Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization

Current Biology

Volumn 11, Issue 13, 2001, Pages 1062-1067

  Nakamura, Masafumi ^a   Zhou, Xiao Zhen ^a   Lu, Kun Ping ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CARBOXY TERMINAL SEQUENCE; GENETIC CONSERVATION; GENETIC REGULATION; MICROTUBULE PROTEIN; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION;

EID: 0035838422     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00297-4     Document Type: Article

References (22)

1. APC binds to the novel protein EB1
2. EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle
3. The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules
4. The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules
5. Teaching tumour suppressors new tricks
6. Yeast Bim1p promotes the G1-specific dynamics of microtubules
7. Mutations in the APC tumour suppressor gene cause chromosomal instability
8. Cancer. A CINtillating new job for the APC tumor suppressor
9. A role for the adenomatous polyposis Coli protein in chromosome segregation
10. Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form
11. BlM1 encodes a microtubule-binding protein in yeast
12. Spindles cotton on to junctions, APC and EB1
13. Molecular linkage underlying microtubule orientation toward cortical sites in yeast
14. Positioning of the mitotic spindle by a cortical-microtubule capture mechanism
15. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein
16. Phosphorylation of the adenomatous polyposis coli protein and its possible regulatory effects in cells
17. Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34
18. Regulation and function of the interaction between the APC tumour suppressor protein and EB1
19. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin
20. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro
21. The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration
22. Wild-type but not mutant APC associates with the microtubule cytoskeleton