Positive and negative regulation of telomerase access to the telomere

Journal of Cell Science

Volumn 113, Issue 19, 2000, Pages 3357-3364

  Evans, S K ^a   Lundblad, V ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cdc13; Lagging strand synthesis; Negative length regulation; Positive length regulation; Rap1; Telomerase access; Telomere; TRF1; TRF2

Indexed keywords

DNA; DNA BINDING PROTEIN; DOUBLE STRANDED DNA; FUNGAL DNA; PROTEIN CDC13P; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME STRUCTURE; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; MAMMAL; MOLECULAR STABILITY; NEGATIVE FEEDBACK; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DNA INTERACTION; REGULATORY MECHANISM; TELOMERE; YEAST;

MAMMALIA;

EID: 0033767689     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.113.19.3357     Document Type: Article

References (85)

1. The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis
2. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
3. TRF1 is a dimer and bends telomeric DNA
4. TRF1 binds a bipartite telomeric site with extreme spatial flexibility
5. Telomeric localization of TRF2, a novel human telobox protein
6. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
7. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
8. Sir proteins, Rif proteins, and Cdc 13p bind Saccharomyces telomeres in vivo
9. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
10. Telomere elongation in immortal human cells without detectable telomerase activity
11. Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae
12. CDC17: An essential gene that prevents telomere elongation in yeast
13. A human telomeric protein
14. Telomere-associated repeats in Chironomus form discrete subfamilies generated by gene conversion
15. Telomerase in yeast
16. Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
17. Regulation of telomere length and function by a Myb-domain protein in fission yeast
18. The catalytic subunit of yeast telomerase
19. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
20. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
21. Processing of telomeric DNA ends requires the passage of a replication fork
22. Est1 and Cdc13 as comediators of telomerase access
23. Coordinate regulation of G- and C strand length during new telomere synthesis
24. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants
25. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
26. Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites
27. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13
28. Yeast Ku as a regulator of chromosomal DNA end structure
29. Telomeres
30. Telomere length regulation
31. TRF1 promotes parallel pairing of telomeric tracts in vitro
32. Mammalian telomeres end in a large duplex loop
33. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
34. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
35. Telomeres and telomerase in aging and cancer
36. A mammalian telomerase-associated protein
37. The Est3 protein is a subunit of yeast telomerase
38. Recombination in telomere-length maintenance
39. Vaults and telomerase share a common subunit, TEP1
40. TIN2, a new regulator of telomere length in human cells
41. The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA
42. Rap1 protein regulates telomere turnover in yeast
43. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
44. Identification of two RNA-binding proteins associated with human telomerase RNA
45. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
46. Identification of human Rap1: Implications for telomere evolution
47. An in vitro assay for Saccharomyces telomerase requires EST1
48. 1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
49. Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3' overhang
50. Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity
51. Reverse transcriptase motifs in the catalytic subunit of telomerase
52. A mutant with a defect in telomere elongation leads to senescence in yeast
53. An alternative pathway for yeast telomere maintenance rescues est1-senescence
54. A protein-counting mechanism for telomere length regulation in yeast
55. Progressive cis-inhibition of telomerase upon telomere elongation
56. Cell cycle restriction of telomere elongation
57. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
58. The terminal DNA structure of mammalian chromosomes
59. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end
60. A telomerase component is defective in the human disease dyskeratosis congenita
61. Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops
62. Two modes of survival of fission yeast without telomerase
63. TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
64. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
65. The telomerase reverse transcriptase: Components and regulation
66. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
67. Telomerase activity does not always imply telomere maintenance
68. The Saccharomyces telomere-binding protein Cdc 13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated Est1 protein
69. The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction
70. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
71. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle
72. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae
73. Transposition of the LINE-like retrotransposon TART to Drosophila chromosome termini
74. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
75. Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes
76. Control of human telomere length by TRF1 and TRF2
77. Association of the Est1 protein with telomerase activity in yeast
78. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae
79. Template boundary in a yeast telomerase specified by RNA structure
80. Control of telomere length by the human telomeric protein TRF1
81. TRF2 protects human telomeres from end-to-end fusions
82. Est1 has the properties of a single-stranded telomere end-binding protein
83. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase
84. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
85. The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA