O'Connell MJ. 1998. A NIMA homologue promotes chromatin condensation in fission yeast. J Cell Sci 111:967-976.
72. Lavin MF, Shiloh Y. 1997. The genetic defect in ataxiatelangiectasia. Annu Rev Immunol 15:177-202.
73. Lee SH, Kim CH. 2002. DNA-dependent protein kinase complex: A multifunctional protein in DNA repair and damage checkpoint. Mol Cell 13:159-166.
74. Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392:569-574.
75. Liao C, Zhao M, Song H, Uchida K, Yokoyama KK, Li T. 2000. Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma. Hepatology 32:721-727.
76. Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276:561-567.
77. Lu KP. 2000. Phosphorylation-dependent prolyl isomerization: A novel cell cycle regulatory mechanism. Prog Cell Cycle Res 4:83-96.
78. Lu KP, Hunter T. 1995. Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell 81:413-424.
79. Lu KP, Hanes SD, Hunter T. 1996. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380:544-547.
80. Lu PJ, Wulf G, Zhou XZ, Davies P, Lu KP. 1999a. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature 399:784-788.
81. Lu PJ, Zhou XZ, Shen M, Lu KP. 1999b. A function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283:1325-1328.
82. Lu KP, Liou YC, Vincent I. 2002a. Proline-directed phosphorylation and isomerization in mitosis and in Alzheimer's disease. BioEssays 25:174-181.
83. Lu KP, Liou YC, Zhou XZ. 2002b. Pinning down the proline-directed phosphorylation signaling. Trends Cell Biol 12:164-172.
84. Marcand S, Gilson E, Shore D. 1997. A protein-counting mechanism for telomere length regulation in yeast. Science 275:986-990.
85. Martin SG, Laroche T, Suka N, Grunstein M, Gasser SM. 1999. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97:621-633.
86. Maser RS, Monsen KJ, Nelms BE, Petrini JH. 1997. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol 17:6087-6096.
87. Matsuyama H, Pan Y, Skoog L, Tribukait B, Naito K, Ekman P, Lichter P, Bergerheim US. 1994. Deletion mapping of chromosome 8p in prostate cancer by fluorescence in situ hybridization. Oncogene 9:3071-3076.
88. McEachern MJ, Blackburn EH. 1995. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature 376:403-409.
89. Metcalfe JA, Parkhill J, Campbell L, Stacey M, Biggs P, Byrd PJ, Taylor AM. 1996. Accelerated telomere shortening in ataxia telangiectasia. Nat Genet 13:350-353.
90. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA. 1997. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90:785-795.
91. Mimori-Kiyosue Y, Shiina N, Tsukita S. 2000. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr Biol 10:865-868.
92. Morgan SE, Lovly C, Pandita TK, Shiloh Y, Kastan MB. 1997. Fragments of ATM, which have dominant-negative or complementing activity. Mol Cell Biol 17:2020-2029.
93. Morrow DM, Tagle DA, Shiloh Y, Collins FS, Hieter P. 1995. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82:831-840.
94. Muhua L, Adames NR, Murphy MD, Shields CR, Cooper JA. 1998. A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein. Nature 393:487-491.
95. Muscheck M, Sukosd F, Pesti T, Kovacs G. 2000. Highdensity deletion mapping of bladder cancer localizes the putative tumor suppressor gene between loci D8S504 and D8S264 at chromosome 8p23.3. Lab Invest 80:1089-1093.
96. Nagai H, Pineau P, Tiollais P, Buendia MA, Dejean A. 1997. Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene 14:2927-2933.
97. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. 1997. Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955-959.
98. Nakamura M, Zhou XZ, Kishi S, Kosugi I, Tsutsui Y, Lu KP. 2001a. A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle. Curr Biol 11:1512-1516.
99. Nakamura M, Zhou XZ, Lu KP. 2001b. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. Curr Biol 11:1062-1067.
100. Nakamura M, Zhou XZ, Lu KP. 2002. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett 514:193-198.
101. Nielsen KV, Briand P. 1989. Cytogenetic analysis of in vitro karyotype evolution in a cell line established from nonmalignant human mammary epithelium. Cancer Genet Cytogenet 39:103-118.
