Sequence-specific and phosphorylation dependent proline isomerization: A potential mitotic regulatory mechanism

Science

Volumn 278, Issue 5345, 1997, Pages 1957-1960

  Yaffe, Michael B ^a   Schutkowski, Mike ^b   Shen, Minhui ^a   Zhou, Xiao Zhen ^a   Stukenberg, P Todd ^c   Rahfeld, Jens Ulrich ^b   Xu, Jian ^a   Kuang, Jian ^d   Kirschner, Marc W ^c   Fischer, Gunter ^b   Cantley, Lewis C ^a,c   Lu, Kun Ping ^a,c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MAX PLANCK RESEARCH UNIT FOR ENZYMOLOGY OF PROTEIN FOLDING   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOMERASE; PHOSPHOPROTEIN;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ISOMERISM; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACID ISOMERASES; ANTIBODIES, MONOCLONAL; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; EPITOPES; HEAT-SHOCK PROTEINS; HELA CELLS; HUMANS; ISOMERISM; MITOSIS; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDE LIBRARY; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROLINE; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; TACROLIMUS BINDING PROTEINS;

EID: 0031438929     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5345.1957     Document Type: Article

References (38)

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38. We thank M. Berne, A. Bernhardt, and B. Hökelmann for peptide synthesis and sequencing and N. Terada for the antibodies to S6 kinase. M.B.Y. is a Howard Hughes Physician-Scientist Fellow. Supported by Deutsche Forschungsgemeinschaft, Fonds der Chemischen Industrie, and Boehringer Ingelheim Stiftung to G.F., and NIH grants GM56203 to L.C.C. and GM56230 to K.P.L.