102. Nishikawa T, Okamura H, Nagadoi A, Konig P, Rhodes D, Nishimura Y. 2001. Solution structure of a telomeric DNA complex of human TRF1. Structure (Camb) 9:1237-1251.
103. O'Connell MJ, Norbury C, Nurse P. 1994. Premature chromatin condensation upon accumulation of NIMA. EMBO J 13:4926-4937.
104. O'Connell MJ, Raleigh JM, Verkade HM, Nurse P. 1997. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J 16:545-554.
105. Ohyashiki JH, Hayashi S, Yahata N, Iwama H, Ando K, Tauchi T, Ohyashiki K. 2001. Impaired telomere regulation mechanism by TRF1 (telomere-binding protein), but not TRF2 expression, in acute leukemia cells. Int J Oncol 18:593-598.
106. Olovnikov AM. 1973. A theory of marginotomy. The imcomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41:181-190.
107. Osmani SA, Pu RT, Morris NR. 1988. Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase. Cell 53:237-244.
108. Osmani AH, McGuire SL, Osmani SA. 1991. Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. Cell 67:283-291.
109. Pandita TK, Pathak S, Geard CR. 1995. Chromosome end associations, telomeres, and telomerase activity in ataxia telangiectasia cells. Cytogenet Cell Genet 71:86-93.
110. Paules RS, Levedakou EN, Wilson SJ, Innes CL, Rhodes N, Tlsty TD, Galloway DA, Donehower LA, Tainsky MA, Kaufmann WK. 1995. Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res 55:1763-1773.
111. Paulovich AG, Hartwell LH. 1995. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82:841-847.
112. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, PiwnicaWorms H. 1997. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216 [see comments]. Science 277:1501-1505.
113. Perinchery G, Bukurov N, Nakajima K, Chang J, Hooda M, Oh BR, Dahiya R. 1999. Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer. Int J Oncol 14:495-500.
114. Pineau P, Nagai H, Prigent S, Wei Y, Gyapay G, Weissenbach J, Tiollais P, Buendia MA, Dejean A. 1999. Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma. Oncogene 18:3127-3134.
115. Rotman G, Shiloh Y. 1999. ATM: A mediator of multiple responses to genotoxic stress. Oncogene 18:6135-6144.
116. Rudolph NS, Latt SA. 1989. Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia. Mutat Res 211:31-41.
117. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96:701-712.
118. Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ. 1996a. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357-360.
119. Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJ. 1996b. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways [see comments]. Science 271:357-360.
120. Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ. 1997. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25 [see comments]. Science 277:1497-1501.
121. Sandell LL, Zakian VA. 1993. Loss of a yeast telomere: Arrest, recovery, and chromosome loss. Cell 75:729-739.
122. Savitsky K, Bar SA, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik R, Patanijali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jasper NGJ, Taylor AMR, Arlett CF, Miki T, Weissman SM, Lovett M, Collin FC, Shiloh Y. 1995. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749-1753.
123. Shao JY, Wang HY, Huang XM, Feng QS, Huang P, Feng BJ, Huang LX, Yu XJ, Li JT, Hu LF, Ernberg I, Zeng YX. 2000. Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from Southern China. Int J Oncol 17:1267-1275.
124. Shay JW, Wright WE. 2001. Telomeres and telomerase: Implications for cancer and aging. Radiat Res 155:188-193.
125. Shen M, Haggblom C, Vogt M, Hunter T, Lu KP. 1997. Characterization and cell cycle regulation of related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis. Proc Natl Acad Sci USA 94:13618-13623.
126. Shen M, Stukenberg PT, Kirschner MW, Lu KP. 1998. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev 12:706-720.
127. Shiloh Y. 1997. Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart. Annu Rev Genet 31:635-662.
128. Shippen-Lentz D, Blackburn EH. 1990. Functional evidence for an RNA template in telomerase. Science 247:546-552.
129. Singer MS, Gottschling DE. 1994. TLC1: Template RNA component of Saccharornyces cerevisiae telomerase. Science 266:404-409.
130. Smilenov LB, Morgan SE, Mellado W, Sawant SG, Kastan MB, Pandita TK. 1997. Influence of ATM function on telomere metabolism. Oncogene 15:2659-2665.
131. Smilenov LB, Dhar S, Pandita TK. 1999. Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment. [In process citation.] Mol Cell Biol 19:6963-6971.
132. Smith S, de Lange T. 2000. Tankyrase promotes telomere elongation in human cells. Curr Biol 10:1299-1302.
133. Smith S, Giriat I, Schmitt A, de Lange T. 1998. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282:1484-1487.
134. Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, de Lange T. 2000. Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20:1659-1668.
135. Stewart SA, Weinberg RA. 2000. Telomerase and human tumorigenesis. Semin Cancer Biol 10:399-406.
136. Stukenberg PT, Kirschner MW. 2001. Pin1 acts catalytically to promote a conformational change in Cdc25. Mol Cell 7:1071-1083.
137. Sun PC, Schmidt AP, Pashia ME, Sunwoo JB, Scholnick SB. 1999. Homozygous deletions define a region of 8p23.2 containing a putative tumor suppressor gene. Genomics 62:184-188.
138. Taylor RS, Ramirez RD, Ogoshi M, Chaffins M, Piatyszek MA, Shay JW. 1996. Detection of telomerase activity in malignant and non-malignant skin conditions. J Invest Dermatol 106:759-765.
139. van Steensel B, de Lange T. 1997. Control of telomere length by the human telomeric protein Trf1. Nature 385:740-743.
140. Vaziri H, Benchimol S. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 8:279-282.
141. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. 1994. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc Natl Acad Sci USA 91:9857-9860.
142. Watson JD. 1972. Origin of cancatemeric T7 DNA. Nat New Biol 239:197-201.
143. Weinert TA, Kiser GL, Hartwell LH. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8:652-665.
144. Winkler KE, Swenson KI, Kornbluth S, Means AR. 2000. Requirement of the prolyl isomerase Pin1 for the replication checkpoint. Science 287:1644-1647.
145. Wu G, Lee WH, Chen PL. 2000. NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. J Biol Chem 275:30618-30622.
146. Xia SJ, Shammas MA, Shmookler RJ. 1996. Reduced telomere length in ataxia-telangiectasia fibroblasts. Mutat Res 364:1-11.
147. Xu Y, Baltimore D. 1996. Dual roles of ATM in the cellular response to radiation and in cell growth control. Gene Dev 10:2401-2410.
148. Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Gene Dev 10:2411-2422.
149. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld J, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. 1997. Sequence-specific and phosphorylation-dependent proline isomerization: A potential mitotic regulatory mechanism. Science 278:1957-1960.
150. Yamada K, Yajima T, Yagihashi A, Kobayashi D, Koyanagi Y, Asanuma K, Yamada M, Moriai R, Kameshima H, Watanabe N. 2000. Role of human telomerase reverse transcriptase and telomeric-repeat binding factor proteins 1 and 2 in human hematopoietic cells. Jpn J Cancer Res 91:1278-1284.
151. Young AC, Chavez M, Giambernardi TA, Mattern V, McGill JR, Harris JM, Sarosdy MF, Patel P, Sakaguchi AY. 1997. Organization and expression of human telomere repeat binding factor genes. Somat Cell Mol Genet 23:275-286.
152. Yu GL, Bradley JD, Attardi LD, Blackburn EH. 1990. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344:126-132.
153. Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. 1999. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 13:2388-2399.
154. Zhou XZ, Lu KP. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107:347-359.
155. Zhou XZ, Kops O, Werner A, Lu PJ, Shen M, Stoller G, Küllertz G, Stark M, Fischer G, Lu KP. 2000. Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol Cell 6:873-883.
156. Ziv Y, Bar-Shira A, Pecker I, Russell P, Jorgensen TJ, Tsarfati I, Shiloh Y. 1997. Recombinant ATM protein complements the cellular A-T phenotype. Oncogene 15:159-167.